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The map label for this gene is napC

Identifier: 15672288

GI number: 15672288

Start: 304960

End: 306153

Strand: Reverse

Name: napC

Synonym: L104969

Alternate gene names: 15672288

Gene position: 306153-304960 (Counterclockwise)

Preceding gene: 15672289

Following gene: 15672280

Centisome position: 12.94

GC content: 40.37

Gene sequence:

>1194_bases
ATGAAAATTAATAAACACGCCCTCACTTTTGGGCTTATCACCACTTTCCTGACAGGACTTGGTTTTACAATCATCTCACC
AGTCGTTCCTTTTATGGTCGCACCTTTTGCTAATGCTCATGACCAAGCACTCATTGTTACTAGTTTAATGGCAATCTATG
CACTATGTACTTTCTTTGCCGCTCCTGCTCTTGGTTCTTTATCAGACCGCTTTGGTCGTAAACCTATCTTACTGATTTCT
TTAGCTGGCTCTGCTCTTGGTTATCTTATCTTTGGCTTAGCTGGTAGTCTCTGGATGCTTTTTCTCGGACGAATCATTGA
TGGTTTAACTGGTGGAAATATCGTGACCCTTTTTGCTTACTTCGCTGATATTACTGATGAAGAAAATCGAACTAAAGTTT
TTGGTTGGACAGCCGCCGCTGTTGGTGTTGGAACAATTTCTGGCCCAACAGTTGGAGGACTTCTAGCTCATTTTGGCAAT
TCAGTTCCCTTTTACTTCGGCGCCCTAATCTCAATCGCCAATCTTCTTTACGGTGCATTCGTAATGAACGAGAGCTTGCC
CGAAACTCATCGCACACGTAATTTTTCCCTTAAACAACTCAATCCTTTCACTCAACTTTTTCAGCTCTTACGCATGAAAA
ATCTCAATCGTCTGCTCTTTGCCGGTATCTTACTTTGGCTACCAAATGGTGCACTCCAAGCAATTATTAGTCAATTTTCA
TTAGATTCTTTTGCTTGGACGCCTGTATTAATTGGTCTAGCCATATCCATCATGGGTTTAATGGATATCTTGACTCAAAT
CTTTATCATGCCAAGACTTCTAAAATTAGCTAATGAAGATAAACTCATCCGTTTGGCACTAGTCTGCGAAATTATTGCTT
ACCTTCTTTTCGCACTTTCTGCTTTTTCTAAAATGTGGCCCTTCTTCATTCTGGCAATGTTTATCTTTGCTTTTGGAGAT
AGTATTTTTGGAACTGCCTTTAACGGTAAACTTTCAAAATCAGCGACTTCTTCCGAACAAGGTAAACTTCAAGGTGGAAG
TCAAGCACTTCAAGCACTTACTCGCGTGATAGGCCCTTTAATTGGTGGACAAATCTATATCAGCCTTGGTCATTTCGCTC
CAGCACTCATGGGATTTATCTTTCTAATTATCGCTCTACTTGTGCTATCAAAAACAAAGTCAGACCAAGAATGA

Upstream 100 bases:

>100_bases
AAAACAAAATTTTGAACCTGCCTGTTGGGCAAAACCACCAATTTTTCTAAATTTCATCGCTTCAACACAGTCGGGCTCAT
ATCTTATGGAGGTTTTACCT

Downstream 100 bases:

>100_bases
ATAAAAAAAATCACCTCAAAAAGGTGATTTTTTATTTATTATAATTTTTCAGAAATTTCTTTGATTGATTTATCAACGTC
AGCCTTTTGGCTATCAATCA

Product: multidrug-efflux transporter

Products: NA

Alternate protein names: TetA(C) [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MKINKHALTFGLITTFLTGLGFTIISPVVPFMVAPFANAHDQALIVTSLMAIYALCTFFAAPALGSLSDRFGRKPILLIS
LAGSALGYLIFGLAGSLWMLFLGRIIDGLTGGNIVTLFAYFADITDEENRTKVFGWTAAAVGVGTISGPTVGGLLAHFGN
SVPFYFGALISIANLLYGAFVMNESLPETHRTRNFSLKQLNPFTQLFQLLRMKNLNRLLFAGILLWLPNGALQAIISQFS
LDSFAWTPVLIGLAISIMGLMDILTQIFIMPRLLKLANEDKLIRLALVCEIIAYLLFALSAFSKMWPFFILAMFIFAFGD
SIFGTAFNGKLSKSATSSEQGKLQGGSQALQALTRVIGPLIGGQIYISLGHFAPALMGFIFLIIALLVLSKTKSDQE

Sequences:

>Translated_397_residues
MKINKHALTFGLITTFLTGLGFTIISPVVPFMVAPFANAHDQALIVTSLMAIYALCTFFAAPALGSLSDRFGRKPILLIS
LAGSALGYLIFGLAGSLWMLFLGRIIDGLTGGNIVTLFAYFADITDEENRTKVFGWTAAAVGVGTISGPTVGGLLAHFGN
SVPFYFGALISIANLLYGAFVMNESLPETHRTRNFSLKQLNPFTQLFQLLRMKNLNRLLFAGILLWLPNGALQAIISQFS
LDSFAWTPVLIGLAISIMGLMDILTQIFIMPRLLKLANEDKLIRLALVCEIIAYLLFALSAFSKMWPFFILAMFIFAFGD
SIFGTAFNGKLSKSATSSEQGKLQGGSQALQALTRVIGPLIGGQIYISLGHFAPALMGFIFLIIALLVLSKTKSDQE
>Mature_397_residues
MKINKHALTFGLITTFLTGLGFTIISPVVPFMVAPFANAHDQALIVTSLMAIYALCTFFAAPALGSLSDRFGRKPILLIS
LAGSALGYLIFGLAGSLWMLFLGRIIDGLTGGNIVTLFAYFADITDEENRTKVFGWTAAAVGVGTISGPTVGGLLAHFGN
SVPFYFGALISIANLLYGAFVMNESLPETHRTRNFSLKQLNPFTQLFQLLRMKNLNRLLFAGILLWLPNGALQAIISQFS
LDSFAWTPVLIGLAISIMGLMDILTQIFIMPRLLKLANEDKLIRLALVCEIIAYLLFALSAFSKMWPFFILAMFIFAFGD
SIFGTAFNGKLSKSATSSEQGKLQGGSQALQALTRVIGPLIGGQIYISLGHFAPALMGFIFLIIALLVLSKTKSDQE

Specific function: Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Homo sapiens, GI94721311, Length=337, Percent_Identity=24.3323442136499, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI39753965, Length=354, Percent_Identity=23.728813559322, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI217416366, Length=419, Percent_Identity=24.582338902148, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI87081738, Length=218, Percent_Identity=28.8990825688073, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71996331, Length=373, Percent_Identity=22.5201072386059, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17551570, Length=364, Percent_Identity=22.8021978021978, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI17738085, Length=366, Percent_Identity=24.3169398907104, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI21357569, Length=324, Percent_Identity=24.6913580246914, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24656463, Length=323, Percent_Identity=24.4582043343653, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24656468, Length=323, Percent_Identity=24.4582043343653, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI161080926, Length=323, Percent_Identity=24.4582043343653, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI161080924, Length=323, Percent_Identity=24.4582043343653, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI221513297, Length=162, Percent_Identity=27.1604938271605, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24667557, Length=217, Percent_Identity=25.3456221198157, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43004; Mature: 43004

Theoretical pI: Translated: 9.88; Mature: 9.88

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKINKHALTFGLITTFLTGLGFTIISPVVPFMVAPFANAHDQALIVTSLMAIYALCTFFA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
APALGSLSDRFGRKPILLISLAGSALGYLIFGLAGSLWMLFLGRIIDGLTGGNIVTLFAY
HCCCCHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
FADITDEENRTKVFGWTAAAVGVGTISGPTVGGLLAHFGNSVPFYFGALISIANLLYGAF
HHHCCCCCCCEEEEEEHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
VMNESLPETHRTRNFSLKQLNPFTQLFQLLRMKNLNRLLFAGILLWLPNGALQAIISQFS
HHCCCCCHHHHCCCCCHHHCCHHHHHHHHHHHHCHHHHHHHHHHHHCCCHHHHHHHHHHC
LDSFAWTPVLIGLAISIMGLMDILTQIFIMPRLLKLANEDKLIRLALVCEIIAYLLFALS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
AFSKMWPFFILAMFIFAFGDSIFGTAFNGKLSKSATSSEQGKLQGGSQALQALTRVIGPL
HHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
IGGQIYISLGHFAPALMGFIFLIIALLVLSKTKSDQE
HCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKINKHALTFGLITTFLTGLGFTIISPVVPFMVAPFANAHDQALIVTSLMAIYALCTFFA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
APALGSLSDRFGRKPILLISLAGSALGYLIFGLAGSLWMLFLGRIIDGLTGGNIVTLFAY
HCCCCHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
FADITDEENRTKVFGWTAAAVGVGTISGPTVGGLLAHFGNSVPFYFGALISIANLLYGAF
HHHCCCCCCCEEEEEEHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
VMNESLPETHRTRNFSLKQLNPFTQLFQLLRMKNLNRLLFAGILLWLPNGALQAIISQFS
HHCCCCCHHHHCCCCCHHHCCHHHHHHHHHHHHCHHHHHHHHHHHHCCCHHHHHHHHHHC
LDSFAWTPVLIGLAISIMGLMDILTQIFIMPRLLKLANEDKLIRLALVCEIIAYLLFALS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
AFSKMWPFFILAMFIFAFGDSIFGTAFNGKLSKSATSSEQGKLQGGSQALQALTRVIGPL
HHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
IGGQIYISLGHFAPALMGFIFLIIALLVLSKTKSDQE
HCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 383387; 6337373; 6307828; 1517220 [H]