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The map label for this gene is thrS

Identifier: 13471046

GI number: 13471046

Start: 738204

End: 740180

Strand: Reverse

Name: thrS

Synonym: mll0914

Alternate gene names: 13471046

Gene position: 740180-738204 (Counterclockwise)

Preceding gene: 13471048

Following gene: 13471045

Centisome position: 10.52

GC content: 62.06

Gene sequence:

>1977_bases
ATGCTGAATTCCGTTTCCCTGACATTTCCCGATGGGTCCGTCCGCGACTACGACGCGGCGATGACCGGTGCCGGCCTTGC
CGAATCAATCTCGAAGTCGCTTGCCAAGAAGGCCGTCGCCTATGCCATTAACGGCACCGTGCGCGACCTCTCCGACCCGC
TCGGCAAGTCCGGCAAAGTCGAGATCATCACCCGCGACGATGCGCGCGCTCTTGAGCTTATCCGCCACGACACCGCGCAC
GTGCTGGCGGAGGCTGTGCAGGAATTGTGGCCGGGAACGCAGGTGACCATCGGACCGGTGATCGAGAACGGATTCTATTA
CGACTTCGCCCGCAACGAGCCGTTCACGCCGGACGATTTCCCGGTGATCGAGAAGAAGATGCGCGAGATCATCGCGCGCA
ACAAGCCGTTCACCAAGGAAGTCTGGTCGCGCGACAAGGCGAAAAAGGTGTTCGCCGACAAGGGCGAGCGTTACAAGCTC
GAACTGATCGACGCCATTCCCGAGGATCAGGACCTCAAGATCTACGCGCAGGGCGACTGGTTCGACCTCTGCCGTGGCCC
GCACATGGCCTCGACCGGCCAGATCGGCAACGCCTTCAAGCTGATGAAGGTGGCTGGCGCCTATTGGCGCGGCGATTCGA
ACAACCCGATGCTGACGCGCATCTACGGCACGGCCTGGGCCGACCAGGCGCAGCTCGAAGCCTACCAGACGATGCTGGAG
GAGGCCGAGAAGCGCGACCACCGCAAGCTTGGCCGCGAGATGGACCTCTTCCATTTCCAGGAAGAGGGGCCGGGTGTCGT
CTTCTGGCACGCCAAGGGCTGGAAGATGTTTCAGAACCTGGTCAACTATATGCGCCGCCGCCTCGACGAGCAGGGCTACC
AGGAGGTCAACGCGCCGCAGGTGCTCGACAAGAGCCTGTGGGAAACGTCAGGCCATTGGGGCTGGTATCGCGACGCCATG
TTCAAGGTGACGGTCGCCGGCGACGATACTGACGACGACCGCGTCTTTGCACTGAAGCCGATGAACTGCCCGGGCCATGT
GCAGATATTCAAGCATGGGTTGAAGTCCTATCGCGATCTGCCCGTAAAACTTGCGGAATTCGGCAATGTGCATCGCTACG
AACCGTCGGGTGCGCTGCACGGGCTGATGCGCGTGCGCGGCTTCACGCAGGATGATGCGCATATCTTCTGCACCGAGGAG
CAGCTGGCGTCGGAGTGCCTGCGCATCAACGATCTGATCCTGTCGACCTATGCCGATTTCGGTTTTGACGAAATCAGCGT
CAAGCTGTCGACGCGGCCCGACAAGCGTGTCGGCACCGACGAGGCCTGGGACCATGCCGAGGCGATCATGGGCAGCGTGC
TGGAGACGATCAGGACGCGGTCCGGCAACCGGATCAAGACCTCGATCAATCCGGGCGAGGGCGCCTTTTACGGGCCGAAG
TTCGAATATGTGCTGAAGGATGCCATCGGCCGCGAATGGCAGTGCGGCACCACGCAGGTCGATTTCAACCTGCCGGAACG
CTTTGGCGCCTTCTATATCGGCTCGGATTCGGAGAAGAAGCAGCCGGTCATGGTGCACCGCGCCATCTGCGGTTCAATGG
AGCGTTTCCTCGGCATCCTGATCGAGAACTATTCCGGCCATTTCCCGCTGTGGTTCGCGCCGCAGCAGGTGGTGGTGGCA
ACGATCACCTCCGAGGCGGACGGCTACGCGACCGAGGTCGTGGCAAAGCTGAAGGCCGCGGGGCTGCTGGCGGAAGCCGA
TCTGCGCAACGAGAAGATCAACTACAAGGTCCGCGAACACTCGCTAGCGAAGGTGCCGGTCATTCTCGTGTGTGGCAAGC
GCGAGGCTGAGGAACAGACGGTCAACATCCGCCGGCTCGGCTCGCGCGACCAGGAATCGCTTGGCCTTGCCGAGGCGATC
GCGCAGCTGACCGAAGAGGCAGTAACGCCGGACCGCAGGCGCAAACGCGCTGCCTGA

Upstream 100 bases:

>100_bases
TTACCTTATGCATGCCGTAACCCCAAAATCGCCATACACTTTTGGGCGACATGCATTTCAACCACCCGCGCTCGTTTGCG
GGACTGGATAGGAGAACCAT

Downstream 100 bases:

>100_bases
TCCGCATAGTTCCCAGGAATGGCGGTGGAGCGATCCACCGCCATTTTCATATCCCTGTCACGCCAACCTTGTAACGAGCC
CTCATGCTCAAGCTGAAGAC

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 658; Mature: 658

Protein sequence:

>658_residues
MLNSVSLTFPDGSVRDYDAAMTGAGLAESISKSLAKKAVAYAINGTVRDLSDPLGKSGKVEIITRDDARALELIRHDTAH
VLAEAVQELWPGTQVTIGPVIENGFYYDFARNEPFTPDDFPVIEKKMREIIARNKPFTKEVWSRDKAKKVFADKGERYKL
ELIDAIPEDQDLKIYAQGDWFDLCRGPHMASTGQIGNAFKLMKVAGAYWRGDSNNPMLTRIYGTAWADQAQLEAYQTMLE
EAEKRDHRKLGREMDLFHFQEEGPGVVFWHAKGWKMFQNLVNYMRRRLDEQGYQEVNAPQVLDKSLWETSGHWGWYRDAM
FKVTVAGDDTDDDRVFALKPMNCPGHVQIFKHGLKSYRDLPVKLAEFGNVHRYEPSGALHGLMRVRGFTQDDAHIFCTEE
QLASECLRINDLILSTYADFGFDEISVKLSTRPDKRVGTDEAWDHAEAIMGSVLETIRTRSGNRIKTSINPGEGAFYGPK
FEYVLKDAIGREWQCGTTQVDFNLPERFGAFYIGSDSEKKQPVMVHRAICGSMERFLGILIENYSGHFPLWFAPQQVVVA
TITSEADGYATEVVAKLKAAGLLAEADLRNEKINYKVREHSLAKVPVILVCGKREAEEQTVNIRRLGSRDQESLGLAEAI
AQLTEEAVTPDRRRKRAA

Sequences:

