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The map label for this gene is proC

Identifier: 15601960

GI number: 15601960

Start: 120334

End: 121161

Strand: Reverse

Name: proC

Synonym: PM0095

Alternate gene names: 15601960

Gene position: 121161-120334 (Counterclockwise)

Preceding gene: 15601963

Following gene: 15601959

Centisome position: 5.37

GC content: 43.96

Gene sequence:

>828_bases
ATGCAAGCGAAATCAATTTGCTTTATCGGTGGCGGGAATATGGCACAAGCCATTATTTTTGGTTTACTCAAACAAGGCTA
CCCGGCTAATCAAATCACTGTCAGCGATCCAAATGCGGCAAAACGTCAATGTCTCGCTGAAAAAGGGGTAAATACTGTTG
AAGCAAGTCAGACAGATACGCAAGATGCGGTGGAAACATCAGAGGTTTTACTGCTCGCCGTCAAACCACAAATGATTGCC
GCAGTTTGCCAAGGATTAAGTGCGGTCGATTTTAGCCAAAAATTAGTGATTTCAATTGCAGCAGGGGTTTCAGTAACAAA
ATTACAATCACGTTTGCCCACCGCAAAGCAAATTGTACGCGTGATGCCTAATACGCCTGCGTTAGTGGCAGAAGGTATGT
CAGGCCTATTCGCACAGAACAGCTTGAAACCTGAATACAAACAATTCACACAAGATTTGCTCAATGCGGTGGGAAAAACC
TGTTGGGTAACTCAAGAAGCAGATATGCACACCATTACTGCAGGCTCAGGCAGTAGTCCGGCGTATTTTTTCTTATTTAT
GGAGGCAATGCAACAGGCATTGTGTCAAATGAATATGGACGAAGACACCGCTCGCTTATTAGTGCAACAATCCGCTTTAG
GCGCAGCAAAAATGGTGATAGAAAATCCTGACTTACCGATTGCGACATTGCGTGAAAATGTCACGTCAAAAGGTGGTACA
ACGGCGGCAGCATTGCAGGTATTGAATCAACAACAGTTACAACATATCGTCCAGCAGGCGATGCAAGCTTGTGTCGAACG
TTCTCAACAAATGGAAAAATTGTTTTAA

Upstream 100 bases:

>100_bases
AAACCATAGTTTGTTCCTTCTTTTTTAAGGTAGAATAAGCAACTTATGTCGTATTTGCGACAAAATAATTCAGTATTGTA
ACGTAGTTCGAGAGAAAAAT

Downstream 100 bases:

>100_bases
TGAAAATTTCAGCATTTAACTGGCTTGCTTTAAGCTTCTTTGGGTATTTTTGTGCTTATGGCGTGTTCGTGCCTTTCTTT
CCTGTCTGGCTAAAATCACA

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR

Number of amino acids: Translated: 275; Mature: 275

Protein sequence:

>275_residues
MQAKSICFIGGGNMAQAIIFGLLKQGYPANQITVSDPNAAKRQCLAEKGVNTVEASQTDTQDAVETSEVLLLAVKPQMIA
AVCQGLSAVDFSQKLVISIAAGVSVTKLQSRLPTAKQIVRVMPNTPALVAEGMSGLFAQNSLKPEYKQFTQDLLNAVGKT
CWVTQEADMHTITAGSGSSPAYFFLFMEAMQQALCQMNMDEDTARLLVQQSALGAAKMVIENPDLPIATLRENVTSKGGT
TAAALQVLNQQQLQHIVQQAMQACVERSQQMEKLF

Sequences:

>Translated_275_residues
MQAKSICFIGGGNMAQAIIFGLLKQGYPANQITVSDPNAAKRQCLAEKGVNTVEASQTDTQDAVETSEVLLLAVKPQMIA
AVCQGLSAVDFSQKLVISIAAGVSVTKLQSRLPTAKQIVRVMPNTPALVAEGMSGLFAQNSLKPEYKQFTQDLLNAVGKT
CWVTQEADMHTITAGSGSSPAYFFLFMEAMQQALCQMNMDEDTARLLVQQSALGAAKMVIENPDLPIATLRENVTSKGGT
TAAALQVLNQQQLQHIVQQAMQACVERSQQMEKLF
>Mature_275_residues
MQAKSICFIGGGNMAQAIIFGLLKQGYPANQITVSDPNAAKRQCLAEKGVNTVEASQTDTQDAVETSEVLLLAVKPQMIA
AVCQGLSAVDFSQKLVISIAAGVSVTKLQSRLPTAKQIVRVMPNTPALVAEGMSGLFAQNSLKPEYKQFTQDLLNAVGKT
CWVTQEADMHTITAGSGSSPAYFFLFMEAMQQALCQMNMDEDTARLLVQQSALGAAKMVIENPDLPIATLRENVTSKGGT
TAAALQVLNQQQLQHIVQQAMQACVERSQQMEKLF

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family

Homologues:

Organism=Homo sapiens, GI198041662, Length=273, Percent_Identity=30.4029304029304, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI24797095, Length=276, Percent_Identity=30.7971014492754, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI24797097, Length=276, Percent_Identity=30.7971014492754, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI21361454, Length=276, Percent_Identity=30.7971014492754, Blast_Score=119, Evalue=3e-27,
Organism=Escherichia coli, GI1786585, Length=277, Percent_Identity=36.4620938628159, Blast_Score=152, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17569021, Length=268, Percent_Identity=33.5820895522388, Blast_Score=136, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17540664, Length=285, Percent_Identity=29.1228070175439, Blast_Score=100, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6320861, Length=285, Percent_Identity=26.3157894736842, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21358587, Length=271, Percent_Identity=34.3173431734317, Blast_Score=135, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24648116, Length=281, Percent_Identity=30.2491103202847, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24647700, Length=171, Percent_Identity=36.2573099415205, Blast_Score=99, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): P5CR_PASMU (Q9CPE8)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_245032.1
- ProteinModelPortal:   Q9CPE8
- SMR:   Q9CPE8
- GeneID:   1243442
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM0095
- NMPDR:   fig|272843.1.peg.95
- HOGENOM:   HBG726602
- OMA:   APSGHSK
- ProtClustDB:   PRK11880
- BioCyc:   PMUL272843:PM0095-MONOMER
- BRENDA:   1.5.1.2
- GO:   GO:0005737
- GO:   GO:0005488
- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR11645
- PIRSF:   PIRSF000193
- TIGRFAMs:   TIGR00112

Pfam domain/function: PF03807 F420_oxidored; SSF48179 6DGDH_C_like

EC number: =1.5.1.2

Molecular weight: Translated: 29557; Mature: 29557

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAKSICFIGGGNMAQAIIFGLLKQGYPANQITVSDPNAAKRQCLAEKGVNTVEASQTDT
CCCCCEEEEECCHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHCCCCEECCCCCH
QDAVETSEVLLLAVKPQMIAAVCQGLSAVDFSQKLVISIAAGVSVTKLQSRLPTAKQIVR
HHHHHHHHEEEEEECHHHHHHHHCCCHHCCHHHHHHHHHHCCCHHHHHHHHCCHHHHHHH
VMPNTPALVAEGMSGLFAQNSLKPEYKQFTQDLLNAVGKTCWVTQEADMHTITAGSGSSP
HCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCHHEEEECCCCCEEEECCCCCCC
AYFFLFMEAMQQALCQMNMDEDTARLLVQQSALGAAKMVIENPDLPIATLRENVTSKGGT
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHCCCCH
TAAALQVLNQQQLQHIVQQAMQACVERSQQMEKLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQAKSICFIGGGNMAQAIIFGLLKQGYPANQITVSDPNAAKRQCLAEKGVNTVEASQTDT
CCCCCEEEEECCHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHCCCCEECCCCCH
QDAVETSEVLLLAVKPQMIAAVCQGLSAVDFSQKLVISIAAGVSVTKLQSRLPTAKQIVR
HHHHHHHHEEEEEECHHHHHHHHCCCHHCCHHHHHHHHHHCCCHHHHHHHHCCHHHHHHH
VMPNTPALVAEGMSGLFAQNSLKPEYKQFTQDLLNAVGKTCWVTQEADMHTITAGSGSSP
HCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCHHEEEECCCCCEEEECCCCCCC
AYFFLFMEAMQQALCQMNMDEDTARLLVQQSALGAAKMVIENPDLPIATLRENVTSKGGT
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHCCCCH
TAAALQVLNQQQLQHIVQQAMQACVERSQQMEKLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100