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The map label for this gene is lctO

Identifier: 15673234

GI number: 15673234

Start: 1278985

End: 1280136

Strand: Reverse

Name: lctO

Synonym: L78730

Alternate gene names: 15673234

Gene position: 1280136-1278985 (Counterclockwise)

Preceding gene: 15673235

Following gene: 15673232

Centisome position: 54.11

GC content: 38.19

Gene sequence:

>1152_bases
ATGCATCTATCATCTACAGATGTAAACTTTATAAAAAATAGGAGAACTAAGATGACTTATAAAACTAGTACTGAAAACAA
AGCGTTAGAAATTGTAAATGTTAAATCACTTGAAGGTAAAGTGAAACAAAGTATGGAGGCTGCGGGAAATAAAGGTGGCT
TTGGCTATATTCGTGGTGGCTCTGAAGATGAGTGGACACTGAATGAAAATACATCAGCATTTAACAAAAAACAAATTATG
CCTCGAGTATTGAGAGGAATTGATTCTGCAGATTTAAGTACCTCACTCTTTGGTATAAAACTAAAAACACCAATTATCCA
AGCGCCAGTTGCCGCCCAAGGCCTTGCTCATGCAGAAGGAGAAGTTGCAACTGCTAAAGCGATGGCTGAAGTTGGCTCAA
TCTTTTCAATTAGTACTTACGGAAGTACATCAGTGGAAGACGCCGCAAAAGCAGCACCAGATGCACCGCAATTTTTCCAA
TTATATATGAGTAAAGATGATAAATTTAATGAATTTCTTTTGAAAAAAGCTGTATCAGCTGGAGTTAAGGCGATTATTTT
AACCGCTGATTCAACACTAGGTGGCTATCGAGAAGAAGACATTGTCAATCATTTCCAATTTCCTTTTCCAATGCCAAATC
TAGCTGCTTTTTCAGAAAGTGATGGAACGGGCAAGGGAATCAGCGAAATCTATGCAGCAGCAAAACAAGGTCTTGTTTTA
GAAGATATTCAAAAAATTAAAAAAATAACTAATCTTCCTGTAATTGTTAAGGGGGTTCAATCTCCTATAGATGCAGATGA
TGCCATTAACGCTGGGGCAGACGGTATCTGGGTTTCAAATCATGGGGGAAGACAATTAGATGGAGGACCTGCTTCAATTG
ATGTCCTACCCCTCATCGCCAAAAGTGTTAATCATCGAGTTCCTATTGTTTTTGATAGTGGAGTTAGACGTGGGGAACAT
GTCTTCAAAGCTTTAGCACAAGGAGCAGATGTTGTTGCGGTAGGTCGACCAGTTCTTTATGGGTTGAATTTAGGGGGAGC
CAAAGGTGTTCAATCTGTTTTTGAACACTTAAACAAAGAGCTAAGTATTACTATGCAACTTGCTGGAACAAAAAATATTG
AAGAAATCAAACATACCTCATTGATTGACTAA

Upstream 100 bases:

>100_bases
AGAGTAGTTTTGCTACTTTTTTAATTTATCTTTTTATATAAGTTTTAGTTTTTTTAAAATAAATCTTTCATTTGTGTATT
TTTTAAAAATAAGATGTATA

Downstream 100 bases:

>100_bases
TAGTTCAAATAAAAAAGTACCTTATTAGAGGTACTTTTTTTATCCTTATCCTATTTGATAAAATAGTTAGTTTTGAAAGT
TCATTTGATCAATTTTTGAA

Product: L-lactate oxidase

Products: NA

Alternate protein names: Lactate oxidase [H]

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MHLSSTDVNFIKNRRTKMTYKTSTENKALEIVNVKSLEGKVKQSMEAAGNKGGFGYIRGGSEDEWTLNENTSAFNKKQIM
PRVLRGIDSADLSTSLFGIKLKTPIIQAPVAAQGLAHAEGEVATAKAMAEVGSIFSISTYGSTSVEDAAKAAPDAPQFFQ
LYMSKDDKFNEFLLKKAVSAGVKAIILTADSTLGGYREEDIVNHFQFPFPMPNLAAFSESDGTGKGISEIYAAAKQGLVL
EDIQKIKKITNLPVIVKGVQSPIDADDAINAGADGIWVSNHGGRQLDGGPASIDVLPLIAKSVNHRVPIVFDSGVRRGEH
VFKALAQGADVVAVGRPVLYGLNLGGAKGVQSVFEHLNKELSITMQLAGTKNIEEIKHTSLID

Sequences:

>Translated_383_residues
MHLSSTDVNFIKNRRTKMTYKTSTENKALEIVNVKSLEGKVKQSMEAAGNKGGFGYIRGGSEDEWTLNENTSAFNKKQIM
PRVLRGIDSADLSTSLFGIKLKTPIIQAPVAAQGLAHAEGEVATAKAMAEVGSIFSISTYGSTSVEDAAKAAPDAPQFFQ
LYMSKDDKFNEFLLKKAVSAGVKAIILTADSTLGGYREEDIVNHFQFPFPMPNLAAFSESDGTGKGISEIYAAAKQGLVL
EDIQKIKKITNLPVIVKGVQSPIDADDAINAGADGIWVSNHGGRQLDGGPASIDVLPLIAKSVNHRVPIVFDSGVRRGEH
VFKALAQGADVVAVGRPVLYGLNLGGAKGVQSVFEHLNKELSITMQLAGTKNIEEIKHTSLID
>Mature_383_residues
MHLSSTDVNFIKNRRTKMTYKTSTENKALEIVNVKSLEGKVKQSMEAAGNKGGFGYIRGGSEDEWTLNENTSAFNKKQIM
PRVLRGIDSADLSTSLFGIKLKTPIIQAPVAAQGLAHAEGEVATAKAMAEVGSIFSISTYGSTSVEDAAKAAPDAPQFFQ
LYMSKDDKFNEFLLKKAVSAGVKAIILTADSTLGGYREEDIVNHFQFPFPMPNLAAFSESDGTGKGISEIYAAAKQGLVL
EDIQKIKKITNLPVIVKGVQSPIDADDAINAGADGIWVSNHGGRQLDGGPASIDVLPLIAKSVNHRVPIVFDSGVRRGEH
VFKALAQGADVVAVGRPVLYGLNLGGAKGVQSVFEHLNKELSITMQLAGTKNIEEIKHTSLID

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=338, Percent_Identity=40.2366863905325, Blast_Score=257, Evalue=1e-68,
Organism=Homo sapiens, GI54234014, Length=322, Percent_Identity=36.0248447204969, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI7705393, Length=322, Percent_Identity=36.0248447204969, Blast_Score=216, Evalue=3e-56,
Organism=Escherichia coli, GI1790033, Length=356, Percent_Identity=33.9887640449438, Blast_Score=191, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI193208036, Length=334, Percent_Identity=39.2215568862275, Blast_Score=217, Evalue=7e-57,
Organism=Caenorhabditis elegans, GI32566217, Length=249, Percent_Identity=38.1526104417671, Blast_Score=147, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6323587, Length=360, Percent_Identity=33.3333333333333, Blast_Score=174, Evalue=3e-44,
Organism=Drosophila melanogaster, GI281363140, Length=373, Percent_Identity=38.3378016085791, Blast_Score=234, Evalue=5e-62,
Organism=Drosophila melanogaster, GI78707190, Length=373, Percent_Identity=38.3378016085791, Blast_Score=234, Evalue=5e-62,
Organism=Drosophila melanogaster, GI78707188, Length=364, Percent_Identity=38.7362637362637, Blast_Score=233, Evalue=1e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.13.12.4 [H]

Molecular weight: Translated: 40972; Mature: 40972

Theoretical pI: Translated: 7.32; Mature: 7.32

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLSSTDVNFIKNRRTKMTYKTSTENKALEIVNVKSLEGKVKQSMEAAGNKGGFGYIRGG
CCCCCCCHHHHHCCCCEEEEEECCCCCEEEEEEEHHHHHHHHHHHHHCCCCCCEEEEECC
SEDEWTLNENTSAFNKKQIMPRVLRGIDSADLSTSLFGIKLKTPIIQAPVAAQGLAHAEG
CCCCEEECCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCEECCHHHHCCHHCCC
EVATAKAMAEVGSIFSISTYGSTSVEDAAKAAPDAPQFFQLYMSKDDKFNEFLLKKAVSA
CHHHHHHHHHHCCEEEEECCCCCCHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHC
GVKAIILTADSTLGGYREEDIVNHFQFPFPMPNLAAFSESDGTGKGISEIYAAAKQGLVL
CCEEEEEEECCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCH
EDIQKIKKITNLPVIVKGVQSPIDADDAINAGADGIWVSNHGGRQLDGGPASIDVLPLIA
HHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHH
KSVNHRVPIVFDSGVRRGEHVFKALAQGADVVAVGRPVLYGLNLGGAKGVQSVFEHLNKE
HHHCCCCCEEECCCCCHHHHHHHHHHCCCCEEEECCCEEEEECCCCHHHHHHHHHHCCCC
LSITMQLAGTKNIEEIKHTSLID
EEEEEEECCCCCHHHHHHHHCCC
>Mature Secondary Structure
MHLSSTDVNFIKNRRTKMTYKTSTENKALEIVNVKSLEGKVKQSMEAAGNKGGFGYIRGG
CCCCCCCHHHHHCCCCEEEEEECCCCCEEEEEEEHHHHHHHHHHHHHCCCCCCEEEEECC
SEDEWTLNENTSAFNKKQIMPRVLRGIDSADLSTSLFGIKLKTPIIQAPVAAQGLAHAEG
CCCCEEECCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCEECCHHHHCCHHCCC
EVATAKAMAEVGSIFSISTYGSTSVEDAAKAAPDAPQFFQLYMSKDDKFNEFLLKKAVSA
CHHHHHHHHHHCCEEEEECCCCCCHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHC
GVKAIILTADSTLGGYREEDIVNHFQFPFPMPNLAAFSESDGTGKGISEIYAAAKQGLVL
CCEEEEEEECCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCH
EDIQKIKKITNLPVIVKGVQSPIDADDAINAGADGIWVSNHGGRQLDGGPASIDVLPLIA
HHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHH
KSVNHRVPIVFDSGVRRGEHVFKALAQGADVVAVGRPVLYGLNLGGAKGVQSVFEHLNKE
HHHCCCCCEEECCCCCHHHHHHHHHHCCCCEEEECCCEEEEECCCCHHHHHHHHHHCCCC
LSITMQLAGTKNIEEIKHTSLID
EEEEEEECCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2324094; 3571231 [H]