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The map label for this gene is adhA

Identifier: 15673789

GI number: 15673789

Start: 1872404

End: 1873426

Strand: Reverse

Name: adhA

Synonym: L55758

Alternate gene names: 15673789

Gene position: 1873426-1872404 (Counterclockwise)

Preceding gene: 30024056

Following gene: 15673787

Centisome position: 79.19

GC content: 39.2

Gene sequence:

>1023_bases
ATGAAAGCAGCAGTAGTAAGACACAATCCAGATGGTTATGCGGACCTTGTTGAAAAGGAACTTCGAGCAATCAAACCTAA
TGAAGCTTTGCTTGACATGGAGTATTGTGGAGTCTGTCATACCGATTTGCACGTTGCAGCAGGTGATTATGGCAACAAAG
CAGGGACTGTTCTTGGTCATGAAGGAATTGGAATTGTCAAAGAAATTGGAACTGATGTAAGCTCGCTTCAAGTTGGTGAT
CGGGTTTCAGTGGCTTGGTTCTTTGAAGGATGTGGTCACTGTGAATACTGTGTATCTGGTAATGAAACTTTTTGTCGAGA
AGTTAAAAATGCAGGATATTCAGTTGATGGCGGAATGGCTGAAGAAGCAATTGTTGTTGCCGATTATGCTGTCAAAGTTC
CTGACGGACTTGACCCAATTGAAGCTAGCTCAATTACTTGTGCTGGAGTAACAACTTACAAAGCAATCAAAGTATCAGGA
GTAAAACCTGGTGATTGGCAAGTAATTTTTGGTGCTGGAGGACTTGGAAATTTAGCAATTCAATATGCTAAAAATGTTTT
TGGAGCAAAAGTAATTGCTGTTGATATTAATCAAGATAAATTAAATTTAGCTAAAAAAATTGGAGCTGATGTGATTATCA
ATTCTGGTGATGTAAATCCAGTTGATGAAATTAAAAAAATAACTGGCGGCTTAGGAGCACAAAGTGCAATAGTTTGTGCT
GTTGCAAGGATTGCTTTTGAACAAGCGGTTGCTTCTTTGAAACCTATGGGCAAAATGGTTGCTGTGGCACTTCCCAATAC
TGAGATGACTTTATCAGTTCCAACAGTTGTTTTTGACGGAGTGGAGGTTGCAGGTTCACTTGTCGGAACAAGACTTGACT
TGGCAGAAGCTTTTCAATTTGGAGCAGAGGGTAAGGTAAAACCAATTGTTGCGACACGCAAACTGGAAGAAATCAATGAT
ATTATTGATGAAATGAAGGCAGGAAAAATTGAAGGCCGAATGGTCATTGATTTTACTAAATAA

Upstream 100 bases:

>100_bases
ATGTTTTTGTTACTTTAAATGATACAAAATGAAGTGAAAAGTGATATAATAAAACAAAAGAAAGCGTTTACAAAATTTTA
TATATAGAGGAGACTTTCTT

Downstream 100 bases:

>100_bases
ATATAAAAGAGGCGATGCAGATGAATTCAAAAAATTTGGTCAATTACTCAAGTGATGAATTTAACAATCTTTCGCAATTT
CAACAAGAAGAAATTACAAA

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: ADH [H]

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MKAAVVRHNPDGYADLVEKELRAIKPNEALLDMEYCGVCHTDLHVAAGDYGNKAGTVLGHEGIGIVKEIGTDVSSLQVGD
RVSVAWFFEGCGHCEYCVSGNETFCREVKNAGYSVDGGMAEEAIVVADYAVKVPDGLDPIEASSITCAGVTTYKAIKVSG
VKPGDWQVIFGAGGLGNLAIQYAKNVFGAKVIAVDINQDKLNLAKKIGADVIINSGDVNPVDEIKKITGGLGAQSAIVCA
VARIAFEQAVASLKPMGKMVAVALPNTEMTLSVPTVVFDGVEVAGSLVGTRLDLAEAFQFGAEGKVKPIVATRKLEEIND
IIDEMKAGKIEGRMVIDFTK

Sequences:

>Translated_340_residues
MKAAVVRHNPDGYADLVEKELRAIKPNEALLDMEYCGVCHTDLHVAAGDYGNKAGTVLGHEGIGIVKEIGTDVSSLQVGD
RVSVAWFFEGCGHCEYCVSGNETFCREVKNAGYSVDGGMAEEAIVVADYAVKVPDGLDPIEASSITCAGVTTYKAIKVSG
VKPGDWQVIFGAGGLGNLAIQYAKNVFGAKVIAVDINQDKLNLAKKIGADVIINSGDVNPVDEIKKITGGLGAQSAIVCA
VARIAFEQAVASLKPMGKMVAVALPNTEMTLSVPTVVFDGVEVAGSLVGTRLDLAEAFQFGAEGKVKPIVATRKLEEIND
IIDEMKAGKIEGRMVIDFTK
>Mature_340_residues
MKAAVVRHNPDGYADLVEKELRAIKPNEALLDMEYCGVCHTDLHVAAGDYGNKAGTVLGHEGIGIVKEIGTDVSSLQVGD
RVSVAWFFEGCGHCEYCVSGNETFCREVKNAGYSVDGGMAEEAIVVADYAVKVPDGLDPIEASSITCAGVTTYKAIKVSG
VKPGDWQVIFGAGGLGNLAIQYAKNVFGAKVIAVDINQDKLNLAKKIGADVIINSGDVNPVDEIKKITGGLGAQSAIVCA
VARIAFEQAVASLKPMGKMVAVALPNTEMTLSVPTVVFDGVEVAGSLVGTRLDLAEAFQFGAEGKVKPIVATRKLEEIND
IIDEMKAGKIEGRMVIDFTK

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=368, Percent_Identity=28.2608695652174, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI34577061, Length=355, Percent_Identity=28.4507042253521, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI4501929, Length=364, Percent_Identity=28.2967032967033, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI71565154, Length=231, Percent_Identity=30.7359307359307, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI71743840, Length=312, Percent_Identity=26.9230769230769, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI262073058, Length=312, Percent_Identity=26.9230769230769, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI156627571, Length=316, Percent_Identity=27.8481012658228, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI156523966, Length=357, Percent_Identity=25.7703081232493, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI4501939, Length=357, Percent_Identity=25.7703081232493, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI71565152, Length=252, Percent_Identity=27.3809523809524, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI194239674, Length=324, Percent_Identity=23.7654320987654, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI13236495, Length=324, Percent_Identity=23.7654320987654, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI87081918, Length=338, Percent_Identity=63.6094674556213, Blast_Score=399, Evalue=1e-112,
Organism=Escherichia coli, GI87082401, Length=334, Percent_Identity=26.0479041916168, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1786518, Length=329, Percent_Identity=28.5714285714286, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1790045, Length=324, Percent_Identity=26.5432098765432, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI1788073, Length=260, Percent_Identity=27.6923076923077, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1788075, Length=305, Percent_Identity=25.2459016393443, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1786552, Length=366, Percent_Identity=29.5081967213115, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1787863, Length=351, Percent_Identity=27.0655270655271, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI87082125, Length=357, Percent_Identity=26.6106442577031, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1790718, Length=197, Percent_Identity=31.4720812182741, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI226510992, Length=292, Percent_Identity=26.7123287671233, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1788407, Length=220, Percent_Identity=29.0909090909091, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786825, Length=242, Percent_Identity=29.7520661157025, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1790485, Length=314, Percent_Identity=26.4331210191083, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71988145, Length=327, Percent_Identity=35.7798165137615, Blast_Score=185, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17562582, Length=318, Percent_Identity=37.7358490566038, Blast_Score=174, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI17562584, Length=318, Percent_Identity=35.2201257861635, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17562876, Length=248, Percent_Identity=33.0645161290323, Blast_Score=111, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI17562878, Length=239, Percent_Identity=30.1255230125523, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17565904, Length=230, Percent_Identity=29.1304347826087, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI25146526, Length=217, Percent_Identity=29.4930875576037, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71997431, Length=211, Percent_Identity=29.3838862559242, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323729, Length=321, Percent_Identity=39.2523364485981, Blast_Score=209, Evalue=4e-55,
Organism=Saccharomyces cerevisiae, GI6323961, Length=344, Percent_Identity=36.046511627907, Blast_Score=199, Evalue=4e-52,
Organism=Saccharomyces cerevisiae, GI6319621, Length=344, Percent_Identity=35.7558139534884, Blast_Score=195, Evalue=7e-51,
Organism=Saccharomyces cerevisiae, GI6324486, Length=337, Percent_Identity=36.4985163204748, Blast_Score=191, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6319949, Length=341, Percent_Identity=24.3401759530792, Blast_Score=108, Evalue=8e-25,
Organism=Saccharomyces cerevisiae, GI6320033, Length=352, Percent_Identity=30.1136363636364, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6323980, Length=319, Percent_Identity=28.2131661442006, Blast_Score=102, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6323099, Length=304, Percent_Identity=29.6052631578947, Blast_Score=100, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6319955, Length=315, Percent_Identity=28.2539682539683, Blast_Score=97, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6322619, Length=315, Percent_Identity=28.2539682539683, Blast_Score=97, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6319258, Length=267, Percent_Identity=26.2172284644195, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6319257, Length=324, Percent_Identity=26.5432098765432, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6319520, Length=243, Percent_Identity=25.9259259259259, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17737897, Length=199, Percent_Identity=29.6482412060301, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI17137530, Length=199, Percent_Identity=29.6482412060301, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI17737895, Length=223, Percent_Identity=30.9417040358744, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR006140
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 35778; Mature: 35778

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAAVVRHNPDGYADLVEKELRAIKPNEALLDMEYCGVCHTDLHVAAGDYGNKAGTVLGH
CCCEEEEECCCCHHHHHHHHHHHCCCCCCEEEHHHCCCCCCCEEEEECCCCCCCCEEECC
EGIGIVKEIGTDVSSLQVGDRVSVAWFFEGCGHCEYCVSGNETFCREVKNAGYSVDGGMA
CCCHHHHHHCCCHHHEECCCCEEEEEEECCCCCEEEEECCCHHHHHHHHHCCCCCCCCCC
EEAIVVADYAVKVPDGLDPIEASSITCAGVTTYKAIKVSGVKPGDWQVIFGAGGLGNLAI
CCEEEEEEEEEECCCCCCCCCCCCEEEECEEEEEEEEECCCCCCCCEEEEECCCCHHHHH
QYAKNVFGAKVIAVDINQDKLNLAKKIGADVIINSGDVNPVDEIKKITGGLGAQSAIVCA
HHHHHHCCCEEEEEECCCHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCCHHHHHHH
VARIAFEQAVASLKPMGKMVAVALPNTEMTLSVPTVVFDGVEVAGSLVGTRLDLAEAFQF
HHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEECCEEECCHHHHHHHHHHHHHHHHHHHC
GAEGKVKPIVATRKLEEINDIIDEMKAGKIEGRMVIDFTK
CCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCEEEEEECC
>Mature Secondary Structure
MKAAVVRHNPDGYADLVEKELRAIKPNEALLDMEYCGVCHTDLHVAAGDYGNKAGTVLGH
CCCEEEEECCCCHHHHHHHHHHHCCCCCCEEEHHHCCCCCCCEEEEECCCCCCCCEEECC
EGIGIVKEIGTDVSSLQVGDRVSVAWFFEGCGHCEYCVSGNETFCREVKNAGYSVDGGMA
CCCHHHHHHCCCHHHEECCCCEEEEEEECCCCCEEEEECCCHHHHHHHHHCCCCCCCCCC
EEAIVVADYAVKVPDGLDPIEASSITCAGVTTYKAIKVSGVKPGDWQVIFGAGGLGNLAI
CCEEEEEEEEEECCCCCCCCCCCCEEEECEEEEEEEEECCCCCCCCEEEEECCCCHHHHH
QYAKNVFGAKVIAVDINQDKLNLAKKIGADVIINSGDVNPVDEIKKITGGLGAQSAIVCA
HHHHHHCCCEEEEEECCCHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCCHHHHHHH
VARIAFEQAVASLKPMGKMVAVALPNTEMTLSVPTVVFDGVEVAGSLVGTRLDLAEAFQF
HHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEECCEEECCHHHHHHHHHHHHHHHHHHHC
GAEGKVKPIVATRKLEEINDIIDEMKAGKIEGRMVIDFTK
CCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA