Click here to switch to the map view.

The map label for this gene is clpE

Identifier: 15672539

GI number: 15672539

Start: 550405

End: 552651

Strand: Direct

Name: clpE

Synonym: L0221

Alternate gene names: 15672539

Gene position: 550405-552651 (Clockwise)

Preceding gene: 15672538

Following gene: 15672541

Centisome position: 23.27

GC content: 38.45

Gene sequence:

>2247_bases
ATGCTTTGTCAAAATTGTAATATTAATGAAGCGACGATTCACCTTTACACAAGTGTAAATGGTCAGAAAAAACAAATTGA
TTTGTGCCAAAACTGTTATCAAATTATGAAATCTGGCGGTCAAGAAGCTTTATTTGGCGCAGGAAATGCCTCAAATGGAA
ATTCTGATGAACCATTTAATCCATTTAATGATATCTTTAGTGCTTTGCACGGTCAAGATTTTAATGGAGCAGCAAGCACT
CAAACTCCACCAACACAAACAGGTGGACGTGGTCCGCGAGGTCCACAAAATCCTCGGGCAAAACAACCTAAAGGAATGTT
AGAAGAATTTGGAATTAACATCACAGAGTCAGCTCGTCGTGGCGAAATTGACCCAGTGATTGGGCGTGATGAAGAAATTA
AACGTGTCATTGAGATTTTAAATCGTAGGACTAAGAATAATCCTGTATTAATTGGTGAACCTGGTGTTGGTAAAACAGCA
GTTGTTGAAGGTTTAGCGCAAAAAATTGTGGACGGAGATGTGCCGCAAAAACTACAAAATAAAGAAGTGATTCGTCTTGA
TGTTGTTTCTCTTGTTCAAGGAACAGGAATTCGTGGACAATTTGAAGAACGGATGCAAAAATTAATGGATGAAATCAGAA
AACGTAATGATGTGATTATGTTTATTGATGAAATTCATGAAATTGTTGGTGCTGGTTCTGCCGGTGATGGCAATATGGAT
GCAGGAAATATCCTAAAACCTGCGCTTGCGCGTGGTGAGCTTCAATTGGTCGGAGCAACAACGCTCAATGAATATCGCAT
CATTGAAAAAGATGCTGCGCTTGAACGCCGGATGCAACCAGTTAAAGTCGATGAACCATCAGTTGATGAAACAATTACTA
TTTTGCGAGGCATTCAAGCACGTTATGAAGATTATCATCATGTGAAATACACTGATGAGGCTATTGAAGCAGCCGCTCAT
TTGTCAAATCGTTACATTCAAGACCGTTTCTTACCAGATAAAGCCATTGACCTTTTGGATGAGTCTGGTTCTAAGAAAAA
TCTAACCTTGAAATTTGTTGATCCTGAAGATATTAATCGTCGGATTGCGGATGCAGAAACGAAGAAAAATGAAGCAACAC
AGGCTGAAGATTTTGAAAAAGCCGCTCATTTCCGTGACCAAATCACTAAACTTCGTGAATTACAAAATCATGAAGTTTCA
GATGATGAAATTCCTGTCATCACTGAAAAAGATATTGAACAAATTGTTGAGCAAAAAACACATATTCCAGTTGGTGATTT
GAAAGAAAAAGAACAAACCCAATTGATTAATTTGGCTGATGATTTGAAAGCACATGTGATTGGTCAGGATGAAGCAGTGG
ATAAGATTGCTAAAGCTATCCGTCGTTCTCGTGTGGGACTTGGTAAACCTAATCGTCCAATTGGTTCTTTCCTTTTCGTT
GGTCCAACAGGTGTTGGTAAAACAGAACTTGCTAAACAATTGGCTAAAGAATTATTTGGCTCAAGTGAAAGTATGATTCG
TTTTGACATGTCGGAATACATGGAAAAACATTCGGTGGCCAAATTGATTGGAGCCCCTCCAGGATATGTGGGTTATGAAG
AAGCTGGTCAATTGACTGAACGTGTTCGTCGTAATCCCTACAGTTTGATTTTATTAGATGAAATCGAAAAAGCACATCCA
GATGTGATGCACATGTTCTTGCAAATTCTTGAAGATGGACGTCTGACAGACGCACAAGGACGGACAGTATCCTTTAAAGA
TAGTTTGATTATTATGACTTCTAATGCCGGAACTGGTAAAGTTGAAGCCTCTGTCGGATTTGGTGCTGCTCGTGAGGGAC
GAACTAAATCAGTGCTTGGTCAGCTTGGCGATTTCTTTAGCCCTGAATTCATGAACCGTTTTGACGGAATAATTGAATTC
TCTGCTTTGAGCAAAGAAAATCTCCTTAAAATTGTTGATTTGATGCTTGATGAAGTCAACGAACAAATTGGACGTAATGA
TATTCATCTTAGTGTCACTCAAGCAGCAAAAGAAAAATTAGTTGATTTAGGTTACAATCCAGCAATGGGTGCTAGACCAC
TTCGTAGAACAATTCAAGAAAATATCGAAGATTCAATTGCTGACTTCTATATTGAACACCCTGAATACAAAGAATTGGTT
GCTGATTTGATTGATGATAAAATTGTTATCTCTAATCAAGCTCAAGAAACAGCAGAAACGACTGATGAAGAAGTTCCTGC
TGAATAA

Upstream 100 bases:

>100_bases
TTTACATCGAAGTTGGTCCTGATTTTAGATTGAATCCTTCCAAACTGTGAAGGGAAAATTAGTTTAAAATTAATTACTGA
GAATTAAGAGGAGGAAAGCG

Downstream 100 bases:

>100_bases
AAAATGTCTGTCAGTAAAATTTTTAGTGATAGAAAAAATAAAATAATGAAATAAAGAAATAATGAAATAATGAAAAATTG
CTGACATGAATCTTGTCAGC

Product: ATP-dependent protease ATP-binding subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 748; Mature: 748

Protein sequence:

>748_residues
MLCQNCNINEATIHLYTSVNGQKKQIDLCQNCYQIMKSGGQEALFGAGNASNGNSDEPFNPFNDIFSALHGQDFNGAAST
QTPPTQTGGRGPRGPQNPRAKQPKGMLEEFGINITESARRGEIDPVIGRDEEIKRVIEILNRRTKNNPVLIGEPGVGKTA
VVEGLAQKIVDGDVPQKLQNKEVIRLDVVSLVQGTGIRGQFEERMQKLMDEIRKRNDVIMFIDEIHEIVGAGSAGDGNMD
AGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPSVDETITILRGIQARYEDYHHVKYTDEAIEAAAH
LSNRYIQDRFLPDKAIDLLDESGSKKNLTLKFVDPEDINRRIADAETKKNEATQAEDFEKAAHFRDQITKLRELQNHEVS
DDEIPVITEKDIEQIVEQKTHIPVGDLKEKEQTQLINLADDLKAHVIGQDEAVDKIAKAIRRSRVGLGKPNRPIGSFLFV
GPTGVGKTELAKQLAKELFGSSESMIRFDMSEYMEKHSVAKLIGAPPGYVGYEEAGQLTERVRRNPYSLILLDEIEKAHP
DVMHMFLQILEDGRLTDAQGRTVSFKDSLIIMTSNAGTGKVEASVGFGAAREGRTKSVLGQLGDFFSPEFMNRFDGIIEF
SALSKENLLKIVDLMLDEVNEQIGRNDIHLSVTQAAKEKLVDLGYNPAMGARPLRRTIQENIEDSIADFYIEHPEYKELV
ADLIDDKIVISNQAQETAETTDEEVPAE

Sequences:

>Translated_748_residues
MLCQNCNINEATIHLYTSVNGQKKQIDLCQNCYQIMKSGGQEALFGAGNASNGNSDEPFNPFNDIFSALHGQDFNGAAST
QTPPTQTGGRGPRGPQNPRAKQPKGMLEEFGINITESARRGEIDPVIGRDEEIKRVIEILNRRTKNNPVLIGEPGVGKTA
VVEGLAQKIVDGDVPQKLQNKEVIRLDVVSLVQGTGIRGQFEERMQKLMDEIRKRNDVIMFIDEIHEIVGAGSAGDGNMD
AGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPSVDETITILRGIQARYEDYHHVKYTDEAIEAAAH
LSNRYIQDRFLPDKAIDLLDESGSKKNLTLKFVDPEDINRRIADAETKKNEATQAEDFEKAAHFRDQITKLRELQNHEVS
DDEIPVITEKDIEQIVEQKTHIPVGDLKEKEQTQLINLADDLKAHVIGQDEAVDKIAKAIRRSRVGLGKPNRPIGSFLFV
GPTGVGKTELAKQLAKELFGSSESMIRFDMSEYMEKHSVAKLIGAPPGYVGYEEAGQLTERVRRNPYSLILLDEIEKAHP
DVMHMFLQILEDGRLTDAQGRTVSFKDSLIIMTSNAGTGKVEASVGFGAAREGRTKSVLGQLGDFFSPEFMNRFDGIIEF
SALSKENLLKIVDLMLDEVNEQIGRNDIHLSVTQAAKEKLVDLGYNPAMGARPLRRTIQENIEDSIADFYIEHPEYKELV
ADLIDDKIVISNQAQETAETTDEEVPAE
>Mature_748_residues
MLCQNCNINEATIHLYTSVNGQKKQIDLCQNCYQIMKSGGQEALFGAGNASNGNSDEPFNPFNDIFSALHGQDFNGAAST
QTPPTQTGGRGPRGPQNPRAKQPKGMLEEFGINITESARRGEIDPVIGRDEEIKRVIEILNRRTKNNPVLIGEPGVGKTA
VVEGLAQKIVDGDVPQKLQNKEVIRLDVVSLVQGTGIRGQFEERMQKLMDEIRKRNDVIMFIDEIHEIVGAGSAGDGNMD
AGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPSVDETITILRGIQARYEDYHHVKYTDEAIEAAAH
LSNRYIQDRFLPDKAIDLLDESGSKKNLTLKFVDPEDINRRIADAETKKNEATQAEDFEKAAHFRDQITKLRELQNHEVS
DDEIPVITEKDIEQIVEQKTHIPVGDLKEKEQTQLINLADDLKAHVIGQDEAVDKIAKAIRRSRVGLGKPNRPIGSFLFV
GPTGVGKTELAKQLAKELFGSSESMIRFDMSEYMEKHSVAKLIGAPPGYVGYEEAGQLTERVRRNPYSLILLDEIEKAHP
DVMHMFLQILEDGRLTDAQGRTVSFKDSLIIMTSNAGTGKVEASVGFGAAREGRTKSVLGQLGDFFSPEFMNRFDGIIEF
SALSKENLLKIVDLMLDEVNEQIGRNDIHLSVTQAAKEKLVDLGYNPAMGARPLRRTIQENIEDSIADFYIEHPEYKELV
ADLIDDKIVISNQAQETAETTDEEVPAE

Specific function: Could be necessary for degrading proteins generated by certain types of stress

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Homo sapiens, GI13540606, Length=302, Percent_Identity=36.0927152317881, Blast_Score=186, Evalue=1e-46,
Organism=Escherichia coli, GI1788943, Length=691, Percent_Identity=46.7438494934877, Blast_Score=595, Evalue=1e-171,
Organism=Escherichia coli, GI1787109, Length=637, Percent_Identity=40.3453689167975, Blast_Score=502, Evalue=1e-143,
Organism=Saccharomyces cerevisiae, GI6320464, Length=690, Percent_Identity=44.3478260869565, Blast_Score=545, Evalue=1e-155,
Organism=Saccharomyces cerevisiae, GI6323002, Length=727, Percent_Identity=40.0275103163686, Blast_Score=481, Evalue=1e-136,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): CLPE_LACLA (Q9CI09)

Other databases:

- EMBL:   AE005176
- PIR:   E86694
- RefSeq:   NP_266713.1
- ProteinModelPortal:   Q9CI09
- SMR:   Q9CI09
- GeneID:   1114176
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L0221
- NMPDR:   fig|272623.1.peg.572
- HOGENOM:   HBG413133
- OMA:   DVPQKLQ
- ProtClustDB:   CLSK876751
- BioCyc:   LLAC272623:L0221-MONOMER
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR001943
- InterPro:   IPR009055
- PRINTS:   PR00300
- SMART:   SM00382

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small; PF02151 UVR; SSF46600 UvrB_C

EC number: NA

Molecular weight: Translated: 83146; Mature: 83146

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00870 CLPAB_1; PS00871 CLPAB_2; PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLCQNCNINEATIHLYTSVNGQKKQIDLCQNCYQIMKSGGQEALFGAGNASNGNSDEPFN
CCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCC
PFNDIFSALHGQDFNGAASTQTPPTQTGGRGPRGPQNPRAKQPKGMLEEFGINITESARR
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCC
GEIDPVIGRDEEIKRVIEILNRRTKNNPVLIGEPGVGKTAVVEGLAQKIVDGDVPQKLQN
CCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCHHHCC
KEVIRLDVVSLVQGTGIRGQFEERMQKLMDEIRKRNDVIMFIDEIHEIVGAGSAGDGNMD
CCEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHCCCCCCCCCCC
AGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPSVDETITILRGIQA
CCHHHHHHHCCCCEEEEECCCCCHHEEHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
RYEDYHHVKYTDEAIEAAAHLSNRYIQDRFLPDKAIDLLDESGSKKNLTLKFVDPEDINR
HHCCCCCCEECHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEEEECCHHHHHH
RIADAETKKNEATQAEDFEKAAHFRDQITKLRELQNHEVSDDEIPVITEKDIEQIVEQKT
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECHHHHHHHHHHHC
HIPVGDLKEKEQTQLINLADDLKAHVIGQDEAVDKIAKAIRRSRVGLGKPNRPIGSFLFV
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEE
GPTGVGKTELAKQLAKELFGSSESMIRFDMSEYMEKHSVAKLIGAPPGYVGYEEAGQLTE
CCCCCCHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
RVRRNPYSLILLDEIEKAHPDVMHMFLQILEDGRLTDAQGRTVSFKDSLIIMTSNAGTGK
HHHCCCCEEEEEHHHHHCCHHHHHHHHHHHHCCCEECCCCCEEEECCCEEEEECCCCCCE
VEASVGFGAAREGRTKSVLGQLGDFFSPEFMNRFDGIIEFSALSKENLLKIVDLMLDEVN
EEECCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHEEHHHCCHHHHHHHHHHHHHHHH
EQIGRNDIHLSVTQAAKEKLVDLGYNPAMGARPLRRTIQENIEDSIADFYIEHPEYKELV
HHHCCCCEEEEHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
ADLIDDKIVISNQAQETAETTDEEVPAE
HHHHCCCEEECCCHHHHHHCCCCCCCCC
>Mature Secondary Structure
MLCQNCNINEATIHLYTSVNGQKKQIDLCQNCYQIMKSGGQEALFGAGNASNGNSDEPFN
CCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCC
PFNDIFSALHGQDFNGAASTQTPPTQTGGRGPRGPQNPRAKQPKGMLEEFGINITESARR
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCC
GEIDPVIGRDEEIKRVIEILNRRTKNNPVLIGEPGVGKTAVVEGLAQKIVDGDVPQKLQN
CCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCHHHCC
KEVIRLDVVSLVQGTGIRGQFEERMQKLMDEIRKRNDVIMFIDEIHEIVGAGSAGDGNMD
CCEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHCCCCCCCCCCC
AGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPSVDETITILRGIQA
CCHHHHHHHCCCCEEEEECCCCCHHEEHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
RYEDYHHVKYTDEAIEAAAHLSNRYIQDRFLPDKAIDLLDESGSKKNLTLKFVDPEDINR
HHCCCCCCEECHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEEEECCHHHHHH
RIADAETKKNEATQAEDFEKAAHFRDQITKLRELQNHEVSDDEIPVITEKDIEQIVEQKT
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECHHHHHHHHHHHC
HIPVGDLKEKEQTQLINLADDLKAHVIGQDEAVDKIAKAIRRSRVGLGKPNRPIGSFLFV
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEE
GPTGVGKTELAKQLAKELFGSSESMIRFDMSEYMEKHSVAKLIGAPPGYVGYEEAGQLTE
CCCCCCHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
RVRRNPYSLILLDEIEKAHPDVMHMFLQILEDGRLTDAQGRTVSFKDSLIIMTSNAGTGK
HHHCCCCEEEEEHHHHHCCHHHHHHHHHHHHCCCEECCCCCEEEECCCEEEEECCCCCCE
VEASVGFGAAREGRTKSVLGQLGDFFSPEFMNRFDGIIEFSALSKENLLKIVDLMLDEVN
EEECCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHEEHHHCCHHHHHHHHHHHHHHHH
EQIGRNDIHLSVTQAAKEKLVDLGYNPAMGARPLRRTIQENIEDSIADFYIEHPEYKELV
HHHCCCCEEEEHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
ADLIDDKIVISNQAQETAETTDEEVPAE
HHHHCCCEEECCCHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471