Click here to switch to the map view.

The map label for this gene is serC

Identifier: 15672585

GI number: 15672585

Start: 593080

End: 594177

Strand: Direct

Name: serC

Synonym: L0083

Alternate gene names: 15672585

Gene position: 593080-594177 (Clockwise)

Preceding gene: 15672584

Following gene: 15672586

Centisome position: 25.07

GC content: 36.34

Gene sequence:

>1098_bases
ATGATTTATAATTTTGGCGCAGGACCCAGTGTACTTCCAAAGGAAGTCTTGAAGAAGGTTCAAGAAGAACTGTTAGACTT
TGAAAAAAGTGGTATGTCAGTGATGGAAATTTCGCATCGCTCCAAGGCTTTCCAAAAAGTAATTGATGAGGCTGAGAACG
ATTTGCGTGATTTGATGTCAATTCCTCAAAACTATAAAATTTTGTTTTTACAAGGGGGAGCTTCCAGTCAATTTTCAATG
GTTCCAATGAATTTGGCAATTGGCAAAAAGGCTTATTACAATATTTCGGGCGCCTTTGGTGAAAAGGCTTATGATGAAGC
GGTGAAATTGAGTCATTTCCTTGATTTGATGGCGATTAGTTTGGGCTCGACTAAAAAAGATAATTATAATCATCTATTGA
AAATTGATAAATCTAAAATTGATGAAAAAAATGGGGCCTATCTCCATTTGACAACGAATAATACGATTGAAGGAACAAGT
ATTTTTCCTGAAAATTTGCCTGAGTTTGCAAGCCTTCCTTTGGTTGCTGATATGAGTTCAAATATTTTGGCGGTTGATTA
TGATGTGAGTAAATTTGGATTAATTTACGCTGGAGCTCAGAAAAATTTAGGTATTGCTGGTTTAACCATTGTCATTATTC
GTGAAGACTTATTGAATGAAGCTGAAAGCCTCTCATCAATGATGGATTATCAGATTTTGGTTGAAAATGGCTCGATGTAC
AATACCCCGCCGACTTTTGCTATTTATGTGGCCGGGCTGGTTTTCAAATGGGTAAAAGCGCAAGGTGGCGTAAAAAAACT
CGAAGAAATGAATCAGAGAAAAGCTCAATTGTTGTATGATTTAATTGACCAATCTGACTTTTATCAGAACCCAATCAAAA
ATAAAGATGAGCGGTCGATTTGCAATGTTGTTTTTACAAGTCCAAGTCAAGAATTGGATGAGCTATTCACCCAAAAAGCT
GAAGAAAAAGGTTTCAAATCACTCAAAGGTCATCGTTCCGTGGGAGGAATGAGAGCAAGTATTTACAACGCTTTTCCTTT
AGAGGGGGTTGTTGAATTAGTGAAATTTATGAAAGAATTTGAAGAGGGATATAAATGA

Upstream 100 bases:

>100_bases
TCAACTGTGTTTTTTTGTCGAACAGTATTTTTTTATATTTGAATTATCAGAAAATTATACTATAATAGTGATTAATAAAT
AATTTGAGGAAGTGAAATCG

Downstream 100 bases:

>100_bases
CTTATCATATCAAAACAATTGGAAATAATATCGACCAAATTGCATTAGATGAAATTGGCGAAGGCTTTCTTGTTAATCAA
GTGTCAGAAGCTGAATCTGA

Product: phosphoserine aminotransferase

Products: NA

Alternate protein names: Phosphohydroxythreonine aminotransferase; PSAT

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MIYNFGAGPSVLPKEVLKKVQEELLDFEKSGMSVMEISHRSKAFQKVIDEAENDLRDLMSIPQNYKILFLQGGASSQFSM
VPMNLAIGKKAYYNISGAFGEKAYDEAVKLSHFLDLMAISLGSTKKDNYNHLLKIDKSKIDEKNGAYLHLTTNNTIEGTS
IFPENLPEFASLPLVADMSSNILAVDYDVSKFGLIYAGAQKNLGIAGLTIVIIREDLLNEAESLSSMMDYQILVENGSMY
NTPPTFAIYVAGLVFKWVKAQGGVKKLEEMNQRKAQLLYDLIDQSDFYQNPIKNKDERSICNVVFTSPSQELDELFTQKA
EEKGFKSLKGHRSVGGMRASIYNAFPLEGVVELVKFMKEFEEGYK

Sequences:

>Translated_365_residues
MIYNFGAGPSVLPKEVLKKVQEELLDFEKSGMSVMEISHRSKAFQKVIDEAENDLRDLMSIPQNYKILFLQGGASSQFSM
VPMNLAIGKKAYYNISGAFGEKAYDEAVKLSHFLDLMAISLGSTKKDNYNHLLKIDKSKIDEKNGAYLHLTTNNTIEGTS
IFPENLPEFASLPLVADMSSNILAVDYDVSKFGLIYAGAQKNLGIAGLTIVIIREDLLNEAESLSSMMDYQILVENGSMY
NTPPTFAIYVAGLVFKWVKAQGGVKKLEEMNQRKAQLLYDLIDQSDFYQNPIKNKDERSICNVVFTSPSQELDELFTQKA
EEKGFKSLKGHRSVGGMRASIYNAFPLEGVVELVKFMKEFEEGYK
>Mature_365_residues
MIYNFGAGPSVLPKEVLKKVQEELLDFEKSGMSVMEISHRSKAFQKVIDEAENDLRDLMSIPQNYKILFLQGGASSQFSM
VPMNLAIGKKAYYNISGAFGEKAYDEAVKLSHFLDLMAISLGSTKKDNYNHLLKIDKSKIDEKNGAYLHLTTNNTIEGTS
IFPENLPEFASLPLVADMSSNILAVDYDVSKFGLIYAGAQKNLGIAGLTIVIIREDLLNEAESLSSMMDYQILVENGSMY
NTPPTFAIYVAGLVFKWVKAQGGVKKLEEMNQRKAQLLYDLIDQSDFYQNPIKNKDERSICNVVFTSPSQELDELFTQKA
EEKGFKSLKGHRSVGGMRASIYNAFPLEGVVELVKFMKEFEEGYK

Specific function: Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine

COG id: COG1932

COG function: function code HE; Phosphoserine aminotransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily

Homologues:

Organism=Homo sapiens, GI17402893, Length=372, Percent_Identity=43.8172043010753, Blast_Score=291, Evalue=6e-79,
Organism=Homo sapiens, GI10863955, Length=367, Percent_Identity=40.0544959128065, Blast_Score=256, Evalue=3e-68,
Organism=Escherichia coli, GI1787136, Length=367, Percent_Identity=49.3188010899183, Blast_Score=336, Evalue=1e-93,
Organism=Caenorhabditis elegans, GI17506897, Length=368, Percent_Identity=42.6630434782609, Blast_Score=290, Evalue=9e-79,
Organism=Saccharomyces cerevisiae, GI6324758, Length=388, Percent_Identity=39.1752577319588, Blast_Score=247, Evalue=2e-66,
Organism=Drosophila melanogaster, GI21356589, Length=369, Percent_Identity=44.7154471544715, Blast_Score=292, Evalue=2e-79,

Paralogues:

None

Copy number: 2500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): SERC_LACLA (Q9CHW5)

Other databases:

- EMBL:   AE005176
- PIR:   C86700
- RefSeq:   NP_266759.1
- ProteinModelPortal:   Q9CHW5
- SMR:   Q9CHW5
- GeneID:   1114223
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L0083
- NMPDR:   fig|272623.1.peg.618
- HOGENOM:   HBG289982
- OMA:   TFAWYLA
- ProtClustDB:   PRK05355
- BioCyc:   LLAC272623:L0083-MONOMER
- BRENDA:   2.6.1.52
- GO:   GO:0005737
- HAMAP:   MF_00160
- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR022278
- InterPro:   IPR003248
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PIRSF:   PIRSF000525
- TIGRFAMs:   TIGR01364

Pfam domain/function: PF00266 Aminotran_5; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.52

Molecular weight: Translated: 40870; Mature: 40870

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: BINDING 40-40 BINDING 99-99 BINDING 155-155 BINDING 177-177 BINDING 200-200

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYNFGAGPSVLPKEVLKKVQEELLDFEKSGMSVMEISHRSKAFQKVIDEAENDLRDLMS
CEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IPQNYKILFLQGGASSQFSMVPMNLAIGKKAYYNISGAFGEKAYDEAVKLSHFLDLMAIS
CCCCCEEEEEECCCCCCEEEEEEHHEECCCCEEECCCHHCCHHHHHHHHHHHHHHHHHHH
LGSTKKDNYNHLLKIDKSKIDEKNGAYLHLTTNNTIEGTSIFPENLPEFASLPLVADMSS
CCCCCCCCCHHHEEECHHHCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHCCCEEEECCC
NILAVDYDVSKFGLIYAGAQKNLGIAGLTIVIIREDLLNEAESLSSMMDYQILVENGSMY
CEEEEECCHHHCEEEEECCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHCEEEEEECCCCC
NTPPTFAIYVAGLVFKWVKAQGGVKKLEEMNQRKAQLLYDLIDQSDFYQNPIKNKDERSI
CCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCHHH
CNVVFTSPSQELDELFTQKAEEKGFKSLKGHRSVGGMRASIYNAFPLEGVVELVKFMKEF
HHEEECCCHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHCCCCHHHHHHHHHHHHHH
EEGYK
HHCCC
>Mature Secondary Structure
MIYNFGAGPSVLPKEVLKKVQEELLDFEKSGMSVMEISHRSKAFQKVIDEAENDLRDLMS
CEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IPQNYKILFLQGGASSQFSMVPMNLAIGKKAYYNISGAFGEKAYDEAVKLSHFLDLMAIS
CCCCCEEEEEECCCCCCEEEEEEHHEECCCCEEECCCHHCCHHHHHHHHHHHHHHHHHHH
LGSTKKDNYNHLLKIDKSKIDEKNGAYLHLTTNNTIEGTSIFPENLPEFASLPLVADMSS
CCCCCCCCCHHHEEECHHHCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHCCCEEEECCC
NILAVDYDVSKFGLIYAGAQKNLGIAGLTIVIIREDLLNEAESLSSMMDYQILVENGSMY
CEEEEECCHHHCEEEEECCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHCEEEEEECCCCC
NTPPTFAIYVAGLVFKWVKAQGGVKKLEEMNQRKAQLLYDLIDQSDFYQNPIKNKDERSI
CCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCHHH
CNVVFTSPSQELDELFTQKAEEKGFKSLKGHRSVGGMRASIYNAFPLEGVVELVKFMKEF
HHEEECCCHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHCCCCHHHHHHHHHHHHHH
EEGYK
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471