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The map label for this gene is pdhA [H]

Identifier: 13470619

GI number: 13470619

Start: 270771

End: 271808

Strand: Direct

Name: pdhA [H]

Synonym: mlr0383

Alternate gene names: 13470619

Gene position: 270771-271808 (Clockwise)

Preceding gene: 13470618

Following gene: 13470620

Centisome position: 3.85

GC content: 60.6

Gene sequence:

>1038_bases
ATGGCCACCGCAGCCAGAAAAGCGCCTGCCAAATCGAAATCCGAAGGCAAATCAGGGCTTTCCGCGCCCAAGCCTGCTGA
ATTCACCAAGGACGAAGAGCTTGCCGCCTATCGGCACATGCTGCTCATCCGCCGCTTCGAGGAAAAGGCCGGCCAGCTCT
ACGGCATGGGCTTCATCGGCGGCTTCTGCCATCTCTATATCGGCCAGGAGGCTGTCGTCACCGGCATGAAGATGGCGCTG
ATCGACGGCGACCAGATGATCACAGCCTATCGCGACCACGGCCACATGCTAGCCATGGAGCTTTCGCCGCGTGGTGTCAT
GGCCGAGCTGACCGGACGCCGTGGCGGCCTGTCCAAGGGCAAGGGCGGCTCCATGCACATGTTCTCTAAGGAGAAGCATT
TTTACGGCGGCCACGGCATTGTCGGCGCGCAGGTGTCGCTCGGCACCGGCCTGGCCTTCGCCAATCGCTACCGCGACAAC
AACAACGTCTCGCTGACCTATTTCGGCGACGGCGCCGCCAACCAGGGCCAGGTCTATGAAAGCTTCAACATGGCCTCGCT
GTGGAAACTGCCGGTGATCTACATCATCGAGAACAACCGCTACGCCATGGGCACCTCGGTGTCGCGATCTTCGGCCGAAA
CCAATTTTTCGCATCGCGGCGCTTCGTTCAAGATTCCGGGCATCCAGGTCGACGGCATGGATGTGCGTGCGGTCAAATCC
GCCGGCGATCAGGCGACCGAATGGTGCCGCGCCGGCAACGGGCCGATCATTCTCGAAATGCAGACCTACCGCTACCGCGG
TCACTCGATGTCTGACCCGGCGAAATACCGCTCGAAGGAAGAAGTGCAGAAGATGCGCTCAGAGCATGACCCGATCGAAC
AGGTCAAGGCTCGGTTGACCGAGAAGAAGTGGGCGACCGAGGACGAGCTCAAGACCATCGACAAGGAGGTTCGCGACATC
GTCGCCGACGCCGCCGAATTTGCCCAGAACGATGCGGAGCCGGATCCGTCCGAGCTCTGGACCGATATCGTATTGTAA

Upstream 100 bases:

>100_bases
CGTGTTAGCCTTGCATAAATCGGTGGGGAGAGCTGATCTTCCCAGGGCGGATTTCATCCTGCCCTAATGTCCGCAAAGAG
ACGCCAACAGGGAGTGATGC

Downstream 100 bases:

>100_bases
GGGGAGGGCCAGGACATGCCGATCGAAATTCTCATGCCCGCTCTCTCGCCAACCATGGAAGAGGGCAATCTTTCCAAGTG
GTTGAAGAACGAGGGCGACA

Product: pyruvate dehydrogenase E1 alpha subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MATAARKAPAKSKSEGKSGLSAPKPAEFTKDEELAAYRHMLLIRRFEEKAGQLYGMGFIGGFCHLYIGQEAVVTGMKMAL
IDGDQMITAYRDHGHMLAMELSPRGVMAELTGRRGGLSKGKGGSMHMFSKEKHFYGGHGIVGAQVSLGTGLAFANRYRDN
NNVSLTYFGDGAANQGQVYESFNMASLWKLPVIYIIENNRYAMGTSVSRSSAETNFSHRGASFKIPGIQVDGMDVRAVKS
AGDQATEWCRAGNGPIILEMQTYRYRGHSMSDPAKYRSKEEVQKMRSEHDPIEQVKARLTEKKWATEDELKTIDKEVRDI
VADAAEFAQNDAEPDPSELWTDIVL

Sequences:

>Translated_345_residues
MATAARKAPAKSKSEGKSGLSAPKPAEFTKDEELAAYRHMLLIRRFEEKAGQLYGMGFIGGFCHLYIGQEAVVTGMKMAL
IDGDQMITAYRDHGHMLAMELSPRGVMAELTGRRGGLSKGKGGSMHMFSKEKHFYGGHGIVGAQVSLGTGLAFANRYRDN
NNVSLTYFGDGAANQGQVYESFNMASLWKLPVIYIIENNRYAMGTSVSRSSAETNFSHRGASFKIPGIQVDGMDVRAVKS
AGDQATEWCRAGNGPIILEMQTYRYRGHSMSDPAKYRSKEEVQKMRSEHDPIEQVKARLTEKKWATEDELKTIDKEVRDI
VADAAEFAQNDAEPDPSELWTDIVL
>Mature_344_residues
ATAARKAPAKSKSEGKSGLSAPKPAEFTKDEELAAYRHMLLIRRFEEKAGQLYGMGFIGGFCHLYIGQEAVVTGMKMALI
DGDQMITAYRDHGHMLAMELSPRGVMAELTGRRGGLSKGKGGSMHMFSKEKHFYGGHGIVGAQVSLGTGLAFANRYRDNN
NVSLTYFGDGAANQGQVYESFNMASLWKLPVIYIIENNRYAMGTSVSRSSAETNFSHRGASFKIPGIQVDGMDVRAVKSA
GDQATEWCRAGNGPIILEMQTYRYRGHSMSDPAKYRSKEEVQKMRSEHDPIEQVKARLTEKKWATEDELKTIDKEVRDIV
ADAAEFAQNDAEPDPSELWTDIVL

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=318, Percent_Identity=53.7735849056604, Blast_Score=347, Evalue=1e-95,
Organism=Homo sapiens, GI291084742, Length=318, Percent_Identity=53.4591194968553, Blast_Score=324, Evalue=7e-89,
Organism=Homo sapiens, GI4505685, Length=318, Percent_Identity=53.4591194968553, Blast_Score=324, Evalue=1e-88,
Organism=Homo sapiens, GI291084744, Length=325, Percent_Identity=52.3076923076923, Blast_Score=317, Evalue=1e-86,
Organism=Homo sapiens, GI291084757, Length=318, Percent_Identity=48.1132075471698, Blast_Score=273, Evalue=2e-73,
Organism=Homo sapiens, GI11386135, Length=317, Percent_Identity=30.5993690851735, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI258645172, Length=317, Percent_Identity=30.5993690851735, Blast_Score=142, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI32564172, Length=317, Percent_Identity=52.0504731861199, Blast_Score=328, Evalue=2e-90,
Organism=Caenorhabditis elegans, GI17536047, Length=317, Percent_Identity=52.0504731861199, Blast_Score=328, Evalue=3e-90,
Organism=Caenorhabditis elegans, GI86563355, Length=264, Percent_Identity=32.9545454545455, Blast_Score=134, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI86563357, Length=264, Percent_Identity=32.9545454545455, Blast_Score=134, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6321026, Length=324, Percent_Identity=50, Blast_Score=317, Evalue=2e-87,
Organism=Drosophila melanogaster, GI24639744, Length=319, Percent_Identity=52.6645768025078, Blast_Score=335, Evalue=4e-92,
Organism=Drosophila melanogaster, GI28571106, Length=319, Percent_Identity=52.6645768025078, Blast_Score=335, Evalue=4e-92,
Organism=Drosophila melanogaster, GI24639740, Length=319, Percent_Identity=52.6645768025078, Blast_Score=334, Evalue=6e-92,
Organism=Drosophila melanogaster, GI24639746, Length=305, Percent_Identity=53.4426229508197, Blast_Score=323, Evalue=1e-88,
Organism=Drosophila melanogaster, GI24639748, Length=319, Percent_Identity=51.7241379310345, Blast_Score=306, Evalue=1e-83,
Organism=Drosophila melanogaster, GI21355903, Length=327, Percent_Identity=27.5229357798165, Blast_Score=113, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 38124; Mature: 37992

Theoretical pI: Translated: 7.77; Mature: 7.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATAARKAPAKSKSEGKSGLSAPKPAEFTKDEELAAYRHMLLIRRFEEKAGQLYGMGFIG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEHHHH
GFCHLYIGQEAVVTGMKMALIDGDQMITAYRDHGHMLAMELSPRGVMAELTGRRGGLSKG
HHHHEEECCHHHHCCEEEEEECCCCEEEEEECCCCEEEEEECCCCEEEEECCCCCCCCCC
KGGSMHMFSKEKHFYGGHGIVGAQVSLGTGLAFANRYRDNNNVSLTYFGDGAANQGQVYE
CCCCEEEEECCCCEECCCCEEEEEEECCCCHHHHHHCCCCCCEEEEEECCCCCCCCCHHH
SFNMASLWKLPVIYIIENNRYAMGTSVSRSSAETNFSHRGASFKIPGIQVDGMDVRAVKS
CCCHHHEECCCEEEEEECCEEEECCCCCCCCCCCCCCCCCCEEECCCEEECCCCHHHHHH
AGDQATEWCRAGNGPIILEMQTYRYRGHSMSDPAKYRSKEEVQKMRSEHDPIEQVKARLT
CCHHHHHHHHCCCCCEEEEEEEEEECCCCCCCHHHHCCHHHHHHHHHCCCHHHHHHHHHH
EKKWATEDELKTIDKEVRDIVADAAEFAQNDAEPDPSELWTDIVL
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCC
>Mature Secondary Structure 
ATAARKAPAKSKSEGKSGLSAPKPAEFTKDEELAAYRHMLLIRRFEEKAGQLYGMGFIG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEHHHH
GFCHLYIGQEAVVTGMKMALIDGDQMITAYRDHGHMLAMELSPRGVMAELTGRRGGLSKG
HHHHEEECCHHHHCCEEEEEECCCCEEEEEECCCCEEEEEECCCCEEEEECCCCCCCCCC
KGGSMHMFSKEKHFYGGHGIVGAQVSLGTGLAFANRYRDNNNVSLTYFGDGAANQGQVYE
CCCCEEEEECCCCEECCCCEEEEEEECCCCHHHHHHCCCCCCEEEEEECCCCCCCCCHHH
SFNMASLWKLPVIYIIENNRYAMGTSVSRSSAETNFSHRGASFKIPGIQVDGMDVRAVKS
CCCHHHEECCCEEEEEECCEEEECCCCCCCCCCCCCCCCCCEEECCCEEECCCCHHHHHH
AGDQATEWCRAGNGPIILEMQTYRYRGHSMSDPAKYRSKEEVQKMRSEHDPIEQVKARLT
CCHHHHHHHHCCCCCEEEEEEEEEECCCCCCCHHHHCCHHHHHHHHHCCCHHHHHHHHHH
EKKWATEDELKTIDKEVRDIVADAAEFAQNDAEPDPSELWTDIVL
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10796014; 11481430 [H]