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The map label for this gene is kinC

Identifier: 15672378

GI number: 15672378

Start: 401554

End: 402996

Strand: Reverse

Name: kinC

Synonym: L0124

Alternate gene names: 15672378

Gene position: 402996-401554 (Counterclockwise)

Preceding gene: 15672379

Following gene: 15672377

Centisome position: 17.04

GC content: 34.58

Gene sequence:

>1443_bases
ATGATTAAATTTTTTAATTCAATGATTTTTAAAGGAGTAGTTGCACACCTACTTCTTTTTGTCATCCTTTTTATGAGCAG
TTTTGATTACAATTTTGCTCATTTAAGTACTTTTATTGGTTATTACTTATTTTCACTCGTCTTTGTTTTAGTCTTTCTCA
ATCAGCAACATCGCATGATTGTGAATGTTTCTAAACAGATGAATGACATAAAAAATGGCTATTTAAATCGCGATAAAATC
CCAAAAGGGACGAGTGAAATCAATGAATTATATGATGAAATTTTAAAACTTGGTGAAGATATTGTTCGCACGCAGAACAA
TCTTGAAAATCAGCGTAATCAATTAGATAGTATTCTCGCATATATGGTTGATGGCGTCATTGCCACCGATCGTCGTGGAA
ATATTATTATGGCCAATAAATCAGCTTTGCACTATTTGAATACAGATAATGATCTCTTGATGCAAAAAAATATTGTTGAA
GTTTTAAAAATTACTGACCAATATAATTTTTATGATTTATTAGAAAAAGAACCTGAAATAACTATTGAGACACATGATTC
TGGGAATGAATCCATTTCGCTCCACATTAAATTTGCCCTCTTTCGTCGTGAATCTGGTTTCATCTCAGGAATTATTGCCG
TCTTACATGATATGACTGAACAAGACAAGGCCGAACGAGAGCGCCGTCTCTTTGTTTCCAATGTTTCTCATGAACTCCGA
ACTCCGCTCACCTCAGTAAAAGCCTACTTGGAAGCACTAGAAGACGGAGCCATTGAGGATAAAGAAACAGCTTCATCCTT
TATTAATGTTTCACTTACTGAAACTAATCGGATGATTCGAATGATTTCCGACCTTTTGACTTTATCAAGAATGGATCAAG
ACCGAATCGTTCTTAATAAAGAAATGATTAATTTAATTGCCTTCTTAGACTATCAAATTAACCGTTTAGACCAAATTTTA
GAAACCGAATCAAACGATTTAATCTCTTCTAATTTCACTCTAGTCAGAAAATACTCTGAACAGCCCATCTGGGTCGAAAT
TGATACCGATAAAATTGCTCAAGTCATTGACAATATCATCGGAAATGCAATTAAGTATTCACCTAAAGGTGGAACTATTA
CAATTTCCGTTGAAAAACGTGAAAGTGATGTTCTAATCTCCATCAGTGACCAAGGAATGGGGATTCCAAAATCTGATTTA
CTTAAGATTTTTGACCGTTTCTACCGAGTTGATAATGCTTCAAGAAATTCAAAAGTTGGGGGGACAGGTTTAGGCCTCTC
TATTGTCCATGATATTGTTAAAATACATGGCGGAACAATTTTTGCAAGTTCTGAAGGAGAAGGAAAAGGAACGACCTTTA
GTTTCACTCTTCCATATTCTTTAGAAGCCGCAGATGACTGGGATGATGGCACTGATGAGTTTGAATTTGAGGATAATGAA
TAA

Upstream 100 bases:

>100_bases
GTTACTGTTCGTCGTTTACGTGAAAAAGTTGAAGATACTCCAAGCCGTCCACAATACGTTTCAACACGCCGCGGGGTTGG
CTACTACATGAGCAACCCAC

Downstream 100 bases:

>100_bases
TTTCCCCTAAAAAGAGTCCATACATATTTGTGGACTCTTTTTTTATGAATAAACCTAGACTTTTACCACAAAAAACTCTC
TTAAGGTAATGAATTTCCTG

Product: sensor protein kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 480; Mature: 480

Protein sequence:

>480_residues
MIKFFNSMIFKGVVAHLLLFVILFMSSFDYNFAHLSTFIGYYLFSLVFVLVFLNQQHRMIVNVSKQMNDIKNGYLNRDKI
PKGTSEINELYDEILKLGEDIVRTQNNLENQRNQLDSILAYMVDGVIATDRRGNIIMANKSALHYLNTDNDLLMQKNIVE
VLKITDQYNFYDLLEKEPEITIETHDSGNESISLHIKFALFRRESGFISGIIAVLHDMTEQDKAERERRLFVSNVSHELR
TPLTSVKAYLEALEDGAIEDKETASSFINVSLTETNRMIRMISDLLTLSRMDQDRIVLNKEMINLIAFLDYQINRLDQIL
ETESNDLISSNFTLVRKYSEQPIWVEIDTDKIAQVIDNIIGNAIKYSPKGGTITISVEKRESDVLISISDQGMGIPKSDL
LKIFDRFYRVDNASRNSKVGGTGLGLSIVHDIVKIHGGTIFASSEGEGKGTTFSFTLPYSLEAADDWDDGTDEFEFEDNE

Sequences:

>Translated_480_residues
MIKFFNSMIFKGVVAHLLLFVILFMSSFDYNFAHLSTFIGYYLFSLVFVLVFLNQQHRMIVNVSKQMNDIKNGYLNRDKI
PKGTSEINELYDEILKLGEDIVRTQNNLENQRNQLDSILAYMVDGVIATDRRGNIIMANKSALHYLNTDNDLLMQKNIVE
VLKITDQYNFYDLLEKEPEITIETHDSGNESISLHIKFALFRRESGFISGIIAVLHDMTEQDKAERERRLFVSNVSHELR
TPLTSVKAYLEALEDGAIEDKETASSFINVSLTETNRMIRMISDLLTLSRMDQDRIVLNKEMINLIAFLDYQINRLDQIL
ETESNDLISSNFTLVRKYSEQPIWVEIDTDKIAQVIDNIIGNAIKYSPKGGTITISVEKRESDVLISISDQGMGIPKSDL
LKIFDRFYRVDNASRNSKVGGTGLGLSIVHDIVKIHGGTIFASSEGEGKGTTFSFTLPYSLEAADDWDDGTDEFEFEDNE
>Mature_480_residues
MIKFFNSMIFKGVVAHLLLFVILFMSSFDYNFAHLSTFIGYYLFSLVFVLVFLNQQHRMIVNVSKQMNDIKNGYLNRDKI
PKGTSEINELYDEILKLGEDIVRTQNNLENQRNQLDSILAYMVDGVIATDRRGNIIMANKSALHYLNTDNDLLMQKNIVE
VLKITDQYNFYDLLEKEPEITIETHDSGNESISLHIKFALFRRESGFISGIIAVLHDMTEQDKAERERRLFVSNVSHELR
TPLTSVKAYLEALEDGAIEDKETASSFINVSLTETNRMIRMISDLLTLSRMDQDRIVLNKEMINLIAFLDYQINRLDQIL
ETESNDLISSNFTLVRKYSEQPIWVEIDTDKIAQVIDNIIGNAIKYSPKGGTITISVEKRESDVLISISDQGMGIPKSDL
LKIFDRFYRVDNASRNSKVGGTGLGLSIVHDIVKIHGGTIFASSEGEGKGTTFSFTLPYSLEAADDWDDGTDEFEFEDNE

Specific function: Member of the two-component regulatory system YycG/YycF involved in the regulation of the ftsAZ operon, the yocH and ykvT, cwlO, lytE, ydjM, yjeA, yoeB genes and the tagAB and tagDEF operons. Probably phosphorylates YycF [H]

COG id: COG5002

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=260, Percent_Identity=31.9230769230769, Blast_Score=124, Evalue=9e-30,
Organism=Escherichia coli, GI1788393, Length=238, Percent_Identity=31.9327731092437, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1786783, Length=228, Percent_Identity=30.2631578947368, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1790436, Length=251, Percent_Identity=30.6772908366534, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI48994928, Length=277, Percent_Identity=28.5198555956679, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI1790551, Length=247, Percent_Identity=29.9595141700405, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1786912, Length=238, Percent_Identity=30.672268907563, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1789149, Length=238, Percent_Identity=33.1932773109244, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1788713, Length=384, Percent_Identity=23.4375, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788549, Length=393, Percent_Identity=26.7175572519084, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI145693157, Length=346, Percent_Identity=24.5664739884393, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1790346, Length=255, Percent_Identity=29.4117647058824, Blast_Score=89, Evalue=9e-19,
Organism=Escherichia coli, GI1790861, Length=218, Percent_Identity=27.5229357798165, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1787894, Length=231, Percent_Identity=27.7056277056277, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1789403, Length=227, Percent_Identity=29.9559471365639, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1788279, Length=241, Percent_Identity=30.2904564315353, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI87082128, Length=254, Percent_Identity=25.5905511811024, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1787374, Length=227, Percent_Identity=26.8722466960352, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 54696; Mature: 54696

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKFFNSMIFKGVVAHLLLFVILFMSSFDYNFAHLSTFIGYYLFSLVFVLVFLNQQHRMI
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
VNVSKQMNDIKNGYLNRDKIPKGTSEINELYDEILKLGEDIVRTQNNLENQRNQLDSILA
EEHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YMVDGVIATDRRGNIIMANKSALHYLNTDNDLLMQKNIVEVLKITDQYNFYDLLEKEPEI
HHHCCEEEECCCCCEEEECCCEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHCCCCCE
TIETHDSGNESISLHIKFALFRRESGFISGIIAVLHDMTEQDKAERERRLFVSNVSHELR
EEEECCCCCCEEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TPLTSVKAYLEALEDGAIEDKETASSFINVSLTETNRMIRMISDLLTLSRMDQDRIVLNK
CCHHHHHHHHHHHHCCCCCCHHHHHHHEEEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHH
EMINLIAFLDYQINRLDQILETESNDLISSNFTLVRKYSEQPIWVEIDTDKIAQVIDNII
HHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCEEEECCCCCEEEEECHHHHHHHHHHHH
GNAIKYSPKGGTITISVEKRESDVLISISDQGMGIPKSDLLKIFDRFYRVDNASRNSKVG
CCCEEECCCCCEEEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
GTGLGLSIVHDIVKIHGGTIFASSEGEGKGTTFSFTLPYSLEAADDWDDGTDEFEFEDNE
CCCCHHHHHHHHHHHCCCEEEECCCCCCCCCEEEEECCEEECCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MIKFFNSMIFKGVVAHLLLFVILFMSSFDYNFAHLSTFIGYYLFSLVFVLVFLNQQHRMI
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
VNVSKQMNDIKNGYLNRDKIPKGTSEINELYDEILKLGEDIVRTQNNLENQRNQLDSILA
EEHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YMVDGVIATDRRGNIIMANKSALHYLNTDNDLLMQKNIVEVLKITDQYNFYDLLEKEPEI
HHHCCEEEECCCCCEEEECCCEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHCCCCCE
TIETHDSGNESISLHIKFALFRRESGFISGIIAVLHDMTEQDKAERERRLFVSNVSHELR
EEEECCCCCCEEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TPLTSVKAYLEALEDGAIEDKETASSFINVSLTETNRMIRMISDLLTLSRMDQDRIVLNK
CCHHHHHHHHHHHHCCCCCCHHHHHHHEEEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHH
EMINLIAFLDYQINRLDQILETESNDLISSNFTLVRKYSEQPIWVEIDTDKIAQVIDNII
HHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCEEEECCCCCEEEEECHHHHHHHHHHHH
GNAIKYSPKGGTITISVEKRESDVLISISDQGMGIPKSDLLKIFDRFYRVDNASRNSKVG
CCCEEECCCCCEEEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
GTGLGLSIVHDIVKIHGGTIFASSEGEGKGTTFSFTLPYSLEAADDWDDGTDEFEFEDNE
CCCCHHHHHHHHHHHCCCEEEECCCCCCCCCEEEEECCEEECCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 9829949; 10878122; 11758928 [H]