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The map label for this gene is aaeB [H]

Identifier: 13471035

GI number: 13471035

Start: 726540

End: 728606

Strand: Direct

Name: aaeB [H]

Synonym: mlr0902

Alternate gene names: 13471035

Gene position: 726540-728606 (Clockwise)

Preceding gene: 13471034

Following gene: 13471037

Centisome position: 10.33

GC content: 65.75

Gene sequence:

>2067_bases
GTGACCTGGGCGCGGCTGAAAGCCTATTTCGAGACGAGCCTGGCCGGGTTGACGCAGCCGACGCGCTCGGACTGGATTTT
CGCCCTGCGCACCGTTTCGGCCGGCCTGATTGCGCTGCTTGCCGCCTATGCCCTCAAGCTCGACCACCCGCAATGGGCGA
TGATGACGGTGTTCATCGTCGCCCAGCCTGTCGCGGGTATGGTGCTGGCGAAGGGTTTCTACCGGTTGCTCGGCACGCTG
GCCGGCGGGCTGGCGGCGATCGGCATCACCACTGTCTTCGGCACCAACCCATGGGTTCTGGTGACGGTGCTCGCCGTCTG
GATCGGCATCTGCACCTTCGTTTCCTCATTGCTGCGCAATCCCGAAGCCTATGGTGCGGCACTTGCCGGCTACACGGCGA
TGATCATCGGCCTGCCTGCCTTCGGACAGCCGCATCTGGTCGTCGATCTCGCTGTCGCCCGTTGCGCGGAAATCGTGCTT
GGCATCGTCTGCGCCGGCGTGACCAGCCGGCTGATCCTGCCGAAACTGGCCAGCGATGCCATCATATCGCGGCTGAAGCG
CTGCATTCTCGACCTTGCCACCTATGCCGCGGGCGCCTTCTCGGGAGGTGATACAGCGACACTTTCCGCACTGCATCGCA
AACTCGTCGCGGACACCCAGACACTTGGCGAAATGCGCGCCTATGCAAGGCTGGAAGCGCCGAGCTTCGCGCCGCGTGCC
CACCCGGTGCGGCGCACCATCGGACAATTGCTCTCGGCCCTGTCGGCGGCACGCGCCCTGCATTCGCACGCCGCTCCGAA
AAACGCAGCCCTCATCCCGGTGCGTTCGCAATTGCAGGCCCTTGTCGGCGATTTGGCAACAAAGCCCGGCGCACTGGACG
ATACGGCACCCTGGGTGGAACAGCTCGACGCCATCTCGGCCAGGGCCCGGCAACTGCCCGATGCTTCAATCGACCAGGGT
GACGACAGGGTCGGCACCATCACCCGCCTCACCATCGCCGCCGATTTCGCCGAGGCGCTCAAGCAGGTGCTGCGCGGGCT
CGATGCCTTGCGCGCGCCGGTCACAGGTACCGGCCGCGCCGGCAGGCAGCCTGCGCTGGTGGTGCACCGCGACTACCCCG
GCGCATCGCGCAATGCCGTGCGTGCCGCCCTTGCCACCCTGCTGGTCGCGGCCTTCTGGCTGACGACGAAATGGTCCGAG
GCGGCGGGCACGGTCATTCTCGTTGCCGTCGTATCCAGCCTTTTCGCCGCTCGCCCCGATCCGGTGCAGGTGTCCTGGGG
CTTCTTCAAGGGCACGCTGCTGGCTTTGCCCTTTGCCTTTCTCATCGGCCAGATCGCATTGCCTGCTTTGCCCGGCTTCG
GCTGGTTCGTGCTGTTCGTTGTGCCGATCCTGGTGCCGACGGCGCTGGGCATGGCCAATCCGCGCTATGTCGGCATAGCC
ACGGCCTTCGCCATCAACTTCCTCGCTTTCCTCAGCCCGCATCAGGCGATGACCTACGATCCTGGCCCGTTCTTCGCCGG
CTCGGCGTCCGTTCTGGTAGGCATTCTGCTGGCGATCGGCGTCTTCATTGTCGTGCTGCCCGCCGATCCGTGGCTCGCGG
CGAACCGGATCGTACGGGCCATGCGCGAGGATTTGGCACGGCTTTGCCTGCACGAGCGCGTGCCGAGGCGTTCGGCCTTC
GAAAGCCTCGCCTATGACCGCATCAACCAGCTGATGCCGCTGGTGCAGAATTCCGGCAGGAAGGGTGATGCGGTGCTGGG
CGGCGGCGTCGCCGCCGTCACGGTCGGCCTGGAGATCCTGCGGCTGCGCGGCGCGAGCCAAAACCATGCCATCCCGTCCG
AAACCGCACTTTCGATCGCCAATTTCCTGAGAGGGCTGGCGCGCGAACTGCTGTTCCGCGCCCCCGGCGATCCGCAGACA
GCCACCATTGCTGTCGCCCGGCAGTACGCGGCGAGCATCGCCCAGCGAAACGCCCCCGGCGACATGCTGCAGATCGCGGC
ATCCCTGCGCATCATTGCCGCCGCGATGGAGGATTTTCCCGATTTTTTCGCGAGGGATAAAGCCTAG

