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The map label for this gene is purM

Identifier: 15673506

GI number: 15673506

Start: 1565453

End: 1566469

Strand: Reverse

Name: purM

Synonym: L165202

Alternate gene names: 15673506

Gene position: 1566469-1565453 (Counterclockwise)

Preceding gene: 15673507

Following gene: 15673505

Centisome position: 66.22

GC content: 39.43

Gene sequence:

>1017_bases
GTGTCTGAGAATGCGTATGCAAAATCTGGGGTAGATGTAGAAGCAGGATATGAGGTGGTTTCTCGTATTAAGAAGCATGT
AGCTAAAACCGAACGTTTGGGTGTGCTTGGGGCACTGGGTGGTTTTGGTGGAAGTTTTGATTTATCTGTGCTTGATGTGA
AAGAGCCTGTATTGATTTCGGGGACAGATGGTGTGGGAACTAAATTGATGTTAGCCATTCAAGCAGACAAACATGACACG
ATTGGGATTGATTGCGTAGCCATGTGCGTCAATGATATTATTGCTGCTGGGGCTGAACCACTGTATTTTTTGGATTATAT
TGCCACAGGGAAAAATATTCCTGAAAAATTGGAGCAAGTTGTGGCTGGAGTGGCCGAAGGTTGCTTGCAAGCAGGAGCAG
CGCTGATTGGTGGAGAAACAGCTGAAATGCCCGGAATGTATGATGAAGATGATTACGATTTAGCTGGTTTTGCTGTGGGT
GTGGCTGAAAAATCACAATTAATTGATGGCGAAAAAGATGTGGAAGCGGGCGATGTTTTGCTTGGTCTTGCCTCATCTGG
GATTCATTCTAACGGATACTCTTTGGTTCGGAAAGTTTTTTCTGACTTTGATTTGAATGAATCGTTGCCTGAACTTGACC
AATCTTTGATTGATACTCTTTTAACTCCGACAAAAATCTATGTCAAAGAGCTTTTACCCTTGATTAAACAAAATAAAATA
AAAGGGATTGCTCATATTACAGGCGGAGGATTCCATGAGAATTTACCAAGAATGTTCGGAAATAGCTTGTCAGCTGAAAT
TGTCGAAGGTTCTTGGAATATTTTACCAATTTTCAAAGCTCTTGAAAAATATGGGGATATCAAACATGAAGAAATGTATG
AAATTTTCAATATGGGAATTGGAATGGTAATTGCTGTTGCTCCTGAAAATGCTGAAGCTCTCAAAAAAGTCTTGAATGCA
TTTGAAATTGGTAAAATGGTCAAAAGACAAGATTCAGCAGTAGTGATTAAAAAATAA

Upstream 100 bases:

>100_bases
AATCGAAAAGTTTCAGTACTACCCGCTGGAACTTTTTTTATGTTTGAAAATCATTTAACATGGAAGTAGAATAAAATAAA
TCAGAAAATGGAGAATGACA

Downstream 100 bases:

>100_bases
ATTTTTTCATTGAGAATAGGGGATAGCATGAAATTTGCAGTATTTGCATCAGGAAATGGCTCAAACTTTCAAACACTAGC
TGAACAATTTCCAGACCAAG

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 338; Mature: 337

Protein sequence:

>338_residues
MSENAYAKSGVDVEAGYEVVSRIKKHVAKTERLGVLGALGGFGGSFDLSVLDVKEPVLISGTDGVGTKLMLAIQADKHDT
IGIDCVAMCVNDIIAAGAEPLYFLDYIATGKNIPEKLEQVVAGVAEGCLQAGAALIGGETAEMPGMYDEDDYDLAGFAVG
VAEKSQLIDGEKDVEAGDVLLGLASSGIHSNGYSLVRKVFSDFDLNESLPELDQSLIDTLLTPTKIYVKELLPLIKQNKI
KGIAHITGGGFHENLPRMFGNSLSAEIVEGSWNILPIFKALEKYGDIKHEEMYEIFNMGIGMVIAVAPENAEALKKVLNA
FEIGKMVKRQDSAVVIKK

Sequences:

>Translated_338_residues
MSENAYAKSGVDVEAGYEVVSRIKKHVAKTERLGVLGALGGFGGSFDLSVLDVKEPVLISGTDGVGTKLMLAIQADKHDT
IGIDCVAMCVNDIIAAGAEPLYFLDYIATGKNIPEKLEQVVAGVAEGCLQAGAALIGGETAEMPGMYDEDDYDLAGFAVG
VAEKSQLIDGEKDVEAGDVLLGLASSGIHSNGYSLVRKVFSDFDLNESLPELDQSLIDTLLTPTKIYVKELLPLIKQNKI
KGIAHITGGGFHENLPRMFGNSLSAEIVEGSWNILPIFKALEKYGDIKHEEMYEIFNMGIGMVIAVAPENAEALKKVLNA
FEIGKMVKRQDSAVVIKK
>Mature_337_residues
SENAYAKSGVDVEAGYEVVSRIKKHVAKTERLGVLGALGGFGGSFDLSVLDVKEPVLISGTDGVGTKLMLAIQADKHDTI
GIDCVAMCVNDIIAAGAEPLYFLDYIATGKNIPEKLEQVVAGVAEGCLQAGAALIGGETAEMPGMYDEDDYDLAGFAVGV
AEKSQLIDGEKDVEAGDVLLGLASSGIHSNGYSLVRKVFSDFDLNESLPELDQSLIDTLLTPTKIYVKELLPLIKQNKIK
GIAHITGGGFHENLPRMFGNSLSAEIVEGSWNILPIFKALEKYGDIKHEEMYEIFNMGIGMVIAVAPENAEALKKVLNAF
EIGKMVKRQDSAVVIKK

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=341, Percent_Identity=47.5073313782991, Blast_Score=308, Evalue=6e-84,
Organism=Homo sapiens, GI209869995, Length=341, Percent_Identity=47.5073313782991, Blast_Score=308, Evalue=6e-84,
Organism=Homo sapiens, GI209869993, Length=341, Percent_Identity=47.5073313782991, Blast_Score=308, Evalue=6e-84,
Organism=Escherichia coli, GI1788845, Length=334, Percent_Identity=53.8922155688623, Blast_Score=335, Evalue=2e-93,
Organism=Caenorhabditis elegans, GI17567511, Length=325, Percent_Identity=41.8461538461538, Blast_Score=235, Evalue=3e-62,
Organism=Saccharomyces cerevisiae, GI6321203, Length=340, Percent_Identity=45, Blast_Score=287, Evalue=2e-78,
Organism=Drosophila melanogaster, GI24582400, Length=295, Percent_Identity=43.0508474576271, Blast_Score=233, Evalue=2e-61,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 36139; Mature: 36008

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSENAYAKSGVDVEAGYEVVSRIKKHVAKTERLGVLGALGGFGGSFDLSVLDVKEPVLIS
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEE
GTDGVGTKLMLAIQADKHDTIGIDCVAMCVNDIIAAGAEPLYFLDYIATGKNIPEKLEQV
CCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHH
VAGVAEGCLQAGAALIGGETAEMPGMYDEDDYDLAGFAVGVAEKSQLIDGEKDVEAGDVL
HHHHHHHHHHHCHHHCCCCCCCCCCCCCCCCCCHHHHEECHHHHHHHCCCCCCCCCCHHE
LGLASSGIHSNGYSLVRKVFSDFDLNESLPELDQSLIDTLLTPTKIYVKELLPLIKQNKI
EEHHHCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC
KGIAHITGGGFHENLPRMFGNSLSAEIVEGSWNILPIFKALEKYGDIKHEEMYEIFNMGI
CEEEEECCCCHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCC
GMVIAVAPENAEALKKVLNAFEIGKMVKRQDSAVVIKK
CEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEC
>Mature Secondary Structure 
SENAYAKSGVDVEAGYEVVSRIKKHVAKTERLGVLGALGGFGGSFDLSVLDVKEPVLIS
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEE
GTDGVGTKLMLAIQADKHDTIGIDCVAMCVNDIIAAGAEPLYFLDYIATGKNIPEKLEQV
CCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHH
VAGVAEGCLQAGAALIGGETAEMPGMYDEDDYDLAGFAVGVAEKSQLIDGEKDVEAGDVL
HHHHHHHHHHHCHHHCCCCCCCCCCCCCCCCCCHHHHEECHHHHHHHCCCCCCCCCCHHE
LGLASSGIHSNGYSLVRKVFSDFDLNESLPELDQSLIDTLLTPTKIYVKELLPLIKQNKI
EEHHHCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC
KGIAHITGGGFHENLPRMFGNSLSAEIVEGSWNILPIFKALEKYGDIKHEEMYEIFNMGI
CEEEEECCCCHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCC
GMVIAVAPENAEALKKVLNAFEIGKMVKRQDSAVVIKK
CEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA