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The map label for this gene is deoR [H]

Identifier: 13471822

GI number: 13471822

Start: 1579578

End: 1580321

Strand: Reverse

Name: deoR [H]

Synonym: mll1922

Alternate gene names: 13471822

Gene position: 1580321-1579578 (Counterclockwise)

Preceding gene: 13471823

Following gene: 13471821

Centisome position: 22.46

GC content: 60.08

Gene sequence:

>744_bases
ATGACGGTTCGCAAAGCGCAAAGAACGGCACGGCTGATCGATCTGCTGTCGCAGCGGCGGGTCATCCATCTCAGCGAAGC
GGCGGCGCTGCTCGGCGTTTCCGAGATGACGGTGCGGCGTGACATCGCCACCAACCAGGGACAGATCGCCTATCTCGGCG
GACACATTTTGGCGGCGGCCGAGATCGAAGCCGATATTCCCTATGAACTGGCGACGGCGGCCGACAGCCATGCGGCGGCC
AAGCGCGAAGCCTGCGCGCATGCGGTGCGCAAGATACGGCCCGACGAGACGATCTTCATCGACTGCGGCACGACGCTGAT
CCATCTGGTCGATCTCATTCCCGAAAATTATCAAATAACGGCAATATGTTACGCCATGAATGTGGCGGAACGCCTGAGCC
GCAAGCCCAATGTCACGATTATCATGCTGGGCGGTGTCTATCATCCAGCCTCGGCCTCTTTCTCGGGCACGCATGATTTC
GACATTTTGAACAGCGTCGGCATCAACGTGGCCTTCCTGTCAGCCGCCGGCGTCGATGCCAAGCGCGGCGCCACCTGCGA
GCATTTCCACGAGGCGGTGGTGAAGCAGAAGGTGATGAGCCTGGCGCGCGAAAACTATCTGGTCATCGACTCGAGCAAGA
TCGGCAAGCTCAAGCGGGCCTTTTTCTCGGCCATGGATGGCTTCGACGCTGTCATCACCGAGCATGGCGAGATCGGGCCG
GATTCATTCCAGCCGCAGGCATGA

Upstream 100 bases:

>100_bases
CGCACCTAAAGAGACCTAGGGCGGACTTGGACTGTGGACTTGCATCTGAATGCGGGCGGTTGTTAAAATCCTCACATTTC
AGGATGCACAGGCCCAACGC

Downstream 100 bases:

>100_bases
CTCCGTTTGACTTTTCCTCGTCCTGATGGAAAAGTCACAAAAAAAGTAAGAGAAGTCTCAAAAGGGACTCGACAGGGTAG
GGGACGCGTCAACGGGAGGA

Product: deoxyribose operon repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 247; Mature: 246

Protein sequence:

>247_residues
MTVRKAQRTARLIDLLSQRRVIHLSEAAALLGVSEMTVRRDIATNQGQIAYLGGHILAAAEIEADIPYELATAADSHAAA
KREACAHAVRKIRPDETIFIDCGTTLIHLVDLIPENYQITAICYAMNVAERLSRKPNVTIIMLGGVYHPASASFSGTHDF
DILNSVGINVAFLSAAGVDAKRGATCEHFHEAVVKQKVMSLARENYLVIDSSKIGKLKRAFFSAMDGFDAVITEHGEIGP
DSFQPQA

Sequences:

>Translated_247_residues
MTVRKAQRTARLIDLLSQRRVIHLSEAAALLGVSEMTVRRDIATNQGQIAYLGGHILAAAEIEADIPYELATAADSHAAA
KREACAHAVRKIRPDETIFIDCGTTLIHLVDLIPENYQITAICYAMNVAERLSRKPNVTIIMLGGVYHPASASFSGTHDF
DILNSVGINVAFLSAAGVDAKRGATCEHFHEAVVKQKVMSLARENYLVIDSSKIGKLKRAFFSAMDGFDAVITEHGEIGP
DSFQPQA
>Mature_246_residues
TVRKAQRTARLIDLLSQRRVIHLSEAAALLGVSEMTVRRDIATNQGQIAYLGGHILAAAEIEADIPYELATAADSHAAAK
REACAHAVRKIRPDETIFIDCGTTLIHLVDLIPENYQITAICYAMNVAERLSRKPNVTIIMLGGVYHPASASFSGTHDFD
ILNSVGINVAFLSAAGVDAKRGATCEHFHEAVVKQKVMSLARENYLVIDSSKIGKLKRAFFSAMDGFDAVITEHGEIGPD
SFQPQA

Specific function: This protein is one of the repressors that regulate the expression of deoCABD genes, which encode nucleotide and deoxy ribonucleotide catabolizing enzymes. It also negatively regulates the expression of nupG (a transport protein) and tsx (a pore- forming

COG id: COG1349

COG function: function code KG; Transcriptional regulators of sugar metabolism

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH deoR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787063, Length=234, Percent_Identity=36.3247863247863, Blast_Score=157, Evalue=5e-40,
Organism=Escherichia coli, GI1789519, Length=243, Percent_Identity=27.1604938271605, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1789059, Length=239, Percent_Identity=28.0334728033473, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1790753, Length=238, Percent_Identity=24.7899159663866, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI226510968, Length=233, Percent_Identity=25.3218884120172, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1787540, Length=228, Percent_Identity=26.7543859649123, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1789829, Length=236, Percent_Identity=24.1525423728814, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014036
- InterPro:   IPR001034
- InterPro:   IPR018356
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00455 DeoR; PF08220 HTH_DeoR [H]

EC number: NA

Molecular weight: Translated: 26800; Mature: 26669

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS00894 HTH_DEOR_1 ; PS51000 HTH_DEOR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVRKAQRTARLIDLLSQRRVIHLSEAAALLGVSEMTVRRDIATNQGQIAYLGGHILAAA
CCCHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCEEEEEE
EIEADIPYELATAADSHAAAKREACAHAVRKIRPDETIFIDCGTTLIHLVDLIPENYQIT
EECCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHCCCCCEEE
AICYAMNVAERLSRKPNVTIIMLGGVYHPASASFSGTHDFDILNSVGINVAFLSAAGVDA
EHHHHHHHHHHHCCCCCEEEEEECCEECCCCCCCCCCCCHHHHHHCCCEEEEEEECCCCC
KRGATCEHFHEAVVKQKVMSLARENYLVIDSSKIGKLKRAFFSAMDGFDAVITEHGEIGP
CCCCCHHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHHCCHHHHHHCCCCCCC
DSFQPQA
CCCCCCC
>Mature Secondary Structure 
TVRKAQRTARLIDLLSQRRVIHLSEAAALLGVSEMTVRRDIATNQGQIAYLGGHILAAA
CCHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCEEEEEE
EIEADIPYELATAADSHAAAKREACAHAVRKIRPDETIFIDCGTTLIHLVDLIPENYQIT
EECCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHCCCCCEEE
AICYAMNVAERLSRKPNVTIIMLGGVYHPASASFSGTHDFDILNSVGINVAFLSAAGVDA
EHHHHHHHHHHHCCCCCEEEEEECCEECCCCCCCCCCCCHHHHHHCCCEEEEEEECCCCC
KRGATCEHFHEAVVKQKVMSLARENYLVIDSSKIGKLKRAFFSAMDGFDAVITEHGEIGP
CCCCCHHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHHCCHHHHHHCCCCCCC
DSFQPQA
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]