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The map label for this gene is gapA

Identifier: 15672541

GI number: 15672541

Start: 553716

End: 554729

Strand: Direct

Name: gapA

Synonym: L0004

Alternate gene names: 15672541

Gene position: 553716-554729 (Clockwise)

Preceding gene: 15672539

Following gene: 15672543

Centisome position: 23.41

GC content: 39.64

Gene sequence:

>1014_bases
ATGGTAGTTAAAGTTGGTATTAACGGTTTTGGTCGTATTGGACGTTTGGCATTACGTCGAATTCAAGAAGTCGAAGGAGT
TGAAGTTGCGCATATCAACGATTTGACAGACCCAGCAATGCTTGCACATTTGCTAAAATATGATACAACTCAAGGTCGTT
TTAAAGGGACTGTTGAAGTCAAAGAAGATGGTTTTGATGTCAACGGAAAATTTGTGAAAGTTACGGCTGAACGTAATCCG
GAAGACATTCAATGGGCTGATTCTGGTGTTGAAATTGTGCTTGAAGCCACAGGTTTCTTTGCGACTAAAGAAAAAGCTGA
AAAACATTTGCATCCTGGTGGAGCTAAGAAAGTTTTGATTACGGCACCTGGTGGAAATGATGTTAAAACTGTTGTCTTCA
ATACAAACCACACAATTCTTGACGGAACTGAAACAGTTATTTCTGCCGGTTCTTGTACTACAAATAGTTTAGCACCAATG
GCCGATGCCTTAAATAAAAACTTTGGTGTTAAAGGTGGAACAATGACTACTGTTCACTCTTATACTGGTGACCAAATGAC
CCTTGATGGTCCACATCGTGGCGGAGACTTCCGTCGTGCGCGTGCTGCTGCCGAAAACATTGTTCCAGCATCAAGTGGAG
CGGCTAAAGCAATTGGTCTTGTTTTGCCTGAACTTTCTGGTTTGATGAAAGGTCATGCTCAACGTGTTTCAACTCCAACA
GGCTCAATTACCGAACTTGTTACTGTACTTGAAAAACACGTTACAGTTGACGAAATCAATGAAGCAATGAAAGCTGCCGC
TGATGAAAGCTTTGGCTATAATGTTGATGAAATTGTTTCATCTGATATTATTGGTATGGCTTACGGTTCACTTTTTGATG
CTACATTAACTGAAGTGACTGACCTAAAAGACGGTGGACAATTAGTTAAAACAGCTGCTTGGTATGATAATGAAATGAGT
TTCACTGCTCAATTAATTCGTACTCTTGAATATTTTGCAAAAATTGCTAAATAA

Upstream 100 bases:

>100_bases
GAGATAAGAGATATCTCTAATAGCTATAATTATTTATTTCTATTATAGCAAAAAAAGAGAAGAATCTCATCATCTAAATA
AAAAAACGGAGGACTACATC

Downstream 100 bases:

>100_bases
TAATTTACTTTTATCATTTTCTAAAAACTTGTCAGTAACTTTTACTGACAAGAATTAAAAAGTAGAAAATGAAATAAAAA
ATTACTGACGGAAATTCTGT

Product: glyceraldehyde 3-phosphate dehydrogenase

Products: NA

Alternate protein names: GAPDH

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MVVKVGINGFGRIGRLALRRIQEVEGVEVAHINDLTDPAMLAHLLKYDTTQGRFKGTVEVKEDGFDVNGKFVKVTAERNP
EDIQWADSGVEIVLEATGFFATKEKAEKHLHPGGAKKVLITAPGGNDVKTVVFNTNHTILDGTETVISAGSCTTNSLAPM
ADALNKNFGVKGGTMTTVHSYTGDQMTLDGPHRGGDFRRARAAAENIVPASSGAAKAIGLVLPELSGLMKGHAQRVSTPT
GSITELVTVLEKHVTVDEINEAMKAAADESFGYNVDEIVSSDIIGMAYGSLFDATLTEVTDLKDGGQLVKTAAWYDNEMS
FTAQLIRTLEYFAKIAK

