Definition Lactococcus lactis subsp. lactis Il1403, complete genome.
Accession NC_002662
Length 2,365,589

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The map label for this gene is ppiA

Identifier: 15672347

GI number: 15672347

Start: 368474

End: 369304

Strand: Reverse

Name: ppiA

Synonym: L168484

Alternate gene names: 15672347

Gene position: 369304-368474 (Counterclockwise)

Preceding gene: 15672355

Following gene: 15672342

Centisome position: 15.61

GC content: 34.66

Gene sequence:

>831_bases
ATGAATACGAATAAAAAAAATAATACAATTCTTTTTACAATCTTTGGGATTGTCTTAGTTATTGTCGTTGGACTCCTTGT
TTTCTTTGCAAATCGTCCAAAAACAACTGATAATACAGCAAGTAGTACAAGCACTTCTTCAAGCCAAAAAGTTGATTATC
CAACAAATTATAAATTACATGATGCAGTAAAAAATTCTACAACTGCCCTTAATGATTTGACTTTGCCACAACTTTCTACA
ACTGTTGCTGAGGATGAAGCTGAGGTCGAAATTAAAACGACTGCTGGAAATATCAATATTAAACTTTTCCCTAAATTGGC
CCCTAATGCGGTTCAAAATTTCCTTGTTCTTGCCAAAAATGGTTACTACAAAAATAATGAATTCTTCCGTGTCATCAAAG
ATTTCATGATTCAATCTGGTGACCCTTCTAATCAAGGAACTGGTACTGCTTCAATTTTTGGTGGGAAAACATTTGATACT
GAAATTTCTAATCAACTGTACAATATCCGCGGCGCACTTGCTTTAGCAAATACTGGCCAAGCAAGCTCTAGCAGTTCACA
ATTTTTCATTGTGCAAAATTCCCAAGATATGACCAGTCAAATTCAAGACAAGACTAAATATCCTCAAAAAATAATTGATG
CTTATAAAAAAGGGGGATACCCAAGTTTAGACGGAAGTTACACTGTCTTTGGTCAAGTTATTTCAGGAATGGATGTCGTT
GATAAAATCGCGAAAGCCGAGGTTACATCAAGTGGTTCTGGCGAAGCTTCATCTCCTGTTGACCCTGTAAAAATTAAATC
TGTTAAAATTCTTAAAAACTGGAAATTTTAA

Upstream 100 bases:

>100_bases
CTTTCGTGATTTTTCTATATTCTATACCTTTTTTTTAGAAATTGCAAGAATTAATTTGATAAAAATTTATAATTACTCAT
TTTTATGTTAAAATATTCCT

Downstream 100 bases:

>100_bases
TAAATAAAAAGTTACTGACAGAAAATCTGTCAGTAACTTTTTTATTTCAATAAGTTTTTCATATCTTCTGGCATGTCTAA
TTCAACATGAACCATTTCGT

Product: peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MNTNKKNNTILFTIFGIVLVIVVGLLVFFANRPKTTDNTASSTSTSSSQKVDYPTNYKLHDAVKNSTTALNDLTLPQLST
TVAEDEAEVEIKTTAGNINIKLFPKLAPNAVQNFLVLAKNGYYKNNEFFRVIKDFMIQSGDPSNQGTGTASIFGGKTFDT
EISNQLYNIRGALALANTGQASSSSSQFFIVQNSQDMTSQIQDKTKYPQKIIDAYKKGGYPSLDGSYTVFGQVISGMDVV
DKIAKAEVTSSGSGEASSPVDPVKIKSVKILKNWKF

Sequences:

>Translated_276_residues
MNTNKKNNTILFTIFGIVLVIVVGLLVFFANRPKTTDNTASSTSTSSSQKVDYPTNYKLHDAVKNSTTALNDLTLPQLST
TVAEDEAEVEIKTTAGNINIKLFPKLAPNAVQNFLVLAKNGYYKNNEFFRVIKDFMIQSGDPSNQGTGTASIFGGKTFDT
EISNQLYNIRGALALANTGQASSSSSQFFIVQNSQDMTSQIQDKTKYPQKIIDAYKKGGYPSLDGSYTVFGQVISGMDVV
DKIAKAEVTSSGSGEASSPVDPVKIKSVKILKNWKF
>Mature_276_residues
MNTNKKNNTILFTIFGIVLVIVVGLLVFFANRPKTTDNTASSTSTSSSQKVDYPTNYKLHDAVKNSTTALNDLTLPQLST
TVAEDEAEVEIKTTAGNINIKLFPKLAPNAVQNFLVLAKNGYYKNNEFFRVIKDFMIQSGDPSNQGTGTASIFGGKTFDT
EISNQLYNIRGALALANTGQASSSSSQFFIVQNSQDMTSQIQDKTKYPQKIIDAYKKGGYPSLDGSYTVFGQVISGMDVV
DKIAKAEVTSSGSGEASSPVDPVKIKSVKILKNWKF

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI24308049, Length=159, Percent_Identity=39.622641509434, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI19557636, Length=186, Percent_Identity=34.9462365591398, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI7706339, Length=178, Percent_Identity=37.0786516853933, Blast_Score=104, Evalue=8e-23,
Organism=Homo sapiens, GI64276486, Length=184, Percent_Identity=34.2391304347826, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI4505991, Length=153, Percent_Identity=38.562091503268, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI42560244, Length=189, Percent_Identity=33.8624338624339, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI4826932, Length=165, Percent_Identity=35.1515151515151, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI4758950, Length=152, Percent_Identity=37.5, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI20911035, Length=160, Percent_Identity=31.25, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI45439316, Length=160, Percent_Identity=33.75, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI22547215, Length=160, Percent_Identity=33.75, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI22547212, Length=160, Percent_Identity=33.75, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI7657473, Length=160, Percent_Identity=33.75, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI5454154, Length=157, Percent_Identity=35.031847133758, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI303305009, Length=167, Percent_Identity=32.9341317365269, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI5031987, Length=169, Percent_Identity=33.1360946745562, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI150418007, Length=152, Percent_Identity=34.8684210526316, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1789763, Length=193, Percent_Identity=34.7150259067358, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1786736, Length=184, Percent_Identity=34.7826086956522, Blast_Score=85, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI71980594, Length=185, Percent_Identity=35.1351351351351, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71980590, Length=160, Percent_Identity=36.875, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71997782, Length=186, Percent_Identity=34.4086021505376, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17506311, Length=184, Percent_Identity=34.7826086956522, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17532641, Length=161, Percent_Identity=35.4037267080745, Blast_Score=95, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17539496, Length=160, Percent_Identity=37.5, Blast_Score=94, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17506307, Length=156, Percent_Identity=37.8205128205128, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17552780, Length=174, Percent_Identity=35.632183908046, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17565860, Length=184, Percent_Identity=32.0652173913043, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17539498, Length=154, Percent_Identity=31.8181818181818, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17532643, Length=158, Percent_Identity=35.4430379746835, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI32563659, Length=162, Percent_Identity=29.6296296296296, Blast_Score=71, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6320359, Length=173, Percent_Identity=33.5260115606936, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323562, Length=176, Percent_Identity=32.3863636363636, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6321848, Length=177, Percent_Identity=31.638418079096, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI17986117, Length=184, Percent_Identity=35.8695652173913, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI19922376, Length=185, Percent_Identity=31.3513513513514, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24652460, Length=161, Percent_Identity=35.4037267080745, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21357249, Length=104, Percent_Identity=43.2692307692308, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI19922912, Length=182, Percent_Identity=36.2637362637363, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI20130249, Length=153, Percent_Identity=37.9084967320261, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17647301, Length=182, Percent_Identity=36.2637362637363, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24664125, Length=175, Percent_Identity=33.1428571428571, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21357783, Length=175, Percent_Identity=33.1428571428571, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24650807, Length=160, Percent_Identity=34.375, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21355677, Length=168, Percent_Identity=30.952380952381, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 29975; Mature: 29975

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTNKKNNTILFTIFGIVLVIVVGLLVFFANRPKTTDNTASSTSTSSSQKVDYPTNYKLH
CCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHH
DAVKNSTTALNDLTLPQLSTTVAEDEAEVEIKTTAGNINIKLFPKLAPNAVQNFLVLAKN
HHHCCCCHHHCCCCCCHHHHHHCCCCCEEEEEEECCEEEEEEECCCCHHHHHHEEEEECC
GYYKNNEFFRVIKDFMIQSGDPSNQGTGTASIFGGKTFDTEISNQLYNIRGALALANTGQ
CCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHEEEEEECCCC
ASSSSSQFFIVQNSQDMTSQIQDKTKYPQKIIDAYKKGGYPSLDGSYTVFGQVISGMDVV
CCCCCCEEEEEECCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHHHHHHHCCHHHH
DKIAKAEVTSSGSGEASSPVDPVKIKSVKILKNWKF
HHHHHHHHCCCCCCCCCCCCCCEEEEEEEEEECCCC
>Mature Secondary Structure
MNTNKKNNTILFTIFGIVLVIVVGLLVFFANRPKTTDNTASSTSTSSSQKVDYPTNYKLH
CCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHH
DAVKNSTTALNDLTLPQLSTTVAEDEAEVEIKTTAGNINIKLFPKLAPNAVQNFLVLAKN
HHHCCCCHHHCCCCCCHHHHHHCCCCCEEEEEEECCEEEEEEECCCCHHHHHHEEEEECC
GYYKNNEFFRVIKDFMIQSGDPSNQGTGTASIFGGKTFDTEISNQLYNIRGALALANTGQ
CCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHEEEEEECCCC
ASSSSSQFFIVQNSQDMTSQIQDKTKYPQKIIDAYKKGGYPSLDGSYTVFGQVISGMDVV
CCCCCCEEEEEECCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHHHHHHHCCHHHH
DKIAKAEVTSSGSGEASSPVDPVKIKSVKILKNWKF
HHHHHHHHCCCCCCCCCCCCCCEEEEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA