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The map label for this gene is clpP

Identifier: 15672655

GI number: 15672655

Start: 672374

End: 672973

Strand: Reverse

Name: clpP

Synonym: L72391

Alternate gene names: 15672655

Gene position: 672973-672374 (Counterclockwise)

Preceding gene: 15672658

Following gene: 15672644

Centisome position: 28.45

GC content: 37.67

Gene sequence:

>600_bases
ATGGGTTATTTAGTACCTACCGTTATTGAACAATCAAGCCGTGGCGAACGTGCTTATGATATTTATTCACGACTTTTAAA
AGACCGCATTATCATGCTGACAGGACCTGTTGAAGATGGAATGGCAAATTCTATCATTGCTCAACTTCTTTTCTTGGATG
CACAAGATAACACTAAAGATATTTATCTCTACGTAAATACACCTGGTGGTTCTGTATCTGCTGGTCTTGCCATTGTTGAT
ACAATGAATTTTATCAAATCAGATGTTCAAACTATCGTTATGGGAATGGCTGCCTCTATGGGAACAATCATTGCTTCAAG
CGGAACAAAAGGCAAACGATTCATGTTGCCAAATGCTGAATATCTTATTCACCAACCAATGGGTGGTACAGGTCAAGGCA
CTCAACAAACTGATATGGCTATTGTTGCTGAGCAACTTTTGAAAACTCGTAAACGTTTGGAACAAATTCTTGCTGATAAT
TCCAACCGTTCACTTGAACAAATTCACAAAGATGCCGAACGTGACCATTGGATGGATGCCAAAGAAACTTTGGAATATGG
TTTCATCGATGAAATTATGGAAAATAATTCCTTAAAATAA

Upstream 100 bases:

>100_bases
CCTTTTTTGACCAATGAGTTATAATATAGAAAAATAAACAAATGAATTCAATTTTATCTAAAATTAAATTCATATCTTAT
TTATAAAGGAGATTCAATCT

Downstream 100 bases:

>100_bases
TGATGTAAATCTTAAAGGCCCTGATTTCAGGGCTTTTTTATTTTTCTGATTATCAATCTATTTTTTTAATATGTTTTTAT
AAAATCAATTAAAACGTCGG

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp

Number of amino acids: Translated: 199; Mature: 198

Protein sequence:

>199_residues
MGYLVPTVIEQSSRGERAYDIYSRLLKDRIIMLTGPVEDGMANSIIAQLLFLDAQDNTKDIYLYVNTPGGSVSAGLAIVD
TMNFIKSDVQTIVMGMAASMGTIIASSGTKGKRFMLPNAEYLIHQPMGGTGQGTQQTDMAIVAEQLLKTRKRLEQILADN
SNRSLEQIHKDAERDHWMDAKETLEYGFIDEIMENNSLK

Sequences:

>Translated_199_residues
MGYLVPTVIEQSSRGERAYDIYSRLLKDRIIMLTGPVEDGMANSIIAQLLFLDAQDNTKDIYLYVNTPGGSVSAGLAIVD
TMNFIKSDVQTIVMGMAASMGTIIASSGTKGKRFMLPNAEYLIHQPMGGTGQGTQQTDMAIVAEQLLKTRKRLEQILADN
SNRSLEQIHKDAERDHWMDAKETLEYGFIDEIMENNSLK
>Mature_198_residues
GYLVPTVIEQSSRGERAYDIYSRLLKDRIIMLTGPVEDGMANSIIAQLLFLDAQDNTKDIYLYVNTPGGSVSAGLAIVDT
MNFIKSDVQTIVMGMAASMGTIIASSGTKGKRFMLPNAEYLIHQPMGGTGQGTQQTDMAIVAEQLLKTRKRLEQILADNS
NRSLEQIHKDAERDHWMDAKETLEYGFIDEIMENNSLK

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=190, Percent_Identity=48.9473684210526, Blast_Score=200, Evalue=5e-52,
Organism=Escherichia coli, GI1786641, Length=194, Percent_Identity=56.701030927835, Blast_Score=237, Evalue=5e-64,
Organism=Caenorhabditis elegans, GI17538017, Length=192, Percent_Identity=46.3541666666667, Blast_Score=189, Evalue=7e-49,
Organism=Drosophila melanogaster, GI20129427, Length=192, Percent_Identity=46.3541666666667, Blast_Score=192, Evalue=1e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP_LACLA (Q9CHQ3)

Other databases:

- EMBL:   AE005176
- PIR:   A86709
- RefSeq:   NP_266829.1
- ProteinModelPortal:   Q9CHQ3
- SMR:   Q9CHQ3
- GeneID:   1114297
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L72391
- NMPDR:   fig|272623.1.peg.691
- HOGENOM:   HBG558421
- OMA:   SPMEAQD
- ProtClustDB:   PRK00277
- BioCyc:   LLAC272623:L72391-MONOMER
- BRENDA:   3.4.21.92
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 22083; Mature: 21951

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 99-99 ACT_SITE 124-124

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
6.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGYLVPTVIEQSSRGERAYDIYSRLLKDRIIMLTGPVEDGMANSIIAQLLFLDAQDNTKD
CCCCCHHHHHCCCCCCHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCE
IYLYVNTPGGSVSAGLAIVDTMNFIKSDVQTIVMGMAASMGTIIASSGTKGKRFMLPNAE
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEECCCCC
YLIHQPMGGTGQGTQQTDMAIVAEQLLKTRKRLEQILADNSNRSLEQIHKDAERDHWMDA
EEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCH
KETLEYGFIDEIMENNSLK
HHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
GYLVPTVIEQSSRGERAYDIYSRLLKDRIIMLTGPVEDGMANSIIAQLLFLDAQDNTKD
CCCCHHHHHCCCCCCHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCE
IYLYVNTPGGSVSAGLAIVDTMNFIKSDVQTIVMGMAASMGTIIASSGTKGKRFMLPNAE
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEECCCCC
YLIHQPMGGTGQGTQQTDMAIVAEQLLKTRKRLEQILADNSNRSLEQIHKDAERDHWMDA
EEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCH
KETLEYGFIDEIMENNSLK
HHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471