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The map label for this gene is zwf2 [H]

Identifier: 13473564

GI number: 13473564

Start: 3361698

End: 3363125

Strand: Direct

Name: zwf2 [H]

Synonym: mlr4207

Alternate gene names: 13473564

Gene position: 3361698-3363125 (Clockwise)

Preceding gene: 13473563

Following gene: 13473565

Centisome position: 47.78

GC content: 64.57

Gene sequence:

>1428_bases
ATGTCGAAAAGCCGAAGGCCGGCAAGTGACGCCACAGCGGGAGACGCACGCATGAGCCAGGAACGGTCCGACACGCTGGT
GCTCTTCGGCGCCACCGGCGACCTCGCCCACAAGAAGATATTTCCGGCGCTTTACCAGATGGTCGCCAAGGGCACGCTCA
CCGAACCGGTGATCGGCGTCGCCTTCGACGCCTGGGACATCAAGCAGTTGCAGGCCCGCGCCCGCGACGGCATCGTCAAC
GCGCTGGGCAAGATCGACGAGAAGGTGTTCGCCAAATTCGCTTCGTTGCTGCGCTATGTCAGCGGCGACTACCGCGATCC
GGCCACCTTCGAGAAACTGAAGACCGCGCTTGGCACCGCCCAGCGGCCGCTGCACTACATGGCGGTGCCGCCGACCATGT
TCGAGACTGTCGTTCAAGGGTTGGAGCAGTCGGGAACCGCGCGTGGCGCACGGCTGATGGTGGAAAAGCCGTTCGGCCAT
GATCTGCAGTCGGCGCGCTGGCTGAACCGGGTGCTGCATCTGGTGTTCGACGAACAGTCGATCTTCCGCATCGACCACTA
TCTCGGCAAGGAAGCGATCCAGAACCTGCTTTATTTCCGCTTCGCCAATTCCTTCCTCGAGCCGATCTGGAACCGCAATT
TCGTCGAGAGCGTGCAGATCACCATGGCCGAGGATTTCGGAGTCGAGGGGCGCGGCCGCTTCTATGACGATGTCGGCTGC
ATAAGGGATGTCATCGAGAACCATCTGCTCAACATCCTCCTGCTGCTGGCCATGGAGCCGCCGGTCGGCCGCTCCGCCGA
CGACCTGATCGACGAGAAGGTCCAGGTGCTCCGGGCGATCCGGACGCTGACGAAAGACGATGTCGTGCGCGGCCAGTTCA
CCGGCTATCTCGCCGAGCCCGGCGTGGCGCCGAATTCGCCGGTCGAAACCTTCGCTGCGGTGCGGTTCTTCGTCGACACA
TGGCGCTGGCAGGACGTGCCGTTCTTCATTCGCGCCGGCAAGAACATGCCGGTGCATGTTACGGAAGTGGTGGTGCGGCT
GAAGCGCCCGCCGCTCGACGTCTTCGACCCGATCAAGCCCGCCGACCAGAATTACGTGCGCTTCCGCATCGACCCGCAGG
TGGTGATCGCCATAGGCGCGCAGCGCAAGGCGCCCGGCGACGACATGGTCGGCGAGCAGGTGGAACTGACGGCGCTCGAC
GACAGCAAGGCCGACATGCCGCCTTACGAGCGCCTGATCGGCGACGCCATGAACGGCAATGGCCAGCTCTTCACCCGCCA
GGACGCGGCCGAGCTCGCCTGGCGCATCGTCGGGCCGGTGCTTGGCGACACCACGCCGCCGCATCTCTACGAGCCGAAAA
CATGGGGACCGGCGCACGCCATGGCCGGCTTCGGGCCGCCCAATGGCTGGATCGACCCGGTGGCATGA

Upstream 100 bases:

>100_bases
CCGGTGCTGTCCTCGGCGCTGTTCGACCGCTTCTCCTCGCAAGGCGAATCCGAATTCGCCGACAAGCTGTTGTCCGCCAT
GCGCTATGCCTTCGGCGGCC

Downstream 100 bases:

>100_bases
GTGGAGGGGACGCGATGGCCAAGGCGGTGAAGCAACCGGCACCCGACGCCGAGCAGATCGTTCTGGCGATCGACATTGGC
GGCTCGCACGTCAAGATCCT

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 475; Mature: 474

Protein sequence:

>475_residues
MSKSRRPASDATAGDARMSQERSDTLVLFGATGDLAHKKIFPALYQMVAKGTLTEPVIGVAFDAWDIKQLQARARDGIVN
ALGKIDEKVFAKFASLLRYVSGDYRDPATFEKLKTALGTAQRPLHYMAVPPTMFETVVQGLEQSGTARGARLMVEKPFGH
DLQSARWLNRVLHLVFDEQSIFRIDHYLGKEAIQNLLYFRFANSFLEPIWNRNFVESVQITMAEDFGVEGRGRFYDDVGC
IRDVIENHLLNILLLLAMEPPVGRSADDLIDEKVQVLRAIRTLTKDDVVRGQFTGYLAEPGVAPNSPVETFAAVRFFVDT
WRWQDVPFFIRAGKNMPVHVTEVVVRLKRPPLDVFDPIKPADQNYVRFRIDPQVVIAIGAQRKAPGDDMVGEQVELTALD
DSKADMPPYERLIGDAMNGNGQLFTRQDAAELAWRIVGPVLGDTTPPHLYEPKTWGPAHAMAGFGPPNGWIDPVA

Sequences:

>Translated_475_residues
MSKSRRPASDATAGDARMSQERSDTLVLFGATGDLAHKKIFPALYQMVAKGTLTEPVIGVAFDAWDIKQLQARARDGIVN
ALGKIDEKVFAKFASLLRYVSGDYRDPATFEKLKTALGTAQRPLHYMAVPPTMFETVVQGLEQSGTARGARLMVEKPFGH
DLQSARWLNRVLHLVFDEQSIFRIDHYLGKEAIQNLLYFRFANSFLEPIWNRNFVESVQITMAEDFGVEGRGRFYDDVGC
IRDVIENHLLNILLLLAMEPPVGRSADDLIDEKVQVLRAIRTLTKDDVVRGQFTGYLAEPGVAPNSPVETFAAVRFFVDT
WRWQDVPFFIRAGKNMPVHVTEVVVRLKRPPLDVFDPIKPADQNYVRFRIDPQVVIAIGAQRKAPGDDMVGEQVELTALD
DSKADMPPYERLIGDAMNGNGQLFTRQDAAELAWRIVGPVLGDTTPPHLYEPKTWGPAHAMAGFGPPNGWIDPVA
>Mature_474_residues
SKSRRPASDATAGDARMSQERSDTLVLFGATGDLAHKKIFPALYQMVAKGTLTEPVIGVAFDAWDIKQLQARARDGIVNA
LGKIDEKVFAKFASLLRYVSGDYRDPATFEKLKTALGTAQRPLHYMAVPPTMFETVVQGLEQSGTARGARLMVEKPFGHD
LQSARWLNRVLHLVFDEQSIFRIDHYLGKEAIQNLLYFRFANSFLEPIWNRNFVESVQITMAEDFGVEGRGRFYDDVGCI
RDVIENHLLNILLLLAMEPPVGRSADDLIDEKVQVLRAIRTLTKDDVVRGQFTGYLAEPGVAPNSPVETFAAVRFFVDTW
RWQDVPFFIRAGKNMPVHVTEVVVRLKRPPLDVFDPIKPADQNYVRFRIDPQVVIAIGAQRKAPGDDMVGEQVELTALDD
SKADMPPYERLIGDAMNGNGQLFTRQDAAELAWRIVGPVLGDTTPPHLYEPKTWGPAHAMAGFGPPNGWIDPVA

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=450, Percent_Identity=36, Blast_Score=273, Evalue=2e-73,
Organism=Homo sapiens, GI109389365, Length=450, Percent_Identity=36, Blast_Score=273, Evalue=2e-73,
Organism=Homo sapiens, GI52145310, Length=343, Percent_Identity=34.6938775510204, Blast_Score=167, Evalue=3e-41,
Organism=Escherichia coli, GI1788158, Length=468, Percent_Identity=37.3931623931624, Blast_Score=305, Evalue=5e-84,
Organism=Caenorhabditis elegans, GI17538218, Length=509, Percent_Identity=33.2023575638507, Blast_Score=265, Evalue=4e-71,
Organism=Saccharomyces cerevisiae, GI6324088, Length=470, Percent_Identity=35.3191489361702, Blast_Score=275, Evalue=1e-74,
Organism=Drosophila melanogaster, GI24643350, Length=465, Percent_Identity=35.9139784946237, Blast_Score=270, Evalue=2e-72,
Organism=Drosophila melanogaster, GI24643352, Length=465, Percent_Identity=35.9139784946237, Blast_Score=269, Evalue=3e-72,
Organism=Drosophila melanogaster, GI221513548, Length=471, Percent_Identity=28.4501061571125, Blast_Score=179, Evalue=3e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 53046; Mature: 52915

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKSRRPASDATAGDARMSQERSDTLVLFGATGDLAHKKIFPALYQMVAKGTLTEPVIGV
CCCCCCCCCCCCCCHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCEE
AFDAWDIKQLQARARDGIVNALGKIDEKVFAKFASLLRYVSGDYRDPATFEKLKTALGTA
EECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
QRPLHYMAVPPTMFETVVQGLEQSGTARGARLMVEKPFGHDLQSARWLNRVLHLVFDEQS
HCCCEEEECCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCH
IFRIDHYLGKEAIQNLLYFRFANSFLEPIWNRNFVESVQITMAEDFGVEGRGRFYDDVGC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHEEEEHHCCCCCCCCCCHHHHHH
IRDVIENHLLNILLLLAMEPPVGRSADDLIDEKVQVLRAIRTLTKDDVVRGQFTGYLAEP
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCC
GVAPNSPVETFAAVRFFVDTWRWQDVPFFIRAGKNMPVHVTEVVVRLKRPPLDVFDPIKP
CCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCC
ADQNYVRFRIDPQVVIAIGAQRKAPGDDMVGEQVELTALDDSKADMPPYERLIGDAMNGN
CCCCEEEEEECCEEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHCCCCC
GQLFTRQDAAELAWRIVGPVLGDTTPPHLYEPKTWGPAHAMAGFGPPNGWIDPVA
CCEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
SKSRRPASDATAGDARMSQERSDTLVLFGATGDLAHKKIFPALYQMVAKGTLTEPVIGV
CCCCCCCCCCCCCHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCEE
AFDAWDIKQLQARARDGIVNALGKIDEKVFAKFASLLRYVSGDYRDPATFEKLKTALGTA
EECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
QRPLHYMAVPPTMFETVVQGLEQSGTARGARLMVEKPFGHDLQSARWLNRVLHLVFDEQS
HCCCEEEECCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCH
IFRIDHYLGKEAIQNLLYFRFANSFLEPIWNRNFVESVQITMAEDFGVEGRGRFYDDVGC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHEEEEHHCCCCCCCCCCHHHHHH
IRDVIENHLLNILLLLAMEPPVGRSADDLIDEKVQVLRAIRTLTKDDVVRGQFTGYLAEP
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCC
GVAPNSPVETFAAVRFFVDTWRWQDVPFFIRAGKNMPVHVTEVVVRLKRPPLDVFDPIKP
CCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCC
ADQNYVRFRIDPQVVIAIGAQRKAPGDDMVGEQVELTALDDSKADMPPYERLIGDAMNGN
CCCCEEEEEECCEEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHCCCCC
GQLFTRQDAAELAWRIVGPVLGDTTPPHLYEPKTWGPAHAMAGFGPPNGWIDPVA
CCEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]