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The map label for this gene is ponA

Identifier: 15672525

GI number: 15672525

Start: 529170

End: 531164

Strand: Reverse

Name: ponA

Synonym: L129183

Alternate gene names: 15672525

Gene position: 531164-529170 (Counterclockwise)

Preceding gene: 15672526

Following gene: 15672524

Centisome position: 22.45

GC content: 38.5

Gene sequence:

>1995_bases
ATGTGGACGGCAGTAAAATTATTTTTAATTGCTTTCTTTTCTTTAATTATCCTAGCCTTAGCCGCTGGGGGCGCCGTTTT
CGTTTATTATGCTAAGGATGCACCTGCACTCACTTTGGACAAACTTGAATCTAAACCTTCTACTAAAGTTTATGACTCTA
GCGAAAAAGTGGTGGCAACTTTAGGAGCTGAACAAAGAAATCTGGTTAAAACTGATAATATTCCAGTAATGTTGGTTAAT
GCGGTTACTTCTATTGAAGACCATCGTTTCTTCAATACTCGTGGAATTGACCCCATTCGGATTGCTGGAGCTTTTGTTAA
TAATTTAAAAGGTGGTTCTTTAAACGGTGGTTCTACACTTGATATGCAGCTCATTAAGCTTTCATTCTTCTCAACCGATG
AATCAGACCAAACTTTGAGTGTTAAAATTCAAGAAGCTTGGATGGCCTTAAAATTAGACCAAAAATGGACCAAGGAGCAA
ATTTTTACAGCTTATGTTAATAAGGTTAATATGGCAAATGGTTATTATGGAATGGGAACTGCTTCCCAAGCCTATTATGG
CAAAGATTTAACTCAGCTTTCAATCGCTCAACTTGCCCTACTTGCTGGAATGCCTCAAGCTCCTAATACTTATAATCCAT
ATACTAACCCTACTTCTGCTAAATGGCGCCGTGATATGGTTATCCGTGCAATGCGTCGTTACGATAAAATTACAGCTGAA
GAAGAAAAGAAAGCACTGGCTACCCCAATTGATGATGGACTTCAACCTTTAAAACAAAGTGTAACTATTCCAAGTTATGC
TGATAATTTCCTCAAACAGGCAATTGCTCAAGCTAAAACTTTGGCTGGAGATGATATTTTGACTGAGGGAGCTAAAATTT
ATACTACTCTTGATACAACAGCCCAACAAAATCTATATAATATTGTTAACACTGGCAACTATATCACTTATCCAGATGAT
ACAATGCAAGTTGCTTCAACTGTTACTGATGTCAAAACAGGTGCTGTAATTGCACAAATTGGTGGTCGTAATCAACCAAG
CAATGTTACTTTTGGCTTTAACCAAGCCGTGCAAACAGACCGAGATTGGGGTTCGACCATGAAGCCAATTGTCGACTACG
GTCCAGCTTTTGAAAATAATATTTATACTTCAACTAATAATTATGTTTCCGATTCCCCAACTACTTATCCAAATGGAACG
CCTTTAAAAAACTGGGATAATACTTATTTTGGTTCAATGACTGTCAAAAGTGCCTTAGCACTTTCACGTAACATCCCAGC
TGTTAAAACTTTAATCAATGTTGGACTAGATAATTCTAGCAAATTTGTTAATGGTCTAGGAATTACTTTAGATCCTCTGG
AATACTCTAATGCCATCTCTAGTAACTCTAAAAATGGTGGAGCAAGTTCTGAAAAAATGGCTGCTGCTTATGCTGCCTTC
TCAAATGGTGGGATTTACACTAAACCTTATTATGTTTCCAAAGTTGTCTTCCCCGATGGTCGTACAGTTGAATACAAACC
GGACCGCTCACGAGCAATGCAAGCCTCAACCGCTTATATCATGACCAATATTCTTCAAAGTGTTTTAACATTGCCACTTT
CTGAATCTGTTGGTTCTTACGCTGCTGTTCCCGGCTTAGCAGCCGCTGGTAAAACTGGTACATCTAACTATACAGATAGT
GAAATGGATCAAATCACTGAGAAATACGGTTCCCTTCCAGGTATGGTTTCTCCAGACGAAAACTTTGTTGGTTATACTCC
TCAGTATTCAATGGCTGTTTGGACCGGTTATTCAAATCGAATGACGCCAATTTATGGTACAAGTACTCAGATTGCAACCA
AAGTTTTCTCATCTATGATGACTCAACTTACTCCTGATCCTTCATCTGTTGCGACATGGACAATGCCTGAGGGTGTTAGT
CAAGAAGGAACTGCTCTTGTTAAAACAGATAGTTCTGGTCAAACAATAAGTCAATCCTCCGCTAATGGTAGTTAA

Upstream 100 bases:

>100_bases
GAAATTGTGAATAAACTTTGTGAGGTACAGTAAAATTTCTACTAAATCTAAGAAAAATAAACAAAAAAAACGTACGAAAC
GCGGTTCCGCCAAATCTAAA

Downstream 100 bases:

>100_bases
ATGAAAATTGAAAAAATTGTTAATAAAATTGCTCAGGAGAATACATATCTCCTGAGCAATTCTACTTCACATCTCATTAT
TGATCCTGGAAGTGATTCGT

Product: penicillin-binding protein 1A

Products: NA

Alternate protein names: PBP-1A [H]

Number of amino acids: Translated: 664; Mature: 664

Protein sequence:

>664_residues
MWTAVKLFLIAFFSLIILALAAGGAVFVYYAKDAPALTLDKLESKPSTKVYDSSEKVVATLGAEQRNLVKTDNIPVMLVN
AVTSIEDHRFFNTRGIDPIRIAGAFVNNLKGGSLNGGSTLDMQLIKLSFFSTDESDQTLSVKIQEAWMALKLDQKWTKEQ
IFTAYVNKVNMANGYYGMGTASQAYYGKDLTQLSIAQLALLAGMPQAPNTYNPYTNPTSAKWRRDMVIRAMRRYDKITAE
EEKKALATPIDDGLQPLKQSVTIPSYADNFLKQAIAQAKTLAGDDILTEGAKIYTTLDTTAQQNLYNIVNTGNYITYPDD
TMQVASTVTDVKTGAVIAQIGGRNQPSNVTFGFNQAVQTDRDWGSTMKPIVDYGPAFENNIYTSTNNYVSDSPTTYPNGT
PLKNWDNTYFGSMTVKSALALSRNIPAVKTLINVGLDNSSKFVNGLGITLDPLEYSNAISSNSKNGGASSEKMAAAYAAF
SNGGIYTKPYYVSKVVFPDGRTVEYKPDRSRAMQASTAYIMTNILQSVLTLPLSESVGSYAAVPGLAAAGKTGTSNYTDS
EMDQITEKYGSLPGMVSPDENFVGYTPQYSMAVWTGYSNRMTPIYGTSTQIATKVFSSMMTQLTPDPSSVATWTMPEGVS
QEGTALVKTDSSGQTISQSSANGS

Sequences:

>Translated_664_residues
MWTAVKLFLIAFFSLIILALAAGGAVFVYYAKDAPALTLDKLESKPSTKVYDSSEKVVATLGAEQRNLVKTDNIPVMLVN
AVTSIEDHRFFNTRGIDPIRIAGAFVNNLKGGSLNGGSTLDMQLIKLSFFSTDESDQTLSVKIQEAWMALKLDQKWTKEQ
IFTAYVNKVNMANGYYGMGTASQAYYGKDLTQLSIAQLALLAGMPQAPNTYNPYTNPTSAKWRRDMVIRAMRRYDKITAE
EEKKALATPIDDGLQPLKQSVTIPSYADNFLKQAIAQAKTLAGDDILTEGAKIYTTLDTTAQQNLYNIVNTGNYITYPDD
TMQVASTVTDVKTGAVIAQIGGRNQPSNVTFGFNQAVQTDRDWGSTMKPIVDYGPAFENNIYTSTNNYVSDSPTTYPNGT
PLKNWDNTYFGSMTVKSALALSRNIPAVKTLINVGLDNSSKFVNGLGITLDPLEYSNAISSNSKNGGASSEKMAAAYAAF
SNGGIYTKPYYVSKVVFPDGRTVEYKPDRSRAMQASTAYIMTNILQSVLTLPLSESVGSYAAVPGLAAAGKTGTSNYTDS
EMDQITEKYGSLPGMVSPDENFVGYTPQYSMAVWTGYSNRMTPIYGTSTQIATKVFSSMMTQLTPDPSSVATWTMPEGVS
QEGTALVKTDSSGQTISQSSANGS
>Mature_664_residues
MWTAVKLFLIAFFSLIILALAAGGAVFVYYAKDAPALTLDKLESKPSTKVYDSSEKVVATLGAEQRNLVKTDNIPVMLVN
AVTSIEDHRFFNTRGIDPIRIAGAFVNNLKGGSLNGGSTLDMQLIKLSFFSTDESDQTLSVKIQEAWMALKLDQKWTKEQ
IFTAYVNKVNMANGYYGMGTASQAYYGKDLTQLSIAQLALLAGMPQAPNTYNPYTNPTSAKWRRDMVIRAMRRYDKITAE
EEKKALATPIDDGLQPLKQSVTIPSYADNFLKQAIAQAKTLAGDDILTEGAKIYTTLDTTAQQNLYNIVNTGNYITYPDD
TMQVASTVTDVKTGAVIAQIGGRNQPSNVTFGFNQAVQTDRDWGSTMKPIVDYGPAFENNIYTSTNNYVSDSPTTYPNGT
PLKNWDNTYFGSMTVKSALALSRNIPAVKTLINVGLDNSSKFVNGLGITLDPLEYSNAISSNSKNGGASSEKMAAAYAAF
SNGGIYTKPYYVSKVVFPDGRTVEYKPDRSRAMQASTAYIMTNILQSVLTLPLSESVGSYAAVPGLAAAGKTGTSNYTDS
EMDQITEKYGSLPGMVSPDENFVGYTPQYSMAVWTGYSNRMTPIYGTSTQIATKVFSSMMTQLTPDPSSVATWTMPEGVS
QEGTALVKTDSSGQTISQSSANGS

Specific function: Cell wall formation [H]

COG id: COG0744

COG function: function code M; Membrane carboxypeptidase (penicillin-binding protein)

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786343, Length=606, Percent_Identity=29.042904290429, Blast_Score=163, Evalue=3e-41,
Organism=Escherichia coli, GI1788867, Length=583, Percent_Identity=28.4734133790738, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI87082258, Length=376, Percent_Identity=27.9255319148936, Blast_Score=145, Evalue=9e-36,
Organism=Escherichia coli, GI1789601, Length=228, Percent_Identity=24.5614035087719, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001264
- InterPro:   IPR011816
- InterPro:   IPR001460 [H]

Pfam domain/function: PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.2.-; 3.4.-.-

Molecular weight: Translated: 71937; Mature: 71937

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWTAVKLFLIAFFSLIILALAAGGAVFVYYAKDAPALTLDKLESKPSTKVYDSSEKVVAT
CCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEHHHHCCCCCCCEECCCCCEEEE
LGAEQRNLVKTDNIPVMLVNAVTSIEDHRFFNTRGIDPIRIAGAFVNNLKGGSLNGGSTL
CCCCCCCCEECCCCCEEEEEHHHHHHHCCEECCCCCCHHHHHHHHHHCCCCCCCCCCCEE
DMQLIKLSFFSTDESDQTLSVKIQEAWMALKLDQKWTKEQIFTAYVNKVNMANGYYGMGT
EEEEEEEEEECCCCCCCEEEEEEEHHHEEEECCHHHHHHHHHHHHHHHEECCCCEECCCC
ASQAYYGKDLTQLSIAQLALLAGMPQAPNTYNPYTNPTSAKWRRDMVIRAMRRYDKITAE
CCCHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHH
EEKKALATPIDDGLQPLKQSVTIPSYADNFLKQAIAQAKTLAGDDILTEGAKIYTTLDTT
HHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHCCCEEEEEECHH
AQQNLYNIVNTGNYITYPDDTMQVASTVTDVKTGAVIAQIGGRNQPSNVTFGFNQAVQTD
HHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHCCEEEEECCCCCCCCCEEECCCHHHCCC
RDWGSTMKPIVDYGPAFENNIYTSTNNYVSDSPTTYPNGTPLKNWDNTYFGSMTVKSALA
CCCCCHHHHHHHCCCCCCCCEEECCCCEECCCCCCCCCCCCCCCCCCCEECCHHHHHHHH
LSRNIPAVKTLINVGLDNSSKFVNGLGITLDPLEYSNAISSNSKNGGASSEKMAAAYAAF
HHCCCHHHHHHHHHCCCCCCHHHCCCCCEECCHHHHHHHCCCCCCCCCCHHHHHHHHHHH
SNGGIYTKPYYVSKVVFPDGRTVEYKPDRSRAMQASTAYIMTNILQSVLTLPLSESVGSY
CCCCEEECCEEEEEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCH
AAVPGLAAAGKTGTSNYTDSEMDQITEKYGSLPGMVSPDENFVGYTPQYSMAVWTGYSNR
HHCCCCHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEECCCCC
MTPIYGTSTQIATKVFSSMMTQLTPDPSSVATWTMPEGVSQEGTALVKTDSSGQTISQSS
CCEEECCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCEEEEECCCCCEECCCC
ANGS
CCCC
>Mature Secondary Structure
MWTAVKLFLIAFFSLIILALAAGGAVFVYYAKDAPALTLDKLESKPSTKVYDSSEKVVAT
CCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEHHHHCCCCCCCEECCCCCEEEE
LGAEQRNLVKTDNIPVMLVNAVTSIEDHRFFNTRGIDPIRIAGAFVNNLKGGSLNGGSTL
CCCCCCCCEECCCCCEEEEEHHHHHHHCCEECCCCCCHHHHHHHHHHCCCCCCCCCCCEE
DMQLIKLSFFSTDESDQTLSVKIQEAWMALKLDQKWTKEQIFTAYVNKVNMANGYYGMGT
EEEEEEEEEECCCCCCCEEEEEEEHHHEEEECCHHHHHHHHHHHHHHHEECCCCEECCCC
ASQAYYGKDLTQLSIAQLALLAGMPQAPNTYNPYTNPTSAKWRRDMVIRAMRRYDKITAE
CCCHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHH
EEKKALATPIDDGLQPLKQSVTIPSYADNFLKQAIAQAKTLAGDDILTEGAKIYTTLDTT
HHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHCCCEEEEEECHH
AQQNLYNIVNTGNYITYPDDTMQVASTVTDVKTGAVIAQIGGRNQPSNVTFGFNQAVQTD
HHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHCCEEEEECCCCCCCCCEEECCCHHHCCC
RDWGSTMKPIVDYGPAFENNIYTSTNNYVSDSPTTYPNGTPLKNWDNTYFGSMTVKSALA
CCCCCHHHHHHHCCCCCCCCEEECCCCEECCCCCCCCCCCCCCCCCCCEECCHHHHHHHH
LSRNIPAVKTLINVGLDNSSKFVNGLGITLDPLEYSNAISSNSKNGGASSEKMAAAYAAF
HHCCCHHHHHHHHHCCCCCCHHHCCCCCEECCHHHHHHHCCCCCCCCCCHHHHHHHHHHH
SNGGIYTKPYYVSKVVFPDGRTVEYKPDRSRAMQASTAYIMTNILQSVLTLPLSESVGSY
CCCCEEECCEEEEEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCH
AAVPGLAAAGKTGTSNYTDSEMDQITEKYGSLPGMVSPDENFVGYTPQYSMAVWTGYSNR
HHCCCCHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEECCCCC
MTPIYGTSTQIATKVFSSMMTQLTPDPSSVATWTMPEGVSQEGTALVKTDSSGQTISQSS
CCEEECCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCEEEEECCCCCEECCCC
ANGS
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1624444 [H]