Click here to switch to the map view.

The map label for this gene is thiL

Identifier: 15673553

GI number: 15673553

Start: 1611996

End: 1613135

Strand: Reverse

Name: thiL

Synonym: L11745

Alternate gene names: 15673553

Gene position: 1613135-1611996 (Counterclockwise)

Preceding gene: 15673555

Following gene: 15673552

Centisome position: 68.19

GC content: 37.98

Gene sequence:

>1140_bases
GTGAAAGAAATTGTAATCATTGACGCCTTAAGAACACCAGTTGGAAGATACGACGGTGCTCTTGCTGAATATTCAGCAGC
AGAACTTGGGACACATGTTGTTTCAAACTTATTGTCAAAACATGAAAATATAAAATCAGATGTTGAACAAGTTATTTTTG
GGAATGTTCTTCAAGCTGGTAATGGTCAAAATATAGCACGTCAAATTGCGATTCATAGTGGTCTATCTAATACAGTGCCC
GCTTCAACAATCAACGAAGTTTGTGGTTCAGGAATGAAAGCAGTGATTTTAGCTAAACAACTTTTACAGCTTGGTGAAGC
AGAAGTTGTAATCGCTGGTGGGACAGAATCTATGTCTAATGCCCCAATTATAAAGAATCGAAAAACTCAAGAAGAAACAT
TAAGTATGTTAAATGATGGCTTAGTTGATGCCTTCTCAGGAATTTCTATGGGGATTATTGGTGAAACTATTGCTGAACAA
TTTGATATAAGTCGAGCAGACCAAGACGCTTTTGCGCAAAACTCTCAAGAAAAAGCGGTCGCTGCAAGTCAAGCCGGAAT
TTTTAAAGAAGAGATTGTTGCGATTGGAGAAGTCGGAGTCGACGAAACACCACGTCCTTCTTCTAGTTTAGAAAAATTAG
CCACTTTAAGGACAGCTTTCAAAGAAAATGGAACTGTGACAGCAGGTAATTCTTCTCCTGTTAATGATGGAGCTTCAGCT
GTCATTCTTGCAACGAAAGACTATGCTGAAAAACATGGGATTCCGTACCTAGCAGAACTAGTTGATAGTACAGAAGTTGG
AATTGACCCTGCTATTATGGGAGTTTCACCAATTGAAGCTATCAAAAAATTAATTAATCGTTCAGAGCTTGAACTTTCAG
ATATTGACCTGTTTGAAATTAATGAAGCATTTGCAGCATCAAGTCTTGCTGTCAATCGTGAACTTGGTTTAAATGAATCA
CAAGTTAACATTTATGGTGGTGCAATTGCATTAGGTCATGCTATCGGTTCAAGTGGTTCTAAAATTCTCACGACTTTGTC
TTATGCCTTAAAACGTGAGCAAAAACGCTATGGAATTGCTAGTCTTTGTATCGGTGGAGGCCTAGGTTTGGCTGTTCTTT
TAAAAAATCCTAACCTTTAA

Upstream 100 bases:

>100_bases
GAATAGAGTCATTGATTAGATATTGTTTATTAATTTAATGTAAAGAGACTTTGACAAAAGTAGTTTAAAATATGCTATAA
TGGCTTTCGGAGGTTCATTC

Downstream 100 bases:

