Click here to switch to the map view.

The map label for this gene is dltA

Identifier: 15673243

GI number: 15673243

Start: 1291765

End: 1293264

Strand: Reverse

Name: dltA

Synonym: L91510

Alternate gene names: 15673243

Gene position: 1293264-1291765 (Counterclockwise)

Preceding gene: 15673244

Following gene: 15673242

Centisome position: 54.67

GC content: 37.13

Gene sequence:

>1500_bases
ATGAAATTATTAGAACAAATTTTTGAAATTGCAAAAAAAGAACCAGACCTTATTGTACTTGCCGAGCGTGAGCAGAAATT
TACTTACCGTCAATTATTTGCCGCGGTTTCACATATCTCAGAACAAATCAATGAACGCAATTTAAATCAGCGTCCAATCT
TGATTTTCGGTAAAAACGATTTTATCACTTTAGCAGCCATGCTTGCGACAAATTTAAGGGGTCACGCTTATATTCCTGTT
GATGCTCACACACCATTTGAGCGGACAGAAATGATTAAATCAGCGGCAAAACCAGCGGCGGTACTCACTACAGTTGAGCT
GTCAGCAGATTTTGAAGCACTTTTTACTGACAGAATTTCTCTTGAACTTACTGACCAGATTTTGACTGACAAACTTCCAG
CACTTGATTTTTCTAAAGCTGTTTCTGGAAATGACAGCAATTATATTATTTATACTTCTGGAACAACAGGAGTCCCAAAA
GGTGTTGAAGTCAGTCATGATAATCTTGTGACTTTCACCAATTGGATGAACAATGATTTTATGAAAATTGAAAATAATCA
AATCTTGTCACAAGCCCTTTACAGCTTTGATTTATCAATTTTCAGCTTGTATCCAAGTCTTACAACTGGCGGAACATTAA
TTTCACTCTCACGTGACGAAACAACCAACTTCAAATTACTTTTTGAGCGTTTGAACAAAACGGTCATTAATACTTGGATT
TCAACACCATCATTTGTTGATATTTGCTTATTGGACCCTTCGTTCACTGAGAAAGAACACCCTCAATTAGTTCAATTTAT
TCTCTGCGGTGAAGAATTAACAAAGAAAACAGCAGAAAAATTACTAACAGCTTTTCCGTCAGCAAATATATACAATACCT
ATGGTCCAACAGAAGCAACAGGAGCCATTTCGTCAGTAAAAATCACGAAAGAATTACTGACAGAAAATGATCGTGTCCCA
ATTGGTTTTGCCAAACCAGGTGTTGACTTAAAAATTATGGATAAGGAAATCATCATTGTTGGTGATTCGGTAGCCAAAGG
TTACTTTGAAAATCCAGAAAAAACTGAGCAAGCCTTTTTCACAGTCGACGGAAAACCCGCTTATCATACAGGAGATGCCG
GTTCAATTTCGGCTGACGGAATGCTCCGTTACCAAGGACGAATTGATTTTCAAGTTAAATTTAATGGATTCCGTATTGAA
CTTCAAGATATTGAAGCCAATATTCAAAACTTAAAAGAGATTGAAAAAGCGGTAGTCTTACCGAAAACGAATGACCAGCA
TAAAGTCACCGCATTAATCGCTTATTTAGAAACAGAAAAAACATTTGAAGACCGTGCAGCCGAACGCGCCTTCACAAAAG
AACTCAAAGCTGAACTTTCAAAAACAATTATGGATTACATGATGCCAACTAAGTTTGTTTATCTTAAAAAGTTCCCATTG
AATCAAAATGGCAAAGTTGACCGCAAGGCACTCGCCCAAAAAGAGCGAGGTGACAACTAG

Upstream 100 bases:

>100_bases
AATTATTTTAATTCTGCTCTATCTTTATTCCTACAGTCATACTGGCGGAGCACACTTTATCTATAACGAATTTTAGAGAG
AATTATCGAAGGAGTTAATT

Downstream 100 bases:

>100_bases
TGCAACCCTATTCAACACCCTTTTACTTCGTGATTTTAGGACTTGCTTTAATTCCTATCGTTATTGCCCAGCTTCTGGGC
AAAAAACTCATGTGGTATCA

Product: D-alanine--poly(phosphoribitol) ligase subunit 1

Products: NA

Alternate protein names: D-alanine-D-alanyl carrier protein ligase; DCL; D-alanine-activating enzyme; DAE

Number of amino acids: Translated: 499; Mature: 499

Protein sequence:

>499_residues
MKLLEQIFEIAKKEPDLIVLAEREQKFTYRQLFAAVSHISEQINERNLNQRPILIFGKNDFITLAAMLATNLRGHAYIPV
DAHTPFERTEMIKSAAKPAAVLTTVELSADFEALFTDRISLELTDQILTDKLPALDFSKAVSGNDSNYIIYTSGTTGVPK
GVEVSHDNLVTFTNWMNNDFMKIENNQILSQALYSFDLSIFSLYPSLTTGGTLISLSRDETTNFKLLFERLNKTVINTWI
STPSFVDICLLDPSFTEKEHPQLVQFILCGEELTKKTAEKLLTAFPSANIYNTYGPTEATGAISSVKITKELLTENDRVP
IGFAKPGVDLKIMDKEIIIVGDSVAKGYFENPEKTEQAFFTVDGKPAYHTGDAGSISADGMLRYQGRIDFQVKFNGFRIE
LQDIEANIQNLKEIEKAVVLPKTNDQHKVTALIAYLETEKTFEDRAAERAFTKELKAELSKTIMDYMMPTKFVYLKKFPL
NQNGKVDRKALAQKERGDN

Sequences:

>Translated_499_residues
MKLLEQIFEIAKKEPDLIVLAEREQKFTYRQLFAAVSHISEQINERNLNQRPILIFGKNDFITLAAMLATNLRGHAYIPV
DAHTPFERTEMIKSAAKPAAVLTTVELSADFEALFTDRISLELTDQILTDKLPALDFSKAVSGNDSNYIIYTSGTTGVPK
GVEVSHDNLVTFTNWMNNDFMKIENNQILSQALYSFDLSIFSLYPSLTTGGTLISLSRDETTNFKLLFERLNKTVINTWI
STPSFVDICLLDPSFTEKEHPQLVQFILCGEELTKKTAEKLLTAFPSANIYNTYGPTEATGAISSVKITKELLTENDRVP
IGFAKPGVDLKIMDKEIIIVGDSVAKGYFENPEKTEQAFFTVDGKPAYHTGDAGSISADGMLRYQGRIDFQVKFNGFRIE
LQDIEANIQNLKEIEKAVVLPKTNDQHKVTALIAYLETEKTFEDRAAERAFTKELKAELSKTIMDYMMPTKFVYLKKFPL
NQNGKVDRKALAQKERGDN
>Mature_499_residues
MKLLEQIFEIAKKEPDLIVLAEREQKFTYRQLFAAVSHISEQINERNLNQRPILIFGKNDFITLAAMLATNLRGHAYIPV
DAHTPFERTEMIKSAAKPAAVLTTVELSADFEALFTDRISLELTDQILTDKLPALDFSKAVSGNDSNYIIYTSGTTGVPK
GVEVSHDNLVTFTNWMNNDFMKIENNQILSQALYSFDLSIFSLYPSLTTGGTLISLSRDETTNFKLLFERLNKTVINTWI
STPSFVDICLLDPSFTEKEHPQLVQFILCGEELTKKTAEKLLTAFPSANIYNTYGPTEATGAISSVKITKELLTENDRVP
IGFAKPGVDLKIMDKEIIIVGDSVAKGYFENPEKTEQAFFTVDGKPAYHTGDAGSISADGMLRYQGRIDFQVKFNGFRIE
LQDIEANIQNLKEIEKAVVLPKTNDQHKVTALIAYLETEKTFEDRAAERAFTKELKAELSKTIMDYMMPTKFVYLKKFPL
NQNGKVDRKALAQKERGDN

Specific function: Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp

COG id: COG1020

COG function: function code Q; Non-ribosomal peptide synthetase modules and related proteins

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. DltA subfamily

Homologues:

Organism=Homo sapiens, GI156151445, Length=382, Percent_Identity=25.6544502617801, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI38505220, Length=383, Percent_Identity=24.2819843342037, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI115511026, Length=380, Percent_Identity=25.2631578947368, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI42544132, Length=380, Percent_Identity=23.6842105263158, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1786801, Length=516, Percent_Identity=27.3255813953488, Blast_Score=155, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI32563687, Length=489, Percent_Identity=25.3578732106339, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17558820, Length=461, Percent_Identity=28.4164859002169, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17550940, Length=437, Percent_Identity=27.2311212814645, Blast_Score=95, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17556356, Length=354, Percent_Identity=25.4237288135593, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71985884, Length=385, Percent_Identity=23.6363636363636, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6319591, Length=563, Percent_Identity=23.2682060390764, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6319699, Length=376, Percent_Identity=26.063829787234, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24648676, Length=456, Percent_Identity=29.6052631578947, Blast_Score=142, Evalue=7e-34,
Organism=Drosophila melanogaster, GI18859661, Length=380, Percent_Identity=22.8947368421053, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21355181, Length=383, Percent_Identity=22.976501305483, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21356947, Length=363, Percent_Identity=24.2424242424242, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24648260, Length=483, Percent_Identity=21.9461697722567, Blast_Score=72, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DLTA_LACLA (Q9CG49)

Other databases:

- EMBL:   AE005176
- PIR:   E86782
- RefSeq:   NP_267417.1
- ProteinModelPortal:   Q9CG49
- PhosSite:   Q9CG49
- GeneID:   1114910
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L91510
- NMPDR:   fig|272623.1.peg.1296
- HOGENOM:   HBG320748
- OMA:   FICTEEL
- ProtClustDB:   PRK04813
- BioCyc:   LLAC272623:L91510-MONOMER
- BRENDA:   6.1.1.13
- GO:   GO:0005737
- HAMAP:   MF_00593
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR010072
- PANTHER:   PTHR11968:SF34
- TIGRFAMs:   TIGR01734

Pfam domain/function: PF00501 AMP-binding

EC number: =6.1.1.13

Molecular weight: Translated: 56172; Mature: 56172

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00455 AMP_BINDING; PS00697 DNA_LIGASE_A1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLEQIFEIAKKEPDLIVLAEREQKFTYRQLFAAVSHISEQINERNLNQRPILIFGKND
CHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCC
FITLAAMLATNLRGHAYIPVDAHTPFERTEMIKSAAKPAAVLTTVELSADFEALFTDRIS
HHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHCCEE
LELTDQILTDKLPALDFSKAVSGNDSNYIIYTSGTTGVPKGVEVSHDNLVTFTNWMNNDF
EEEHHHHHHCCCCCCCHHHHCCCCCCCEEEEECCCCCCCCCCEECCCCEEEEEECCCCCE
MKIENNQILSQALYSFDLSIFSLYPSLTTGGTLISLSRDETTNFKLLFERLNKTVINTWI
EEECCHHHHHHHHHHHCCHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHC
STPSFVDICLLDPSFTEKEHPQLVQFILCGEELTKKTAEKLLTAFPSANIYNTYGPTEAT
CCCCEEEEEEECCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEECCCCCCHH
GAISSVKITKELLTENDRVPIGFAKPGVDLKIMDKEIIIVGDSVAKGYFENPEKTEQAFF
CCHHHHHHHHHHHCCCCCCEEEECCCCCCEEEECCEEEEEECHHHCCCCCCCCCCCCEEE
TVDGKPAYHTGDAGSISADGMLRYQGRIDFQVKFNGFRIELQDIEANIQNLKEIEKAVVL
EECCCCCEECCCCCCCCCCCEEEECCEEEEEEEECCEEEEEEHHHHHHHHHHHHHHHEEC
PKTNDQHKVTALIAYLETEKTFEDRAAERAFTKELKAELSKTIMDYMMPTKFVYLKKFPL
CCCCCCHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCC
NQNGKVDRKALAQKERGDN
CCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MKLLEQIFEIAKKEPDLIVLAEREQKFTYRQLFAAVSHISEQINERNLNQRPILIFGKND
CHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCC
FITLAAMLATNLRGHAYIPVDAHTPFERTEMIKSAAKPAAVLTTVELSADFEALFTDRIS
HHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHCCEE
LELTDQILTDKLPALDFSKAVSGNDSNYIIYTSGTTGVPKGVEVSHDNLVTFTNWMNNDF
EEEHHHHHHCCCCCCCHHHHCCCCCCCEEEEECCCCCCCCCCEECCCCEEEEEECCCCCE
MKIENNQILSQALYSFDLSIFSLYPSLTTGGTLISLSRDETTNFKLLFERLNKTVINTWI
EEECCHHHHHHHHHHHCCHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHC
STPSFVDICLLDPSFTEKEHPQLVQFILCGEELTKKTAEKLLTAFPSANIYNTYGPTEAT
CCCCEEEEEEECCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEECCCCCCHH
GAISSVKITKELLTENDRVPIGFAKPGVDLKIMDKEIIIVGDSVAKGYFENPEKTEQAFF
CCHHHHHHHHHHHCCCCCCEEEECCCCCCEEEECCEEEEEECHHHCCCCCCCCCCCCEEE
TVDGKPAYHTGDAGSISADGMLRYQGRIDFQVKFNGFRIELQDIEANIQNLKEIEKAVVL
EECCCCCEECCCCCCCCCCCEEEECCEEEEEEEECCEEEEEEHHHHHHHHHHHHHHHEEC
PKTNDQHKVTALIAYLETEKTFEDRAAERAFTKELKAELSKTIMDYMMPTKFVYLKKFPL
CCCCCCHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCC
NQNGKVDRKALAQKERGDN
CCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471