Sequences:

>Translated_337_residues
MVVKVGINGFGRIGRLALRRIQEVEGVEVAHINDLTDPAMLAHLLKYDTTQGRFKGTVEVKEDGFDVNGKFVKVTAERNP
EDIQWADSGVEIVLEATGFFATKEKAEKHLHPGGAKKVLITAPGGNDVKTVVFNTNHTILDGTETVISAGSCTTNSLAPM
ADALNKNFGVKGGTMTTVHSYTGDQMTLDGPHRGGDFRRARAAAENIVPASSGAAKAIGLVLPELSGLMKGHAQRVSTPT
GSITELVTVLEKHVTVDEINEAMKAAADESFGYNVDEIVSSDIIGMAYGSLFDATLTEVTDLKDGGQLVKTAAWYDNEMS
FTAQLIRTLEYFAKIAK
>Mature_337_residues
MVVKVGINGFGRIGRLALRRIQEVEGVEVAHINDLTDPAMLAHLLKYDTTQGRFKGTVEVKEDGFDVNGKFVKVTAERNP
EDIQWADSGVEIVLEATGFFATKEKAEKHLHPGGAKKVLITAPGGNDVKTVVFNTNHTILDGTETVISAGSCTTNSLAPM
ADALNKNFGVKGGTMTTVHSYTGDQMTLDGPHRGGDFRRARAAAENIVPASSGAAKAIGLVLPELSGLMKGHAQRVSTPT
GSITELVTVLEKHVTVDEINEAMKAAADESFGYNVDEIVSSDIIGMAYGSLFDATLTEVTDLKDGGQLVKTAAWYDNEMS
FTAQLIRTLEYFAKIAK

Specific function: Second phase of glycolysis; first step. [C]

COG id: COG0057

COG function: function code G; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI7669492, Length=336, Percent_Identity=41.9642857142857, Blast_Score=251, Evalue=8e-67,
Organism=Homo sapiens, GI7657116, Length=334, Percent_Identity=40.4191616766467, Blast_Score=242, Evalue=3e-64,
Organism=Escherichia coli, GI1788079, Length=339, Percent_Identity=46.0176991150442, Blast_Score=288, Evalue=4e-79,
Organism=Escherichia coli, GI1789295, Length=344, Percent_Identity=36.3372093023256, Blast_Score=214, Evalue=9e-57,
Organism=Caenorhabditis elegans, GI17568413, Length=340, Percent_Identity=44.4117647058823, Blast_Score=260, Evalue=7e-70,
Organism=Caenorhabditis elegans, GI32566163, Length=340, Percent_Identity=44.4117647058823, Blast_Score=260, Evalue=8e-70,
Organism=Caenorhabditis elegans, GI17534677, Length=340, Percent_Identity=43.5294117647059, Blast_Score=254, Evalue=5e-68,
Organism=Caenorhabditis elegans, GI17534679, Length=340, Percent_Identity=43.5294117647059, Blast_Score=253, Evalue=1e-67,
Organism=Saccharomyces cerevisiae, GI6322409, Length=339, Percent_Identity=41.2979351032448, Blast_Score=258, Evalue=1e-69,
Organism=Saccharomyces cerevisiae, GI6321631, Length=339, Percent_Identity=41.2979351032448, Blast_Score=247, Evalue=2e-66,
Organism=Saccharomyces cerevisiae, GI6322468, Length=339, Percent_Identity=40.7079646017699, Blast_Score=242, Evalue=5e-65,
Organism=Drosophila melanogaster, GI17933600, Length=333, Percent_Identity=43.5435435435435, Blast_Score=252, Evalue=2e-67,
Organism=Drosophila melanogaster, GI18110149, Length=333, Percent_Identity=43.5435435435435, Blast_Score=252, Evalue=2e-67,
Organism=Drosophila melanogaster, GI85725000, Length=333, Percent_Identity=44.1441441441441, Blast_Score=252, Evalue=3e-67,
Organism=Drosophila melanogaster, GI22023983, Length=333, Percent_Identity=44.1441441441441, Blast_Score=252, Evalue=3e-67,
Organism=Drosophila melanogaster, GI19922412, Length=332, Percent_Identity=39.4578313253012, Blast_Score=232, Evalue=3e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G3P_LACLA (P52987)

Other databases:

- EMBL:   L36907
- EMBL:   AE005176
- PIR:   G86694
- RefSeq:   NP_266715.1
- ProteinModelPortal:   P52987
- SMR:   P52987
- GeneID:   1114178
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L0004
- NMPDR:   fig|272623.1.peg.574
- HOGENOM:   HBG571736
- OMA:   ERNPEDI
- ProtClustDB:   CLSK697289
- BioCyc:   LLAC272623:L0004-MONOMER
- BRENDA:   1.2.1.12
- GO:   GO:0005737
- GO:   GO:0006096
- InterPro:   IPR020831
- InterPro:   IPR020829
- InterPro:   IPR020828
- InterPro:   IPR006424
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR10836
- PIRSF:   PIRSF000149
- PRINTS:   PR00078
- SMART:   SM00846
- TIGRFAMs:   TIGR01534

Pfam domain/function: PF02800 Gp_dh_C; PF00044 Gp_dh_N

EC number: =1.2.1.12

Molecular weight: Translated: 36057; Mature: 36057

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS00071 GAPDH

Important sites: ACT_SITE 152-152 BINDING 34-34 BINDING 78-78 BINDING 182-182 BINDING 199-199 BINDING 235-235 BINDING 317-317

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVKVGINGFGRIGRLALRRIQEVEGVEVAHINDLTDPAMLAHLLKYDTTQGRFKGTVEV
CEEEEECCCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCCCCEEEEEEE
KEDGFDVNGKFVKVTAERNPEDIQWADSGVEIVLEATGFFATKEKAEKHLHPGGAKKVLI
ECCCCCCCCEEEEEEECCCCCCCEECCCCEEEEEEECCCHHHHHHHHHHCCCCCCCEEEE
TAPGGNDVKTVVFNTNHTILDGTETVISAGSCTTNSLAPMADALNKNFGVKGGTMTTVHS
ECCCCCCEEEEEEECCCEEECCCHHHEECCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEE
YTGDQMTLDGPHRGGDFRRARAAAENIVPASSGAAKAIGLVLPELSGLMKGHAQRVSTPT
CCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
GSITELVTVLEKHVTVDEINEAMKAAADESFGYNVDEIVSSDIIGMAYGSLFDATLTEVT
CHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DLKDGGQLVKTAAWYDNEMSFTAQLIRTLEYFAKIAK
CCCCCCHHEEEHHHCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVVKVGINGFGRIGRLALRRIQEVEGVEVAHINDLTDPAMLAHLLKYDTTQGRFKGTVEV
CEEEEECCCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCCCCEEEEEEE
KEDGFDVNGKFVKVTAERNPEDIQWADSGVEIVLEATGFFATKEKAEKHLHPGGAKKVLI
ECCCCCCCCEEEEEEECCCCCCCEECCCCEEEEEEECCCHHHHHHHHHHCCCCCCCEEEE
TAPGGNDVKTVVFNTNHTILDGTETVISAGSCTTNSLAPMADALNKNFGVKGGTMTTVHS
ECCCCCCEEEEEEECCCEEECCCHHHEECCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEE
YTGDQMTLDGPHRGGDFRRARAAAENIVPASSGAAKAIGLVLPELSGLMKGHAQRVSTPT
CCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
GSITELVTVLEKHVTVDEINEAMKAAADESFGYNVDEIVSSDIIGMAYGSLFDATLTEVT
CHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DLKDGGQLVKTAAWYDNEMSFTAQLIRTLEYFAKIAK
CCCCCCHHEEEHHHCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7773380; 11337471