Definition Lactococcus lactis subsp. lactis Il1403, complete genome.
Accession NC_002662
Length 2,365,589

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The map label for this gene is noxE

Identifier: 15672373

GI number: 15672373

Start: 396586

End: 397926

Strand: Direct

Name: noxE

Synonym: L196579

Alternate gene names: 15672373

Gene position: 396586-397926 (Clockwise)

Preceding gene: 15672372

Following gene: 15672374

Centisome position: 16.76

GC content: 35.79

Gene sequence:

>1341_bases
ATGAAAATCGTAGTTATCGGTACGAACCACGCAGGCATTGCTACAGCAAATACATTAATTGATCGATATCCAGGCCATGA
GATTGTTATGATTGACCGTAACAGTAATATGAGTTACTTGGGGTGTGGGACAGCTATTTGGGTCGGAAGACAAATTGAAA
AACCAGATGAGCTGTTTTATGCCAAAGCAGAAGATTTTGAAAAAAAGGGAGTAAAGATATTAACAGAAACAGAAGTTTCA
GAAATTGACTTTACTAATAAAATGATTTATGCCAAGTCAAAAACTGGAGAAAAGATTACAGAAAGTTATGATAAACTCGT
TCTGGCAACAGGTTCACGTCCAATTATTCCTAACTTGCCAGGAAAAGATCTTAAAGGCATTCATTTTTTAAAACTTTTTC
AAGAAGGGCAAGCCATTGACGAAGAGTTTGCTAAGAATGATGTGAAACGGATTGCTGTGATTGGTGCTGGTTATATTGGG
ACAGAAATTGCTGAAGCTGCCAAACGTCGTGGAAAAGAAGTCCTACTTTTTGATGCAGAAAGTACTTCACTTGCTTCATA
TTATGATGAAGAGTTTGCTAAAGGGATGGATGAAAATCTTGCCCAACATGGAATTGAACTCCATTTTGGGGAATTAGCTC
AAGAGTTTAAGGCAAATGAAAAAGGTCATGTATCACAGATTGTAACTAATAAATCAACTTATGATGTTGACCTCGTTATT
AATTGTATTGGCTTTACAGCCAATAGTGCATTGGCTGGTGAACATTTAGAAACCTTTAAAAATGGAGCAATCAAAGTGGA
TAAACATCAACAAAGTAGTGACCCAGATGTTTCTGCTGTAGGAGATGTTGCCACAATCTATTCTAATGCTTTACAAGACT
TCACCTACATTGCCCTTGCCTCAAACGCTGTTCGCTCAGGGATTGTTGCTGGTCATAATATTGGAGGAAAATCAATAGAG
TCTGTTGGTGTACAAGGTTCTAATGGAATCTCTATTTTTGGTTACAATATGACTTCTACGGGCTTGTCGGTTAAAGCTGC
GAAAAAAATCGGCCTAGAAGTTTCATTTAGTGATTTTGAAGATAAGCAAAAAGCATGGTTCCTTCATGAAAATAATGATA
GTGTGAAAATTCGTATCGTTTATGAAACAAAAAATCGCAGAATTATTGGTGCTCAACTTGCTAGCAAGAGTGAAATAATT
GCAGGAAATATTAATATGTTTAGTTTAGCTATTCAAGAAAAGAAAACGATTGATGAATTAGCCTTACTTGATTTATTCTT
CTTACCACACTTCAATAGTCCATATAATTACATGACTGTTGCAGCTTTAAATGCAAAATAA

Upstream 100 bases:

>100_bases
TTTTCACAAAGTTCACAAGCGCTTACAAAAGAAAATAGAAGGACTTATGCTAAACTGAATAATGTAAAAAGAATTTTACA
TTTAAAGGAGAATTATTAGC

Downstream 100 bases:

>100_bases
ACCATAAAAAATCTATCAATTGATAGATTTTTTATTTTTTTGTGACAAATGTCCTAACTTTACGTATAAAAAGTTAGGAG
GATTTTATTATGAATAAAAC

Product: NADH oxidase

Products: NA

Alternate protein names: NOXase [H]

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MKIVVIGTNHAGIATANTLIDRYPGHEIVMIDRNSNMSYLGCGTAIWVGRQIEKPDELFYAKAEDFEKKGVKILTETEVS
EIDFTNKMIYAKSKTGEKITESYDKLVLATGSRPIIPNLPGKDLKGIHFLKLFQEGQAIDEEFAKNDVKRIAVIGAGYIG
TEIAEAAKRRGKEVLLFDAESTSLASYYDEEFAKGMDENLAQHGIELHFGELAQEFKANEKGHVSQIVTNKSTYDVDLVI
NCIGFTANSALAGEHLETFKNGAIKVDKHQQSSDPDVSAVGDVATIYSNALQDFTYIALASNAVRSGIVAGHNIGGKSIE
SVGVQGSNGISIFGYNMTSTGLSVKAAKKIGLEVSFSDFEDKQKAWFLHENNDSVKIRIVYETKNRRIIGAQLASKSEII
AGNINMFSLAIQEKKTIDELALLDLFFLPHFNSPYNYMTVAALNAK

Sequences:

>Translated_446_residues
MKIVVIGTNHAGIATANTLIDRYPGHEIVMIDRNSNMSYLGCGTAIWVGRQIEKPDELFYAKAEDFEKKGVKILTETEVS
EIDFTNKMIYAKSKTGEKITESYDKLVLATGSRPIIPNLPGKDLKGIHFLKLFQEGQAIDEEFAKNDVKRIAVIGAGYIG
TEIAEAAKRRGKEVLLFDAESTSLASYYDEEFAKGMDENLAQHGIELHFGELAQEFKANEKGHVSQIVTNKSTYDVDLVI
NCIGFTANSALAGEHLETFKNGAIKVDKHQQSSDPDVSAVGDVATIYSNALQDFTYIALASNAVRSGIVAGHNIGGKSIE
SVGVQGSNGISIFGYNMTSTGLSVKAAKKIGLEVSFSDFEDKQKAWFLHENNDSVKIRIVYETKNRRIIGAQLASKSEII
AGNINMFSLAIQEKKTIDELALLDLFFLPHFNSPYNYMTVAALNAK
>Mature_446_residues
MKIVVIGTNHAGIATANTLIDRYPGHEIVMIDRNSNMSYLGCGTAIWVGRQIEKPDELFYAKAEDFEKKGVKILTETEVS
EIDFTNKMIYAKSKTGEKITESYDKLVLATGSRPIIPNLPGKDLKGIHFLKLFQEGQAIDEEFAKNDVKRIAVIGAGYIG
TEIAEAAKRRGKEVLLFDAESTSLASYYDEEFAKGMDENLAQHGIELHFGELAQEFKANEKGHVSQIVTNKSTYDVDLVI
NCIGFTANSALAGEHLETFKNGAIKVDKHQQSSDPDVSAVGDVATIYSNALQDFTYIALASNAVRSGIVAGHNIGGKSIE
SVGVQGSNGISIFGYNMTSTGLSVKAAKKIGLEVSFSDFEDKQKAWFLHENNDSVKIRIVYETKNRRIIGAQLASKSEII
AGNINMFSLAIQEKKTIDELALLDLFFLPHFNSPYNYMTVAALNAK

Specific function: Catalyzes the four-electron reduction of molecular oxygen to water. Active on beta-NADH, but not on alpha-NADH, beta- NADPH or alpha-NADPH. Under aerobic conditions, oxygen acts as the electron acceptor. Under anaerobic conditions, DCIP and MB can replace

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI21389617, Length=286, Percent_Identity=23.7762237762238, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI226437568, Length=286, Percent_Identity=23.7762237762238, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI65787454, Length=286, Percent_Identity=23.7762237762238, Blast_Score=76, Evalue=7e-14,
Organism=Escherichia coli, GI1789065, Length=267, Percent_Identity=28.8389513108614, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1789765, Length=235, Percent_Identity=27.6595744680851, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1789915, Length=194, Percent_Identity=29.3814432989691, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17559934, Length=222, Percent_Identity=26.5765765765766, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24639257, Length=372, Percent_Identity=22.3118279569892, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.6.99.3 [H]

Molecular weight: Translated: 48901; Mature: 48901

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIVVIGTNHAGIATANTLIDRYPGHEIVMIDRNSNMSYLGCGTAIWVGRQIEKPDELFY
CEEEEEECCCCCCCHHHHHHHCCCCCEEEEEECCCCCEEEECCEEEEECCCCCCCHHHEE
AKAEDFEKKGVKILTETEVSEIDFTNKMIYAKSKTGEKITESYDKLVLATGSRPIIPNLP
ECCHHHHHCCCEEEEECCCCCCCCCCEEEEEECCCCHHHHHHHCEEEEEECCCCCCCCCC
GKDLKGIHFLKLFQEGQAIDEEFAKNDVKRIAVIGAGYIGTEIAEAAKRRGKEVLLFDAE
CCCCCCHHHHHHHHCCCHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHCCCEEEEEECC
STSLASYYDEEFAKGMDENLAQHGIELHFGELAQEFKANEKGHVSQIVTNKSTYDVDLVI
CCHHHHHHHHHHHCCHHHHHHHCCCEEEHHHHHHHHHCCCCCCHHHHEECCCCEEEEEEE
NCIGFTANSALAGEHLETFKNGAIKVDKHQQSSDPDVSAVGDVATIYSNALQDFTYIALA
EEECCCCCCCCCHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEEH
SNAVRSGIVAGHNIGGKSIESVGVQGSNGISIFGYNMTSTGLSVKAAKKIGLEVSFSDFE
HHHHHHCCEECCCCCCCCHHHCCCCCCCCEEEEEECCCCCCCEEEEHHHCCEEEEECCCC
DKQKAWFLHENNDSVKIRIVYETKNRRIIGAQLASKSEIIAGNINMFSLAIQEKKTIDEL
CCCEEEEEEECCCEEEEEEEEECCCCEEEEEECCCCCCEEECCCEEEEEEEHHHHHHHHH
ALLDLFFLPHFNSPYNYMTVAALNAK
HHHHHHHCCCCCCCCCEEEEEEECCC
>Mature Secondary Structure
MKIVVIGTNHAGIATANTLIDRYPGHEIVMIDRNSNMSYLGCGTAIWVGRQIEKPDELFY
CEEEEEECCCCCCCHHHHHHHCCCCCEEEEEECCCCCEEEECCEEEEECCCCCCCHHHEE
AKAEDFEKKGVKILTETEVSEIDFTNKMIYAKSKTGEKITESYDKLVLATGSRPIIPNLP
ECCHHHHHCCCEEEEECCCCCCCCCCEEEEEECCCCHHHHHHHCEEEEEECCCCCCCCCC
GKDLKGIHFLKLFQEGQAIDEEFAKNDVKRIAVIGAGYIGTEIAEAAKRRGKEVLLFDAE
CCCCCCHHHHHHHHCCCHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHCCCEEEEEECC
STSLASYYDEEFAKGMDENLAQHGIELHFGELAQEFKANEKGHVSQIVTNKSTYDVDLVI
CCHHHHHHHHHHHCCHHHHHHHCCCEEEHHHHHHHHHCCCCCCHHHHEECCCCEEEEEEE
NCIGFTANSALAGEHLETFKNGAIKVDKHQQSSDPDVSAVGDVATIYSNALQDFTYIALA
EEECCCCCCCCCHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEEH
SNAVRSGIVAGHNIGGKSIESVGVQGSNGISIFGYNMTSTGLSVKAAKKIGLEVSFSDFE
HHHHHHCCEECCCCCCCCHHHCCCCCCCCEEEEEECCCCCCCEEEEHHHCCEEEEECCCC
DKQKAWFLHENNDSVKIRIVYETKNRRIIGAQLASKSEIIAGNINMFSLAIQEKKTIDEL
CCCEEEEEEECCCEEEEEEEEECCCCEEEEEECCCCCCEEECCCEEEEEEEHHHHHHHHH
ALLDLFFLPHFNSPYNYMTVAALNAK
HHHHHHHCCCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11932446 [H]