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The map label for this gene is prsA [H]

Identifier: 15602109

GI number: 15602109

Start: 275133

End: 276080

Strand: Reverse

Name: prsA [H]

Synonym: PM0244

Alternate gene names: 15602109

Gene position: 276080-275133 (Counterclockwise)

Preceding gene: 15602110

Following gene: 15602107

Centisome position: 12.23

GC content: 42.72

Gene sequence:

>948_bases
ATGCCTGATATAAAACTCTTTACTGGTAATGCAACACCAGAACTAGCAAAACGAATTTCTGAACGTTTATATCTCTCATT
AGGTGATGCGACTGTTGGTCGTTTCAGTGATGGAGAAATTCAAGTTCAGATCAATGAAAACGTACGTGGTAGTGATGTGT
TCATTATTCAATCTACTTGTGCCCCAACAAACGATAACCTAATGGAGTTGATTGTCATGGTTGATGCGTTACGTCGAGCA
TCTGCTGGTCGTATTACCGCGGTAATTCCTTATTTTGGTTATGCACGCCAAGATCGTCGTGTCCGCTCTGCTCGTGTACC
GATTACAGCAAAAGTCGTGGCTGACTTCCTTTCTAGTGTAGGTGTCGATCGCGTGTTAACTTGTGATTTACACGCGGAAC
AAATCCAAGGTTTTTTTGATGTGCCTGTTGATAACGTCTTTGGTTCACCTGTATTAGTGCATGATATGTTAAAGAAAATC
GACATGCAAAATCCGATTGTCGTTTCACCAGATATTGGAGGCGTTGTACGTGCCCGCGCTATCGCAAAATTACTGAATGA
TACCGATATGGCAATTATTGATAAACGTCGTCCACGTGCCAATGTAGCACAAGTCATGCATATTATCGGGGATGTTGCAG
GTCGTGATTGTATTCTTGTGGATGATATGATTGATACTGGTGGGACATTATGTAAAGCGGCTGAAGCCTTAAAAGAACGC
GGGGCTAAACGTGTTTTTGCCTATGCGACCCACGCAGTATTCTCTGGCTCGGCTGCGAAAAATCTTGCCAGTGATGCATT
AGATGAGGTGGTAGTAACAGACACGATCCCACTTTCACCAGAAATTAAAGCATTAAACAAAGTCCGCGTATTAACCCTTT
CAGGTATGTTGGCTGAAGCTATTCGTCGTATCAGTAACGAAGAATCAATTTCTGCAATGTTCACCTAG

Upstream 100 bases:

>100_bases
TTTACATAATATGCTAGCGAAAATCAGCTAGCTCGATAATAACGAATTTACTCAACCATTTTTATTTCTTTACAATCTAA
ACCTCGAGGTTCAATTAACA

Downstream 100 bases:

>100_bases
TCAAATGACAAAAAAAGTGCGGTTAAAAATATTGAATTTTTAACCGCACTTTTTTATCTCGATAAGCGTCGTCTTTTATA
GTCTGAGCTGCCGCTCAATT

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 315; Mature: 314

Protein sequence:

>315_residues
MPDIKLFTGNATPELAKRISERLYLSLGDATVGRFSDGEIQVQINENVRGSDVFIIQSTCAPTNDNLMELIVMVDALRRA
SAGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSSVGVDRVLTCDLHAEQIQGFFDVPVDNVFGSPVLVHDMLKKI
DMQNPIVVSPDIGGVVRARAIAKLLNDTDMAIIDKRRPRANVAQVMHIIGDVAGRDCILVDDMIDTGGTLCKAAEALKER
GAKRVFAYATHAVFSGSAAKNLASDALDEVVVTDTIPLSPEIKALNKVRVLTLSGMLAEAIRRISNEESISAMFT

Sequences:

>Translated_315_residues
MPDIKLFTGNATPELAKRISERLYLSLGDATVGRFSDGEIQVQINENVRGSDVFIIQSTCAPTNDNLMELIVMVDALRRA
SAGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSSVGVDRVLTCDLHAEQIQGFFDVPVDNVFGSPVLVHDMLKKI
DMQNPIVVSPDIGGVVRARAIAKLLNDTDMAIIDKRRPRANVAQVMHIIGDVAGRDCILVDDMIDTGGTLCKAAEALKER
GAKRVFAYATHAVFSGSAAKNLASDALDEVVVTDTIPLSPEIKALNKVRVLTLSGMLAEAIRRISNEESISAMFT
>Mature_314_residues
PDIKLFTGNATPELAKRISERLYLSLGDATVGRFSDGEIQVQINENVRGSDVFIIQSTCAPTNDNLMELIVMVDALRRAS
AGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSSVGVDRVLTCDLHAEQIQGFFDVPVDNVFGSPVLVHDMLKKID
MQNPIVVSPDIGGVVRARAIAKLLNDTDMAIIDKRRPRANVAQVMHIIGDVAGRDCILVDDMIDTGGTLCKAAEALKERG
AKRVFAYATHAVFSGSAAKNLASDALDEVVVTDTIPLSPEIKALNKVRVLTLSGMLAEAIRRISNEESISAMFT

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506129, Length=316, Percent_Identity=48.7341772151899, Blast_Score=305, Evalue=4e-83,
Organism=Homo sapiens, GI4506127, Length=316, Percent_Identity=48.7341772151899, Blast_Score=305, Evalue=5e-83,
Organism=Homo sapiens, GI84875539, Length=318, Percent_Identity=48.4276729559748, Blast_Score=304, Evalue=6e-83,
Organism=Homo sapiens, GI28557709, Length=316, Percent_Identity=48.4177215189873, Blast_Score=301, Evalue=6e-82,
Organism=Homo sapiens, GI4506133, Length=343, Percent_Identity=36.734693877551, Blast_Score=200, Evalue=1e-51,
Organism=Homo sapiens, GI194018537, Length=343, Percent_Identity=36.734693877551, Blast_Score=194, Evalue=6e-50,
Organism=Homo sapiens, GI310128524, Length=145, Percent_Identity=30.3448275862069, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI310115209, Length=145, Percent_Identity=30.3448275862069, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI310118259, Length=145, Percent_Identity=30.3448275862069, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI310119946, Length=145, Percent_Identity=30.3448275862069, Blast_Score=76, Evalue=4e-14,
Organism=Escherichia coli, GI1787458, Length=314, Percent_Identity=87.5796178343949, Blast_Score=560, Evalue=1e-161,
Organism=Caenorhabditis elegans, GI25149168, Length=316, Percent_Identity=48.1012658227848, Blast_Score=306, Evalue=1e-83,
Organism=Caenorhabditis elegans, GI17554702, Length=316, Percent_Identity=48.1012658227848, Blast_Score=305, Evalue=1e-83,
Organism=Caenorhabditis elegans, GI71989924, Length=316, Percent_Identity=48.1012658227848, Blast_Score=304, Evalue=3e-83,
Organism=Caenorhabditis elegans, GI17554704, Length=311, Percent_Identity=47.588424437299, Blast_Score=297, Evalue=6e-81,
Organism=Caenorhabditis elegans, GI17570245, Length=336, Percent_Identity=36.0119047619048, Blast_Score=207, Evalue=5e-54,
Organism=Saccharomyces cerevisiae, GI6320946, Length=314, Percent_Identity=46.8152866242038, Blast_Score=279, Evalue=4e-76,
Organism=Saccharomyces cerevisiae, GI6321776, Length=317, Percent_Identity=47.6340694006309, Blast_Score=273, Evalue=2e-74,
Organism=Saccharomyces cerevisiae, GI6319403, Length=315, Percent_Identity=46.6666666666667, Blast_Score=271, Evalue=7e-74,
Organism=Saccharomyces cerevisiae, GI6322667, Length=206, Percent_Identity=40.7766990291262, Blast_Score=153, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6324511, Length=111, Percent_Identity=41.4414414414414, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI21355239, Length=316, Percent_Identity=47.4683544303797, Blast_Score=292, Evalue=2e-79,
Organism=Drosophila melanogaster, GI45551540, Length=338, Percent_Identity=44.3786982248521, Blast_Score=283, Evalue=1e-76,
Organism=Drosophila melanogaster, GI24651458, Length=355, Percent_Identity=34.6478873239437, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24651456, Length=355, Percent_Identity=34.6478873239437, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI281362873, Length=355, Percent_Identity=34.6478873239437, Blast_Score=205, Evalue=3e-53,
Organism=Drosophila melanogaster, GI24651454, Length=355, Percent_Identity=34.6478873239437, Blast_Score=205, Evalue=3e-53,
Organism=Drosophila melanogaster, GI45552010, Length=374, Percent_Identity=32.8877005347594, Blast_Score=200, Evalue=1e-51,
Organism=Drosophila melanogaster, GI24651462, Length=374, Percent_Identity=32.8877005347594, Blast_Score=200, Evalue=1e-51,
Organism=Drosophila melanogaster, GI24651464, Length=374, Percent_Identity=32.8877005347594, Blast_Score=200, Evalue=1e-51,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 34194; Mature: 34063

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDIKLFTGNATPELAKRISERLYLSLGDATVGRFSDGEIQVQINENVRGSDVFIIQSTC
CCCCEEEECCCCHHHHHHHHHHHEEEECCCCCCCCCCCEEEEEECCCCCCCEEEEEEECC
APTNDNLMELIVMVDALRRASAGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSSV
CCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHC
GVDRVLTCDLHAEQIQGFFDVPVDNVFGSPVLVHDMLKKIDMQNPIVVSPDIGGVVRARA
CCCEEEEECCCHHHCCCEECCCHHHHCCCHHHHHHHHHHHCCCCCEEECCCCCHHHHHHH
IAKLLNDTDMAIIDKRRPRANVAQVMHIIGDVAGRDCILVDDMIDTGGTLCKAAEALKER
HHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECHHCCCCHHHHHHHHHHHC
GAKRVFAYATHAVFSGSAAKNLASDALDEVVVTDTIPLSPEIKALNKVRVLTLSGMLAEA
CCHHHHHHHHHHHHCCHHHHHHHHHHHHHEEEECCCCCCCCHHHHCEEEEEEHHHHHHHH
IRRISNEESISAMFT
HHHHCCCCCHHEECC
>Mature Secondary Structure 
PDIKLFTGNATPELAKRISERLYLSLGDATVGRFSDGEIQVQINENVRGSDVFIIQSTC
CCCEEEECCCCHHHHHHHHHHHEEEECCCCCCCCCCCEEEEEECCCCCCCEEEEEEECC
APTNDNLMELIVMVDALRRASAGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSSV
CCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHC
GVDRVLTCDLHAEQIQGFFDVPVDNVFGSPVLVHDMLKKIDMQNPIVVSPDIGGVVRARA
CCCEEEEECCCHHHCCCEECCCHHHHCCCHHHHHHHHHHHCCCCCEEECCCCCHHHHHHH
IAKLLNDTDMAIIDKRRPRANVAQVMHIIGDVAGRDCILVDDMIDTGGTLCKAAEALKER
HHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECHHCCCCHHHHHHHHHHHC
GAKRVFAYATHAVFSGSAAKNLASDALDEVVVTDTIPLSPEIKALNKVRVLTLSGMLAEA
CCHHHHHHHHHHHHCCHHHHHHHHHHHHHEEEECCCCCCCCHHHHCEEEEEEHHHHHHHH
IRRISNEESISAMFT
HHHHCCCCCHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA