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The map label for this gene is pepA

Identifier: 15602060

GI number: 15602060

Start: 217973

End: 219457

Strand: Reverse

Name: pepA

Synonym: PM0195

Alternate gene names: 15602060

Gene position: 219457-217973 (Counterclockwise)

Preceding gene: 15602063

Following gene: 15602055

Centisome position: 9.72

GC content: 42.56

Gene sequence:

>1485_bases
ATGGAATATCGCGTAAAATCAACCGCACTTTTAGACATAAAAAGTAATATTATTATTGGCTTATATGAGAATGGTGAGCT
ATCACCATCCGCACAAAAAATCGATGAAATTTCTCAAGGCTATTTAAGCAAATTGATTCAATCTGGCGAAATCAAAGGTA
AACTTGGACAAGTTTTGGTGTTACGTCATGTTCCTAACTACAGCGCAGAACGTGTTTTCGTGGTAGGCGCTGGTAAAAAA
GGTGAGATTAACGAGAAACAATTTAAACAACTTATTCAAGACACTATCAACGCTGTTAAAGCCACCAGTGCAAAAGAGGT
TATCAGCTACTTGTCTGATATCAAGATTAAAGATCGTGATCTCTACTGGAATATCCGTTTTAGCGTTGAAACCCTCGAAA
CCAGCATCTATCAGTTCGAACAATTTAAAAGTAAAAAAAGCGAACAAGATGTGGCATTAACAGATGTCATTTTTAGCGCG
GAAGGCGATGTTGCACAACAAGCTGTTAATCATGCCAAAGCAATTGCTTTAGGTGTACGCGCCGCCAAAGATGTAGCGAA
CTGTCCACCTAATGTTTGCAATCCTGTTTATTTAGCCGAACAAGCAAACGCGTTAGCCACACGATCTGACCTGATTAAAA
CTACTGTACTCGGTGAAAAAGACATGGCTGACTTAGGCATGAACGCTTACTTAGCGGTTTCACAAGGTTCTGTCAATGAA
GCACAACTCTCCCTTATCGAATATCGTAATCATCCTAATCCAGATGCCAAGCCCATTGTGTTAGTCGGCAAAGGACTGAC
TTTTGATGCCGGTGGCATCTCGTTAAAGCCAGCTGAAGGCATGGATGAAATGAAATATGATATGGGCGGTGCCGCTTCTG
TCTATGGAGTCATGAATGCCATTGCTGAATTAAAACTGCCATTAAACGTGATTGGCGTGTTAGCAGGTTGTGAAAATTTA
CCAGACGGTAATGCCTATCGACCGGGTGATATTTTAACCACAATGAAAGGCTTAACGGTTGAAGTACTCAATACCGACGC
GGAAGGGCGCTTAGTGTTATGTGATACGCTCACTTATGTAGAACGCTTTGAACCTGAACTGGTGATTGATGTGGCGACCT
TAACTGGCGCTTGCGTAGTAGCACTGGGTGCACATAACAGCGGTTTAATCTCTACTGATGATAAATTAGCCAAAGATCTC
GAACTCGCCGCGGCTCAAAGTACCGATAAAGCTTGGCGTTTGCCACTTGGTGAAGAATATCAAGAACAGCTGAAATCTAA
CTTTGCCGATTTAGCGAATATTGGTGGTCGTTGGGGCGGTGCCATTACTGCTGGCGCATTTTTATCCAACTTCACCGATA
AATATCGCTGGGCGCATTTAGATATCGCAGGTACTGCTTGGTTACAAGGCGCAAACAAAGGAGCTACGGGTCGCCCTGTT
CCTTTACTGGTACAATTCTTAATTAACCAAGCGACAGGTAAATAA

Upstream 100 bases:

>100_bases
CTTGCAATTTATATAGAATAGTTTAGTTTCAAGACTGCTTAATTTTCGTATGATAACGTATTTTTAAGGTGAAAACAGTA
AAAATCTTTGTGAGGACAAC

Downstream 100 bases:

>100_bases
TCCCCCTAGCCACGACTAAAATCAAAAAGTGCGGTCAAAAATATCTCTATTTTTACCGCACTTTTACGATGATGTTTGAT
TCATCACTGCACTATAAATT

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 494; Mature: 494

Protein sequence:

