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The map label for this gene is serA

Identifier: 15672586

GI number: 15672586

Start: 594174

End: 595370

Strand: Direct

Name: serA

Synonym: L0084

Alternate gene names: 15672586

Gene position: 594174-595370 (Clockwise)

Preceding gene: 15672585

Following gene: 15672587

Centisome position: 25.12

GC content: 37.51

Gene sequence:

>1197_bases
ATGACTTATCATATCAAAACAATTGGAAATAATATCGACCAAATTGCATTAGATGAAATTGGCGAAGGCTTTCTTGTTAA
TCAAGTGTCAGAAGCTGAATCTGACGCATTTATTTGTCGGGCTCAGCCTTTCCACGATTATGAATTTTCCAAAGCGCTTT
TGGCGATTGGACGTGCTGGTGCTGGTTTTAATAATATTCCGATAGAAAAGTGTGCCAGTAAAGGGATTGTAGTCTTTAAT
GCGCCTGGTGGGAATGCCAATGCGGTTAAAGAATTAGTTTTGTCAATGATGATTTTTGGAACACGTAATTTAAAACCAGC
AAACAAATGGTTGACTGGTCAAAAAGGCGATGATAATACCATTGATGGGGCGGTTGAACATGGGAAAAAGGCGTTTTCTG
GTTCTGAAATTTCAGGAAAAACTTTAGGGGTAATTGGCCTTGGGAATATTGGTTCAAAAGTTGCCAATGATGCACAGCGT
TTAGGAATGAGAGTTATTGGTTATGACCCTTATCTTTCAATTGAGCACGCTTGGAACTTGTCACATCATGTTAAAAGAGT
GAATGATTTGGCTGAGATTTTTGAGAAGGCAGATTATATCACGGTTCATACGCCAGCGACGGATGAAACGACGAAAATGC
TCAATTGGAAAAATTTATCTAAGTGTAAAAAGGGAGTGATTTTGCTCAATTATGCACGAGATGAGATTACGGATAAAGAA
GCAGTGCTTAAAGCGATTGATGAGGGAATTGTCCGCTTTTTTGGAACGGATTTTGGTTCTGAAAAATTTTATCATCATCC
ACAAGTTTTTTTAACTCCTCATTTAGGTGGTTCAACGGCGGAAGCGAGTTTAAATTGCACAAGAATGGCTCTGGATTCTG
TTCAAACTTATTTGAAAACTGGCGAAATTATTAATTCAGTCAATTTTCCACGTGTTTTGCAAGAGTTGAATACGCCTTAT
CGTGTGACCTTAATCAATAAAAATGTGCCTAATGTTGTGGCTCAAATTTCACTTGCGGTGGCAGCAGAAAATATTAATAT
TGCTAATATTGTTAATCGTGGTCAAGGAGATTATGCCTATACTTTACTTGACTTGGATGAAAAAGATGAAGGAAAGTTGG
CGGCTTTAGTTTCACGTTTTGAGGCTGCTGATAATATTATTCGTGTTCGCTTAATTGAAAATCAGAGTTTAGTTTAA

Upstream 100 bases:

>100_bases
GTTCCGTGGGAGGAATGAGAGCAAGTATTTACAACGCTTTTCCTTTAGAGGGGGTTGTTGAATTAGTGAAATTTATGAAA
GAATTTGAAGAGGGATATAA

Downstream 100 bases:

>100_bases
AAAACGAATGGAAAAGGAAGAAAATGGCTGCAAAAGGATTACTTGTGATGGATGTGGATAGCACATTGATTGAAGAAGAG
GTCATTGATCTCTTAGGGGA

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MTYHIKTIGNNIDQIALDEIGEGFLVNQVSEAESDAFICRAQPFHDYEFSKALLAIGRAGAGFNNIPIEKCASKGIVVFN
APGGNANAVKELVLSMMIFGTRNLKPANKWLTGQKGDDNTIDGAVEHGKKAFSGSEISGKTLGVIGLGNIGSKVANDAQR
LGMRVIGYDPYLSIEHAWNLSHHVKRVNDLAEIFEKADYITVHTPATDETTKMLNWKNLSKCKKGVILLNYARDEITDKE
AVLKAIDEGIVRFFGTDFGSEKFYHHPQVFLTPHLGGSTAEASLNCTRMALDSVQTYLKTGEIINSVNFPRVLQELNTPY
RVTLINKNVPNVVAQISLAVAAENINIANIVNRGQGDYAYTLLDLDEKDEGKLAALVSRFEAADNIIRVRLIENQSLV

Sequences:

>Translated_398_residues
MTYHIKTIGNNIDQIALDEIGEGFLVNQVSEAESDAFICRAQPFHDYEFSKALLAIGRAGAGFNNIPIEKCASKGIVVFN
APGGNANAVKELVLSMMIFGTRNLKPANKWLTGQKGDDNTIDGAVEHGKKAFSGSEISGKTLGVIGLGNIGSKVANDAQR
LGMRVIGYDPYLSIEHAWNLSHHVKRVNDLAEIFEKADYITVHTPATDETTKMLNWKNLSKCKKGVILLNYARDEITDKE
AVLKAIDEGIVRFFGTDFGSEKFYHHPQVFLTPHLGGSTAEASLNCTRMALDSVQTYLKTGEIINSVNFPRVLQELNTPY
RVTLINKNVPNVVAQISLAVAAENINIANIVNRGQGDYAYTLLDLDEKDEGKLAALVSRFEAADNIIRVRLIENQSLV
>Mature_397_residues
TYHIKTIGNNIDQIALDEIGEGFLVNQVSEAESDAFICRAQPFHDYEFSKALLAIGRAGAGFNNIPIEKCASKGIVVFNA
PGGNANAVKELVLSMMIFGTRNLKPANKWLTGQKGDDNTIDGAVEHGKKAFSGSEISGKTLGVIGLGNIGSKVANDAQRL
GMRVIGYDPYLSIEHAWNLSHHVKRVNDLAEIFEKADYITVHTPATDETTKMLNWKNLSKCKKGVILLNYARDEITDKEA
VLKAIDEGIVRFFGTDFGSEKFYHHPQVFLTPHLGGSTAEASLNCTRMALDSVQTYLKTGEIINSVNFPRVLQELNTPYR
VTLINKNVPNVVAQISLAVAAENINIANIVNRGQGDYAYTLLDLDEKDEGKLAALVSRFEAADNIIRVRLIENQSLV

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=271, Percent_Identity=35.7933579335793, Blast_Score=155, Evalue=7e-38,
Organism=Homo sapiens, GI61743967, Length=274, Percent_Identity=30.6569343065693, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI4557497, Length=273, Percent_Identity=30.7692307692308, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI145580578, Length=271, Percent_Identity=31.3653136531365, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI4557499, Length=271, Percent_Identity=31.3653136531365, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI145580575, Length=274, Percent_Identity=31.3868613138686, Blast_Score=103, Evalue=4e-22,
Organism=Escherichia coli, GI1789279, Length=354, Percent_Identity=29.6610169491525, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1787645, Length=197, Percent_Identity=29.9492385786802, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI87082289, Length=282, Percent_Identity=22.6950354609929, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=295, Percent_Identity=32.8813559322034, Blast_Score=147, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI25147481, Length=207, Percent_Identity=27.536231884058, Blast_Score=87, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320925, Length=371, Percent_Identity=28.5714285714286, Blast_Score=142, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6322116, Length=371, Percent_Identity=28.0323450134771, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6324055, Length=268, Percent_Identity=23.134328358209, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6321253, Length=191, Percent_Identity=28.7958115183246, Blast_Score=63, Evalue=7e-11,
Organism=Drosophila melanogaster, GI19921140, Length=258, Percent_Identity=35.6589147286822, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24646446, Length=239, Percent_Identity=29.2887029288703, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24646448, Length=239, Percent_Identity=29.2887029288703, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24646452, Length=239, Percent_Identity=29.2887029288703, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24646450, Length=239, Percent_Identity=29.2887029288703, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI62472511, Length=239, Percent_Identity=29.2887029288703, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI28574286, Length=245, Percent_Identity=21.2244897959184, Blast_Score=72, Evalue=7e-13,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 43638; Mature: 43507

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYHIKTIGNNIDQIALDEIGEGFLVNQVSEAESDAFICRAQPFHDYEFSKALLAIGRAG
CEEEEEECCCCCHHHHHHHCCCCEEEECHHCCCCCEEEEECCCCCCHHHHHHHHHHHCCC
AGFNNIPIEKCASKGIVVFNAPGGNANAVKELVLSMMIFGTRNLKPANKWLTGQKGDDNT
CCCCCCCHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCC
IDGAVEHGKKAFSGSEISGKTLGVIGLGNIGSKVANDAQRLGMRVIGYDPYLSIEHAWNL
CCHHHHHCHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHCCEEEEECCCEEEEHHHCCH
SHHVKRVNDLAEIFEKADYITVHTPATDETTKMLNWKNLSKCKKGVILLNYARDEITDKE
HHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHCCCCCHHHHHCCEEEEEECCHHCCCHH
AVLKAIDEGIVRFFGTDFGSEKFYHHPQVFLTPHLGGSTAEASLNCTRMALDSVQTYLKT
HHHHHHHHHHHHHHCCCCCCCCCEECCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHH
GEIINSVNFPRVLQELNTPYRVTLINKNVPNVVAQISLAVAAENINIANIVNRGQGDYAY
HHHHHCCCHHHHHHHCCCCEEEEEECCCCCHHHHHHHHEEEECCCCHHHHHCCCCCCEEE
TLLDLDEKDEGKLAALVSRFEAADNIIRVRLIENQSLV
EEEECCCCCCCHHHHHHHHHHHHCCEEEEEEECCCCCC
>Mature Secondary Structure 
TYHIKTIGNNIDQIALDEIGEGFLVNQVSEAESDAFICRAQPFHDYEFSKALLAIGRAG
EEEEEECCCCCHHHHHHHCCCCEEEECHHCCCCCEEEEECCCCCCHHHHHHHHHHHCCC
AGFNNIPIEKCASKGIVVFNAPGGNANAVKELVLSMMIFGTRNLKPANKWLTGQKGDDNT
CCCCCCCHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCC
IDGAVEHGKKAFSGSEISGKTLGVIGLGNIGSKVANDAQRLGMRVIGYDPYLSIEHAWNL
CCHHHHHCHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHCCEEEEECCCEEEEHHHCCH
SHHVKRVNDLAEIFEKADYITVHTPATDETTKMLNWKNLSKCKKGVILLNYARDEITDKE
HHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHCCCCCHHHHHCCEEEEEECCHHCCCHH
AVLKAIDEGIVRFFGTDFGSEKFYHHPQVFLTPHLGGSTAEASLNCTRMALDSVQTYLKT
HHHHHHHHHHHHHHCCCCCCCCCEECCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHH
GEIINSVNFPRVLQELNTPYRVTLINKNVPNVVAQISLAVAAENINIANIVNRGQGDYAY
HHHHHCCCHHHHHHHCCCCEEEEEECCCCCHHHHHHHHEEEECCCCHHHHHCCCCCCEEE
TLLDLDEKDEGKLAALVSRFEAADNIIRVRLIENQSLV
EEEECCCCCCCHHHHHHHHHHHHCCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]