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The map label for this gene is otcA

Identifier: 15673682

GI number: 15673682

Start: 1756548

End: 1757570

Strand: Reverse

Name: otcA

Synonym: L0113

Alternate gene names: 15673682

Gene position: 1757570-1756548 (Counterclockwise)

Preceding gene: 15673683

Following gene: 15673681

Centisome position: 74.3

GC content: 37.63

Gene sequence:

>1023_bases
ATGGTAACAACAAACAAACGTGATTTCATCACAACAGAAGATTACACTAAAGAAGAAATTCTTGATATTGTAACACTGGG
CTTAAAAATCAAAGCAGCGATTAAAAATGGCTACTATCCACCACTTCTTAAAAACAAATCACTAGGAATGATTTTCCAAC
AAACATCAACTCGTACTCGTGTTTCCTTTGAAACAGCTATGACTCAATTAGGAGGACATGCAGAATATTTAGCACCTGGT
CAAATTCAACTCGGTGGTCATGAAACAATAGAAGATACAAGCACAGTTCTTTCTAGATTGCTTGATATCATCATGGCGCG
TGTTGATCGTCATGAATCAGTTAATAACCTTGCAAAACATACAACCATTCCAGTTCTTAACGGGATGTCAGACTATAATC
ACCCAACACAAGAAGTCGGTGATTTGACTACAATGATTGAACATTTACCAGCTGGTAAAAAATTAGAAGATTGTAAAGTT
GTCTTTGTCGGTGATGCGACTCAAGTTTGTTTCTCATTAGGTTTAATCGCAACTAAAATGGGAATGCACTTTGTTCATTT
TGGCCCTAAAGGCTACCAACTTAATGAAGAACATCAAGCAAAATTAGCTGCAAATTGTGAGGTTTCTGGTGGTACTTATG
AAGTAACAGACGATGAAGAATCAATTGTCGGTGCAGATTTCCTTTATACAGATGTTTGGTACGGTTTGTATGATGCAGAA
CTATCAGAAGAAGAACGTCTAGCGATTTTCTTCCCTAAATATCAAGTGACACCTGAGATGATGGCAAAAGCAGGAGCACA
TACAAAATTTATGCATTGTCTTCCAGCTTCAAGAGGTGAAGAAGTTGTTGATGCGGTTATTGATGGTCCAAACTCAATTT
GTTTTGACGAAGCCGAAAATCGCTTGACTTCAATCCGTGCCCTCCTTGTTTGGTTGATGTCTGATTATGCTGAAAAAAAT
CCTTATGATTTGAAAGCACAAGCCAAAGCTAAGGCTGAGTTAGAGGCTTACTTAGCCAAATAA

Upstream 100 bases:

>100_bases
AAATCCTAGAGTTGATTGTTTTATATTTTTGCTCTTGATATACTGAAATCGTTCCCAAGAGGGAAGTCAAATAACTATTT
TATTCAGGAGGAATAAAGAA

Downstream 100 bases:

>100_bases
GAAAGAGTATTATTTATGGAAAATGGAAAGGAAAAATTTAGTCTGTTTAGTGCTATTCTTTCTGTCATTTGTGTTGTTTT
TGTTGCCGAAGCAGCAGCAC

Product: putrescine carbamoyltransferase

Products: NA

Alternate protein names: PTC; PTCase; Putrescine transcarbamoylase; Putrescine transcarbamylase

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MVTTNKRDFITTEDYTKEEILDIVTLGLKIKAAIKNGYYPPLLKNKSLGMIFQQTSTRTRVSFETAMTQLGGHAEYLAPG
QIQLGGHETIEDTSTVLSRLLDIIMARVDRHESVNNLAKHTTIPVLNGMSDYNHPTQEVGDLTTMIEHLPAGKKLEDCKV
VFVGDATQVCFSLGLIATKMGMHFVHFGPKGYQLNEEHQAKLAANCEVSGGTYEVTDDEESIVGADFLYTDVWYGLYDAE
LSEEERLAIFFPKYQVTPEMMAKAGAHTKFMHCLPASRGEEVVDAVIDGPNSICFDEAENRLTSIRALLVWLMSDYAEKN
PYDLKAQAKAKAELEAYLAK

Sequences:

>Translated_340_residues
MVTTNKRDFITTEDYTKEEILDIVTLGLKIKAAIKNGYYPPLLKNKSLGMIFQQTSTRTRVSFETAMTQLGGHAEYLAPG
QIQLGGHETIEDTSTVLSRLLDIIMARVDRHESVNNLAKHTTIPVLNGMSDYNHPTQEVGDLTTMIEHLPAGKKLEDCKV
VFVGDATQVCFSLGLIATKMGMHFVHFGPKGYQLNEEHQAKLAANCEVSGGTYEVTDDEESIVGADFLYTDVWYGLYDAE
LSEEERLAIFFPKYQVTPEMMAKAGAHTKFMHCLPASRGEEVVDAVIDGPNSICFDEAENRLTSIRALLVWLMSDYAEKN
PYDLKAQAKAKAELEAYLAK
>Mature_340_residues
MVTTNKRDFITTEDYTKEEILDIVTLGLKIKAAIKNGYYPPLLKNKSLGMIFQQTSTRTRVSFETAMTQLGGHAEYLAPG
QIQLGGHETIEDTSTVLSRLLDIIMARVDRHESVNNLAKHTTIPVLNGMSDYNHPTQEVGDLTTMIEHLPAGKKLEDCKV
VFVGDATQVCFSLGLIATKMGMHFVHFGPKGYQLNEEHQAKLAANCEVSGGTYEVTDDEESIVGADFLYTDVWYGLYDAE
LSEEERLAIFFPKYQVTPEMMAKAGAHTKFMHCLPASRGEEVVDAVIDGPNSICFDEAENRLTSIRALLVWLMSDYAEKN
PYDLKAQAKAKAELEAYLAK