>494_residues
MEYRVKSTALLDIKSNIIIGLYENGELSPSAQKIDEISQGYLSKLIQSGEIKGKLGQVLVLRHVPNYSAERVFVVGAGKK
GEINEKQFKQLIQDTINAVKATSAKEVISYLSDIKIKDRDLYWNIRFSVETLETSIYQFEQFKSKKSEQDVALTDVIFSA
EGDVAQQAVNHAKAIALGVRAAKDVANCPPNVCNPVYLAEQANALATRSDLIKTTVLGEKDMADLGMNAYLAVSQGSVNE
AQLSLIEYRNHPNPDAKPIVLVGKGLTFDAGGISLKPAEGMDEMKYDMGGAASVYGVMNAIAELKLPLNVIGVLAGCENL
PDGNAYRPGDILTTMKGLTVEVLNTDAEGRLVLCDTLTYVERFEPELVIDVATLTGACVVALGAHNSGLISTDDKLAKDL
ELAAAQSTDKAWRLPLGEEYQEQLKSNFADLANIGGRWGGAITAGAFLSNFTDKYRWAHLDIAGTAWLQGANKGATGRPV
PLLVQFLINQATGK

Sequences:

>Translated_494_residues
MEYRVKSTALLDIKSNIIIGLYENGELSPSAQKIDEISQGYLSKLIQSGEIKGKLGQVLVLRHVPNYSAERVFVVGAGKK
GEINEKQFKQLIQDTINAVKATSAKEVISYLSDIKIKDRDLYWNIRFSVETLETSIYQFEQFKSKKSEQDVALTDVIFSA
EGDVAQQAVNHAKAIALGVRAAKDVANCPPNVCNPVYLAEQANALATRSDLIKTTVLGEKDMADLGMNAYLAVSQGSVNE
AQLSLIEYRNHPNPDAKPIVLVGKGLTFDAGGISLKPAEGMDEMKYDMGGAASVYGVMNAIAELKLPLNVIGVLAGCENL
PDGNAYRPGDILTTMKGLTVEVLNTDAEGRLVLCDTLTYVERFEPELVIDVATLTGACVVALGAHNSGLISTDDKLAKDL
ELAAAQSTDKAWRLPLGEEYQEQLKSNFADLANIGGRWGGAITAGAFLSNFTDKYRWAHLDIAGTAWLQGANKGATGRPV
PLLVQFLINQATGK
>Mature_494_residues
MEYRVKSTALLDIKSNIIIGLYENGELSPSAQKIDEISQGYLSKLIQSGEIKGKLGQVLVLRHVPNYSAERVFVVGAGKK
GEINEKQFKQLIQDTINAVKATSAKEVISYLSDIKIKDRDLYWNIRFSVETLETSIYQFEQFKSKKSEQDVALTDVIFSA
EGDVAQQAVNHAKAIALGVRAAKDVANCPPNVCNPVYLAEQANALATRSDLIKTTVLGEKDMADLGMNAYLAVSQGSVNE
AQLSLIEYRNHPNPDAKPIVLVGKGLTFDAGGISLKPAEGMDEMKYDMGGAASVYGVMNAIAELKLPLNVIGVLAGCENL
PDGNAYRPGDILTTMKGLTVEVLNTDAEGRLVLCDTLTYVERFEPELVIDVATLTGACVVALGAHNSGLISTDDKLAKDL
ELAAAQSTDKAWRLPLGEEYQEQLKSNFADLANIGGRWGGAITAGAFLSNFTDKYRWAHLDIAGTAWLQGANKGATGRPV
PLLVQFLINQATGK

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=513, Percent_Identity=32.7485380116959, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI47155554, Length=321, Percent_Identity=31.1526479750779, Blast_Score=116, Evalue=6e-26,
Organism=Escherichia coli, GI1790710, Length=497, Percent_Identity=59.7585513078471, Blast_Score=605, Evalue=1e-174,
Organism=Escherichia coli, GI87082123, Length=361, Percent_Identity=38.2271468144044, Blast_Score=191, Evalue=8e-50,
Organism=Caenorhabditis elegans, GI17556903, Length=299, Percent_Identity=31.1036789297659, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17565172, Length=320, Percent_Identity=27.1875, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI20129969, Length=493, Percent_Identity=30.0202839756592, Blast_Score=208, Evalue=7e-54,
Organism=Drosophila melanogaster, GI21355645, Length=493, Percent_Identity=28.8032454361055, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24662223, Length=493, Percent_Identity=28.8032454361055, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24662227, Length=496, Percent_Identity=28.6290322580645, Blast_Score=194, Evalue=2e-49,
Organism=Drosophila melanogaster, GI161077148, Length=508, Percent_Identity=28.1496062992126, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI20130057, Length=508, Percent_Identity=28.1496062992126, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI24661038, Length=499, Percent_Identity=27.8557114228457, Blast_Score=179, Evalue=4e-45,
Organism=Drosophila melanogaster, GI21355725, Length=499, Percent_Identity=27.6553106212425, Blast_Score=178, Evalue=9e-45,
Organism=Drosophila melanogaster, GI19922386, Length=495, Percent_Identity=28.4848484848485, Blast_Score=174, Evalue=2e-43,
Organism=Drosophila melanogaster, GI20129963, Length=501, Percent_Identity=27.3453093812375, Blast_Score=172, Evalue=6e-43,
Organism=Drosophila melanogaster, GI221379063, Length=316, Percent_Identity=29.746835443038, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI221379062, Length=316, Percent_Identity=29.746835443038, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI21357381, Length=316, Percent_Identity=29.746835443038, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24646701, Length=371, Percent_Identity=24.5283018867925, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24646703, Length=371, Percent_Identity=24.5283018867925, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI21358201, Length=371, Percent_Identity=24.5283018867925, Blast_Score=82, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_PASMU (P57823)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_245132.1
- ProteinModelPortal:   P57823
- SMR:   P57823
- MEROPS:   M17.003
- PRIDE:   P57823
- GeneID:   1243542
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM0195
- NMPDR:   fig|272843.1.peg.195
- HOGENOM:   HBG742580
- OMA:   ELHKPCE
- ProtClustDB:   PRK00913
- BioCyc:   PMUL272843:PM0195-MONOMER
- BRENDA:   3.4.11.1
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 53300; Mature: 53300

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 276-276 ACT_SITE 350-350

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYRVKSTALLDIKSNIIIGLYENGELSPSAQKIDEISQGYLSKLIQSGEIKGKLGQVLV
CCEEECCEEEEEECCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
LRHVPNYSAERVFVVGAGKKGEINEKQFKQLIQDTINAVKATSAKEVISYLSDIKIKDRD
EEECCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCEEECCE
LYWNIRFSVETLETSIYQFEQFKSKKSEQDVALTDVIFSAEGDVAQQAVNHAKAIALGVR
EEEEEEEEHHHHHHHHHHHHHHHHCCCCCCEEEEHEEECCCCHHHHHHHHHHHHHHHHHH
AAKDVANCPPNVCNPVYLAEQANALATRSDLIKTTVLGEKDMADLGMNAYLAVSQGSVNE
HHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCEEEEEECCCCCH
AQLSLIEYRNHPNPDAKPIVLVGKGLTFDAGGISLKPAEGMDEMKYDMGGAASVYGVMNA
HHHHHHHHCCCCCCCCCEEEEEECCCEECCCCEEECCCCCHHHHHHCCCCHHHHHHHHHH
IAELKLPLNVIGVLAGCENLPDGNAYRPGDILTTMKGLTVEVLNTDAEGRLVLCDTLTYV
HHHHCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCEEEEEECCCCCCEEEEEHHHHH
ERFEPELVIDVATLTGACVVALGAHNSGLISTDDKLAKDLELAAAQSTDKAWRLPLGEEY
HHCCCCEEEEEHHHCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEECCCCHHH
QEQLKSNFADLANIGGRWGGAITAGAFLSNFTDKYRWAHLDIAGTAWLQGANKGATGRPV
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHEEEEEEECHHHHCCCCCCCCCCCCH
PLLVQFLINQATGK
HHHHHHHHHHCCCC
>Mature Secondary Structure
MEYRVKSTALLDIKSNIIIGLYENGELSPSAQKIDEISQGYLSKLIQSGEIKGKLGQVLV
CCEEECCEEEEEECCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
LRHVPNYSAERVFVVGAGKKGEINEKQFKQLIQDTINAVKATSAKEVISYLSDIKIKDRD
EEECCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCEEECCE
LYWNIRFSVETLETSIYQFEQFKSKKSEQDVALTDVIFSAEGDVAQQAVNHAKAIALGVR
EEEEEEEEHHHHHHHHHHHHHHHHCCCCCCEEEEHEEECCCCHHHHHHHHHHHHHHHHHH
AAKDVANCPPNVCNPVYLAEQANALATRSDLIKTTVLGEKDMADLGMNAYLAVSQGSVNE
HHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCEEEEEECCCCCH
AQLSLIEYRNHPNPDAKPIVLVGKGLTFDAGGISLKPAEGMDEMKYDMGGAASVYGVMNA
HHHHHHHHCCCCCCCCCEEEEEECCCEECCCCEEECCCCCHHHHHHCCCCHHHHHHHHHH
IAELKLPLNVIGVLAGCENLPDGNAYRPGDILTTMKGLTVEVLNTDAEGRLVLCDTLTYV
HHHHCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCEEEEEECCCCCCEEEEEHHHHH
ERFEPELVIDVATLTGACVVALGAHNSGLISTDDKLAKDLELAAAQSTDKAWRLPLGEEY
HHCCCCEEEEEHHHCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEECCCCHHH
QEQLKSNFADLANIGGRWGGAITAGAFLSNFTDKYRWAHLDIAGTAWLQGANKGATGRPV
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHEEEEEEECHHHHCCCCCCCCCCCCH
PLLVQFLINQATGK
HHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100