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The map label for this gene is frdA [H]

Identifier: 15602066

GI number: 15602066

Start: 223584

End: 225383

Strand: Reverse

Name: frdA [H]

Synonym: PM0201

Alternate gene names: 15602066

Gene position: 225383-223584 (Counterclockwise)

Preceding gene: 15602068

Following gene: 229282647

Centisome position: 9.98

GC content: 44.33

Gene sequence:

>1800_bases
GTGCAAACTGTTAATGTCGATATTGCAATTGTAGGTGCTGGTGGCGGTGGTTTACGCGCAGCGATTGCAGCAGCGGAAGC
AAACCCTAACTTAAAAATTGCATTAGTATCAAAAGTTTACCCTATGCGCAGTCATACCGTGGCCGCAGAAGGCGGTGCAG
CTGCCGTTATCAAAGAGGAAGACTCTTATGATAAACACTTCCATGATACTGTGGCGGGTGGCGACTGGTTATGTGAGCAA
GATGTGGTTGAATATTTTGTGCAACATTCACCGGTAGAAATGACTCAACTTGAACGCTGGGGCTGTCCTTGGAGCCGTAA
ACAAGATGGTGATGTCAACGTTCGCCGTTTCGGTGGAATGAAAATTGAGCGTACTTGGTTCGCGGCAGATAAAACCGGTT
TCCACTTATTACACACGTTATTCCAAACGTCCATTCAATATCCGCAAATCGTTCGTTTTGATGAGCACTTCGTCTTAGAT
ATTCTCGTTGATGATGGTCATGCGCGTGGTATGGTTGCCATGAACATGATGGAAGGGACCTTAGTACAAATTAATGCCAA
TGCGGTGGTGATTGCAACGGGTGGTGGTTGCCGTGCATTCCGTTTCAATACCAATGGCGGTATCGTAACAGGGGATGGTC
TTTCAATGGCTTACCGTCACGGTGTACCGTTACGTGATATGGAATTCGTTCAATATCACCCAACAGGTTTACCAAATACC
GGTATTTTAATGACTGAAGGTTGCCGTGGTGAAGGTGGTATTTTGGTCAACAAAGACGGTTACCGTTATCTCCAAGACTA
TGGTCTAGGACCTGAAACACCAATCGGCAAACCTGAAAATAAATATATGGAATTGGGTCCTCGTGATAAAGTTTCACAAG
CCTTCTGGCAAGAATTACAAAAAGGCAACACCTTAAAAACCGCTAAAGGGGTAGATGTTGTACACCTCGATTTACGTCAC
TTAGGTGAAAAATACTTACATGAACGCTTACCATTTATTTGTGAATTAGCGCAAGCATACGAAGGTGTTGATCCTGCCAA
AGCACCAATCCCAGTACGTCCAGTTGTACACTACACGATGGGCGGGATTGAAGTGGACTTCAACAGTGAAACCCGTATCA
AAGGCTTATTCGCTGTTGGTGAATGTGCTTCTTCAGGTTTACATGGAGCAAACCGTTTAGGCTCTAACTCTTTGGCTGAA
TTAGTGGTTCTTGGTCGCGTAGCTGGTGAATACGCCGCACAACGTGCTGTTGAAGCGCCTGCTGTTAACCAAACAGCAGT
AGATGCACAAGCGCGTGATATTGTTCAACGTTTAGAAGACTTATATCACCAAGAAGGTAATGAGTCTTGGTCTGAAATCC
GCGATGAAATGGGTGATGCCATGGAAGAAGGTTGTGGTATTTACCGTACTCAAGAAAGTATGCAAAAAGCCGTGGATAAA
ATTGCAGAACTGAAAGAACGTTACAAACGTATTCGCATCACCGACCGTTCTAGCGTGTTTAACACCAATGTCTTATATAC
GGTTGAATTAGGTTACATCTTAGATGTTGCACAATCTATTGCTAACTCAGCGATTGAGCGTAAGGAATCTCGTGGTGCAC
ACCAACGTTTAGACTACACTGAACGTGACGATGTGAATTACTTGAAACATACCCTTGCTTTCTACAATGGAGATGACGCA
CCGCGTATTGAATATAGCGATGTAAAAATCACGAAATCTCAACCTGCCAAACGTGTTTATGGTGCAGAAGCCGAAGCACA
AGAAGCGGCAAAAGCCAATAAGGAGAACGCAAATGGTTAA

Upstream 100 bases:

>100_bases
AAAAAAGGTTATTAATATCCCAAAATAGTGGCAAAATGAAACTACCCTAATGAACCAATTTCGGTTCCTTTTTACTTTAT
ATTCTGATTGGAGGAATATC

Downstream 100 bases:

>100_bases
TCAAGCAATCATGAATATCGAAGTATTGCGTTACAATCCTGAACAGGACAAAGAACCATACTTACGGACTTATCAAGTGC
CTTACGATAATCAAACGTCA

Product: fumarate reductase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 599; Mature: 599

Protein sequence:

>599_residues
MQTVNVDIAIVGAGGGGLRAAIAAAEANPNLKIALVSKVYPMRSHTVAAEGGAAAVIKEEDSYDKHFHDTVAGGDWLCEQ
DVVEYFVQHSPVEMTQLERWGCPWSRKQDGDVNVRRFGGMKIERTWFAADKTGFHLLHTLFQTSIQYPQIVRFDEHFVLD
ILVDDGHARGMVAMNMMEGTLVQINANAVVIATGGGCRAFRFNTNGGIVTGDGLSMAYRHGVPLRDMEFVQYHPTGLPNT
GILMTEGCRGEGGILVNKDGYRYLQDYGLGPETPIGKPENKYMELGPRDKVSQAFWQELQKGNTLKTAKGVDVVHLDLRH
LGEKYLHERLPFICELAQAYEGVDPAKAPIPVRPVVHYTMGGIEVDFNSETRIKGLFAVGECASSGLHGANRLGSNSLAE
LVVLGRVAGEYAAQRAVEAPAVNQTAVDAQARDIVQRLEDLYHQEGNESWSEIRDEMGDAMEEGCGIYRTQESMQKAVDK
IAELKERYKRIRITDRSSVFNTNVLYTVELGYILDVAQSIANSAIERKESRGAHQRLDYTERDDVNYLKHTLAFYNGDDA
PRIEYSDVKITKSQPAKRVYGAEAEAQEAAKANKENANG

Sequences:

>Translated_599_residues
MQTVNVDIAIVGAGGGGLRAAIAAAEANPNLKIALVSKVYPMRSHTVAAEGGAAAVIKEEDSYDKHFHDTVAGGDWLCEQ
DVVEYFVQHSPVEMTQLERWGCPWSRKQDGDVNVRRFGGMKIERTWFAADKTGFHLLHTLFQTSIQYPQIVRFDEHFVLD
ILVDDGHARGMVAMNMMEGTLVQINANAVVIATGGGCRAFRFNTNGGIVTGDGLSMAYRHGVPLRDMEFVQYHPTGLPNT
GILMTEGCRGEGGILVNKDGYRYLQDYGLGPETPIGKPENKYMELGPRDKVSQAFWQELQKGNTLKTAKGVDVVHLDLRH
LGEKYLHERLPFICELAQAYEGVDPAKAPIPVRPVVHYTMGGIEVDFNSETRIKGLFAVGECASSGLHGANRLGSNSLAE
LVVLGRVAGEYAAQRAVEAPAVNQTAVDAQARDIVQRLEDLYHQEGNESWSEIRDEMGDAMEEGCGIYRTQESMQKAVDK
IAELKERYKRIRITDRSSVFNTNVLYTVELGYILDVAQSIANSAIERKESRGAHQRLDYTERDDVNYLKHTLAFYNGDDA
PRIEYSDVKITKSQPAKRVYGAEAEAQEAAKANKENANG
>Mature_599_residues
MQTVNVDIAIVGAGGGGLRAAIAAAEANPNLKIALVSKVYPMRSHTVAAEGGAAAVIKEEDSYDKHFHDTVAGGDWLCEQ
DVVEYFVQHSPVEMTQLERWGCPWSRKQDGDVNVRRFGGMKIERTWFAADKTGFHLLHTLFQTSIQYPQIVRFDEHFVLD
ILVDDGHARGMVAMNMMEGTLVQINANAVVIATGGGCRAFRFNTNGGIVTGDGLSMAYRHGVPLRDMEFVQYHPTGLPNT
GILMTEGCRGEGGILVNKDGYRYLQDYGLGPETPIGKPENKYMELGPRDKVSQAFWQELQKGNTLKTAKGVDVVHLDLRH
LGEKYLHERLPFICELAQAYEGVDPAKAPIPVRPVVHYTMGGIEVDFNSETRIKGLFAVGECASSGLHGANRLGSNSLAE
LVVLGRVAGEYAAQRAVEAPAVNQTAVDAQARDIVQRLEDLYHQEGNESWSEIRDEMGDAMEEGCGIYRTQESMQKAVDK
IAELKERYKRIRITDRSSVFNTNVLYTVELGYILDVAQSIANSAIERKESRGAHQRLDYTERDDVNYLKHTLAFYNGDDA
PRIEYSDVKITKSQPAKRVYGAEAEAQEAAKANKENANG

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=542, Percent_Identity=38.929889298893, Blast_Score=369, Evalue=1e-102,
Organism=Escherichia coli, GI1790597, Length=583, Percent_Identity=77.5300171526587, Blast_Score=915, Evalue=0.0,
Organism=Escherichia coli, GI1786942, Length=552, Percent_Identity=38.9492753623188, Blast_Score=350, Evalue=1e-97,
Organism=Escherichia coli, GI1788928, Length=562, Percent_Identity=31.8505338078292, Blast_Score=249, Evalue=5e-67,
Organism=Caenorhabditis elegans, GI17505833, Length=535, Percent_Identity=38.5046728971963, Blast_Score=350, Evalue=1e-96,
Organism=Caenorhabditis elegans, GI17550100, Length=543, Percent_Identity=37.0165745856354, Blast_Score=347, Evalue=7e-96,
Organism=Caenorhabditis elegans, GI71986328, Length=432, Percent_Identity=27.5462962962963, Blast_Score=115, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6322701, Length=557, Percent_Identity=39.3177737881508, Blast_Score=387, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6322416, Length=564, Percent_Identity=38.2978723404255, Blast_Score=382, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6320788, Length=497, Percent_Identity=26.3581488933602, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI17137288, Length=598, Percent_Identity=37.9598662207358, Blast_Score=390, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24655642, Length=598, Percent_Identity=37.9598662207358, Blast_Score=390, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24655647, Length=598, Percent_Identity=37.9598662207358, Blast_Score=390, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24663005, Length=603, Percent_Identity=34.9917081260365, Blast_Score=340, Evalue=1e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR005884
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 66175; Mature: 66175

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTVNVDIAIVGAGGGGLRAAIAAAEANPNLKIALVSKVYPMRSHTVAAEGGAAAVIKEE
CCEEEEEEEEEECCCCCHHHEEEEECCCCCEEEEEEECCCCCCCCEEEECCCEEEEEECC
DSYDKHFHDTVAGGDWLCEQDVVEYFVQHSPVEMTQLERWGCPWSRKQDGDVNVRRFGGM
CCCHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCEEEEECCE
KIERTWFAADKTGFHLLHTLFQTSIQYPQIVRFDEHFVLDILVDDGHARGMVAMNMMEGT
EEEEEEEECCCCHHHHHHHHHHHCCCCCCEEEECCEEEEEEEEECCCCCCEEEEEECCCE
LVQINANAVVIATGGGCRAFRFNTNGGIVTGDGLSMAYRHGVPLRDMEFVQYHPTGLPNT
EEEEECCEEEEEECCCEEEEEEECCCCEEECCCCHHHHHCCCCCCCCCEEEECCCCCCCC
GILMTEGCRGEGGILVNKDGYRYLQDYGLGPETPIGKPENKYMELGPRDKVSQAFWQELQ
CEEEECCCCCCCCEEECCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
KGNTLKTAKGVDVVHLDLRHLGEKYLHERLPFICELAQAYEGVDPAKAPIPVRPVVHYTM
CCCCEEECCCCEEEEHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCCCCHHHEEEE
GGIEVDFNSETRIKGLFAVGECASSGLHGANRLGSNSLAELVVLGRVAGEYAAQRAVEAP
CCEEEECCCCCCEEEEEEEHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCC
AVNQTAVDAQARDIVQRLEDLYHQEGNESWSEIRDEMGDAMEEGCGIYRTQESMQKAVDK
CCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEECHHHHHHHHHH
IAELKERYKRIRITDRSSVFNTNVLYTVELGYILDVAQSIANSAIERKESRGAHQRLDYT
HHHHHHHHHHEEEECCCCEECCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCC
ERDDVNYLKHTLAFYNGDDAPRIEYSDVKITKSQPAKRVYGAEAEAQEAAKANKENANG
CCCCHHHHHHHHHHCCCCCCCCEEECCEEEECCCCCHHHCCCCHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MQTVNVDIAIVGAGGGGLRAAIAAAEANPNLKIALVSKVYPMRSHTVAAEGGAAAVIKEE
CCEEEEEEEEEECCCCCHHHEEEEECCCCCEEEEEEECCCCCCCCEEEECCCEEEEEECC
DSYDKHFHDTVAGGDWLCEQDVVEYFVQHSPVEMTQLERWGCPWSRKQDGDVNVRRFGGM
CCCHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCEEEEECCE
KIERTWFAADKTGFHLLHTLFQTSIQYPQIVRFDEHFVLDILVDDGHARGMVAMNMMEGT
EEEEEEEECCCCHHHHHHHHHHHCCCCCCEEEECCEEEEEEEEECCCCCCEEEEEECCCE
LVQINANAVVIATGGGCRAFRFNTNGGIVTGDGLSMAYRHGVPLRDMEFVQYHPTGLPNT
EEEEECCEEEEEECCCEEEEEEECCCCEEECCCCHHHHHCCCCCCCCCEEEECCCCCCCC
GILMTEGCRGEGGILVNKDGYRYLQDYGLGPETPIGKPENKYMELGPRDKVSQAFWQELQ
CEEEECCCCCCCCEEECCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
KGNTLKTAKGVDVVHLDLRHLGEKYLHERLPFICELAQAYEGVDPAKAPIPVRPVVHYTM
CCCCEEECCCCEEEEHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCCCCHHHEEEE
GGIEVDFNSETRIKGLFAVGECASSGLHGANRLGSNSLAELVVLGRVAGEYAAQRAVEAP
CCEEEECCCCCCEEEEEEEHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCC
AVNQTAVDAQARDIVQRLEDLYHQEGNESWSEIRDEMGDAMEEGCGIYRTQESMQKAVDK
CCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEECHHHHHHHHHH
IAELKERYKRIRITDRSSVFNTNVLYTVELGYILDVAQSIANSAIERKESRGAHQRLDYT
HHHHHHHHHHEEEECCCCEECCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCC
ERDDVNYLKHTLAFYNGDDAPRIEYSDVKITKSQPAKRVYGAEAEAQEAAKANKENANG
CCCCHHHHHHHHHHCCCCCCCCEEECCEEEECCCCCHHHCCCCHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]