>Translated_658_residues
MLNSVSLTFPDGSVRDYDAAMTGAGLAESISKSLAKKAVAYAINGTVRDLSDPLGKSGKVEIITRDDARALELIRHDTAH
VLAEAVQELWPGTQVTIGPVIENGFYYDFARNEPFTPDDFPVIEKKMREIIARNKPFTKEVWSRDKAKKVFADKGERYKL
ELIDAIPEDQDLKIYAQGDWFDLCRGPHMASTGQIGNAFKLMKVAGAYWRGDSNNPMLTRIYGTAWADQAQLEAYQTMLE
EAEKRDHRKLGREMDLFHFQEEGPGVVFWHAKGWKMFQNLVNYMRRRLDEQGYQEVNAPQVLDKSLWETSGHWGWYRDAM
FKVTVAGDDTDDDRVFALKPMNCPGHVQIFKHGLKSYRDLPVKLAEFGNVHRYEPSGALHGLMRVRGFTQDDAHIFCTEE
QLASECLRINDLILSTYADFGFDEISVKLSTRPDKRVGTDEAWDHAEAIMGSVLETIRTRSGNRIKTSINPGEGAFYGPK
FEYVLKDAIGREWQCGTTQVDFNLPERFGAFYIGSDSEKKQPVMVHRAICGSMERFLGILIENYSGHFPLWFAPQQVVVA
TITSEADGYATEVVAKLKAAGLLAEADLRNEKINYKVREHSLAKVPVILVCGKREAEEQTVNIRRLGSRDQESLGLAEAI
AQLTEEAVTPDRRRKRAA
>Mature_658_residues
MLNSVSLTFPDGSVRDYDAAMTGAGLAESISKSLAKKAVAYAINGTVRDLSDPLGKSGKVEIITRDDARALELIRHDTAH
VLAEAVQELWPGTQVTIGPVIENGFYYDFARNEPFTPDDFPVIEKKMREIIARNKPFTKEVWSRDKAKKVFADKGERYKL
ELIDAIPEDQDLKIYAQGDWFDLCRGPHMASTGQIGNAFKLMKVAGAYWRGDSNNPMLTRIYGTAWADQAQLEAYQTMLE
EAEKRDHRKLGREMDLFHFQEEGPGVVFWHAKGWKMFQNLVNYMRRRLDEQGYQEVNAPQVLDKSLWETSGHWGWYRDAM
FKVTVAGDDTDDDRVFALKPMNCPGHVQIFKHGLKSYRDLPVKLAEFGNVHRYEPSGALHGLMRVRGFTQDDAHIFCTEE
QLASECLRINDLILSTYADFGFDEISVKLSTRPDKRVGTDEAWDHAEAIMGSVLETIRTRSGNRIKTSINPGEGAFYGPK
FEYVLKDAIGREWQCGTTQVDFNLPERFGAFYIGSDSEKKQPVMVHRAICGSMERFLGILIENYSGHFPLWFAPQQVVVA
TITSEADGYATEVVAKLKAAGLLAEADLRNEKINYKVREHSLAKVPVILVCGKREAEEQTVNIRRLGSRDQESLGLAEAI
AQLTEEAVTPDRRRKRAA

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38202255, Length=645, Percent_Identity=38.7596899224806, Blast_Score=454, Evalue=1e-128,
Organism=Homo sapiens, GI38570111, Length=645, Percent_Identity=37.3643410852713, Blast_Score=444, Evalue=1e-125,
Organism=Homo sapiens, GI20070344, Length=660, Percent_Identity=37.7272727272727, Blast_Score=429, Evalue=1e-120,
Organism=Escherichia coli, GI1788013, Length=644, Percent_Identity=50.9316770186335, Blast_Score=686, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71984184, Length=643, Percent_Identity=39.0357698289269, Blast_Score=469, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI71984192, Length=643, Percent_Identity=39.0357698289269, Blast_Score=469, Evalue=1e-132,
Organism=Saccharomyces cerevisiae, GI6322112, Length=663, Percent_Identity=38.0090497737557, Blast_Score=453, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6322654, Length=424, Percent_Identity=34.4339622641509, Blast_Score=267, Evalue=5e-72,
Organism=Drosophila melanogaster, GI24583842, Length=642, Percent_Identity=38.006230529595, Blast_Score=457, Evalue=1e-128,
Organism=Drosophila melanogaster, GI28574141, Length=642, Percent_Identity=38.006230529595, Blast_Score=457, Evalue=1e-128,
Organism=Drosophila melanogaster, GI24583839, Length=642, Percent_Identity=38.006230529595, Blast_Score=457, Evalue=1e-128,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_RHILO (Q98LR2)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_102615.1
- ProteinModelPortal:   Q98LR2
- SMR:   Q98LR2
- GeneID:   1225278
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mll0914
- NMPDR:   fig|266835.1.peg.720
- HOGENOM:   HBG352811
- OMA:   ARDRPFT
- ProtClustDB:   PRK00413
- BRENDA:   6.1.1.3
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- Gene3D:   G3DSA:3.10.20.30
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD; SSF52954 Anticodon_bd; SSF81271 TGS-like; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 74297; Mature: 74297

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNSVSLTFPDGSVRDYDAAMTGAGLAESISKSLAKKAVAYAINGTVRDLSDPLGKSGKV
CCCCEEEECCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCE
EIITRDDARALELIRHDTAHVLAEAVQELWPGTQVTIGPVIENGFYYDFARNEPFTPDDF
EEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEECCCCCCCCCCC
PVIEKKMREIIARNKPFTKEVWSRDKAKKVFADKGERYKLELIDAIPEDQDLKIYAQGDW
HHHHHHHHHHHHCCCCCCHHHHCCHHHHHHHHCCCCEEEEEEEECCCCCCCEEEEECCCH
FDLCRGPHMASTGQIGNAFKLMKVAGAYWRGDSNNPMLTRIYGTAWADQAQLEAYQTMLE
HHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHH
EAEKRDHRKLGREMDLFHFQEEGPGVVFWHAKGWKMFQNLVNYMRRRLDEQGYQEVNAPQ
HHHHHHHHHHCCCCCCEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHH
VLDKSLWETSGHWGWYRDAMFKVTVAGDDTDDDRVFALKPMNCPGHVQIFKHGLKSYRDL
HHHHHHHHCCCCCCEEECEEEEEEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCC
PVKLAEFGNVHRYEPSGALHGLMRVRGFTQDDAHIFCTEEQLASECLRINDLILSTYADF
CHHHHHCCCCEEECCCHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHCC
GFDEISVKLSTRPDKRVGTDEAWDHAEAIMGSVLETIRTRSGNRIKTSINPGEGAFYGPK
CCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCH
FEYVLKDAIGREWQCGTTQVDFNLPERFGAFYIGSDSEKKQPVMVHRAICGSMERFLGIL
HHHHHHHHCCCCCCCCCEEEECCCHHHHCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHH
IENYSGHFPLWFAPQQVVVATITSEADGYATEVVAKLKAAGLLAEADLRNEKINYKVREH
HHCCCCCCCEEECCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCC
SLAKVPVILVCGKREAEEQTVNIRRLGSRDQESLGLAEAIAQLTEEAVTPDRRRKRAA
CCCCCCEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHCCC
>Mature Secondary Structure
MLNSVSLTFPDGSVRDYDAAMTGAGLAESISKSLAKKAVAYAINGTVRDLSDPLGKSGKV
CCCCEEEECCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCE
EIITRDDARALELIRHDTAHVLAEAVQELWPGTQVTIGPVIENGFYYDFARNEPFTPDDF
EEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEECCCCCCCCCCC
PVIEKKMREIIARNKPFTKEVWSRDKAKKVFADKGERYKLELIDAIPEDQDLKIYAQGDW
HHHHHHHHHHHHCCCCCCHHHHCCHHHHHHHHCCCCEEEEEEEECCCCCCCEEEEECCCH
FDLCRGPHMASTGQIGNAFKLMKVAGAYWRGDSNNPMLTRIYGTAWADQAQLEAYQTMLE
HHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHH
EAEKRDHRKLGREMDLFHFQEEGPGVVFWHAKGWKMFQNLVNYMRRRLDEQGYQEVNAPQ
HHHHHHHHHHCCCCCCEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHH
VLDKSLWETSGHWGWYRDAMFKVTVAGDDTDDDRVFALKPMNCPGHVQIFKHGLKSYRDL
HHHHHHHHCCCCCCEEECEEEEEEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCC
PVKLAEFGNVHRYEPSGALHGLMRVRGFTQDDAHIFCTEEQLASECLRINDLILSTYADF
CHHHHHCCCCEEECCCHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHCC
GFDEISVKLSTRPDKRVGTDEAWDHAEAIMGSVLETIRTRSGNRIKTSINPGEGAFYGPK
CCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCH
FEYVLKDAIGREWQCGTTQVDFNLPERFGAFYIGSDSEKKQPVMVHRAICGSMERFLGIL
HHHHHHHHCCCCCCCCCEEEECCCHHHHCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHH
IENYSGHFPLWFAPQQVVVATITSEADGYATEVVAKLKAAGLLAEADLRNEKINYKVREH
HHCCCCCCCEEECCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCC
SLAKVPVILVCGKREAEEQTVNIRRLGSRDQESLGLAEAIAQLTEEAVTPDRRRKRAA
CCCCCCEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968