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The map label for this gene is gnd

Identifier: 15672604

GI number: 15672604

Start: 607913

End: 609331

Strand: Direct

Name: gnd

Synonym: L0046

Alternate gene names: 15672604

Gene position: 607913-609331 (Clockwise)

Preceding gene: 15672603

Following gene: 15672605

Centisome position: 25.7

GC content: 39.68

Gene sequence:

>1419_bases
ATGGCACAAGCAAACTTTGGTGTTGTCGGAATGGCTGTAATGGGGAAAAACCTTGCACTCAACGTAGAGTCACGTGGTTA
TACCGTTGCAATTTACAACCGTACGACTTCAAAAACTGAAGAAGTTTATAAAGAACATCAAGATAAGAATCTTGTTCTCA
CTAAAACACTTGAAGAATTTGTTGGAAGTCTTGAAAAACCACGTCGTATCATGCTCATGGTTCAAGCAGGAGCAGCGACA
GATGCGACAATTAAATCACTTTTACCACTCTTGGATAAAGGCGATATCTTGATTGATGGTGGAAATACTCATTTCCCAGA
CACAATGCGTCGTAATGCTGAACTTGCAGACTCAGGTATTAACTTCATCGGTACAGGAGTTTCTGGTGGTGAAAAAGGTG
CGCTTTTAGGCCCATCAATGATGCCTGGTGGTCAAAAAGAAGCCTACGATTTGGTTGCACCAATTTTTGAACAAATCGCA
GCTAAAGCTCCTCAAGATGGTAAACCATGTGTGGCTTACATGGGAGCAAACGGTGCTGGACATTACGTTAAAATGGTTCA
CAACGGAATTGAGTACGGCGATATGCAATTGATTGCTGAATCTTATGATTTGTTGAAACGTGTTCTTGGTCTTAGCAATG
CAGAAATTCAAGCCATTTTTGAAGAATGGAATGAAGGCGAACTTGATAGCTACCTCATTGAAATCACTAAAGAAGTATTG
AAACGTAAAGATGATGAAGGCGAAGGCTACATCGTTGATAAAATTCTTGATAAAGCAGGAAACAAAGGAACTGGTAAATG
GACTTCAGAGTCTGCCCTTGACCTTGGTGTACCACTTCCATTGATTACAGAATCAGTATTTGCTCGTTACATTTCAACTT
ATAAAGATGAACGTGTTAAAGCAAGCAAAGTTTTATCTGGACCAGCGGTTAATTTCTCAGGCGATAAAAAAGAAGTCATT
GAAAAAATCCGCAAAGCGCTATATTTCTCAAAAATTATGAGTTATGCTCAAGGATTTGCTCAACTTCGTAAAGCTTCTGA
AGAATTTGATTGGGACTTGCCTTACGGTACAATTGCACAAATTTGGCGTGCTGGATGTATCATTCGTGCAGAATTCCTCC
AAAATATTACTGATGCTTTCGACAAAGATAGCGAACTTGAAAACCTCTTGCTTGATGACTACTTTGTAGACATCACAAAA
CGTTATCAAGAAGCTGTTCGTGATGTAGTTTCACTTGCTGTTCAAGCAGGAATTCCAATTCCAACATTCACATCAGCAAT
TAGCTACTACGATAGCTATCGTTCTGAAAATCTTCCAGCTAACTTGATTCAAGCCCAACGTGATTACTTCGGTGCTCACA
CTTATGAACGTACAGACAAAGCTGGAATCTTCCACTACGACTGGTACACAGAAGATTAA

Upstream 100 bases:

>100_bases
TGTCATGTAAAATATTTACATACTTAACTATGGTAATTGGAAATAAATTGCGTTATACTATATAGTATAGAATATAAAGA
AATACTCTGGAGGATTTCAA

Downstream 100 bases:

>100_bases
GTTGAAAAATAATTAATTAAAAGCTAGAATTTTCTAGCTTTTTTTCTTATAAATTTTGCAGTATTCTTTAGACCATTTTT
TAACAAAAAATCAAGAAATT

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 472; Mature: 471

Protein sequence:

>472_residues
MAQANFGVVGMAVMGKNLALNVESRGYTVAIYNRTTSKTEEVYKEHQDKNLVLTKTLEEFVGSLEKPRRIMLMVQAGAAT
DATIKSLLPLLDKGDILIDGGNTHFPDTMRRNAELADSGINFIGTGVSGGEKGALLGPSMMPGGQKEAYDLVAPIFEQIA
AKAPQDGKPCVAYMGANGAGHYVKMVHNGIEYGDMQLIAESYDLLKRVLGLSNAEIQAIFEEWNEGELDSYLIEITKEVL
KRKDDEGEGYIVDKILDKAGNKGTGKWTSESALDLGVPLPLITESVFARYISTYKDERVKASKVLSGPAVNFSGDKKEVI
EKIRKALYFSKIMSYAQGFAQLRKASEEFDWDLPYGTIAQIWRAGCIIRAEFLQNITDAFDKDSELENLLLDDYFVDITK
RYQEAVRDVVSLAVQAGIPIPTFTSAISYYDSYRSENLPANLIQAQRDYFGAHTYERTDKAGIFHYDWYTED

Sequences:

>Translated_472_residues
MAQANFGVVGMAVMGKNLALNVESRGYTVAIYNRTTSKTEEVYKEHQDKNLVLTKTLEEFVGSLEKPRRIMLMVQAGAAT
DATIKSLLPLLDKGDILIDGGNTHFPDTMRRNAELADSGINFIGTGVSGGEKGALLGPSMMPGGQKEAYDLVAPIFEQIA
AKAPQDGKPCVAYMGANGAGHYVKMVHNGIEYGDMQLIAESYDLLKRVLGLSNAEIQAIFEEWNEGELDSYLIEITKEVL
KRKDDEGEGYIVDKILDKAGNKGTGKWTSESALDLGVPLPLITESVFARYISTYKDERVKASKVLSGPAVNFSGDKKEVI
EKIRKALYFSKIMSYAQGFAQLRKASEEFDWDLPYGTIAQIWRAGCIIRAEFLQNITDAFDKDSELENLLLDDYFVDITK
RYQEAVRDVVSLAVQAGIPIPTFTSAISYYDSYRSENLPANLIQAQRDYFGAHTYERTDKAGIFHYDWYTED
>Mature_471_residues
AQANFGVVGMAVMGKNLALNVESRGYTVAIYNRTTSKTEEVYKEHQDKNLVLTKTLEEFVGSLEKPRRIMLMVQAGAATD
ATIKSLLPLLDKGDILIDGGNTHFPDTMRRNAELADSGINFIGTGVSGGEKGALLGPSMMPGGQKEAYDLVAPIFEQIAA
KAPQDGKPCVAYMGANGAGHYVKMVHNGIEYGDMQLIAESYDLLKRVLGLSNAEIQAIFEEWNEGELDSYLIEITKEVLK
RKDDEGEGYIVDKILDKAGNKGTGKWTSESALDLGVPLPLITESVFARYISTYKDERVKASKVLSGPAVNFSGDKKEVIE
KIRKALYFSKIMSYAQGFAQLRKASEEFDWDLPYGTIAQIWRAGCIIRAEFLQNITDAFDKDSELENLLLDDYFVDITKR
YQEAVRDVVSLAVQAGIPIPTFTSAISYYDSYRSENLPANLIQAQRDYFGAHTYERTDKAGIFHYDWYTED

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI40068518, Length=471, Percent_Identity=56.687898089172, Blast_Score=517, Evalue=1e-146,
Organism=Escherichia coli, GI1788341, Length=468, Percent_Identity=68.8034188034188, Blast_Score=666, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17542558, Length=473, Percent_Identity=50.7399577167019, Blast_Score=499, Evalue=1e-141,
Organism=Saccharomyces cerevisiae, GI6321695, Length=458, Percent_Identity=52.8384279475983, Blast_Score=505, Evalue=1e-144,
Organism=Saccharomyces cerevisiae, GI6321977, Length=456, Percent_Identity=52.8508771929825, Blast_Score=489, Evalue=1e-139,
Organism=Drosophila melanogaster, GI24639279, Length=470, Percent_Identity=52.1276595744681, Blast_Score=485, Evalue=1e-137,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): 6PGD_LACLA (Q9CHU6)

Other databases:

- EMBL:   AE005176
- PIR:   F86702
- RefSeq:   NP_266778.1
- ProteinModelPortal:   Q9CHU6
- SMR:   Q9CHU6
- GeneID:   1114242
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L0046
- NMPDR:   fig|272623.1.peg.637
- HOGENOM:   HBG286913
- OMA:   CIIRAGF
- ProtClustDB:   PRK09287
- BioCyc:   LLAC272623:L0046-MONOMER
- BRENDA:   1.1.1.44
- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183
- Gene3D:   G3DSA:1.20.5.320
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PIRSF:   PIRSF000109
- PRINTS:   PR00076
- TIGRFAMs:   TIGR00873

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2; SSF48179 6DGDH_C_like

EC number: =1.1.1.44

Molecular weight: Translated: 52425; Mature: 52294

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00461 6PGD

Important sites: ACT_SITE 184-184 ACT_SITE 191-191 BINDING 102-102 BINDING 102-102 BINDING 192-192 BINDING 262-262 BINDING 289-289 BINDING 447-447 BINDING 453-453

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQANFGVVGMAVMGKNLALNVESRGYTVAIYNRTTSKTEEVYKEHQDKNLVLTKTLEEF
CCCCCCCEEEHEECCCCEEEEEECCCEEEEEEECCCHHHHHHHHHHCCCCEEHHHHHHHH
VGSLEKPRRIMLMVQAGAATDATIKSLLPLLDKGDILIDGGNTHFPDTMRRNAELADSGI
HHHHCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHCCHHHHCCC
NFIGTGVSGGEKGALLGPSMMPGGQKEAYDLVAPIFEQIAAKAPQDGKPCVAYMGANGAG
CEEECCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCC
HYVKMVHNGIEYGDMQLIAESYDLLKRVLGLSNAEIQAIFEEWNEGELDSYLIEITKEVL
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHH
KRKDDEGEGYIVDKILDKAGNKGTGKWTSESALDLGVPLPLITESVFARYISTYKDERVK
HCCCCCCCCEEHHHHHHHCCCCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHH
ASKVLSGPAVNFSGDKKEVIEKIRKALYFSKIMSYAQGFAQLRKASEEFDWDLPYGTIAQ
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
IWRAGCIIRAEFLQNITDAFDKDSELENLLLDDYFVDITKRYQEAVRDVVSLAVQAGIPI
HHHHCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PTFTSAISYYDSYRSENLPANLIQAQRDYFGAHTYERTDKAGIFHYDWYTED
CHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEECCEECC
>Mature Secondary Structure 
AQANFGVVGMAVMGKNLALNVESRGYTVAIYNRTTSKTEEVYKEHQDKNLVLTKTLEEF
CCCCCCEEEHEECCCCEEEEEECCCEEEEEEECCCHHHHHHHHHHCCCCEEHHHHHHHH
VGSLEKPRRIMLMVQAGAATDATIKSLLPLLDKGDILIDGGNTHFPDTMRRNAELADSGI
HHHHCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHCCHHHHCCC
NFIGTGVSGGEKGALLGPSMMPGGQKEAYDLVAPIFEQIAAKAPQDGKPCVAYMGANGAG
CEEECCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCC
HYVKMVHNGIEYGDMQLIAESYDLLKRVLGLSNAEIQAIFEEWNEGELDSYLIEITKEVL
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHH
KRKDDEGEGYIVDKILDKAGNKGTGKWTSESALDLGVPLPLITESVFARYISTYKDERVK
HCCCCCCCCEEHHHHHHHCCCCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHH
ASKVLSGPAVNFSGDKKEVIEKIRKALYFSKIMSYAQGFAQLRKASEEFDWDLPYGTIAQ
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
IWRAGCIIRAEFLQNITDAFDKDSELENLLLDDYFVDITKRYQEAVRDVVSLAVQAGIPI
HHHHCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PTFTSAISYYDSYRSENLPANLIQAQRDYFGAHTYERTDKAGIFHYDWYTED
CHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEECCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471