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The map label for this gene is kynA [H]

Identifier: 13470820

GI number: 13470820

Start: 485837

End: 486634

Strand: Direct

Name: kynA [H]

Synonym: mlr0620

Alternate gene names: 13470820

Gene position: 485837-486634 (Clockwise)

Preceding gene: 13470819

Following gene: 13470825

Centisome position: 6.9

GC content: 62.16

Gene sequence:

>798_bases
ATGTCGTTCAACGAGCGCATGTCCTACAGCGACTATCTGCACCTGGAAAAAGTGCTGGAGGCACAGACGCCGCTGTCGTC
GGCGCATGACGAGATGCTGTTCATCATCCAGCACCAGACCTCGGAGCTCTGGATGAAACTCGCTCTGCATGAGATCGGCG
CCGCCATCCGCTCCATTCGCGCTGACCGGCTCGAGCCGAGCTTCAAGATGCTGTCGCGCGTCGCCCGGATTTTCGAGCAG
CTCAACAATGCCTGGGACGTGCTGCGCACGATGACTCCAAGCGAATACACCGAGTTCCGCGACGCGCTCGGCCAGTCCTC
TGGCTTCCAGTCCTGGCAGTACCGCGCCATCGAGTTCATGGCCGGCAACCGCAACCTGGCAATGCTCGGACCCCACAAAC
ACCGGCCGGACCTCAGCGGCAAGCTGGAGGCAATCCTGGCCGAGCCGTCGCTCTATGATGAAGCGTTGCTGCTTCTGGCG
CGCAACGGGTTCGACATCGGCGCCGACGCCAGGCGCACGGACTGGCGCGAGACGCGCACCGAGAACGAAGAAGTCCTGGT
CGCCTGGCAGACCGTCTACCGCGATCCGCAGCGCTACTGGATGTTCTATGAGCTGGCCGAGAAGCTGGTGGATTTCGAAG
ACTATTTCCGCCGCTGGCGTTTCAATCACGTCACGACGGTCGAGCGCATCATTGGCCTGAAGCGCGGCACCGGCGGCACC
TCAGGCGCATCCTATCTGAAGAAGATGCTCGAGGTCGTGCTGTTTCCCGAACTGTGGACGGTCCGCACGCGGCTCTGA

Upstream 100 bases:

>100_bases
CCCTGCCCAAGACCCAGACCGGCAAGATCCAGCGCTTCCGGCTGCGCACGGAGAAAATCAATTGAGCGAGCCCTACGATC
CGGCGTCCGAAGGCGCACAG

Downstream 100 bases:

>100_bases
GGTCTCAGGTCACCGCCGTCTTCACGGCAAAACGCGCTTCCTGCCAGGCGCCGGTACGCAAAATGTCCTCCAGCACCTCG
ACCGCTTGCCAGACGTCCTT

Product: tryptophan 2,3-dioxygenase

Products: NA

Alternate protein names: TDO; Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; TO; TRPO; Tryptophan pyrrolase; Tryptophanase [H]

Number of amino acids: Translated: 265; Mature: 264

Protein sequence:

>265_residues
MSFNERMSYSDYLHLEKVLEAQTPLSSAHDEMLFIIQHQTSELWMKLALHEIGAAIRSIRADRLEPSFKMLSRVARIFEQ
LNNAWDVLRTMTPSEYTEFRDALGQSSGFQSWQYRAIEFMAGNRNLAMLGPHKHRPDLSGKLEAILAEPSLYDEALLLLA
RNGFDIGADARRTDWRETRTENEEVLVAWQTVYRDPQRYWMFYELAEKLVDFEDYFRRWRFNHVTTVERIIGLKRGTGGT
SGASYLKKMLEVVLFPELWTVRTRL

Sequences:

>Translated_265_residues
MSFNERMSYSDYLHLEKVLEAQTPLSSAHDEMLFIIQHQTSELWMKLALHEIGAAIRSIRADRLEPSFKMLSRVARIFEQ
LNNAWDVLRTMTPSEYTEFRDALGQSSGFQSWQYRAIEFMAGNRNLAMLGPHKHRPDLSGKLEAILAEPSLYDEALLLLA
RNGFDIGADARRTDWRETRTENEEVLVAWQTVYRDPQRYWMFYELAEKLVDFEDYFRRWRFNHVTTVERIIGLKRGTGGT
SGASYLKKMLEVVLFPELWTVRTRL
>Mature_264_residues
SFNERMSYSDYLHLEKVLEAQTPLSSAHDEMLFIIQHQTSELWMKLALHEIGAAIRSIRADRLEPSFKMLSRVARIFEQL
NNAWDVLRTMTPSEYTEFRDALGQSSGFQSWQYRAIEFMAGNRNLAMLGPHKHRPDLSGKLEAILAEPSLYDEALLLLAR
NGFDIGADARRTDWRETRTENEEVLVAWQTVYRDPQRYWMFYELAEKLVDFEDYFRRWRFNHVTTVERIIGLKRGTGGTS
GASYLKKMLEVVLFPELWTVRTRL

Specific function: Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring [H]

COG id: COG3483

COG function: function code E; Tryptophan 2,3-dioxygenase (vermilion)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tryptophan 2,3-dioxygenase family [H]

Homologues:

Organism=Homo sapiens, GI5032165, Length=125, Percent_Identity=39.2, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI32564651, Length=135, Percent_Identity=34.8148148148148, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17552370, Length=134, Percent_Identity=33.5820895522388, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17530891, Length=124, Percent_Identity=39.5161290322581, Blast_Score=81, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017485
- InterPro:   IPR004981 [H]

Pfam domain/function: PF03301 Trp_dioxygenase [H]

EC number: =1.13.11.11 [H]

Molecular weight: Translated: 31108; Mature: 30977

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFNERMSYSDYLHLEKVLEAQTPLSSAHDEMLFIIQHQTSELWMKLALHEIGAAIRSIR
CCCCHHCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHH
ADRLEPSFKMLSRVARIFEQLNNAWDVLRTMTPSEYTEFRDALGQSSGFQSWQYRAIEFM
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHEEEE
AGNRNLAMLGPHKHRPDLSGKLEAILAEPSLYDEALLLLARNGFDIGADARRTDWRETRT
ECCCCEEEECCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHCC
ENEEVLVAWQTVYRDPQRYWMFYELAEKLVDFEDYFRRWRFNHVTTVERIIGLKRGTGGT
CCCCEEEEHHHHHHCHHHHHHHHHHHHHHHCHHHHHHHHCCCHHHHHHHHHHHCCCCCCC
SGASYLKKMLEVVLFPELWTVRTRL
CHHHHHHHHHHHHHCCHHHHHHCCC
>Mature Secondary Structure 
SFNERMSYSDYLHLEKVLEAQTPLSSAHDEMLFIIQHQTSELWMKLALHEIGAAIRSIR
CCCHHCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHH
ADRLEPSFKMLSRVARIFEQLNNAWDVLRTMTPSEYTEFRDALGQSSGFQSWQYRAIEFM
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHEEEE
AGNRNLAMLGPHKHRPDLSGKLEAILAEPSLYDEALLLLARNGFDIGADARRTDWRETRT
ECCCCEEEECCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHCC
ENEEVLVAWQTVYRDPQRYWMFYELAEKLVDFEDYFRRWRFNHVTTVERIIGLKRGTGGT
CCCCEEEEHHHHHHCHHHHHHHHHHHHHHHCHHHHHHHHCCCHHHHHHHHHHHCCCCCCC
SGASYLKKMLEVVLFPELWTVRTRL
CHHHHHHHHHHHHHCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA