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The map label for this gene is lysS

Identifier: 15672355

GI number: 15672355

Start: 375784

End: 377268

Strand: Reverse

Name: lysS

Synonym: L0347

Alternate gene names: 15672355

Gene position: 377268-375784 (Counterclockwise)

Preceding gene: 15672356

Following gene: 15672347

Centisome position: 15.95

GC content: 38.86

Gene sequence:

>1485_bases
TTGGCTGAAATCGAAGAACTTAATGACCAAATGAAAGTCCGCCGTGAAAAAATGGAAAACCTGCGCGAAGCGGGAATTGA
CCCATTTGGACATAAATTTACACGTACGCACAACTCACAAGAACTACACGAAGCTTATGACGAAAAGACGAAAGAAGAAT
TGCATGAACTTGCGCTTTCAGGAATTGTCGCTGGTCGTTTGATGACTAAACGTGGTAAAGGTAAAGTCGGTTTCGCCCAT
CTTCAAGACCGCGAAGGCCAAATTCAACTTTATGTTCGTAAAGATGAAGTCGGCGAAGAAAATTATGAAATTTTCAAAAA
AGCTGACCTCGGAGATTTCCTTGGTGTTGAAGGCGAAATCATGAAAACTGACATGGGTGAATTGTCAATTAAAGCAAAAA
AATTGACTTTCCTCTCAAAAGCGCTTCGTCCTTTGCCTGAAAAATTCCATGGTTTGACTGACACTGAAACACGTTATCGT
AAACGTTATTTGGATTTGATTTCAAATAAAGAAAGCTTCAATCGTTTTGTCACTCGTTCTAAAATTATCAGTGAAATCCG
TCGTTATATGGATGGTCGTGGATATCTTGAAGTTGAAACTCCAGTACTTAACAATGAAGCCGGTGGTGCTGCTGCTCGTC
CATTCTACACACATCATAACAGTCTTGATATTGATATGGCGCTTCGTATTGCAACTGAATTACACTTGAAACGTTTGATT
GTTGGTGGAATGGAAAAAGTTTATGAACTTGGCCGTGTCTTCCGTAACGAAGGAATGGATATGACTCATAATCCAGAATT
CACAACAATGGAATCTTATGAAGCTTATGCTGATTTTGAAGATATCATGGATTTGACAGAAGGAATCTTCCAACATGTTG
CTAAAACAGTGGTTGGTCAAGATGTTCTTGAATACGATGGTAAAGAAATTAATGTTGGCGGAAAATTCAAACGTGTTCAC
ATGGTTGATGCCATCAAGGAAGTTGCTGGAGTTGATTTCTGGCCTGAGATGACTTTTGAAGAAGCAACAGCTCTTGCAAA
AGAACATGATATTCATGTTGAAAAACATTTCACTTCTGTTGGTCATATCATTAACGAATTCTTTGAAAAATATGTTGAAG
AAACTTTGATTCAACCTACTTTCGTTTTTGGTCATCCAAAAGAAATTTCACCACTTGCTAAAATGAATGAAAAAGACCCA
CGTTTTACTGACCGTTTTGAACTTTTCATCAACGGTAAAGAATACGCCAATGCTTTCAGCGAATTGAATGACCCAATTGA
CCAATTGGAACGTTTTGAAGCTCAAGCTAAAGCTAAAGAACTTGGAGATGATGAAGCAACTGGTGTCGATTACGATTATG
TTGAAGCACTCGAACACGGTATGCCACCAACAGGTGGACTCGGTATCGGGATTGATCGCTTAGTGATGCTCTTTACTGGC
ACAACTTCAATCCGTGACGTTTTGCTTTTCCCAACTATGAAATAA

Upstream 100 bases:

>100_bases
TCAAGCCTATGCTTAAAGCGTTTACTGACAAAAAAATTTCTGTTAATTTTTTGAAAATATGTTAAAATAGAGAGAATAAA
AAATTACAAGGAGTACTATT

Downstream 100 bases:

>100_bases
AAAATAAAAACCGCTTTTTGATGTGCACCCCAAAAGTTAGACTTTTTATCCAAGCAGAAATACTTGGATTTTTTTAATTG
TTTTGGTAATTCAAGCGAAA

Product: lysyl-tRNA synthetase

Products: NA

Alternate protein names: Lysine--tRNA ligase; LysRS

Number of amino acids: Translated: 494; Mature: 493

Protein sequence:

>494_residues
MAEIEELNDQMKVRREKMENLREAGIDPFGHKFTRTHNSQELHEAYDEKTKEELHELALSGIVAGRLMTKRGKGKVGFAH
LQDREGQIQLYVRKDEVGEENYEIFKKADLGDFLGVEGEIMKTDMGELSIKAKKLTFLSKALRPLPEKFHGLTDTETRYR
KRYLDLISNKESFNRFVTRSKIISEIRRYMDGRGYLEVETPVLNNEAGGAAARPFYTHHNSLDIDMALRIATELHLKRLI
VGGMEKVYELGRVFRNEGMDMTHNPEFTTMESYEAYADFEDIMDLTEGIFQHVAKTVVGQDVLEYDGKEINVGGKFKRVH
MVDAIKEVAGVDFWPEMTFEEATALAKEHDIHVEKHFTSVGHIINEFFEKYVEETLIQPTFVFGHPKEISPLAKMNEKDP
RFTDRFELFINGKEYANAFSELNDPIDQLERFEAQAKAKELGDDEATGVDYDYVEALEHGMPPTGGLGIGIDRLVMLFTG
TTSIRDVLLFPTMK

Sequences:

>Translated_494_residues
MAEIEELNDQMKVRREKMENLREAGIDPFGHKFTRTHNSQELHEAYDEKTKEELHELALSGIVAGRLMTKRGKGKVGFAH
LQDREGQIQLYVRKDEVGEENYEIFKKADLGDFLGVEGEIMKTDMGELSIKAKKLTFLSKALRPLPEKFHGLTDTETRYR
KRYLDLISNKESFNRFVTRSKIISEIRRYMDGRGYLEVETPVLNNEAGGAAARPFYTHHNSLDIDMALRIATELHLKRLI
VGGMEKVYELGRVFRNEGMDMTHNPEFTTMESYEAYADFEDIMDLTEGIFQHVAKTVVGQDVLEYDGKEINVGGKFKRVH
MVDAIKEVAGVDFWPEMTFEEATALAKEHDIHVEKHFTSVGHIINEFFEKYVEETLIQPTFVFGHPKEISPLAKMNEKDP
RFTDRFELFINGKEYANAFSELNDPIDQLERFEAQAKAKELGDDEATGVDYDYVEALEHGMPPTGGLGIGIDRLVMLFTG
TTSIRDVLLFPTMK
>Mature_493_residues
AEIEELNDQMKVRREKMENLREAGIDPFGHKFTRTHNSQELHEAYDEKTKEELHELALSGIVAGRLMTKRGKGKVGFAHL
QDREGQIQLYVRKDEVGEENYEIFKKADLGDFLGVEGEIMKTDMGELSIKAKKLTFLSKALRPLPEKFHGLTDTETRYRK
RYLDLISNKESFNRFVTRSKIISEIRRYMDGRGYLEVETPVLNNEAGGAAARPFYTHHNSLDIDMALRIATELHLKRLIV
GGMEKVYELGRVFRNEGMDMTHNPEFTTMESYEAYADFEDIMDLTEGIFQHVAKTVVGQDVLEYDGKEINVGGKFKRVHM
VDAIKEVAGVDFWPEMTFEEATALAKEHDIHVEKHFTSVGHIINEFFEKYVEETLIQPTFVFGHPKEISPLAKMNEKDPR
FTDRFELFINGKEYANAFSELNDPIDQLERFEAQAKAKELGDDEATGVDYDYVEALEHGMPPTGGLGIGIDRLVMLFTGT
TSIRDVLLFPTMK

Specific function: Unknown

COG id: COG1190

COG function: function code J; Lysyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI194272210, Length=503, Percent_Identity=41.7495029821074, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI5031815, Length=503, Percent_Identity=41.7495029821074, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI45439306, Length=458, Percent_Identity=21.8340611353712, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI40789249, Length=279, Percent_Identity=25.8064516129032, Blast_Score=81, Evalue=3e-15,
Organism=Escherichia coli, GI1789256, Length=498, Percent_Identity=53.8152610441767, Blast_Score=523, Evalue=1e-150,
Organism=Escherichia coli, GI1790571, Length=496, Percent_Identity=52.0161290322581, Blast_Score=506, Evalue=1e-145,
Organism=Escherichia coli, GI87082379, Length=331, Percent_Identity=30.8157099697885, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1788173, Length=254, Percent_Identity=27.5590551181102, Blast_Score=91, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17535927, Length=502, Percent_Identity=43.6254980079681, Blast_Score=395, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17535925, Length=502, Percent_Identity=43.6254980079681, Blast_Score=395, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI71994340, Length=501, Percent_Identity=43.7125748502994, Blast_Score=394, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI32566633, Length=173, Percent_Identity=28.3236994219653, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6320242, Length=506, Percent_Identity=44.4664031620553, Blast_Score=398, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6324256, Length=514, Percent_Identity=33.4630350194552, Blast_Score=231, Evalue=3e-61,
Organism=Saccharomyces cerevisiae, GI6323011, Length=464, Percent_Identity=23.7068965517241, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24640851, Length=514, Percent_Identity=42.6070038910506, Blast_Score=387, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24640849, Length=514, Percent_Identity=42.6070038910506, Blast_Score=386, Evalue=1e-107,
Organism=Drosophila melanogaster, GI17136276, Length=465, Percent_Identity=23.6559139784946, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24584738, Length=280, Percent_Identity=26.7857142857143, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: 1200 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYK_LACLA (Q9CII7)

Other databases:

- EMBL:   AE005176
- PIR:   E86671
- RefSeq:   NP_266529.1
- ProteinModelPortal:   Q9CII7
- SMR:   Q9CII7
- GeneID:   1113984
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L0347
- NMPDR:   fig|272623.1.peg.381
- HOGENOM:   HBG631383
- OMA:   RNEGMDH
- ProtClustDB:   PRK00484
- BioCyc:   LLAC272623:L0347-MONOMER
- BRENDA:   6.1.1.6
- GO:   GO:0005737
- HAMAP:   MF_00252
- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR002313
- InterPro:   IPR018149
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365
- Gene3D:   G3DSA:2.40.50.140
- PANTHER:   PTHR22594
- PANTHER:   PTHR22594:SF4
- PRINTS:   PR00982
- TIGRFAMs:   TIGR00499

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti; SSF50249 Nucleic_acid_OB

EC number: =6.1.1.6

Molecular weight: Translated: 56616; Mature: 56485

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEIEELNDQMKVRREKMENLREAGIDPFGHKFTRTHNSQELHEAYDEKTKEELHELALS
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
GIVAGRLMTKRGKGKVGFAHLQDREGQIQLYVRKDEVGEENYEIFKKADLGDFLGVEGEI
HHHHHHHHHCCCCCCEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHCCCHHHCCCCCEE
MKTDMGELSIKAKKLTFLSKALRPLPEKFHGLTDTETRYRKRYLDLISNKESFNRFVTRS
EECCCCHHHHHHHHHHHHHHHHHHCHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHH
KIISEIRRYMDGRGYLEVETPVLNNEAGGAAARPFYTHHNSLDIDMALRIATELHLKRLI
HHHHHHHHHHCCCCEEEEECCEECCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHH
VGGMEKVYELGRVFRNEGMDMTHNPEFTTMESYEAYADFEDIMDLTEGIFQHVAKTVVGQ
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
DVLEYDGKEINVGGKFKRVHMVDAIKEVAGVDFWPEMTFEEATALAKEHDIHVEKHFTSV
HHHHCCCCEECCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHH
GHIINEFFEKYVEETLIQPTFVFGHPKEISPLAKMNEKDPRFTDRFELFINGKEYANAFS
HHHHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHCCCCCCCCCCEEEEEECCHHHHHHHH
ELNDPIDQLERFEAQAKAKELGDDEATGVDYDYVEALEHGMPPTGGLGIGIDRLVMLFTG
HHCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHCC
TTSIRDVLLFPTMK
CHHHHHHHCCCCCC
>Mature Secondary Structure 
AEIEELNDQMKVRREKMENLREAGIDPFGHKFTRTHNSQELHEAYDEKTKEELHELALS
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
GIVAGRLMTKRGKGKVGFAHLQDREGQIQLYVRKDEVGEENYEIFKKADLGDFLGVEGEI
HHHHHHHHHCCCCCCEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHCCCHHHCCCCCEE
MKTDMGELSIKAKKLTFLSKALRPLPEKFHGLTDTETRYRKRYLDLISNKESFNRFVTRS
EECCCCHHHHHHHHHHHHHHHHHHCHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHH
KIISEIRRYMDGRGYLEVETPVLNNEAGGAAARPFYTHHNSLDIDMALRIATELHLKRLI
HHHHHHHHHHCCCCEEEEECCEECCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHH
VGGMEKVYELGRVFRNEGMDMTHNPEFTTMESYEAYADFEDIMDLTEGIFQHVAKTVVGQ
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
DVLEYDGKEINVGGKFKRVHMVDAIKEVAGVDFWPEMTFEEATALAKEHDIHVEKHFTSV
HHHHCCCCEECCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHH
GHIINEFFEKYVEETLIQPTFVFGHPKEISPLAKMNEKDPRFTDRFELFINGKEYANAFS
HHHHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHCCCCCCCCCCEEEEEECCHHHHHHHH
ELNDPIDQLERFEAQAKAKELGDDEATGVDYDYVEALEHGMPPTGGLGIGIDRLVMLFTG
HHCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHCC
TTSIRDVLLFPTMK
CHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471