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The map label for this gene is fabG [H]

Identifier: 13471131

GI number: 13471131

Start: 842930

End: 843760

Strand: Reverse

Name: fabG [H]

Synonym: mll1017

Alternate gene names: 13471131

Gene position: 843760-842930 (Counterclockwise)

Preceding gene: 13471132

Following gene: 13471130

Centisome position: 11.99

GC content: 60.53

Gene sequence:

>831_bases
ATGCTGGAACAGGTTTCCCCGGCTGCAATCGGCGCTGCTATGCCCGAGAAAGCAGCGTCCATCAACCGCGGGCTTGCCAT
TGTGACGGGAGGCCGTCGTGGCATCGGGCGAGCCATCTGTTGTGAACTCGCGCAGGCGGGTTTCGACATCGCTGTCATTG
ATATCGTCGACGATGAGAATGCCAGCGAGACTGTCAATCTTGTCCGCAGGCACGGGCGAAATGCTGCCTTTTATCGCAAG
GACATATCCGAAACCTCGGACAATACGGCCTTGATAGAGCGCATCGAAGCCGATCTGGGGGGGGCCACTTGCCTGGTCAA
CAACGCTGGCGTCCAGGTTTCAGTGCGTGGCGATCTACTCGATGTTTCCGAGGAGAGCTTCGACCGGCTCGTCGGTATCA
ATCTGCGCGGCACGTTCTTCTTCACCCAGGCCGTCGCTCGCGCGATGATTTCCCGGCCGCATGTCCGGCTCGAACGATCG
GTCGTGACGATCACCTCTGCGAACGCAGGCTTGGTCTCGCCGGAAAAAGGGCCGTACTGCATATCCAAGGCTGGACTGTC
GATGGCTTCCCAGCAGTTCGCCATTCGTCTGGCGGATACAGGCATCCGGGTGCACGAGATTCGCCCAGGCCTGATCCAGA
CCGACATGACCGCAGACGTCTATGAGAAATATTCGGCGCAGGTCGAAGCCGGACAACTCTCGGCAATCAGACGGTGGGGG
CAGCCTGAAGACATTGCCCGCGGGGTGGCGACGCTGGCCGTCGGCGGCATGCCATTCAGCACCGGGGACATCTACCACAT
CGGCGGCGGCATGCAGATGCATCGCCTGTGA

Upstream 100 bases:

>100_bases
AGCTTGGCTATGCGGAAGTTGAGATCCAGCGCCTGCTGACGTCAAAGGCCGTGGTCGCATCCCGCGAAAAGGATGATGCG
GTGGCAAGGAAGGCTTCGTG

Downstream 100 bases:

>100_bases
GCTTTTTTTGAGGAACCGTGAAAACGATTTCTCGGTTTGGAGACGAGGATGAAGGACGCAGTTCTCGAAATGCGCGGCAT
CCACAAGCGCTTTCCGGGTG

Product: 3-ketoacyl-(acyl-carrier-protein) reductase

Products: NA

Alternate protein names: 3-ketoacyl-acyl carrier protein reductase [H]

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MLEQVSPAAIGAAMPEKAASINRGLAIVTGGRRGIGRAICCELAQAGFDIAVIDIVDDENASETVNLVRRHGRNAAFYRK
DISETSDNTALIERIEADLGGATCLVNNAGVQVSVRGDLLDVSEESFDRLVGINLRGTFFFTQAVARAMISRPHVRLERS
VVTITSANAGLVSPEKGPYCISKAGLSMASQQFAIRLADTGIRVHEIRPGLIQTDMTADVYEKYSAQVEAGQLSAIRRWG
QPEDIARGVATLAVGGMPFSTGDIYHIGGGMQMHRL

Sequences:

>Translated_276_residues
MLEQVSPAAIGAAMPEKAASINRGLAIVTGGRRGIGRAICCELAQAGFDIAVIDIVDDENASETVNLVRRHGRNAAFYRK
DISETSDNTALIERIEADLGGATCLVNNAGVQVSVRGDLLDVSEESFDRLVGINLRGTFFFTQAVARAMISRPHVRLERS
VVTITSANAGLVSPEKGPYCISKAGLSMASQQFAIRLADTGIRVHEIRPGLIQTDMTADVYEKYSAQVEAGQLSAIRRWG
QPEDIARGVATLAVGGMPFSTGDIYHIGGGMQMHRL
>Mature_276_residues
MLEQVSPAAIGAAMPEKAASINRGLAIVTGGRRGIGRAICCELAQAGFDIAVIDIVDDENASETVNLVRRHGRNAAFYRK
DISETSDNTALIERIEADLGGATCLVNNAGVQVSVRGDLLDVSEESFDRLVGINLRGTFFFTQAVARAMISRPHVRLERS
VVTITSANAGLVSPEKGPYCISKAGLSMASQQFAIRLADTGIRVHEIRPGLIQTDMTADVYEKYSAQVEAGQLSAIRRWG
QPEDIARGVATLAVGGMPFSTGDIYHIGGGMQMHRL

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=261, Percent_Identity=33.3333333333333, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI32483357, Length=246, Percent_Identity=31.3008130081301, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI40254992, Length=247, Percent_Identity=28.7449392712551, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI4758504, Length=261, Percent_Identity=26.8199233716475, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI210032110, Length=213, Percent_Identity=27.2300469483568, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI5031737, Length=248, Percent_Identity=26.6129032258064, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI19923817, Length=262, Percent_Identity=24.0458015267176, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI126723750, Length=254, Percent_Identity=27.1653543307087, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1787335, Length=254, Percent_Identity=33.4645669291339, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1789378, Length=249, Percent_Identity=28.9156626506024, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI1790717, Length=245, Percent_Identity=27.7551020408163, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1789208, Length=257, Percent_Identity=29.5719844357977, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788459, Length=249, Percent_Identity=27.3092369477912, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI2367175, Length=250, Percent_Identity=29.6, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI87082100, Length=255, Percent_Identity=28.6274509803922, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87082160, Length=251, Percent_Identity=25.4980079681275, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787905, Length=252, Percent_Identity=32.5396825396825, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1789057, Length=260, Percent_Identity=25, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI2367365, Length=243, Percent_Identity=27.9835390946502, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17560676, Length=251, Percent_Identity=31.8725099601594, Blast_Score=101, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17561402, Length=265, Percent_Identity=29.4339622641509, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI25147288, Length=249, Percent_Identity=30.1204819277108, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17555706, Length=259, Percent_Identity=28.957528957529, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI115534694, Length=245, Percent_Identity=26.530612244898, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71994604, Length=271, Percent_Identity=26.1992619926199, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562906, Length=245, Percent_Identity=29.3877551020408, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17562910, Length=255, Percent_Identity=29.0196078431373, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17538480, Length=244, Percent_Identity=27.8688524590164, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17536025, Length=258, Percent_Identity=27.1317829457364, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17551412, Length=255, Percent_Identity=27.4509803921569, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17559104, Length=243, Percent_Identity=27.9835390946502, Blast_Score=71, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI71994600, Length=255, Percent_Identity=23.921568627451, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17536651, Length=259, Percent_Identity=26.6409266409266, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17508651, Length=258, Percent_Identity=26.3565891472868, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17560332, Length=244, Percent_Identity=30.327868852459, Blast_Score=68, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17567345, Length=214, Percent_Identity=25.7009345794392, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI193204405, Length=248, Percent_Identity=26.6129032258064, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24639444, Length=249, Percent_Identity=33.7349397590361, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI23397609, Length=259, Percent_Identity=30.5019305019305, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI21355319, Length=249, Percent_Identity=28.9156626506024, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28571526, Length=260, Percent_Identity=28.4615384615385, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21357041, Length=250, Percent_Identity=28, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24644339, Length=254, Percent_Identity=27.1653543307087, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21355631, Length=187, Percent_Identity=32.620320855615, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI17737361, Length=259, Percent_Identity=27.4131274131274, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI281364892, Length=186, Percent_Identity=28.494623655914, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24649181, Length=249, Percent_Identity=26.9076305220884, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011284
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.100 [H]

Molecular weight: Translated: 29515; Mature: 29515

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEQVSPAAIGAAMPEKAASINRGLAIVTGGRRGIGRAICCELAQAGFDIAVIDIVDDEN
CCCCCCCHHHHCCCCHHHHHHCCCEEEEECCCCCCHHHHHHHHHHCCCCEEEEEEECCCC
ASETVNLVRRHGRNAAFYRKDISETSDNTALIERIEADLGGATCLVNNAGVQVSVRGDLL
HHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEECCCEEEEECCCEE
DVSEESFDRLVGINLRGTFFFTQAVARAMISRPHVRLERSVVTITSANAGLVSPEKGPYC
ECCHHHHHHEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEEEEEEECCCCCCCCCCCCEE
ISKAGLSMASQQFAIRLADTGIRVHEIRPGLIQTDMTADVYEKYSAQVEAGQLSAIRRWG
EEHHCHHHHCCEEEEEEECCCEEEEECCCCEEECCCHHHHHHHHHCCCCHHHHHHHHHCC
QPEDIARGVATLAVGGMPFSTGDIYHIGGGMQMHRL
CHHHHHHHHHHHEECCCCCCCCCEEEECCCEEECCC
>Mature Secondary Structure
MLEQVSPAAIGAAMPEKAASINRGLAIVTGGRRGIGRAICCELAQAGFDIAVIDIVDDEN
CCCCCCCHHHHCCCCHHHHHHCCCEEEEECCCCCCHHHHHHHHHHCCCCEEEEEEECCCC
ASETVNLVRRHGRNAAFYRKDISETSDNTALIERIEADLGGATCLVNNAGVQVSVRGDLL
HHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEECCCEEEEECCCEE
DVSEESFDRLVGINLRGTFFFTQAVARAMISRPHVRLERSVVTITSANAGLVSPEKGPYC
ECCHHHHHHEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEEEEEEECCCCCCCCCCCCEE
ISKAGLSMASQQFAIRLADTGIRVHEIRPGLIQTDMTADVYEKYSAQVEAGQLSAIRRWG
EEHHCHHHHCCEEEEEEECCCEEEEECCCCEEECCCHHHHHHHHHCCCCHHHHHHHHHCC
QPEDIARGVATLAVGGMPFSTGDIYHIGGGMQMHRL
CHHHHHHHHHHHEECCCCCCCCCEEEECCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8759840; 9384377; 9534248; 8654983 [H]