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The map label for this gene is purN

Identifier: 15673505

GI number: 15673505

Start: 1564877

End: 1565425

Strand: Reverse

Name: purN

Synonym: L164626

Alternate gene names: 15673505

Gene position: 1565425-1564877 (Counterclockwise)

Preceding gene: 15673506

Following gene: 15673504

Centisome position: 66.17

GC content: 38.62

Gene sequence:

>549_bases
ATGAAATTTGCAGTATTTGCATCAGGAAATGGCTCAAACTTTCAAACACTAGCTGAACAATTTCCAGACCAAGTGAAATT
TGTTTTTTCAGACCATCATGATGCTTATGTACTTGAACGTGCTGAGCGATTAGGGGTGGCAAAGGCAAGTTTGGAGTTAA
AAGAATTTTCTTCAAAAGTGGATTATGAAAAGGCCTTGGTGGAAATTTTAAAAGATCAAGAAATTGATTTAATTCTCTTG
GCGGGCTACATGAAAATTATTGGTGCGACGGTGTTATCAAAATATAAAGGAAAGATAATCAATGTTCACCCTTCTTATCT
TCCGGATTTTGCCGGTTCACCTCATGCGATTGAAGAATCACATGAGGCAAAAAAGGGGTTGGGAATCAGTATTCATTATG
TTGATGAGGGGGTTGATACTGGGGAATTGATTGCTCAAATCTCGCTCGCTTATCACGAAGATTTAGAAGTCTATGAGCGT
TCTGTTCATGAAGCAGAGCACAAGCTCTATCCAGAAGTCGTTCGCCAAATTATACTTCATCAGCAATGA

Upstream 100 bases:

>100_bases
AAAAGTCTTGAATGCATTTGAAATTGGTAAAATGGTCAAAAGACAAGATTCAGCAGTAGTGATTAAAAAATAAATTTTTT
CATTGAGAATAGGGGATAGC

Downstream 100 bases:

>100_bases
TGAAGTTTTTTTCTTACGTTTTAGCTTAATAAAAATAAGAGAAAATTTTCAGTTCTTTTAAGAAAATAAAACATCTAAAA
TACTTTTATAAGCGCTATTT

Product: phosphoribosylglycinamide formyltransferase

Products: NA

Alternate protein names: 5'-phosphoribosylglycinamide transformylase; GAR transformylase; GART [H]

Number of amino acids: Translated: 182; Mature: 182

Protein sequence:

>182_residues
MKFAVFASGNGSNFQTLAEQFPDQVKFVFSDHHDAYVLERAERLGVAKASLELKEFSSKVDYEKALVEILKDQEIDLILL
AGYMKIIGATVLSKYKGKIINVHPSYLPDFAGSPHAIEESHEAKKGLGISIHYVDEGVDTGELIAQISLAYHEDLEVYER
SVHEAEHKLYPEVVRQIILHQQ

Sequences:

>Translated_182_residues
MKFAVFASGNGSNFQTLAEQFPDQVKFVFSDHHDAYVLERAERLGVAKASLELKEFSSKVDYEKALVEILKDQEIDLILL
AGYMKIIGATVLSKYKGKIINVHPSYLPDFAGSPHAIEESHEAKKGLGISIHYVDEGVDTGELIAQISLAYHEDLEVYER
SVHEAEHKLYPEVVRQIILHQQ
>Mature_182_residues
MKFAVFASGNGSNFQTLAEQFPDQVKFVFSDHHDAYVLERAERLGVAKASLELKEFSSKVDYEKALVEILKDQEIDLILL
AGYMKIIGATVLSKYKGKIINVHPSYLPDFAGSPHAIEESHEAKKGLGISIHYVDEGVDTGELIAQISLAYHEDLEVYER
SVHEAEHKLYPEVVRQIILHQQ

Specific function: De novo purine biosynthesis; third step. [C]

COG id: COG0299

COG function: function code F; Folate-dependent phosphoribosylglycinamide formyltransferase PurN

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GART family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=184, Percent_Identity=32.0652173913043, Blast_Score=106, Evalue=1e-23,
Organism=Homo sapiens, GI209869995, Length=184, Percent_Identity=32.0652173913043, Blast_Score=106, Evalue=1e-23,
Organism=Homo sapiens, GI209869993, Length=184, Percent_Identity=32.0652173913043, Blast_Score=106, Evalue=1e-23,
Organism=Escherichia coli, GI1788846, Length=185, Percent_Identity=32.972972972973, Blast_Score=99, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17567511, Length=182, Percent_Identity=30.7692307692308, Blast_Score=90, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6320616, Length=196, Percent_Identity=31.1224489795918, Blast_Score=75, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24582400, Length=187, Percent_Identity=33.1550802139037, Blast_Score=111, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002376
- InterPro:   IPR001555
- InterPro:   IPR004607 [H]

Pfam domain/function: PF00551 Formyl_trans_N [H]

EC number: =2.1.2.2 [H]

Molecular weight: Translated: 20482; Mature: 20482

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFAVFASGNGSNFQTLAEQFPDQVKFVFSDHHDAYVLERAERLGVAKASLELKEFSSKV
CEEEEEECCCCCCHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHC
DYEKALVEILKDQEIDLILLAGYMKIIGATVLSKYKGKIINVHPSYLPDFAGSPHAIEES
CHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCHHHH
HEAKKGLGISIHYVDEGVDTGELIAQISLAYHEDLEVYERSVHEAEHKLYPEVVRQIILH
HHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
QQ
CC
>Mature Secondary Structure
MKFAVFASGNGSNFQTLAEQFPDQVKFVFSDHHDAYVLERAERLGVAKASLELKEFSSKV
CEEEEEECCCCCCHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHC
DYEKALVEILKDQEIDLILLAGYMKIIGATVLSKYKGKIINVHPSYLPDFAGSPHAIEES
CHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCHHHH
HEAKKGLGISIHYVDEGVDTGELIAQISLAYHEDLEVYERSVHEAEHKLYPEVVRQIILH
HHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
QQ
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3036807; 9384377 [H]