Specific function: Catalyzes the phosphorolysis of N-carbamoylputrescine to form carbamoyl phosphate and putrescine. Is involved in the degradation pathway of the polyamine agmatine

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family. PTCase subfamily

Homologues:

Organism=Homo sapiens, GI38788445, Length=321, Percent_Identity=38.3177570093458, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI18105007, Length=313, Percent_Identity=23.961661341853, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI1786469, Length=326, Percent_Identity=36.8098159509202, Blast_Score=193, Evalue=1e-50,
Organism=Escherichia coli, GI1790703, Length=329, Percent_Identity=35.5623100303951, Blast_Score=185, Evalue=4e-48,
Organism=Escherichia coli, GI48994908, Length=355, Percent_Identity=24.7887323943662, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI2367364, Length=328, Percent_Identity=28.3536585365854, Blast_Score=74, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322373, Length=309, Percent_Identity=32.0388349514563, Blast_Score=153, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6322331, Length=272, Percent_Identity=25, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTC_LACLA (Q9CEY4)

Other databases:

- EMBL:   AE005176
- PIR:   D86837
- RefSeq:   NP_267856.1
- ProteinModelPortal:   Q9CEY4
- SMR:   Q9CEY4
- GeneID:   1115363
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L0113
- NMPDR:   fig|272623.1.peg.1744
- HOGENOM:   HBG579429
- OMA:   GGHETIE
- ProtClustDB:   PRK02255
- BioCyc:   LLAC272623:L0113-MONOMER
- BRENDA:   2.1.3.3
- HAMAP:   MF_02102
- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002292
- PRINTS:   PR00100
- PRINTS:   PR00102
- TIGRFAMs:   TIGR00658

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N; SSF53671 Asp/Orn_carbamoyltranf

EC number: =2.1.3.6

Molecular weight: Translated: 37845; Mature: 37845

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: BINDING 107-107 BINDING 134-134

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTTNKRDFITTEDYTKEEILDIVTLGLKIKAAIKNGYYPPLLKNKSLGMIFQQTSTRTR
CCCCCCCCCCCCCCCCHHHHHHHHHHHHEEEEEHHCCCCCCCCCCCCCCEEEECCCCCCE
VSFETAMTQLGGHAEYLAPGQIQLGGHETIEDTSTVLSRLLDIIMARVDRHESVNNLAKH
EHHHHHHHHHCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TTIPVLNGMSDYNHPTQEVGDLTTMIEHLPAGKKLEDCKVVFVGDATQVCFSLGLIATKM
CCCHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHH
GMHFVHFGPKGYQLNEEHQAKLAANCEVSGGTYEVTDDEESIVGADFLYTDVWYGLYDAE
CCEEEEECCCCCCCCHHHHHHEEECEEECCCEEEECCCCCHHCCHHHHHHHHHHHHHCCC
LSEEERLAIFFPKYQVTPEMMAKAGAHTKFMHCLPASRGEEVVDAVIDGPNSICFDEAEN
CCCCCEEEEEECCCCCCHHHHHHCCCCHHHHHHCCCCCCHHHHHHHHCCCCCEEHHHHHH
RLTSIRALLVWLMSDYAEKNPYDLKAQAKAKAELEAYLAK
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVTTNKRDFITTEDYTKEEILDIVTLGLKIKAAIKNGYYPPLLKNKSLGMIFQQTSTRTR
CCCCCCCCCCCCCCCCHHHHHHHHHHHHEEEEEHHCCCCCCCCCCCCCCEEEECCCCCCE
VSFETAMTQLGGHAEYLAPGQIQLGGHETIEDTSTVLSRLLDIIMARVDRHESVNNLAKH
EHHHHHHHHHCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TTIPVLNGMSDYNHPTQEVGDLTTMIEHLPAGKKLEDCKVVFVGDATQVCFSLGLIATKM
CCCHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHH
GMHFVHFGPKGYQLNEEHQAKLAANCEVSGGTYEVTDDEESIVGADFLYTDVWYGLYDAE
CCEEEEECCCCCCCCHHHHHHEEECEEECCCEEEECCCCCHHCCHHHHHHHHHHHHHCCC
LSEEERLAIFFPKYQVTPEMMAKAGAHTKFMHCLPASRGEEVVDAVIDGPNSICFDEAEN
CCCCCEEEEEECCCCCCHHHHHHCCCCHHHHHHCCCCCCHHHHHHHHCCCCCEEHHHHHH
RLTSIRALLVWLMSDYAEKNPYDLKAQAKAKAELEAYLAK
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471