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The map label for this gene is lpxH

Identifier: 15601967

GI number: 15601967

Start: 126559

End: 127278

Strand: Reverse

Name: lpxH

Synonym: PM0102

Alternate gene names: 15601967

Gene position: 127278-126559 (Counterclockwise)

Preceding gene: 15601970

Following gene: 15601966

Centisome position: 5.64

GC content: 41.25

Gene sequence:

>720_bases
ATGAAAAAGACCTATTTTATTGCTGATTTACATCTCAGTGAAAATCGCCCTCATTTAACTCACCTCTTTTGTGATTTTAT
GCAACAGCTTGCGCCACAGGCTGAGGCACTTTACATTTTGGGCGATTTATTTGATTTTTGGATCGGTGATGATGAAGAAT
CTGCGTTAATTCACACCGTCCAGCAACAGATTCACGCCCTGAGTGCACAAGGCGTAAAATGTTACTTCCAACATGGTAAT
CGTGATTTTCTGATTGGCAAACGCTTTGCCGCAGCCTGTGGTATGACATTATTACCTACTTATCAAAGGATTGCATTATA
TGGTGAGTCTGTTTTACTTTGTCATGGCGATACACTGTGTATTGATGATGTTGCCTATCAACAATACCGAAAAAAAGTGC
ATCAAAAATGGCGCCAGTGGCTATTTCTACATCTTCCACTAAAAGTGCGGTTAAAGATCGCAGAGAAAATTCGAGCACGC
AGTAAAGCCGATAAAAAAAGGAAGTCTGAGGAAATAATGGATGTCAATCCTGACTTTGTGTTACAGACTTTTGCCCAATT
TGGCGTTAAAAAAATCATTCACGGGCACACGCATCGTCAACATATTCATCATATTCCACCGCACTTTACCCGTATTGTGC
TCGGCGATTGGGGCGATACTGCGTCTATTCTCGAAGTCAATGAGCAGCAACAGGTGCGTTTTTTAACAGGAAAGGAGTAA

Upstream 100 bases:

>100_bases
CTTGAAATATTTGGCTAAGTATAGCGAAATTGCCGGAATATGTGTATAAATCAACATAAAAAATGTGCTACTCTAAATAA
AAAAGACATGTATAAAACAG

Downstream 100 bases:

>100_bases
CTTATGGCTGATCCACATATTCAATCGCCGATGGATATTTGGGATTATCTCACGGTGATTTTATACCGTTCAGGCTTTGT
CTTAGCAGGCATCATGACAC

Product: UDP-2,3-diacylglucosamine hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MKKTYFIADLHLSENRPHLTHLFCDFMQQLAPQAEALYILGDLFDFWIGDDEESALIHTVQQQIHALSAQGVKCYFQHGN
RDFLIGKRFAAACGMTLLPTYQRIALYGESVLLCHGDTLCIDDVAYQQYRKKVHQKWRQWLFLHLPLKVRLKIAEKIRAR
SKADKKRKSEEIMDVNPDFVLQTFAQFGVKKIIHGHTHRQHIHHIPPHFTRIVLGDWGDTASILEVNEQQQVRFLTGKE

Sequences:

>Translated_239_residues
MKKTYFIADLHLSENRPHLTHLFCDFMQQLAPQAEALYILGDLFDFWIGDDEESALIHTVQQQIHALSAQGVKCYFQHGN
RDFLIGKRFAAACGMTLLPTYQRIALYGESVLLCHGDTLCIDDVAYQQYRKKVHQKWRQWLFLHLPLKVRLKIAEKIRAR
SKADKKRKSEEIMDVNPDFVLQTFAQFGVKKIIHGHTHRQHIHHIPPHFTRIVLGDWGDTASILEVNEQQQVRFLTGKE
>Mature_239_residues
MKKTYFIADLHLSENRPHLTHLFCDFMQQLAPQAEALYILGDLFDFWIGDDEESALIHTVQQQIHALSAQGVKCYFQHGN
RDFLIGKRFAAACGMTLLPTYQRIALYGESVLLCHGDTLCIDDVAYQQYRKKVHQKWRQWLFLHLPLKVRLKIAEKIRAR
SKADKKRKSEEIMDVNPDFVLQTFAQFGVKKIIHGHTHRQHIHHIPPHFTRIVLGDWGDTASILEVNEQQQVRFLTGKE

Specific function: Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP

COG id: COG2908

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxH family

Homologues:

Organism=Escherichia coli, GI1786735, Length=228, Percent_Identity=50.8771929824561, Blast_Score=223, Evalue=1e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXH_PASMU (Q9CPE3)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_245039.1
- ProteinModelPortal:   Q9CPE3
- SMR:   Q9CPE3
- GeneID:   1243449
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM0102
- NMPDR:   fig|272843.1.peg.102
- HOGENOM:   HBG288883
- OMA:   CHGDTLC
- ProtClustDB:   PRK05340
- BioCyc:   PMUL272843:PM0102-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00575
- InterPro:   IPR010138
- TIGRFAMs:   TIGR01854

Pfam domain/function: NA

EC number: 3.6.1.-

Molecular weight: Translated: 27855; Mature: 27855

Theoretical pI: Translated: 8.72; Mature: 8.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKTYFIADLHLSENRPHLTHLFCDFMQQLAPQAEALYILGDLFDFWIGDDEESALIHTV
CCCEEEEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHH
QQQIHALSAQGVKCYFQHGNRDFLIGKRFAAACGMTLLPTYQRIALYGESVLLCHGDTLC
HHHHHHHHCCCEEEEEECCCEEEEEHHHHHHHCCCHHHHHHHHHHHHCCEEEEEECCEEE
IDDVAYQQYRKKVHQKWRQWLFLHLPLKVRLKIAEKIRARSKADKKRKSEEIMDVNPDFV
HHHHHHHHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
LQTFAQFGVKKIIHGHTHRQHIHHIPPHFTRIVLGDWGDTASILEVNEQQQVRFLTGKE
HHHHHHHHHHHHHHCCHHHHHHCCCCCCCEEEEEECCCCCCCEEECCCCHHEEEECCCC
>Mature Secondary Structure
MKKTYFIADLHLSENRPHLTHLFCDFMQQLAPQAEALYILGDLFDFWIGDDEESALIHTV
CCCEEEEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHH
QQQIHALSAQGVKCYFQHGNRDFLIGKRFAAACGMTLLPTYQRIALYGESVLLCHGDTLC
HHHHHHHHCCCEEEEEECCCEEEEEHHHHHHHCCCHHHHHHHHHHHHCCEEEEEECCEEE
IDDVAYQQYRKKVHQKWRQWLFLHLPLKVRLKIAEKIRARSKADKKRKSEEIMDVNPDFV
HHHHHHHHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
LQTFAQFGVKKIIHGHTHRQHIHHIPPHFTRIVLGDWGDTASILEVNEQQQVRFLTGKE
HHHHHHHHHHHHHHCCHHHHHHCCCCCCCEEEEEECCCCCCCEEECCCCHHEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100