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The map label for this gene is adk [H]

Identifier: 15602149

GI number: 15602149

Start: 323720

End: 324364

Strand: Reverse

Name: adk [H]

Synonym: PM0284

Alternate gene names: 15602149

Gene position: 324364-323720 (Counterclockwise)

Preceding gene: 15602150

Following gene: 15602141

Centisome position: 14.37

GC content: 42.95

Gene sequence:

>645_bases
ATGAAAATTATCCTATTAGGTGCACCGGGTGCGGGGAAAGGGACACAAGCGCAATTTATTATGAATAAATTTGGCATTCC
ACAAATTTCAACGGGTGATATGTTGCGTGGTGCAATCAAAGCAGGGACAGACTTAGGTAAACAAGCAAAAACCTTAATGG
ATGCGGGTCAATTAGTGCCAGATGATTTAATCATTTCATTAGTGAAAGAACGTGTTGCACAAGCCGATTGTGCCAAAGGT
TTCTTATTAGACGGCTTCCCACGCACCATTCCACAAGCGGATGCATTAAAAACAGTCGGTATCCAAATTGACTACGTTTT
AGAGTTTGATGTGCCTGATGAAGTGATCGTAGAACGTATGAGTGGTCGCCGTGTACACCAAGCCTCAGGTCGTACTTATC
ACGTCGTTTACAACCCACCAAAAGTAGAAGGGAAAGATGACGTGACTGGCGAAGACTTAATCATCCGTGCCGATGATAAA
CCTGAAACTGTATTAGATCGCTTAAAAGTGTATCACTCCACCACGAAACCATTAGTGGACTACTACCAAGCAGAAGCGAA
AGCGGGTAACACCAAGTACTTCCGCTTAGACGGGACGAAAAAAGTGGAAGAAGTGAGTCAAGAATTAGATACTATTTTAG
CGTAA

Upstream 100 bases:

>100_bases
TTTGTTTTATTCCGAAAACAATGAAAAATCACACTGCACCTTGTCATGAAAAACACAAGGTGCGGTAAAAAATCTGATTA
TTTTACTCAATGAGGTCATT

Downstream 100 bases:

>100_bases
TTTGTTTTTATCAAAAAAGGCTGTTTAATACAGCCTTTTTTGTTATCTAGTTAAAAGAGATAATCACTATTAACTTGTTA
TCTAGATATTTGTCCAAATA

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MKIILLGAPGAGKGTQAQFIMNKFGIPQISTGDMLRGAIKAGTDLGKQAKTLMDAGQLVPDDLIISLVKERVAQADCAKG
FLLDGFPRTIPQADALKTVGIQIDYVLEFDVPDEVIVERMSGRRVHQASGRTYHVVYNPPKVEGKDDVTGEDLIIRADDK
PETVLDRLKVYHSTTKPLVDYYQAEAKAGNTKYFRLDGTKKVEEVSQELDTILA

Sequences:

>Translated_214_residues
MKIILLGAPGAGKGTQAQFIMNKFGIPQISTGDMLRGAIKAGTDLGKQAKTLMDAGQLVPDDLIISLVKERVAQADCAKG
FLLDGFPRTIPQADALKTVGIQIDYVLEFDVPDEVIVERMSGRRVHQASGRTYHVVYNPPKVEGKDDVTGEDLIIRADDK
PETVLDRLKVYHSTTKPLVDYYQAEAKAGNTKYFRLDGTKKVEEVSQELDTILA
>Mature_214_residues
MKIILLGAPGAGKGTQAQFIMNKFGIPQISTGDMLRGAIKAGTDLGKQAKTLMDAGQLVPDDLIISLVKERVAQADCAKG
FLLDGFPRTIPQADALKTVGIQIDYVLEFDVPDEVIVERMSGRRVHQASGRTYHVVYNPPKVEGKDDVTGEDLIIRADDK
PETVLDRLKVYHSTTKPLVDYYQAEAKAGNTKYFRLDGTKKVEEVSQELDTILA

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=187, Percent_Identity=45.4545454545455, Blast_Score=190, Evalue=9e-49,
Organism=Homo sapiens, GI4502013, Length=187, Percent_Identity=45.4545454545455, Blast_Score=190, Evalue=1e-48,
Organism=Homo sapiens, GI19923437, Length=202, Percent_Identity=45.5445544554455, Blast_Score=181, Evalue=5e-46,
Organism=Homo sapiens, GI310110345, Length=184, Percent_Identity=41.8478260869565, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI53832003, Length=184, Percent_Identity=41.8478260869565, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI8051579, Length=184, Percent_Identity=41.8478260869565, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI53832001, Length=184, Percent_Identity=41.8478260869565, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI4502011, Length=182, Percent_Identity=31.3186813186813, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI22749187, Length=140, Percent_Identity=32.8571428571429, Blast_Score=98, Evalue=5e-21,
Organism=Homo sapiens, GI7706497, Length=222, Percent_Identity=30.1801801801802, Blast_Score=91, Evalue=5e-19,
Organism=Homo sapiens, GI28144899, Length=186, Percent_Identity=25.8064516129032, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI28144897, Length=186, Percent_Identity=25.8064516129032, Blast_Score=83, Evalue=1e-16,
Organism=Homo sapiens, GI21450759, Length=139, Percent_Identity=26.6187050359712, Blast_Score=74, Evalue=7e-14,
Organism=Homo sapiens, GI237858799, Length=246, Percent_Identity=24.390243902439, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI1786680, Length=214, Percent_Identity=71.0280373831776, Blast_Score=320, Evalue=5e-89,
Organism=Caenorhabditis elegans, GI17552384, Length=218, Percent_Identity=41.2844036697248, Blast_Score=185, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17537943, Length=192, Percent_Identity=37.5, Blast_Score=132, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17567503, Length=187, Percent_Identity=34.7593582887701, Blast_Score=117, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17550688, Length=216, Percent_Identity=25.462962962963, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17533833, Length=188, Percent_Identity=27.1276595744681, Blast_Score=77, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6320432, Length=188, Percent_Identity=47.3404255319149, Blast_Score=191, Evalue=9e-50,
Organism=Saccharomyces cerevisiae, GI6321018, Length=187, Percent_Identity=47.0588235294118, Blast_Score=159, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6322828, Length=212, Percent_Identity=28.7735849056604, Blast_Score=97, Evalue=1e-21,
Organism=Drosophila melanogaster, GI22026816, Length=214, Percent_Identity=47.196261682243, Blast_Score=204, Evalue=3e-53,
Organism=Drosophila melanogaster, GI17737899, Length=202, Percent_Identity=42.0792079207921, Blast_Score=163, Evalue=7e-41,
Organism=Drosophila melanogaster, GI24645822, Length=202, Percent_Identity=42.0792079207921, Blast_Score=163, Evalue=7e-41,
Organism=Drosophila melanogaster, GI24663208, Length=216, Percent_Identity=28.2407407407407, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17647141, Length=216, Percent_Identity=28.2407407407407, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI221459597, Length=215, Percent_Identity=28.8372093023256, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21356893, Length=215, Percent_Identity=28.8372093023256, Blast_Score=89, Evalue=1e-18,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 23461; Mature: 23461

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIILLGAPGAGKGTQAQFIMNKFGIPQISTGDMLRGAIKAGTDLGKQAKTLMDAGQLVP
CEEEEEECCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCH
DDLIISLVKERVAQADCAKGFLLDGFPRTIPQADALKTVGIQIDYVLEFDVPDEVIVERM
HHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCHHHEEECEEEEEEEEECCCHHHHHHHH
SGRRVHQASGRTYHVVYNPPKVEGKDDVTGEDLIIRADDKPETVLDRLKVYHSTTKPLVD
CCCEEECCCCCEEEEEECCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCHHHHH
YYQAEAKAGNTKYFRLDGTKKVEEVSQELDTILA
HHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKIILLGAPGAGKGTQAQFIMNKFGIPQISTGDMLRGAIKAGTDLGKQAKTLMDAGQLVP
CEEEEEECCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCH
DDLIISLVKERVAQADCAKGFLLDGFPRTIPQADALKTVGIQIDYVLEFDVPDEVIVERM
HHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCHHHEEECEEEEEEEEECCCHHHHHHHH
SGRRVHQASGRTYHVVYNPPKVEGKDDVTGEDLIIRADDKPETVLDRLKVYHSTTKPLVD
CCCEEECCCCCEEEEEECCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCHHHHH
YYQAEAKAGNTKYFRLDGTKKVEEVSQELDTILA
HHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA