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The map label for this gene is frdB [H]

Identifier: 229282647

GI number: 229282647

Start: 222821

End: 223591

Strand: Reverse

Name: frdB [H]

Synonym: PM0200

Alternate gene names: 229282647

Gene position: 223591-222821 (Counterclockwise)

Preceding gene: 15602066

Following gene: 15602064

Centisome position: 9.9

GC content: 41.25

Gene sequence:

>771_bases
ATGGTTAATCAAGCAATCATGAATATCGAAGTATTGCGTTACAATCCTGAACAGGACAAAGAACCATACTTACGGACTTA
TCAAGTGCCTTACGATAATCAAACGTCATTGCTTGATGCGTTAGGCTATATTAAAGACAAATTAGAGCCTGAACTTTCTT
ATCGTTGGTCTTGTCGTATGGCGATCTGTGGTTCATGCGGGATGATGGTTAACAACAAGCCAAAATTAGCCTGTAAAACG
TTCTTACGCGACTATAGCGGTCATATGCGTATTGAGCCATTGGCGAATTTCCCAATTGAGCGTGATTTGGTCGTTGATTT
AAGCCACTTTATTGAAAGCTTAGAAGCCATTAAGCCTTATATTATCGGCAACCAAGCACCTGCATTAGACGGTAAACCGC
ATCCATCTTCCGAATTAGCCAAAAGCCGTACGAAACAAACACCAGCACAACTTGAGAAATATCGTACTTTCTCAATGTGT
ATCAACTGTGGTTTATGCTATGCCGCTTGCCCACAATTTGGTTTAAATCCTGAGTTTGTTGGACCTGCTGCATTAACGCT
TGCACATCGTTACAACCTTGATAACCGTGACCACGGTAAAGAAGAACGGATGAAGATTATTAATGGTAAAAATGGGGTGT
GGAGCTGTACATTTGTTGGCTATTGTTCGGAAGTCTGTCCAAAACACGTCGATCCAGCTTCCGCGGTAAACCAAGGTAAA
GTCGAAAGTGCAAAAGACTTTGTAATTGCAATGCTTAAACCGCAAAAGTAA

Upstream 100 bases:

>100_bases
TATAGCGATGTAAAAATCACGAAATCTCAACCTGCCAAACGTGTTTATGGTGCAGAAGCCGAAGCACAAGAAGCGGCAAA
AGCCAATAAGGAGAACGCAA

Downstream 100 bases:

>100_bases
GGAGTGTAAAATGACAGCAACAACCAGTAAACGCAAAAAATACGTGCGTGAAATGAAACCAACTTGGTGGAAAAAGTTAG
ATTTTTACAAACTTTATATT

Product: fumarate reductase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MVNQAIMNIEVLRYNPEQDKEPYLRTYQVPYDNQTSLLDALGYIKDKLEPELSYRWSCRMAICGSCGMMVNNKPKLACKT
FLRDYSGHMRIEPLANFPIERDLVVDLSHFIESLEAIKPYIIGNQAPALDGKPHPSSELAKSRTKQTPAQLEKYRTFSMC
INCGLCYAACPQFGLNPEFVGPAALTLAHRYNLDNRDHGKEERMKIINGKNGVWSCTFVGYCSEVCPKHVDPASAVNQGK
VESAKDFVIAMLKPQK

Sequences:

>Translated_256_residues
MVNQAIMNIEVLRYNPEQDKEPYLRTYQVPYDNQTSLLDALGYIKDKLEPELSYRWSCRMAICGSCGMMVNNKPKLACKT
FLRDYSGHMRIEPLANFPIERDLVVDLSHFIESLEAIKPYIIGNQAPALDGKPHPSSELAKSRTKQTPAQLEKYRTFSMC
INCGLCYAACPQFGLNPEFVGPAALTLAHRYNLDNRDHGKEERMKIINGKNGVWSCTFVGYCSEVCPKHVDPASAVNQGK
VESAKDFVIAMLKPQK
>Mature_256_residues
MVNQAIMNIEVLRYNPEQDKEPYLRTYQVPYDNQTSLLDALGYIKDKLEPELSYRWSCRMAICGSCGMMVNNKPKLACKT
FLRDYSGHMRIEPLANFPIERDLVVDLSHFIESLEAIKPYIIGNQAPALDGKPHPSSELAKSRTKQTPAQLEKYRTFSMC
INCGLCYAACPQFGLNPEFVGPAALTLAHRYNLDNRDHGKEERMKIINGKNGVWSCTFVGYCSEVCPKHVDPASAVNQGK
VESAKDFVIAMLKPQK

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=239, Percent_Identity=30.9623430962343, Blast_Score=125, Evalue=5e-29,
Organism=Escherichia coli, GI1790596, Length=255, Percent_Identity=72.156862745098, Blast_Score=391, Evalue=1e-110,
Organism=Escherichia coli, GI1786943, Length=240, Percent_Identity=36.6666666666667, Blast_Score=146, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17533915, Length=239, Percent_Identity=32.2175732217573, Blast_Score=131, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6322987, Length=239, Percent_Identity=32.2175732217573, Blast_Score=130, Evalue=2e-31,
Organism=Drosophila melanogaster, GI17137106, Length=239, Percent_Identity=32.2175732217573, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24643156, Length=238, Percent_Identity=31.0924369747899, Blast_Score=127, Evalue=6e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006058
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 28888; Mature: 28888

Theoretical pI: Translated: 8.04; Mature: 8.04

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
7.8 %Cys+Met (Translated Protein)
4.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
7.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVNQAIMNIEVLRYNPEQDKEPYLRTYQVPYDNQTSLLDALGYIKDKLEPELSYRWSCRM
CCCCCEEEEEEEEECCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEE
AICGSCGMMVNNKPKLACKTFLRDYSGHMRIEPLANFPIERDLVVDLSHFIESLEAIKPY
EEECCCCCEECCCCHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCE
IIGNQAPALDGKPHPSSELAKSRTKQTPAQLEKYRTFSMCINCGLCYAACPQFGLNPEFV
EECCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCC
GPAALTLAHRYNLDNRDHGKEERMKIINGKNGVWSCTFVGYCSEVCPKHVDPASAVNQGK
CHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCEEEEHHHHHHHHHCCCCCCCHHHHCCCC
VESAKDFVIAMLKPQK
CCCCCCEEEEEECCCC
>Mature Secondary Structure
MVNQAIMNIEVLRYNPEQDKEPYLRTYQVPYDNQTSLLDALGYIKDKLEPELSYRWSCRM
CCCCCEEEEEEEEECCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEE
AICGSCGMMVNNKPKLACKTFLRDYSGHMRIEPLANFPIERDLVVDLSHFIESLEAIKPY
EEECCCCCEECCCCHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCE
IIGNQAPALDGKPHPSSELAKSRTKQTPAQLEKYRTFSMCINCGLCYAACPQFGLNPEFV
EECCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCC
GPAALTLAHRYNLDNRDHGKEERMKIINGKNGVWSCTFVGYCSEVCPKHVDPASAVNQGK
CHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCEEEEHHHHHHHHHCCCCCCCHHHHCCCC
VESAKDFVIAMLKPQK
CCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]