>100_bases
AAATTATTGTGGTTTAAACAAGTAATTTTTAAGAAATTAATGGAGGAATTGCCCAGCTTATCTGGGCATTTTTGAAAATA
TGAGAAAAAAATTTTATCAA

Product: acetyl coenzyme A acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MKEIVIIDALRTPVGRYDGALAEYSAAELGTHVVSNLLSKHENIKSDVEQVIFGNVLQAGNGQNIARQIAIHSGLSNTVP
ASTINEVCGSGMKAVILAKQLLQLGEAEVVIAGGTESMSNAPIIKNRKTQEETLSMLNDGLVDAFSGISMGIIGETIAEQ
FDISRADQDAFAQNSQEKAVAASQAGIFKEEIVAIGEVGVDETPRPSSSLEKLATLRTAFKENGTVTAGNSSPVNDGASA
VILATKDYAEKHGIPYLAELVDSTEVGIDPAIMGVSPIEAIKKLINRSELELSDIDLFEINEAFAASSLAVNRELGLNES
QVNIYGGAIALGHAIGSSGSKILTTLSYALKREQKRYGIASLCIGGGLGLAVLLKNPNL

Sequences:

>Translated_379_residues
MKEIVIIDALRTPVGRYDGALAEYSAAELGTHVVSNLLSKHENIKSDVEQVIFGNVLQAGNGQNIARQIAIHSGLSNTVP
ASTINEVCGSGMKAVILAKQLLQLGEAEVVIAGGTESMSNAPIIKNRKTQEETLSMLNDGLVDAFSGISMGIIGETIAEQ
FDISRADQDAFAQNSQEKAVAASQAGIFKEEIVAIGEVGVDETPRPSSSLEKLATLRTAFKENGTVTAGNSSPVNDGASA
VILATKDYAEKHGIPYLAELVDSTEVGIDPAIMGVSPIEAIKKLINRSELELSDIDLFEINEAFAASSLAVNRELGLNES
QVNIYGGAIALGHAIGSSGSKILTTLSYALKREQKRYGIASLCIGGGLGLAVLLKNPNL
>Mature_379_residues
MKEIVIIDALRTPVGRYDGALAEYSAAELGTHVVSNLLSKHENIKSDVEQVIFGNVLQAGNGQNIARQIAIHSGLSNTVP
ASTINEVCGSGMKAVILAKQLLQLGEAEVVIAGGTESMSNAPIIKNRKTQEETLSMLNDGLVDAFSGISMGIIGETIAEQ
FDISRADQDAFAQNSQEKAVAASQAGIFKEEIVAIGEVGVDETPRPSSSLEKLATLRTAFKENGTVTAGNSSPVNDGASA
VILATKDYAEKHGIPYLAELVDSTEVGIDPAIMGVSPIEAIKKLINRSELELSDIDLFEINEAFAASSLAVNRELGLNES
QVNIYGGAIALGHAIGSSGSKILTTLSYALKREQKRYGIASLCIGGGLGLAVLLKNPNL

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=389, Percent_Identity=44.4730077120823, Blast_Score=327, Evalue=1e-89,
Organism=Homo sapiens, GI167614485, Length=392, Percent_Identity=40.0510204081633, Blast_Score=275, Evalue=7e-74,
Organism=Homo sapiens, GI4557237, Length=392, Percent_Identity=39.030612244898, Blast_Score=265, Evalue=5e-71,
Organism=Homo sapiens, GI4501853, Length=396, Percent_Identity=38.8888888888889, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI4504327, Length=421, Percent_Identity=29.4536817102138, Blast_Score=171, Evalue=9e-43,
Organism=Homo sapiens, GI194353979, Length=379, Percent_Identity=29.287598944591, Blast_Score=120, Evalue=3e-27,
Organism=Escherichia coli, GI87082165, Length=391, Percent_Identity=46.5473145780051, Blast_Score=337, Evalue=1e-93,
Organism=Escherichia coli, GI1788554, Length=394, Percent_Identity=43.9086294416244, Blast_Score=297, Evalue=9e-82,
Organism=Escherichia coli, GI1787663, Length=400, Percent_Identity=38.25, Blast_Score=276, Evalue=1e-75,
Organism=Escherichia coli, GI48994986, Length=401, Percent_Identity=37.1571072319202, Blast_Score=249, Evalue=2e-67,
Organism=Escherichia coli, GI1788683, Length=416, Percent_Identity=30.5288461538462, Blast_Score=173, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI133906874, Length=392, Percent_Identity=40.8163265306122, Blast_Score=286, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI25147385, Length=378, Percent_Identity=35.7142857142857, Blast_Score=237, Evalue=6e-63,
Organism=Caenorhabditis elegans, GI17535921, Length=389, Percent_Identity=37.2750642673522, Blast_Score=230, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17551802, Length=422, Percent_Identity=31.5165876777251, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17535917, Length=372, Percent_Identity=30.9139784946237, Blast_Score=152, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6325229, Length=387, Percent_Identity=40.0516795865633, Blast_Score=265, Evalue=1e-71,
Organism=Saccharomyces cerevisiae, GI6322031, Length=397, Percent_Identity=36.0201511335013, Blast_Score=232, Evalue=7e-62,
Organism=Drosophila melanogaster, GI24655093, Length=386, Percent_Identity=44.0414507772021, Blast_Score=318, Evalue=5e-87,
Organism=Drosophila melanogaster, GI24640423, Length=390, Percent_Identity=38.7179487179487, Blast_Score=266, Evalue=2e-71,
Organism=Drosophila melanogaster, GI17648125, Length=391, Percent_Identity=38.1074168797954, Blast_Score=247, Evalue=7e-66,
Organism=Drosophila melanogaster, GI17137578, Length=421, Percent_Identity=32.0665083135392, Blast_Score=188, Evalue=5e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 39760; Mature: 39760

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: PS00098 THIOLASE_1 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEIVIIDALRTPVGRYDGALAEYSAAELGTHVVSNLLSKHENIKSDVEQVIFGNVLQAG
CCCEEEEECHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NGQNIARQIAIHSGLSNTVPASTINEVCGSGMKAVILAKQLLQLGEAEVVIAGGTESMSN
CCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCC
APIIKNRKTQEETLSMLNDGLVDAFSGISMGIIGETIAEQFDISRADQDAFAQNSQEKAV
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHCCCHHHHH
AASQAGIFKEEIVAIGEVGVDETPRPSSSLEKLATLRTAFKENGTVTAGNSSPVNDGASA
HHHHHCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCE
VILATKDYAEKHGIPYLAELVDSTEVGIDPAIMGVSPIEAIKKLINRSELELSDIDLFEI
EEEEEHHHHHHCCCHHHHHHHCCHHCCCCHHHCCCCHHHHHHHHHCCCCCCCCCCCCEEH
NEAFAASSLAVNRELGLNESQVNIYGGAIALGHAIGSSGSKILTTLSYALKREQKRYGIA
HHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHH
SLCIGGGLGLAVLLKNPNL
HHHHCCCCEEEEEEECCCC
>Mature Secondary Structure
MKEIVIIDALRTPVGRYDGALAEYSAAELGTHVVSNLLSKHENIKSDVEQVIFGNVLQAG
CCCEEEEECHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NGQNIARQIAIHSGLSNTVPASTINEVCGSGMKAVILAKQLLQLGEAEVVIAGGTESMSN
CCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCC
APIIKNRKTQEETLSMLNDGLVDAFSGISMGIIGETIAEQFDISRADQDAFAQNSQEKAV
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHCCCHHHHH
AASQAGIFKEEIVAIGEVGVDETPRPSSSLEKLATLRTAFKENGTVTAGNSSPVNDGASA
HHHHHCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCE
VILATKDYAEKHGIPYLAELVDSTEVGIDPAIMGVSPIEAIKKLINRSELELSDIDLFEI
EEEEEHHHHHHCCCHHHHHHHCCHHCCCCHHHCCCCHHHHHHHHHCCCCCCCCCCCCEEH
NEAFAASSLAVNRELGLNESQVNIYGGAIALGHAIGSSGSKILTTLSYALKREQKRYGIA
HHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHH
SLCIGGGLGLAVLLKNPNL
HHHHCCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]