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The map label for this gene is mutM

Identifier: 15672335

GI number: 15672335

Start: 357841

End: 358659

Strand: Direct

Name: mutM

Synonym: L0271

Alternate gene names: 15672335

Gene position: 357841-358659 (Clockwise)

Preceding gene: 15672334

Following gene: 15672336

Centisome position: 15.13

GC content: 36.02

Gene sequence:

>819_bases
ATGCCAGAGTTACCAGAAGTTGAAACAGTGAGAAGAGAGCTTGAAAAAAGAATTGTTGGACAAAAAATTGTATCTATAGA
AGCCACTTATCCAAGAATGGTTTTAACTGGTTTTGAGCAATTGAAAAAAGAATTGACAGGAAAAACCATTCATGGCATTT
CACGTCGCGGAAAATATTTAATTTTTGAAATTGGCGAGAAAGATCGTTTGATTTCTCATCTGCGGATGGAAGGAAAATAT
CGACTTGCAAGTCTCAATGTTCCAATGGAAAAACATGACCATTTAGCCCTTAAATTTACTGACGAACAATTAATTTATGC
TGACGTAAGAAAATTTGGGACTTGGGAACTGATTTCTACTGACCAAGTCCTTCCATATTTTTTGAAGAAAAACATTGGTC
CGGAGCCAACTTATGAAACTTTTGATGAACAGATTTTCCGAGAAAAATTGCAGAAATCGACAAAGAAAATTAAACCTTTT
CTACTTGAACAAACATTAGTGGCTGGACTTGGAAATATTTACGTTGATGAAGTGCTCTGGCTAGCAAAGATTCATCCAGA
AAAAGTGGCAAATCAACTGACAGAAAGTTCTATTCATCTTTTACATGATTCTATCATTGAAATTTTGCAAAAAGCAATTA
AATTAGGCGGCTCAAGCATCAGAACTTATAGTGCCTTAGGTTCAACAGGAAAAATGCAGGACGAATTACGAGTGTATGGA
AAAACAGGGGAAAAATGTGTGCGTTGTGGCAATGAAATTCAAAAAATAAAAGTGGCTGGTCGGGGGACCCACTTTTGCCC
ATTCTGTCAGCAAAAATAA

Upstream 100 bases:

>100_bases
TATTTAAATTTAATTTAGAATACAAAAGAAAGTTGTCAGTAAAAAATGAATTAAAATTTACTGACAGACTTGTTAGTAAA
TTTTTTGATGTGAGGGAAAA

Downstream 100 bases:

>100_bases
TGACTTGATTTTTACTGACAGCTTTTAAAAATTAATTTAAAAAACTCAGTGACAAAGTTAATAAAAAAACGTATAGATAG
AATATAGGGGCTTATAAAAA

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM [H]

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MPELPEVETVRRELEKRIVGQKIVSIEATYPRMVLTGFEQLKKELTGKTIHGISRRGKYLIFEIGEKDRLISHLRMEGKY
RLASLNVPMEKHDHLALKFTDEQLIYADVRKFGTWELISTDQVLPYFLKKNIGPEPTYETFDEQIFREKLQKSTKKIKPF
LLEQTLVAGLGNIYVDEVLWLAKIHPEKVANQLTESSIHLLHDSIIEILQKAIKLGGSSIRTYSALGSTGKMQDELRVYG
KTGEKCVRCGNEIQKIKVAGRGTHFCPFCQQK

Sequences:

>Translated_272_residues
MPELPEVETVRRELEKRIVGQKIVSIEATYPRMVLTGFEQLKKELTGKTIHGISRRGKYLIFEIGEKDRLISHLRMEGKY
RLASLNVPMEKHDHLALKFTDEQLIYADVRKFGTWELISTDQVLPYFLKKNIGPEPTYETFDEQIFREKLQKSTKKIKPF
LLEQTLVAGLGNIYVDEVLWLAKIHPEKVANQLTESSIHLLHDSIIEILQKAIKLGGSSIRTYSALGSTGKMQDELRVYG
KTGEKCVRCGNEIQKIKVAGRGTHFCPFCQQK
>Mature_271_residues
PELPEVETVRRELEKRIVGQKIVSIEATYPRMVLTGFEQLKKELTGKTIHGISRRGKYLIFEIGEKDRLISHLRMEGKYR
LASLNVPMEKHDHLALKFTDEQLIYADVRKFGTWELISTDQVLPYFLKKNIGPEPTYETFDEQIFREKLQKSTKKIKPFL
LEQTLVAGLGNIYVDEVLWLAKIHPEKVANQLTESSIHLLHDSIIEILQKAIKLGGSSIRTYSALGSTGKMQDELRVYGK
TGEKCVRCGNEIQKIKVAGRGTHFCPFCQQK

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1790066, Length=273, Percent_Identity=35.8974358974359, Blast_Score=174, Evalue=6e-45,
Organism=Escherichia coli, GI1786932, Length=286, Percent_Identity=22.7272727272727, Blast_Score=86, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =3.2.2.23; =4.2.99.18 [H]

Molecular weight: Translated: 31216; Mature: 31085

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: PS01242 ZF_FPG_1 ; PS51066 ZF_FPG_2 ; PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETVRRELEKRIVGQKIVSIEATYPRMVLTGFEQLKKELTGKTIHGISRRGKYL
CCCCCCHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCEE
IFEIGEKDRLISHLRMEGKYRLASLNVPMEKHDHLALKFTDEQLIYADVRKFGTWELIST
EEEECCHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEECCCHHHHHHHHHCCCEEEECC
DQVLPYFLKKNIGPEPTYETFDEQIFREKLQKSTKKIKPFLLEQTLVAGLGNIYVDEVLW
CHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAKIHPEKVANQLTESSIHLLHDSIIEILQKAIKLGGSSIRTYSALGSTGKMQDELRVYG
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHC
KTGEKCVRCGNEIQKIKVAGRGTHFCPFCQQK
CCHHHHHHCCCHHHEEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
PELPEVETVRRELEKRIVGQKIVSIEATYPRMVLTGFEQLKKELTGKTIHGISRRGKYL
CCCCCHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCEE
IFEIGEKDRLISHLRMEGKYRLASLNVPMEKHDHLALKFTDEQLIYADVRKFGTWELIST
EEEECCHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEECCCHHHHHHHHHCCCEEEECC
DQVLPYFLKKNIGPEPTYETFDEQIFREKLQKSTKKIKPFLLEQTLVAGLGNIYVDEVLW
CHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAKIHPEKVANQLTESSIHLLHDSIIEILQKAIKLGGSSIRTYSALGSTGKMQDELRVYG
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHC
KTGEKCVRCGNEIQKIKVAGRGTHFCPFCQQK
CCHHHHHHCCCHHHEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7704272; 1514816 [H]