Upstream 100 bases:

>100_bases
TCCGCTTCATCCAGGAGCGTGCCGAATTCGCCGAGACGGAAGTGCTGGATATCTAGCCGCGGGCCAGTTTAGCTTGCGCT
TCCGATATGGAGACCGGCAC

Downstream 100 bases:

>100_bases
GCCGCCGCAATGGCCAGCGCGTGACCCCGCGCGTTCTCGCGCAGCGCGTCGAGATGGATCGACTTGACCAGGGCCGCGAG
ATCGCCTTCCGCGGATTGCC

Product: hypothetical protein

Products: NA

Alternate protein names: pHBA efflux pump protein B [H]

Number of amino acids: Translated: 688; Mature: 687

Protein sequence:

>688_residues
MTWARLKAYFETSLAGLTQPTRSDWIFALRTVSAGLIALLAAYALKLDHPQWAMMTVFIVAQPVAGMVLAKGFYRLLGTL
AGGLAAIGITTVFGTNPWVLVTVLAVWIGICTFVSSLLRNPEAYGAALAGYTAMIIGLPAFGQPHLVVDLAVARCAEIVL
GIVCAGVTSRLILPKLASDAIISRLKRCILDLATYAAGAFSGGDTATLSALHRKLVADTQTLGEMRAYARLEAPSFAPRA
HPVRRTIGQLLSALSAARALHSHAAPKNAALIPVRSQLQALVGDLATKPGALDDTAPWVEQLDAISARARQLPDASIDQG
DDRVGTITRLTIAADFAEALKQVLRGLDALRAPVTGTGRAGRQPALVVHRDYPGASRNAVRAALATLLVAAFWLTTKWSE
AAGTVILVAVVSSLFAARPDPVQVSWGFFKGTLLALPFAFLIGQIALPALPGFGWFVLFVVPILVPTALGMANPRYVGIA
TAFAINFLAFLSPHQAMTYDPGPFFAGSASVLVGILLAIGVFIVVLPADPWLAANRIVRAMREDLARLCLHERVPRRSAF
ESLAYDRINQLMPLVQNSGRKGDAVLGGGVAAVTVGLEILRLRGASQNHAIPSETALSIANFLRGLARELLFRAPGDPQT
ATIAVARQYAASIAQRNAPGDMLQIAASLRIIAAAMEDFPDFFARDKA

Sequences:

>Translated_688_residues
MTWARLKAYFETSLAGLTQPTRSDWIFALRTVSAGLIALLAAYALKLDHPQWAMMTVFIVAQPVAGMVLAKGFYRLLGTL
AGGLAAIGITTVFGTNPWVLVTVLAVWIGICTFVSSLLRNPEAYGAALAGYTAMIIGLPAFGQPHLVVDLAVARCAEIVL
GIVCAGVTSRLILPKLASDAIISRLKRCILDLATYAAGAFSGGDTATLSALHRKLVADTQTLGEMRAYARLEAPSFAPRA
HPVRRTIGQLLSALSAARALHSHAAPKNAALIPVRSQLQALVGDLATKPGALDDTAPWVEQLDAISARARQLPDASIDQG
DDRVGTITRLTIAADFAEALKQVLRGLDALRAPVTGTGRAGRQPALVVHRDYPGASRNAVRAALATLLVAAFWLTTKWSE
AAGTVILVAVVSSLFAARPDPVQVSWGFFKGTLLALPFAFLIGQIALPALPGFGWFVLFVVPILVPTALGMANPRYVGIA
TAFAINFLAFLSPHQAMTYDPGPFFAGSASVLVGILLAIGVFIVVLPADPWLAANRIVRAMREDLARLCLHERVPRRSAF
ESLAYDRINQLMPLVQNSGRKGDAVLGGGVAAVTVGLEILRLRGASQNHAIPSETALSIANFLRGLARELLFRAPGDPQT
ATIAVARQYAASIAQRNAPGDMLQIAASLRIIAAAMEDFPDFFARDKA
>Mature_687_residues
TWARLKAYFETSLAGLTQPTRSDWIFALRTVSAGLIALLAAYALKLDHPQWAMMTVFIVAQPVAGMVLAKGFYRLLGTLA
GGLAAIGITTVFGTNPWVLVTVLAVWIGICTFVSSLLRNPEAYGAALAGYTAMIIGLPAFGQPHLVVDLAVARCAEIVLG
IVCAGVTSRLILPKLASDAIISRLKRCILDLATYAAGAFSGGDTATLSALHRKLVADTQTLGEMRAYARLEAPSFAPRAH
PVRRTIGQLLSALSAARALHSHAAPKNAALIPVRSQLQALVGDLATKPGALDDTAPWVEQLDAISARARQLPDASIDQGD
DRVGTITRLTIAADFAEALKQVLRGLDALRAPVTGTGRAGRQPALVVHRDYPGASRNAVRAALATLLVAAFWLTTKWSEA
AGTVILVAVVSSLFAARPDPVQVSWGFFKGTLLALPFAFLIGQIALPALPGFGWFVLFVVPILVPTALGMANPRYVGIAT
AFAINFLAFLSPHQAMTYDPGPFFAGSASVLVGILLAIGVFIVVLPADPWLAANRIVRAMREDLARLCLHERVPRRSAFE
SLAYDRINQLMPLVQNSGRKGDAVLGGGVAAVTVGLEILRLRGASQNHAIPSETALSIANFLRGLARELLFRAPGDPQTA
TIAVARQYAASIAQRNAPGDMLQIAASLRIIAAAMEDFPDFFARDKA

Specific function: Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell [H]

COG id: COG1289

COG function: function code S; Predicted membrane protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aromatic acid exporter ArAE (TC 2.A.85) family [H]

Homologues:

Organism=Escherichia coli, GI1789636, Length=521, Percent_Identity=27.447216890595, Blast_Score=149, Evalue=9e-37,
Organism=Escherichia coli, GI1787933, Length=622, Percent_Identity=25.5627009646302, Blast_Score=139, Evalue=6e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006726 [H]

Pfam domain/function: PF04632 FUSC [H]

EC number: NA

Molecular weight: Translated: 72939; Mature: 72808

Theoretical pI: Translated: 10.32; Mature: 10.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TWARLKAYFETSLAGLTQPTRSDWIFALRTVSAGLIALLAAYALKLDHPQWAMMTVFIV
CHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
AQPVAGMVLAKGFYRLLGTLAGGLAAIGITTVFGTNPWVLVTVLAVWIGICTFVSSLLRN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCC
PEAYGAALAGYTAMIIGLPAFGQPHLVVDLAVARCAEIVLGIVCAGVTSRLILPKLASDA
CHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IISRLKRCILDLATYAAGAFSGGDTATLSALHRKLVADTQTLGEMRAYARLEAPSFAPRA
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
HPVRRTIGQLLSALSAARALHSHAAPKNAALIPVRSQLQALVGDLATKPGALDDTAPWVE
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHCCCCCCCCCHHHHH
QLDAISARARQLPDASIDQGDDRVGTITRLTIAADFAEALKQVLRGLDALRAPVTGTGRA
HHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GRQPALVVHRDYPGASRNAVRAALATLLVAAFWLTTKWSEAAGTVILVAVVSSLFAARPD
CCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHCCHHHHHHHHHHHHHCCCC
PVQVSWGFFKGTLLALPFAFLIGQIALPALPGFGWFVLFVVPILVPTALGMANPRYVGIA
CCEEECHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHH
TAFAINFLAFLSPHQAMTYDPGPFFAGSASVLVGILLAIGVFIVVLPADPWLAANRIVRA
HHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHH
MREDLARLCLHERVPRRSAFESLAYDRINQLMPLVQNSGRKGDAVLGGGVAAVTVGLEIL
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCHHHHHHHHHHH
RLRGASQNHAIPSETALSIANFLRGLARELLFRAPGDPQTATIAVARQYAASIAQRNAPG
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCH
DMLQIAASLRIIAAAMEDFPDFFARDKA
HHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA