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The map label for this gene is pyrC [H]

Identifier: 13470873

GI number: 13470873

Start: 537254

End: 538540

Strand: Direct

Name: pyrC [H]

Synonym: mlr0687

Alternate gene names: 13470873

Gene position: 537254-538540 (Clockwise)

Preceding gene: 13470872

Following gene: 13470874

Centisome position: 7.64

GC content: 66.74

Gene sequence:

>1287_bases
ATGAGCACGACAGTCTTTGAACGCGCCCGCATCGTCGACCCTTCGCGCGGCATCGACGAAGTCGGCTCCGTCATCGTCGA
GGGCCGCAAGATCGTTGCCGCCGGCAAGGCGACGTTGAACCAGGGCGCGCCCGAGGGCGCTATCATCGTCGACTGCGCCG
GCAAGGCGATCATTCCCGGCCTGATCGATGGCCGCGTCTTCATCGGCGAGCCGGGCGGCGAGCATCGCGAAACCATCGCT
TCTGCCAGCGTCGCCGCGGCCGCCGGCGGCGTCACCTCTGTCGTCATGATGCCCGATACCGATCCGGTGATCGACAATGT
CGCGCTGGTCGAGTTCGTGCTGCGCACCGCCAAGGACACGGCGATCGTCAACATCTTCCCGGCGGCTGCGATCACCAAGG
GCCTCGACGGCCGCGAGATGACCGAGTTCGGCCTGTTGCGCGAGGCCGGCGCCGTCGCCTTCACCGATGGCCGCCACACC
ATCGCCAGTTCACTGGTGATGCGCCGGGCGCTCACCTATGCCCGCGATTTCGGCGCCACCATCGTGCACGAGACGCAGGA
TGCCGACCTCGGTTCGTCAGGCGTGATGAATGAAGGTCTGTACGCCAGTTGGCTCGGCCTCTCCGGCATTCCGCGCGAAG
CCGAATCGATCCCGCTCGAGCGCGATCTGGCTTTGGCGCGGCTGACGCGCGGCTCCTACCATGCGGCAAAGATCTCGACG
GCGATGGCGGCCAACGCCGTGACGCGCGCCAAGGCTGACGGCGCTGCCGTAACGTCAGGCGTGTCGATCCACAACCTGTC
GCTCAATGAAAACGATGTCGGCGAATACCGCACCTTCTTCCGCCTGACGCCGCCATTGCGCGCCGAGGAAGACCGGCTGG
CGATGATCGAGGCGGTCAGGGACGGCACGGTCGATATCATCGTCTCCTCGCACGATCCGCAGGATGTCGACACCAAGCGC
CTGCCCTTCGCCGACGCCGCGGCCGGCGCCATCGGGCTGGAGACGCTGCTGGGTGCCGCCTTGCGGCTCTACCACAATGG
CGACGTGCCCTTGCTTCGGCTGGTCGAAACGCTGTCCACCGCGCCGGCAAGGCTGTTCGGACTGCCCGGCGGCACGCTGA
CGCCGGGCTCAGTCGCCGACCTCGCGCTCGTCGATCTCGACGAACCCTGGATCGTCAGCGAAAGCGGCATCCGCTCGCGC
TCGAAGAACACCTGTTTCGAAGGCGCGCGCCTGCAAGGCAAGGTCTTGCAAACGCTGGTCGCGGGCCGCACAGTGTTCTC
GGCATAG

Upstream 100 bases:

>100_bases
AGCAGGTGGAGATGGGCGTCGCCGTGCGCATGGCGGTGATGGAAGCGCTGCTCGACCCCCGTCGTAATCAAGAGGGCCGC
AAACAGGAGGGTCGCGGCGC

Downstream 100 bases:

>100_bases
ACCGGGAACGGGCGTCGCGCCTGATCGGGCTGCGCTGGGGAAATGCGGGGGAAACAATGACTTACGGCCTAATCCTGGCG
CTGGTATTCGGCTACCTCTT

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MSTTVFERARIVDPSRGIDEVGSVIVEGRKIVAAGKATLNQGAPEGAIIVDCAGKAIIPGLIDGRVFIGEPGGEHRETIA
SASVAAAAGGVTSVVMMPDTDPVIDNVALVEFVLRTAKDTAIVNIFPAAAITKGLDGREMTEFGLLREAGAVAFTDGRHT
IASSLVMRRALTYARDFGATIVHETQDADLGSSGVMNEGLYASWLGLSGIPREAESIPLERDLALARLTRGSYHAAKIST
AMAANAVTRAKADGAAVTSGVSIHNLSLNENDVGEYRTFFRLTPPLRAEEDRLAMIEAVRDGTVDIIVSSHDPQDVDTKR
LPFADAAAGAIGLETLLGAALRLYHNGDVPLLRLVETLSTAPARLFGLPGGTLTPGSVADLALVDLDEPWIVSESGIRSR
SKNTCFEGARLQGKVLQTLVAGRTVFSA

Sequences:

>Translated_428_residues
MSTTVFERARIVDPSRGIDEVGSVIVEGRKIVAAGKATLNQGAPEGAIIVDCAGKAIIPGLIDGRVFIGEPGGEHRETIA
SASVAAAAGGVTSVVMMPDTDPVIDNVALVEFVLRTAKDTAIVNIFPAAAITKGLDGREMTEFGLLREAGAVAFTDGRHT
IASSLVMRRALTYARDFGATIVHETQDADLGSSGVMNEGLYASWLGLSGIPREAESIPLERDLALARLTRGSYHAAKIST
AMAANAVTRAKADGAAVTSGVSIHNLSLNENDVGEYRTFFRLTPPLRAEEDRLAMIEAVRDGTVDIIVSSHDPQDVDTKR
LPFADAAAGAIGLETLLGAALRLYHNGDVPLLRLVETLSTAPARLFGLPGGTLTPGSVADLALVDLDEPWIVSESGIRSR
SKNTCFEGARLQGKVLQTLVAGRTVFSA
>Mature_427_residues
STTVFERARIVDPSRGIDEVGSVIVEGRKIVAAGKATLNQGAPEGAIIVDCAGKAIIPGLIDGRVFIGEPGGEHRETIAS
ASVAAAAGGVTSVVMMPDTDPVIDNVALVEFVLRTAKDTAIVNIFPAAAITKGLDGREMTEFGLLREAGAVAFTDGRHTI
ASSLVMRRALTYARDFGATIVHETQDADLGSSGVMNEGLYASWLGLSGIPREAESIPLERDLALARLTRGSYHAAKISTA
MAANAVTRAKADGAAVTSGVSIHNLSLNENDVGEYRTFFRLTPPLRAEEDRLAMIEAVRDGTVDIIVSSHDPQDVDTKRL
PFADAAAGAIGLETLLGAALRLYHNGDVPLLRLVETLSTAPARLFGLPGGTLTPGSVADLALVDLDEPWIVSESGIRSRS
KNTCFEGARLQGKVLQTLVAGRTVFSA

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=403, Percent_Identity=27.2952853598015, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1786722, Length=443, Percent_Identity=24.1534988713318, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI87082175, Length=396, Percent_Identity=23.4848484848485, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI193204318, Length=380, Percent_Identity=27.6315789473684, Blast_Score=111, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6322218, Length=427, Percent_Identity=25.9953161592506, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24642586, Length=401, Percent_Identity=26.6832917705736, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 44892; Mature: 44760

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTVFERARIVDPSRGIDEVGSVIVEGRKIVAAGKATLNQGAPEGAIIVDCAGKAIIPG
CCCCHHHHHCCCCCCCCHHHHHHHHHCCCEEEEECCHHHCCCCCCCEEEEEECCCEECCC
LIDGRVFIGEPGGEHRETIASASVAAAAGGVTSVVMMPDTDPVIDNVALVEFVLRTAKDT
EECCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCC
AIVNIFPAAAITKGLDGREMTEFGLLREAGAVAFTDGRHTIASSLVMRRALTYARDFGAT
EEEEEECHHHHHCCCCCCHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCE
IVHETQDADLGSSGVMNEGLYASWLGLSGIPREAESIPLERDLALARLTRGSYHAAKIST
EEECCCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHCCCHHHHHHHHHCCCCCHHHHHHH
AMAANAVTRAKADGAAVTSGVSIHNLSLNENDVGEYRTFFRLTPPLRAEEDRLAMIEAVR
HHHHHHHHHHCCCCCEEECCCEEEEECCCCCCCHHHEEEEEECCCCCCCCHHHHHHHHHC
DGTVDIIVSSHDPQDVDTKRLPFADAAAGAIGLETLLGAALRLYHNGDVPLLRLVETLST
CCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHC
APARLFGLPGGTLTPGSVADLALVDLDEPWIVSESGIRSRSKNTCFEGARLQGKVLQTLV
CCCEEEECCCCCCCCCCCCCEEEEECCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHH
AGRTVFSA
HCHHHHCC
>Mature Secondary Structure 
STTVFERARIVDPSRGIDEVGSVIVEGRKIVAAGKATLNQGAPEGAIIVDCAGKAIIPG
CCCHHHHHCCCCCCCCHHHHHHHHHCCCEEEEECCHHHCCCCCCCEEEEEECCCEECCC
LIDGRVFIGEPGGEHRETIASASVAAAAGGVTSVVMMPDTDPVIDNVALVEFVLRTAKDT
EECCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCC
AIVNIFPAAAITKGLDGREMTEFGLLREAGAVAFTDGRHTIASSLVMRRALTYARDFGAT
EEEEEECHHHHHCCCCCCHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCE
IVHETQDADLGSSGVMNEGLYASWLGLSGIPREAESIPLERDLALARLTRGSYHAAKIST
EEECCCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHCCCHHHHHHHHHCCCCCHHHHHHH
AMAANAVTRAKADGAAVTSGVSIHNLSLNENDVGEYRTFFRLTPPLRAEEDRLAMIEAVR
HHHHHHHHHHCCCCCEEECCCEEEEECCCCCCCHHHEEEEEECCCCCCCCHHHHHHHHHC
DGTVDIIVSSHDPQDVDTKRLPFADAAAGAIGLETLLGAALRLYHNGDVPLLRLVETLST
CCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHC
APARLFGLPGGTLTPGSVADLALVDLDEPWIVSESGIRSRSKNTCFEGARLQGKVLQTLV
CCCEEEECCCCCCCCCCCCCEEEEECCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHH
AGRTVFSA
HCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA