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The map label for this gene is recU

Identifier: 15672526

GI number: 15672526

Start: 531232

End: 531873

Strand: Reverse

Name: recU

Synonym: L131245

Alternate gene names: 15672526

Gene position: 531873-531232 (Counterclockwise)

Preceding gene: 15672540

Following gene: 15672525

Centisome position: 22.48

GC content: 36.92

Gene sequence:

>642_bases
ATGGTTAATTATCCTAATGGAAGGTCGCGAGCTTACAGCACTGTTCCTAAGAAAAAAAAATCACTGACAGAGCTGTCAGT
AACTAAAAAAAGCACCTCAAAAACCAAAGGGATGGTTGCCTTCGGGAAGCGGGGAATGAATTTTGAAGCTGAAATTAATG
CAACAAATGAGTATTATCTTTCTCGTGGACTTGCAGTTATTCACAAAAAGCCAACACCAATTCAAATCGTTAAAGTAGAT
TATCCACAAAGGAGTCGTGCAAAAATTACAGAAGCTTACTTCAGGCAAGCATCTACTACTGACTACTCTGGAGTCTATAA
AGGTCACTACATCGACTTTGAAGCAAAGGAAACACAGCAAAAAACTGTTTTCCCTCTAAAAAATTTCCATGAGCATCAAA
TTGTTCACATGAGTAATGTTCTCGCTCAAGGGGGAATTGCTTTTGTCCTCTTGCACTTTGCAAGGTTAAATGAAACATAT
CTTCTTCCATCTTCGTGTTTGATTACTTTTTATTACGAAAAAGGCGGTTTAAAGTCAATTCCGCTTTCTCATATTCGCGA
AAATGGCTATAAAATTGAAACGAACCACATTCCTAGAATTCCTTATCTAGAAATTGTGAATAAACTTTGTGAGGTACAGT
AA

Upstream 100 bases:

>100_bases
ATGATTAGTAGTGAATTCATAAATATTTTCCCCTTGTAAAATTTATGTTATAATAGACATTATATAACTAACTGAGAATT
TTATAAAGGTAGAAAACAGA

Downstream 100 bases:

>100_bases
AATTTCTACTAAATCTAAGAAAAATAAACAAAAAAAACGTACGAAACGCGGTTCCGCCAAATCTAAAATGTGGACGGCAG
TAAAATTATTTTTAATTGCT

Product: Holliday junction-specific endonuclease

Products: NA

Alternate protein names: Recombination protein U homolog

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MVNYPNGRSRAYSTVPKKKKSLTELSVTKKSTSKTKGMVAFGKRGMNFEAEINATNEYYLSRGLAVIHKKPTPIQIVKVD
YPQRSRAKITEAYFRQASTTDYSGVYKGHYIDFEAKETQQKTVFPLKNFHEHQIVHMSNVLAQGGIAFVLLHFARLNETY
LLPSSCLITFYYEKGGLKSIPLSHIRENGYKIETNHIPRIPYLEIVNKLCEVQ

Sequences:

>Translated_213_residues
MVNYPNGRSRAYSTVPKKKKSLTELSVTKKSTSKTKGMVAFGKRGMNFEAEINATNEYYLSRGLAVIHKKPTPIQIVKVD
YPQRSRAKITEAYFRQASTTDYSGVYKGHYIDFEAKETQQKTVFPLKNFHEHQIVHMSNVLAQGGIAFVLLHFARLNETY
LLPSSCLITFYYEKGGLKSIPLSHIRENGYKIETNHIPRIPYLEIVNKLCEVQ
>Mature_213_residues
MVNYPNGRSRAYSTVPKKKKSLTELSVTKKSTSKTKGMVAFGKRGMNFEAEINATNEYYLSRGLAVIHKKPTPIQIVKVD
YPQRSRAKITEAYFRQASTTDYSGVYKGHYIDFEAKETQQKTVFPLKNFHEHQIVHMSNVLAQGGIAFVLLHFARLNETY
LLPSSCLITFYYEKGGLKSIPLSHIRENGYKIETNHIPRIPYLEIVNKLCEVQ

Specific function: Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair

COG id: COG3331

COG function: function code R; Penicillin-binding protein-related factor A, putative recombinase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the recU family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RECU_LACLA (Q9CI22)

Other databases:

- EMBL:   AE005176
- PIR:   H86692
- RefSeq:   NP_266700.1
- ProteinModelPortal:   Q9CI22
- SMR:   Q9CI22
- GeneID:   1114163
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L131245
- NMPDR:   fig|272623.1.peg.559
- HOGENOM:   HBG571967
- OMA:   GHYIDFE
- ProtClustDB:   PRK02234
- BioCyc:   LLAC272623:L131245-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00130
- InterPro:   IPR004612
- InterPro:   IPR011335
- PIRSF:   PIRSF037785
- TIGRFAMs:   TIGR00648

Pfam domain/function: PF03838 RecU; SSF52980 Restrict_endonuc_II-like_core

EC number: NA

Molecular weight: Translated: 24369; Mature: 24369

Theoretical pI: Translated: 10.14; Mature: 10.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVNYPNGRSRAYSTVPKKKKSLTELSVTKKSTSKTKGMVAFGKRGMNFEAEINATNEYYL
CCCCCCCCCCHHHCCCHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCEEEEECCCHHHHH
SRGLAVIHKKPTPIQIVKVDYPQRSRAKITEAYFRQASTTDYSGVYKGHYIDFEAKETQQ
HCCEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCC
KTVFPLKNFHEHQIVHMSNVLAQGGIAFVLLHFARLNETYLLPSSCLITFYYEKGGLKSI
CEECCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEECCCCEEEEEEECCCCCCCC
PLSHIRENGYKIETNHIPRIPYLEIVNKLCEVQ
CHHHHHCCCEEEECCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MVNYPNGRSRAYSTVPKKKKSLTELSVTKKSTSKTKGMVAFGKRGMNFEAEINATNEYYL
CCCCCCCCCCHHHCCCHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCEEEEECCCHHHHH
SRGLAVIHKKPTPIQIVKVDYPQRSRAKITEAYFRQASTTDYSGVYKGHYIDFEAKETQQ
HCCEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCC
KTVFPLKNFHEHQIVHMSNVLAQGGIAFVLLHFARLNETYLLPSSCLITFYYEKGGLKSI
CEECCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEECCCCEEEEEEECCCCCCCC
PLSHIRENGYKIETNHIPRIPYLEIVNKLCEVQ
CHHHHHCCCEEEECCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471