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The map label for this gene is engA

Identifier: 15601970

GI number: 15601970

Start: 130030

End: 131562

Strand: Reverse

Name: engA

Synonym: PM0105

Alternate gene names: 15601970

Gene position: 131562-130030 (Counterclockwise)

Preceding gene: 15601971

Following gene: 15601967

Centisome position: 5.83

GC content: 42.92

Gene sequence:

>1533_bases
ATGACAACGCCTGTAGTGGCTCTTGTTGGTCGCCCAAATGTGGGAAAATCAACATTATTTAATCGTCTAACCCGTACGCG
TGATGCGTTGGTGGCGGATTTTCCCGGCTTAACGCGTGACCGTAAATATGGTCAAGCCAATATCGCAGGTTATGATTTTA
TTGTGATCGATACTGGTGGTATTGATGGTACAGAAGAAGGCGTGGAAGAAAAAATGGCAGAGCAATCCTTGCTTGCGATT
GAAGAAGCCGATGTGGTGCTGTTTTTAGTAGATGCCCGTGCAGGCTTAACCTCTGCGGATATTGGTATCGCAAACTATTT
ACGCCAACGCCAAAACAAAATCACGGTAGTCGTTGCCAATAAAACCGATGGCATTGATGCAGATTCCCATTGCGCCGAGT
TCTATCAATTAGGTTTAGGTGAAGTCGAACAAATTGCTGCCTCGCAAGGTCGTGGCGTTTCTGCCTTAATGGAACAAGTA
CTGGCGCCAATTGCAGAAAAAATGAATGCCGAAAGTCCCGAACAAAGTGCGGTAGAAAATACCGATGTTTCTGAAACCGG
CGAACAAGACGAGTGGGATCACGACTTCGACTTTGCTAATGAAGAAGATACCGCCTTGTTAGATGACGCCATTGCGGAAG
AACTGGAAGCACAAGATAAAAATATTAAAATTGCTATCGTTGGTCGCCCAAATGTGGGTAAATCGACCTTAACAAACCGT
ATTCTTGGCGAAGATCGCGTGGTCGTGTACGACTTACCGGGGACAACGCGTGACAGTATTTATATCCCGATGGAACGCGA
TGGTCAGCATTACACCATCATTGACACTGCAGGGGTACGTAAACGGGGTAAAGTCCATTTAGCAGTGGAAAAATTTTCGG
TCATCAAAACCTTACAAGCGATTCAAGATGCCAATGTGGTGTTATTAACTATTGATGCGCGTGAAGGCGTGTCAGATCAA
GACTTATCTTTACTGGGTTTTATACTCAATGCAGGGCGTTCATTGGTCATCGTAGTGAATAAATGGGATGGTTTAAATCA
AGACATTAAAGATCAAGTCAAATCTGAACTTGATCGTCGTTTAGATTTTATTGATTTTGCCCGTGTGCACTTTATTTCCG
CTTTACATGGCAGTGGCGTGGGCAACTTATTTGATTCCATTCAAGAAGCCTATGCTTGTGCGACACAAAAAATGACCACA
TCCATGTTAACCCGTATTTTACAAATGGCAACGGATGAGCATCAGCCGCCGATGATGGGCGGTCGTCGAATTAAATTAAA
ATACGCACACCCGGGCGGTTATAATCCACCCATTATTGTGGTGCATGGTAACCAAATGGATAAATTACCCGATTCGTATA
AACGTTATTTATCCAATTACTATCGTCGTAGTTTGAAAATTATTGGTTCGCCAATCCGCTTATTATTCCAAGAAGGAAAT
AACCCATTTGCAGGTAAACGGAATAAATTGACACCAAATCAATTACGCAAACGCAAACGCTTAATGAAGTTTATTAAAAA
ATCGAAGCGTTAA

Upstream 100 bases:

>100_bases
TTCTTGTACATTTCTCATCTTTGACAAAATCCGCTATAATGATGCCATTTTTGACTGCGCTATGAACCCATAGGCAGAAA
TACTGAATAAGAGGTTTTTT

Downstream 100 bases:

>100_bases
TCAATCTACATGGCGCCCTGTCGATCGGCGCCATATTCTCTGTGTTTTTAAAGGACAACTAGCATGGCGAATAAAAAAAC
CTTACTCCTTTTTCCACTCA

Product: GTP-binding protein EngA

Products: NA

Alternate protein names: GTP-binding protein EngA

Number of amino acids: Translated: 510; Mature: 509

Protein sequence:

>510_residues
MTTPVVALVGRPNVGKSTLFNRLTRTRDALVADFPGLTRDRKYGQANIAGYDFIVIDTGGIDGTEEGVEEKMAEQSLLAI
EEADVVLFLVDARAGLTSADIGIANYLRQRQNKITVVVANKTDGIDADSHCAEFYQLGLGEVEQIAASQGRGVSALMEQV
LAPIAEKMNAESPEQSAVENTDVSETGEQDEWDHDFDFANEEDTALLDDAIAEELEAQDKNIKIAIVGRPNVGKSTLTNR
ILGEDRVVVYDLPGTTRDSIYIPMERDGQHYTIIDTAGVRKRGKVHLAVEKFSVIKTLQAIQDANVVLLTIDAREGVSDQ
DLSLLGFILNAGRSLVIVVNKWDGLNQDIKDQVKSELDRRLDFIDFARVHFISALHGSGVGNLFDSIQEAYACATQKMTT
SMLTRILQMATDEHQPPMMGGRRIKLKYAHPGGYNPPIIVVHGNQMDKLPDSYKRYLSNYYRRSLKIIGSPIRLLFQEGN
NPFAGKRNKLTPNQLRKRKRLMKFIKKSKR

Sequences:

>Translated_510_residues
MTTPVVALVGRPNVGKSTLFNRLTRTRDALVADFPGLTRDRKYGQANIAGYDFIVIDTGGIDGTEEGVEEKMAEQSLLAI
EEADVVLFLVDARAGLTSADIGIANYLRQRQNKITVVVANKTDGIDADSHCAEFYQLGLGEVEQIAASQGRGVSALMEQV
LAPIAEKMNAESPEQSAVENTDVSETGEQDEWDHDFDFANEEDTALLDDAIAEELEAQDKNIKIAIVGRPNVGKSTLTNR
ILGEDRVVVYDLPGTTRDSIYIPMERDGQHYTIIDTAGVRKRGKVHLAVEKFSVIKTLQAIQDANVVLLTIDAREGVSDQ
DLSLLGFILNAGRSLVIVVNKWDGLNQDIKDQVKSELDRRLDFIDFARVHFISALHGSGVGNLFDSIQEAYACATQKMTT
SMLTRILQMATDEHQPPMMGGRRIKLKYAHPGGYNPPIIVVHGNQMDKLPDSYKRYLSNYYRRSLKIIGSPIRLLFQEGN
NPFAGKRNKLTPNQLRKRKRLMKFIKKSKR
>Mature_509_residues
TTPVVALVGRPNVGKSTLFNRLTRTRDALVADFPGLTRDRKYGQANIAGYDFIVIDTGGIDGTEEGVEEKMAEQSLLAIE
EADVVLFLVDARAGLTSADIGIANYLRQRQNKITVVVANKTDGIDADSHCAEFYQLGLGEVEQIAASQGRGVSALMEQVL
APIAEKMNAESPEQSAVENTDVSETGEQDEWDHDFDFANEEDTALLDDAIAEELEAQDKNIKIAIVGRPNVGKSTLTNRI
LGEDRVVVYDLPGTTRDSIYIPMERDGQHYTIIDTAGVRKRGKVHLAVEKFSVIKTLQAIQDANVVLLTIDAREGVSDQD
LSLLGFILNAGRSLVIVVNKWDGLNQDIKDQVKSELDRRLDFIDFARVHFISALHGSGVGNLFDSIQEAYACATQKMTTS
MLTRILQMATDEHQPPMMGGRRIKLKYAHPGGYNPPIIVVHGNQMDKLPDSYKRYLSNYYRRSLKIIGSPIRLLFQEGNN
PFAGKRNKLTPNQLRKRKRLMKFIKKSKR

Specific function: GTPase that plays an essential role in the late steps of ribosome biogenesis

COG id: COG1160

COG function: function code R; Predicted GTPases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH-like domain

Homologues:

Organism=Escherichia coli, GI87082120, Length=507, Percent_Identity=69.6252465483235, Blast_Score=709, Evalue=0.0,
Organism=Escherichia coli, GI2367268, Length=93, Percent_Identity=38.7096774193548, Blast_Score=68, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323665, Length=190, Percent_Identity=28.9473684210526, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DER_PASMU (P57812)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_245042.1
- ProteinModelPortal:   P57812
- SMR:   P57812
- GeneID:   1243452
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM0105
- NMPDR:   fig|272843.1.peg.105
- HOGENOM:   HBG592135
- OMA:   TRDRTYQ
- ProtClustDB:   PRK00093
- BioCyc:   PMUL272843:PM0105-MONOMER
- GO:   GO:0005622
- HAMAP:   MF_00195
- InterPro:   IPR003593
- InterPro:   IPR016484
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:3.30.300.20
- PIRSF:   PIRSF006485
- PRINTS:   PR00326
- SMART:   SM00382
- TIGRFAMs:   TIGR03594
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF01926 MMR_HSR1

EC number: NA

Molecular weight: Translated: 56649; Mature: 56518

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPVVALVGRPNVGKSTLFNRLTRTRDALVADFPGLTRDRKYGQANIAGYDFIVIDTGG
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCC
IDGTEEGVEEKMAEQSLLAIEEADVVLFLVDARAGLTSADIGIANYLRQRQNKITVVVAN
CCCCHHHHHHHHHHHHHHEEECCCEEEEEEECCCCCCHHHHHHHHHHHHHCCEEEEEEEC
KTDGIDADSHCAEFYQLGLGEVEQIAASQGRGVSALMEQVLAPIAEKMNAESPEQSAVEN
CCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHCC
TDVSETGEQDEWDHDFDFANEEDTALLDDAIAEELEAQDKNIKIAIVGRPNVGKSTLTNR
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHH
ILGEDRVVVYDLPGTTRDSIYIPMERDGQHYTIIDTAGVRKRGKVHLAVEKFSVIKTLQA
HCCCCCEEEEECCCCCCCCEEEEECCCCCEEEEEECCCCCCCCCEEEEHHHHHHHHHHHH
IQDANVVLLTIDAREGVSDQDLSLLGFILNAGRSLVIVVNKWDGLNQDIKDQVKSELDRR
HCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHH
LDFIDFARVHFISALHGSGVGNLFDSIQEAYACATQKMTTSMLTRILQMATDEHQPPMMG
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GRRIKLKYAHPGGYNPPIIVVHGNQMDKLPDSYKRYLSNYYRRSLKIIGSPIRLLFQEGN
CEEEEEEEECCCCCCCCEEEEECCCHHCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHCCC
NPFAGKRNKLTPNQLRKRKRLMKFIKKSKR
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TTPVVALVGRPNVGKSTLFNRLTRTRDALVADFPGLTRDRKYGQANIAGYDFIVIDTGG
CCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCC
IDGTEEGVEEKMAEQSLLAIEEADVVLFLVDARAGLTSADIGIANYLRQRQNKITVVVAN
CCCCHHHHHHHHHHHHHHEEECCCEEEEEEECCCCCCHHHHHHHHHHHHHCCEEEEEEEC
KTDGIDADSHCAEFYQLGLGEVEQIAASQGRGVSALMEQVLAPIAEKMNAESPEQSAVEN
CCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHCC
TDVSETGEQDEWDHDFDFANEEDTALLDDAIAEELEAQDKNIKIAIVGRPNVGKSTLTNR
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHH
ILGEDRVVVYDLPGTTRDSIYIPMERDGQHYTIIDTAGVRKRGKVHLAVEKFSVIKTLQA
HCCCCCEEEEECCCCCCCCEEEEECCCCCEEEEEECCCCCCCCCEEEEHHHHHHHHHHHH
IQDANVVLLTIDAREGVSDQDLSLLGFILNAGRSLVIVVNKWDGLNQDIKDQVKSELDRR
HCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHH
LDFIDFARVHFISALHGSGVGNLFDSIQEAYACATQKMTTSMLTRILQMATDEHQPPMMG
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GRRIKLKYAHPGGYNPPIIVVHGNQMDKLPDSYKRYLSNYYRRSLKIIGSPIRLLFQEGN
CEEEEEEEECCCCCCCCEEEEECCCHHCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHCCC
NPFAGKRNKLTPNQLRKRKRLMKFIKKSKR
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100