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The map label for this gene is groEL

Identifier: 13472058

GI number: 13472058

Start: 1799394

End: 1801025

Strand: Reverse

Name: groEL

Synonym: mll2232

Alternate gene names: 13472058

Gene position: 1801025-1799394 (Counterclockwise)

Preceding gene: 13472059

Following gene: 13472057

Centisome position: 25.6

GC content: 64.77

Gene sequence:

>1632_bases
ATGTCTGCCAAGGAAATCAAATTCGCCACCGACGCGCGTGACCGCATGCTGCGCGGCGTCGAGATCCTCACCAATGCGGT
GAAGGTCACGCTGGGCCCCAAGGGCCGCAACGTCATCATCGACAAGGCCTATGGCGCGCCGCGCATCACCAAGGACGGCG
TCACCGTCGCCAAGGAAATCGAGCTTGCCGACAAGTTCGAGAACATGGGCGCGCAGATGGTGCGCGAAGTGGCCTCGAAG
ACCAATGATCTCGCCGGCGACGGTACCACCACCGCGACCGTGCTGGCCGCCTCGATCCTGCGCGAGGGCGCCAAGCTGGT
TGCCGCCGGCATGAACCCGATGGACTTGAAGCGCGGCATCGACCAGGCGGTTGCCGCCGTCGTCGTCGAGATCAAGGCGA
AGGCCAAGAAGGTCAAGTCGTCGGCCGAGATCGCCCAGGTCGGCACCATCGCCGCCAACGGCGATGCAACCGTCGGCGCG
ATGATCGCCAAGGCGATGGACAAGGTCGGCAATGACGGCGTCATCACCGTCGAGGAAGCCAAGACCGCCGAAACCGAACT
CGACGTCGTCGAGGGCATGCAGTTCGACCGTGGCTATCTCAGCCCGTATTTCGTCACCAATGCCGACAAGATGCGCGTCG
AGCTGGAAGAGCCCTATGTGCTCATCCACGAGAAGAAGCTCGGCAATCTGCAGGCGATGCTGCCGATCCTCGAAGCGGTG
GTGCAGAGCGGCAGGCCGCTGCTGATCATCTCCGAGGACGTCGAAGGCGAAGCGCTTGCCACGCTGGTCGTCAACAAATT
GCGCGGCGGCCTCAAGGTCGCGGCCGTCAAGGCGCCGGGCTTCGGTGATCGCCGCAAGGCGATGCTGGAAGACATCGCGG
TGCTGACCGCAGGCCAGATGATTTCCGAGGATCTCGGCATCAAGCTCGAAAACGTCACCATCGAGATGCTCGGCCGCGCC
AAGCGTGTGCTGATCGAGAAGGACACCACCACGATCATCGACGGCGCCGGCACCAAGGCGACCATCCAGGCGCGCGTCGC
CCAGATCAAGGGCCAGATCGAGGAGACCACCTCCGACTACGACAAGGAGAAGCTGCAGGAGCGGCTGGCCAAGCTGTCGG
GCGGCGTTGCCGTCATCCGCGTCGGCGGCGTCACCGAGTCGGAAGTCAAGGAAAAGAAGGACCGCATCGACGATGCGTTG
AACGCGACGCGCGCGGCGGTCGAGGAAGGCATCGTGCCCGGCGGCGGCGTCGCCCTGCTGCGCGCAAGGTCGGCGCTGTC
GGGCCTCAACGGCGCCAATGCCGATGTCACCGCCGGCATTTCGATCGTGCTCAGGGCGCTTGAAGCGCCGATCCGCCAGA
TCGCCGAGAATTCCGGCGTCGAGGGCTCGATCGTCGTCGGCAAGCTCGCCGACAGCAAGGACCACAATCTGGGTTTTGAC
GCCCAGAACGAGACCTATGTCGACATGATCAAGGCCGGCATCGTCGACCCGGCGAAAGTCGTGCGCACCGCACTGCAGGA
CGCCGGCTCGATCGCAGCACTTCTGATCACCGCCGAAGCCATGATCACCGACATCCCGGCCAAGGATGCGGCGCCTGCCG
GCGGTGGCGGCGGCGGGATGGGCGGCTACTAA

Upstream 100 bases:

>100_bases
GTCATCGACAAGAGCGTCGAAGCCAAGAAGGCCGCCTGACTGGAGCGCCGCGCCTTCCGCGCGGGGTTCGTCCACTCCAA
ATTCGAACGGGATTGAAAAA

Downstream 100 bases:

>100_bases
GGATTCAGCCGGTCTGGAAGGTGGTTCATACGAGTCACCTTTTAGCCTGACCTGAATCCGCGCCGGCTCCAGGAGCCGGT
TGCTACCGCCGGGGGATTTT

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 1; Protein Cpn60 1

Number of amino acids: Translated: 543; Mature: 542

Protein sequence:

>543_residues
MSAKEIKFATDARDRMLRGVEILTNAVKVTLGPKGRNVIIDKAYGAPRITKDGVTVAKEIELADKFENMGAQMVREVASK
TNDLAGDGTTTATVLAASILREGAKLVAAGMNPMDLKRGIDQAVAAVVVEIKAKAKKVKSSAEIAQVGTIAANGDATVGA
MIAKAMDKVGNDGVITVEEAKTAETELDVVEGMQFDRGYLSPYFVTNADKMRVELEEPYVLIHEKKLGNLQAMLPILEAV
VQSGRPLLIISEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLEDIAVLTAGQMISEDLGIKLENVTIEMLGRA
KRVLIEKDTTTIIDGAGTKATIQARVAQIKGQIEETTSDYDKEKLQERLAKLSGGVAVIRVGGVTESEVKEKKDRIDDAL
NATRAAVEEGIVPGGGVALLRARSALSGLNGANADVTAGISIVLRALEAPIRQIAENSGVEGSIVVGKLADSKDHNLGFD
AQNETYVDMIKAGIVDPAKVVRTALQDAGSIAALLITAEAMITDIPAKDAAPAGGGGGGMGGY

Sequences:

>Translated_543_residues
MSAKEIKFATDARDRMLRGVEILTNAVKVTLGPKGRNVIIDKAYGAPRITKDGVTVAKEIELADKFENMGAQMVREVASK
TNDLAGDGTTTATVLAASILREGAKLVAAGMNPMDLKRGIDQAVAAVVVEIKAKAKKVKSSAEIAQVGTIAANGDATVGA
MIAKAMDKVGNDGVITVEEAKTAETELDVVEGMQFDRGYLSPYFVTNADKMRVELEEPYVLIHEKKLGNLQAMLPILEAV
VQSGRPLLIISEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLEDIAVLTAGQMISEDLGIKLENVTIEMLGRA
KRVLIEKDTTTIIDGAGTKATIQARVAQIKGQIEETTSDYDKEKLQERLAKLSGGVAVIRVGGVTESEVKEKKDRIDDAL
NATRAAVEEGIVPGGGVALLRARSALSGLNGANADVTAGISIVLRALEAPIRQIAENSGVEGSIVVGKLADSKDHNLGFD
AQNETYVDMIKAGIVDPAKVVRTALQDAGSIAALLITAEAMITDIPAKDAAPAGGGGGGMGGY
>Mature_542_residues
SAKEIKFATDARDRMLRGVEILTNAVKVTLGPKGRNVIIDKAYGAPRITKDGVTVAKEIELADKFENMGAQMVREVASKT
NDLAGDGTTTATVLAASILREGAKLVAAGMNPMDLKRGIDQAVAAVVVEIKAKAKKVKSSAEIAQVGTIAANGDATVGAM
IAKAMDKVGNDGVITVEEAKTAETELDVVEGMQFDRGYLSPYFVTNADKMRVELEEPYVLIHEKKLGNLQAMLPILEAVV
QSGRPLLIISEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLEDIAVLTAGQMISEDLGIKLENVTIEMLGRAK
RVLIEKDTTTIIDGAGTKATIQARVAQIKGQIEETTSDYDKEKLQERLAKLSGGVAVIRVGGVTESEVKEKKDRIDDALN
ATRAAVEEGIVPGGGVALLRARSALSGLNGANADVTAGISIVLRALEAPIRQIAENSGVEGSIVVGKLADSKDHNLGFDA
QNETYVDMIKAGIVDPAKVVRTALQDAGSIAALLITAEAMITDIPAKDAAPAGGGGGGMGGY

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=531, Percent_Identity=52.9190207156309, Blast_Score=553, Evalue=1e-157,
Organism=Homo sapiens, GI31542947, Length=531, Percent_Identity=52.9190207156309, Blast_Score=553, Evalue=1e-157,
Organism=Homo sapiens, GI5453607, Length=546, Percent_Identity=22.7106227106227, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1790586, Length=531, Percent_Identity=65.9133709981168, Blast_Score=690, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=52.7410207939509, Blast_Score=550, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI193210679, Length=222, Percent_Identity=52.2522522522522, Blast_Score=224, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=56.8441064638783, Blast_Score=583, Evalue=1e-167,
Organism=Saccharomyces cerevisiae, GI6322524, Length=503, Percent_Identity=23.8568588469185, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24641193, Length=528, Percent_Identity=53.219696969697, Blast_Score=555, Evalue=1e-158,
Organism=Drosophila melanogaster, GI24641191, Length=528, Percent_Identity=53.219696969697, Blast_Score=555, Evalue=1e-158,
Organism=Drosophila melanogaster, GI45550936, Length=528, Percent_Identity=51.1363636363636, Blast_Score=532, Evalue=1e-151,
Organism=Drosophila melanogaster, GI45550132, Length=528, Percent_Identity=51.1363636363636, Blast_Score=532, Evalue=1e-151,
Organism=Drosophila melanogaster, GI45550935, Length=528, Percent_Identity=51.1363636363636, Blast_Score=532, Evalue=1e-151,
Organism=Drosophila melanogaster, GI17864606, Length=544, Percent_Identity=44.6691176470588, Blast_Score=461, Evalue=1e-130,
Organism=Drosophila melanogaster, GI24584129, Length=533, Percent_Identity=36.2101313320826, Blast_Score=320, Evalue=1e-87,
Organism=Drosophila melanogaster, GI19921262, Length=533, Percent_Identity=36.2101313320826, Blast_Score=320, Evalue=1e-87,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH601_RHILO (Q98IV5)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_103625.1
- ProteinModelPortal:   Q98IV5
- SMR:   Q98IV5
- GeneID:   1226286
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mll2232
- NMPDR:   fig|266835.1.peg.1729
- HOGENOM:   HBG625289
- OMA:   LGNLQAM
- ProtClustDB:   PRK12852
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 56842; Mature: 56711

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAKEIKFATDARDRMLRGVEILTNAVKVTLGPKGRNVIIDKAYGAPRITKDGVTVAKEI
CCCCCEEEHHHHHHHHHHHHHHHHHCEEEEECCCCCEEEEECCCCCCCCCCCCCHHHHHH
ELADKFENMGAQMVREVASKTNDLAGDGTTTATVLAASILREGAKLVAAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCHHHHHHHH
DQAVAAVVVEIKAKAKKVKSSAEIAQVGTIAANGDATVGAMIAKAMDKVGNDGVITVEEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCEEECCCCCHHHHHHHHHHHHCCCCCEEEEECC
KTAETELDVVEGMQFDRGYLSPYFVTNADKMRVELEEPYVLIHEKKLGNLQAMLPILEAV
CCCHHHHHHHHCCCCCCCCCCCEEEECCCCEEEEECCCEEEEEECCCCCHHHHHHHHHHH
VQSGRPLLIISEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLEDIAVLTAGQM
HHCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHH
ISEDLGIKLENVTIEMLGRAKRVLIEKDTTTIIDGAGTKATIQARVAQIKGQIEETTSDY
HHHHHCEEEEEEHHHHHCCHHHEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCHH
DKEKLQERLAKLSGGVAVIRVGGVTESEVKEKKDRIDDALNATRAAVEEGIVPGGGVALL
HHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RARSALSGLNGANADVTAGISIVLRALEAPIRQIAENSGVEGSIVVGKLADSKDHNLGFD
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCC
AQNETYVDMIKAGIVDPAKVVRTALQDAGSIAALLITAEAMITDIPAKDAAPAGGGGGGM
CCCCHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
GGY
CCC
>Mature Secondary Structure 
SAKEIKFATDARDRMLRGVEILTNAVKVTLGPKGRNVIIDKAYGAPRITKDGVTVAKEI
CCCCEEEHHHHHHHHHHHHHHHHHCEEEEECCCCCEEEEECCCCCCCCCCCCCHHHHHH
ELADKFENMGAQMVREVASKTNDLAGDGTTTATVLAASILREGAKLVAAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCHHHHHHHH
DQAVAAVVVEIKAKAKKVKSSAEIAQVGTIAANGDATVGAMIAKAMDKVGNDGVITVEEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCEEECCCCCHHHHHHHHHHHHCCCCCEEEEECC
KTAETELDVVEGMQFDRGYLSPYFVTNADKMRVELEEPYVLIHEKKLGNLQAMLPILEAV
CCCHHHHHHHHCCCCCCCCCCCEEEECCCCEEEEECCCEEEEEECCCCCHHHHHHHHHHH
VQSGRPLLIISEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLEDIAVLTAGQM
HHCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHH
ISEDLGIKLENVTIEMLGRAKRVLIEKDTTTIIDGAGTKATIQARVAQIKGQIEETTSDY
HHHHHCEEEEEEHHHHHCCHHHEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCHH
DKEKLQERLAKLSGGVAVIRVGGVTESEVKEKKDRIDDALNATRAAVEEGIVPGGGVALL
HHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RARSALSGLNGANADVTAGISIVLRALEAPIRQIAENSGVEGSIVVGKLADSKDHNLGFD
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCC
AQNETYVDMIKAGIVDPAKVVRTALQDAGSIAALLITAEAMITDIPAKDAAPAGGGGGGM
CCCCHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
GGY
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968