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The map label for this gene is pbp2B

Identifier: 15672321

GI number: 15672321

Start: 337709

End: 339874

Strand: Direct

Name: pbp2B

Synonym: L137682

Alternate gene names: 15672321

Gene position: 337709-339874 (Clockwise)

Preceding gene: 15672320

Following gene: 15672322

Centisome position: 14.28

GC content: 36.33

Gene sequence:

>2166_bases
ATGTCAGATAATAAAAGAAAAAATGATAAGCGCAAGCAATCCGATAAGTCTAAAAAATCACATAAAGAAGTAAAAATTTT
AAAAGATCCAACTAAATTAATTCCAAAACGAGTGAACCTCTTATTTTTTGTTATCTTTGTTTTGTTTATGATTTTAATTG
GAAAGCTCTTCAATATGCAGGTATTGAATTCACATTTCTACGCCGAAAAATCAATTAGTGCAGGTGGAGATGTTCAAATT
ATTGAAGGTGCGCCTCGCGGAAATATTTATGATGCAACAGGAAAAGCTTTGGCATCTACAGTTGCGGTACAGGCTGTTGA
ATTTACAAGAAGTCAAAATGCTACTGCTGATGAAATTTATCAGGTAGCCAATAAGTTAGCAACTATTTTATCTAATAACA
TTGATGTTGCTGATTTGACAACGCGTGATAAAAAAGACTATTTCTTGGCTAATTCTAAAAATCTAGAAAAAATAGCTAAT
AGTTTATCTGAAAAGGAAAAGAAAGATAAACATGGTAATGATTTAAGTGGTTCACAAATTTATGATGTCGAATTAAGTAA
AGTTAAAGATAGTGACTTGAATTTTACGGCAGAACAAACTTTTGCCGCAAAATTATTCAAAGAAATGAATAGTACCACTA
CTTTTAACACTACTAAAATTGCTACTGGAAGTATTACAGCAGAGCAACAAGCGACAATTGCCGAACAAGAAGGCGATTTA
CCAGGAATTACAATTGGAACTTCTTGGGACCGTTCATATGCTCAAAATTCTTTGACACCACTTATGGGAACTATTACTTC
ACAAAAATCAGGAATTCCAGCAGAGGATTTGGATGCCTATCTTAAAAAAGGTTATCAACGTAATGACCGTGTGGGAACTG
GGCTTCTTGAAAAGGGATACGAAAGTGAACTTCAAGGAACTCATAGTATTAGTAAGGTTAAATTTGACAAAAATGGTGAT
GTTTCTGGAACAAAAACAATCCAAAAAGGAAAACGTGGGGATGATTTAAAATTAACTATTAACCTAGATTTCCAAAACGG
GGTTAATAATATTGTTAAAACACAATTAGATCAACTGATTGCCCAAGGCTATGGTCAGTATAATAGAGGGGCTTATGCTG
TTGTGTTAAATGTTAAAACGGGGGCAGTCTTAGCTTTATCTGGCTATCAACGAGATCCTAATACAGGAACAATTACGGAA
AATACTTTAGGGACTTTCCAAAGTGTCTTCACACCGGGGTCTGTTGTCCAAATGGGAACATTGACTGCTGCTTGGAATGC
TGGTGTAATTTCTGGAAATGACACTTTAACGGCGCAGTCTATTCAATTTAAAGATTCTAATCCTATCAATGACTGGTGGG
GAGACGCTTCACCAATGGCTTTAACAGCTGTTGAAGCTTTGCAATATTCATCAAATACTTACATGATGCAATTGGCAATG
AGAATGTTAGGTGCTCCTTATACGGCAGCTAATCAATTTTTGGATGATACCAACCGAGTAAAAGTTTATGAGCAGTTTCG
TAAGGCTTTTGCTTCTTATGGTTTAGGGGCATCAACTGGTTTTGATATACCTGGAGAATCAACGGGATATCTCCCTTCAG
CTAAATCTGAAGCGGCTTCTGGGGTCAATGTATTGTATGAATCATTTGGTCAGTATGATAATTATACGCCGCTTCAGTTG
GCGGTTTATGCGGCAACTTTAGGAAATAACGGAACTCGTTTGTCACCACATATTGTTCAAGGAATTTATGAAGGTGGAAC
TGACGGACAGCCTGGCACGCTTATCAAAAATATTACTCCTAAAATCATGGATAAGGTAAATATCACTCCCGATAATATGG
ATGTTCTTCATCAGGGGATGTATGCTGTTGTTCATGGGGCTGGTGGATTGACTACTGGTCGTTCAATGGATTCATCAAAG
GTTTCTATTTCTGGTAAAACAGGGACTTCCGAAAGTACAAAAGTATTGGCAGATGGTAGTCAAGTTATTGTAACAGCTAA
TAATGCAGTGGCCTTTGCTCCTTCTGACAACCCAGAAATTGCTATTGCGGTTGTACTTCCAGATAATACTGAAAGTAATG
CTTCAAGTGGAACAAAAGCAAACCAAAGTATTGTAACGGGAATTACTGATTTGTATTATTCAAATGAGGCTTTTCGTAAA
AATTAA

Upstream 100 bases:

>100_bases
AATCAAAATTGTAAGGAAAAGTTTTCATAAATGTGGTAAAATGTTTAAGTACAAATTTTGAATGTAAAAACTATTTATAA
AACTCATTCTTGGAGTCGAA

Downstream 100 bases:

>100_bases
AAAAAGTTCTCTCTGATAGGAGAGGCTTTTTATTTATAAGTGATTGAGAATTCTATCACCTTTCCTTTTCATTTTCAGTC
TTTTATAGTAAAATTAATAA

Product: penicillin-binding protein 2B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 721; Mature: 720

Protein sequence:

>721_residues
MSDNKRKNDKRKQSDKSKKSHKEVKILKDPTKLIPKRVNLLFFVIFVLFMILIGKLFNMQVLNSHFYAEKSISAGGDVQI
IEGAPRGNIYDATGKALASTVAVQAVEFTRSQNATADEIYQVANKLATILSNNIDVADLTTRDKKDYFLANSKNLEKIAN
SLSEKEKKDKHGNDLSGSQIYDVELSKVKDSDLNFTAEQTFAAKLFKEMNSTTTFNTTKIATGSITAEQQATIAEQEGDL
PGITIGTSWDRSYAQNSLTPLMGTITSQKSGIPAEDLDAYLKKGYQRNDRVGTGLLEKGYESELQGTHSISKVKFDKNGD
VSGTKTIQKGKRGDDLKLTINLDFQNGVNNIVKTQLDQLIAQGYGQYNRGAYAVVLNVKTGAVLALSGYQRDPNTGTITE
NTLGTFQSVFTPGSVVQMGTLTAAWNAGVISGNDTLTAQSIQFKDSNPINDWWGDASPMALTAVEALQYSSNTYMMQLAM
RMLGAPYTAANQFLDDTNRVKVYEQFRKAFASYGLGASTGFDIPGESTGYLPSAKSEAASGVNVLYESFGQYDNYTPLQL
AVYAATLGNNGTRLSPHIVQGIYEGGTDGQPGTLIKNITPKIMDKVNITPDNMDVLHQGMYAVVHGAGGLTTGRSMDSSK
VSISGKTGTSESTKVLADGSQVIVTANNAVAFAPSDNPEIAIAVVLPDNTESNASSGTKANQSIVTGITDLYYSNEAFRK
N

Sequences:

>Translated_721_residues
MSDNKRKNDKRKQSDKSKKSHKEVKILKDPTKLIPKRVNLLFFVIFVLFMILIGKLFNMQVLNSHFYAEKSISAGGDVQI
IEGAPRGNIYDATGKALASTVAVQAVEFTRSQNATADEIYQVANKLATILSNNIDVADLTTRDKKDYFLANSKNLEKIAN
SLSEKEKKDKHGNDLSGSQIYDVELSKVKDSDLNFTAEQTFAAKLFKEMNSTTTFNTTKIATGSITAEQQATIAEQEGDL
PGITIGTSWDRSYAQNSLTPLMGTITSQKSGIPAEDLDAYLKKGYQRNDRVGTGLLEKGYESELQGTHSISKVKFDKNGD
VSGTKTIQKGKRGDDLKLTINLDFQNGVNNIVKTQLDQLIAQGYGQYNRGAYAVVLNVKTGAVLALSGYQRDPNTGTITE
NTLGTFQSVFTPGSVVQMGTLTAAWNAGVISGNDTLTAQSIQFKDSNPINDWWGDASPMALTAVEALQYSSNTYMMQLAM
RMLGAPYTAANQFLDDTNRVKVYEQFRKAFASYGLGASTGFDIPGESTGYLPSAKSEAASGVNVLYESFGQYDNYTPLQL
AVYAATLGNNGTRLSPHIVQGIYEGGTDGQPGTLIKNITPKIMDKVNITPDNMDVLHQGMYAVVHGAGGLTTGRSMDSSK
VSISGKTGTSESTKVLADGSQVIVTANNAVAFAPSDNPEIAIAVVLPDNTESNASSGTKANQSIVTGITDLYYSNEAFRK
N
>Mature_720_residues
SDNKRKNDKRKQSDKSKKSHKEVKILKDPTKLIPKRVNLLFFVIFVLFMILIGKLFNMQVLNSHFYAEKSISAGGDVQII
EGAPRGNIYDATGKALASTVAVQAVEFTRSQNATADEIYQVANKLATILSNNIDVADLTTRDKKDYFLANSKNLEKIANS
LSEKEKKDKHGNDLSGSQIYDVELSKVKDSDLNFTAEQTFAAKLFKEMNSTTTFNTTKIATGSITAEQQATIAEQEGDLP
GITIGTSWDRSYAQNSLTPLMGTITSQKSGIPAEDLDAYLKKGYQRNDRVGTGLLEKGYESELQGTHSISKVKFDKNGDV
SGTKTIQKGKRGDDLKLTINLDFQNGVNNIVKTQLDQLIAQGYGQYNRGAYAVVLNVKTGAVLALSGYQRDPNTGTITEN
TLGTFQSVFTPGSVVQMGTLTAAWNAGVISGNDTLTAQSIQFKDSNPINDWWGDASPMALTAVEALQYSSNTYMMQLAMR
MLGAPYTAANQFLDDTNRVKVYEQFRKAFASYGLGASTGFDIPGESTGYLPSAKSEAASGVNVLYESFGQYDNYTPLQLA
VYAATLGNNGTRLSPHIVQGIYEGGTDGQPGTLIKNITPKIMDKVNITPDNMDVLHQGMYAVVHGAGGLTTGRSMDSSKV
SISGKTGTSESTKVLADGSQVIVTANNAVAFAPSDNPEIAIAVVLPDNTESNASSGTKANQSIVTGITDLYYSNEAFRKN

Specific function: Cell Wall Formation; Pbp-2 Is Responsible For The Determination Of The Rod Shape Of The Cell. Its Synthesize Cross- Linked Peptidoglycan From The Lipid Intermediates. [C]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=543, Percent_Identity=23.9410681399632, Blast_Score=92, Evalue=2e-19,
Organism=Escherichia coli, GI1786272, Length=425, Percent_Identity=27.7647058823529, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 77900; Mature: 77769

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDNKRKNDKRKQSDKSKKSHKEVKILKDPTKLIPKRVNLLFFVIFVLFMILIGKLFNMQ
CCCCCCCCHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLNSHFYAEKSISAGGDVQIIEGAPRGNIYDATGKALASTVAVQAVEFTRSQNATADEIY
HHHHHHHHHCCCCCCCCEEEEECCCCCCEECCCHHHHHHHHHHHHHHHHCCCCCCHHHHH
QVANKLATILSNNIDVADLTTRDKKDYFLANSKNLEKIANSLSEKEKKDKHGNDLSGSQI
HHHHHHHHHHCCCCCEEECCCCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCEE
YDVELSKVKDSDLNFTAEQTFAAKLFKEMNSTTTFNTTKIATGSITAEQQATIAEQEGDL
EEEEHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEECEEEEEECCCCCHHHHHHHHHCCCC
PGITIGTSWDRSYAQNSLTPLMGTITSQKSGIPAEDLDAYLKKGYQRNDRVGTGLLEKGY
CCEEECCCCCHHHHHCCCCHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHCCC
ESELQGTHSISKVKFDKNGDVSGTKTIQKGKRGDDLKLTINLDFQNGVNNIVKTQLDQLI
HHHHCCCCCCEEEEECCCCCCCCHHHHHCCCCCCCEEEEEEEEHHHCHHHHHHHHHHHHH
AQGYGQYNRGAYAVVLNVKTGAVLALSGYQRDPNTGTITENTLGTFQSVFTPGSVVQMGT
HHCCCCCCCCEEEEEEEECCCEEEEEECCCCCCCCCCEECCHHHHHHHHCCCCCEEEECC
LTAAWNAGVISGNDTLTAQSIQFKDSNPINDWWGDASPMALTAVEALQYSSNTYMMQLAM
EEEECCCCEECCCCCEEEEEEEECCCCCCCHHCCCCCCHHHHHHHHHHHCCCHHHHHHHH
RMLGAPYTAANQFLDDTNRVKVYEQFRKAFASYGLGASTGFDIPGESTGYLPSAKSEAAS
HHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHH
GVNVLYESFGQYDNYTPLQLAVYAATLGNNGTRLSPHIVQGIYEGGTDGQPGTLIKNITP
HHHHHHHHHCCCCCCCHHEEEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHCCH
KIMDKVNITPDNMDVLHQGMYAVVHGAGGLTTGRSMDSSKVSISGKTGTSESTKVLADGS
HHHHCCCCCCCCHHHHHCCCEEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCEEEECCC
QVIVTANNAVAFAPSDNPEIAIAVVLPDNTESNASSGTKANQSIVTGITDLYYSNEAFRK
EEEEEECCEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHCC
N
C
>Mature Secondary Structure 
SDNKRKNDKRKQSDKSKKSHKEVKILKDPTKLIPKRVNLLFFVIFVLFMILIGKLFNMQ
CCCCCCCHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLNSHFYAEKSISAGGDVQIIEGAPRGNIYDATGKALASTVAVQAVEFTRSQNATADEIY
HHHHHHHHHCCCCCCCCEEEEECCCCCCEECCCHHHHHHHHHHHHHHHHCCCCCCHHHHH
QVANKLATILSNNIDVADLTTRDKKDYFLANSKNLEKIANSLSEKEKKDKHGNDLSGSQI
HHHHHHHHHHCCCCCEEECCCCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCEE
YDVELSKVKDSDLNFTAEQTFAAKLFKEMNSTTTFNTTKIATGSITAEQQATIAEQEGDL
EEEEHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEECEEEEEECCCCCHHHHHHHHHCCCC
PGITIGTSWDRSYAQNSLTPLMGTITSQKSGIPAEDLDAYLKKGYQRNDRVGTGLLEKGY
CCEEECCCCCHHHHHCCCCHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHCCC
ESELQGTHSISKVKFDKNGDVSGTKTIQKGKRGDDLKLTINLDFQNGVNNIVKTQLDQLI
HHHHCCCCCCEEEEECCCCCCCCHHHHHCCCCCCCEEEEEEEEHHHCHHHHHHHHHHHHH
AQGYGQYNRGAYAVVLNVKTGAVLALSGYQRDPNTGTITENTLGTFQSVFTPGSVVQMGT
HHCCCCCCCCEEEEEEEECCCEEEEEECCCCCCCCCCEECCHHHHHHHHCCCCCEEEECC
LTAAWNAGVISGNDTLTAQSIQFKDSNPINDWWGDASPMALTAVEALQYSSNTYMMQLAM
EEEECCCCEECCCCCEEEEEEEECCCCCCCHHCCCCCCHHHHHHHHHHHCCCHHHHHHHH
RMLGAPYTAANQFLDDTNRVKVYEQFRKAFASYGLGASTGFDIPGESTGYLPSAKSEAAS
HHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHH
GVNVLYESFGQYDNYTPLQLAVYAATLGNNGTRLSPHIVQGIYEGGTDGQPGTLIKNITP
HHHHHHHHHCCCCCCCHHEEEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHCCH
KIMDKVNITPDNMDVLHQGMYAVVHGAGGLTTGRSMDSSKVSISGKTGTSESTKVLADGS
HHHHCCCCCCCCHHHHHCCCEEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCEEEECCC
QVIVTANNAVAFAPSDNPEIAIAVVLPDNTESNASSGTKANQSIVTGITDLYYSNEAFRK
EEEEEECCEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHCC
N
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11463916; 2654541 [H]