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The map label for this gene is add

Identifier: 15672269

GI number: 15672269

Start: 287447

End: 288505

Strand: Direct

Name: add

Synonym: L87453

Alternate gene names: 15672269

Gene position: 287447-288505 (Clockwise)

Preceding gene: 15672268

Following gene: 15672274

Centisome position: 12.15

GC content: 34.75

Gene sequence:

>1059_bases
ATGAAAAAGAAAAGGGAGAAACTCGTGCTTAAATCAGAAATTATTGCTCAAATGCCAAAAGTTGAACTTCATTGCCATCT
TGATGGTTCGCTTAGCTTGTCAGTCATTAAAGAACTCGCTAAAAATGCTGGAATTCATATGACAATGTCCGATGAGGAAA
TTTTAGAAAAGGCACAAGCCCCAGAAAATACAAAAAATTTGCTAGAATACCTGCAACGTTTTGATTTCGTCTTACCACTT
TTGCAAACTTATAAGAATTTAGAGTTGGCTGCTTATGATGTTGTCAGACAGGCAGCAAATGATAATATTAAATATATTGA
AATCCGTTTTGCTCCAAGTCAACATCTCTTAGAAAATCTAACCCTTGAAGAAGCAGTAGAGGCTGTCATCGCCGGCCTTT
CTCGTGCAGAAAATGATTTTGATATAAGAGCAAATGCACTCGTTTGTGGATTAAAACAAGAACCAATTCAAAAATTACAA
AAACTGCTGCCACTTTTTGATAAGATTCCTGATGAACATCTTGTCGGATTTGATATGGCGGGTGATGAATTAAATTATCC
ACAGGAAAAATTTGTAGATTTGATTCATGATATAAAAATTAAGGGTGTCAATGTGACGCTTCATGCTGGAGAATGTCCAG
CATGTGAGAAAAATATTTTAGATTCAATTGCAATGGGGGCAAGTCGCATTGGACATGGAATTATGACTAAAAATCTGTCC
GAAGCCGAACAAAAAATGATGATTGAAAAACAAATTGTTTTAGAAATGGCTCCGACTAGCAATTTTCAAACAAAAGCGGT
GACAGAGCTTGCGCAATATCCTTTTAAAGAACTTTATGACAAAGGAATACACGTGACATTAAATACCGATAATCGAATGG
TTTCGGCTACAAATTTAAGCAAAGAATATGAGAAAATCTCAGCTTGGTACCCAGATTTTTCTCTTTCTGATTTTGAAAAA
ATAAATCATTACGCAATTGATGGCGCCTTTATTGGTCAAGAAGAAAAAGAAGAACTTCATCAAAGATTTACCAAAGAATA
CAAAAAAATCTCTGAATAA

Upstream 100 bases:

>100_bases
GCTTTTTCTCACAAAAAAGCGTAGAATAGTAAAAATACATTTTTGAAGGACTTCGAGCTATTTAGCTCGAAATCTTTTAT
ATCATGTAAAATAATATTGA

Downstream 100 bases:

>100_bases
TCAGAGTTTTTTTAGATTAGATGAATTATTATTATTTAATTTCTATCTTAGAAATGATTTGAGCAGCTTGTTCATCAAAT
GAAGTTGGAATGGCAAGCGT

Product: adenosine deaminase

Products: NA

Alternate protein names: Adenosine aminohydrolase

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MKKKREKLVLKSEIIAQMPKVELHCHLDGSLSLSVIKELAKNAGIHMTMSDEEILEKAQAPENTKNLLEYLQRFDFVLPL
LQTYKNLELAAYDVVRQAANDNIKYIEIRFAPSQHLLENLTLEEAVEAVIAGLSRAENDFDIRANALVCGLKQEPIQKLQ
KLLPLFDKIPDEHLVGFDMAGDELNYPQEKFVDLIHDIKIKGVNVTLHAGECPACEKNILDSIAMGASRIGHGIMTKNLS
EAEQKMMIEKQIVLEMAPTSNFQTKAVTELAQYPFKELYDKGIHVTLNTDNRMVSATNLSKEYEKISAWYPDFSLSDFEK
INHYAIDGAFIGQEEKEELHQRFTKEYKKISE

Sequences:

>Translated_352_residues
MKKKREKLVLKSEIIAQMPKVELHCHLDGSLSLSVIKELAKNAGIHMTMSDEEILEKAQAPENTKNLLEYLQRFDFVLPL
LQTYKNLELAAYDVVRQAANDNIKYIEIRFAPSQHLLENLTLEEAVEAVIAGLSRAENDFDIRANALVCGLKQEPIQKLQ
KLLPLFDKIPDEHLVGFDMAGDELNYPQEKFVDLIHDIKIKGVNVTLHAGECPACEKNILDSIAMGASRIGHGIMTKNLS
EAEQKMMIEKQIVLEMAPTSNFQTKAVTELAQYPFKELYDKGIHVTLNTDNRMVSATNLSKEYEKISAWYPDFSLSDFEK
INHYAIDGAFIGQEEKEELHQRFTKEYKKISE
>Mature_352_residues
MKKKREKLVLKSEIIAQMPKVELHCHLDGSLSLSVIKELAKNAGIHMTMSDEEILEKAQAPENTKNLLEYLQRFDFVLPL
LQTYKNLELAAYDVVRQAANDNIKYIEIRFAPSQHLLENLTLEEAVEAVIAGLSRAENDFDIRANALVCGLKQEPIQKLQ
KLLPLFDKIPDEHLVGFDMAGDELNYPQEKFVDLIHDIKIKGVNVTLHAGECPACEKNILDSIAMGASRIGHGIMTKNLS
EAEQKMMIEKQIVLEMAPTSNFQTKAVTELAQYPFKELYDKGIHVTLNTDNRMVSATNLSKEYEKISAWYPDFSLSDFEK
INHYAIDGAFIGQEEKEELHQRFTKEYKKISE

Specific function: Unknown

COG id: COG1816

COG function: function code F; Adenosine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosine and AMP deaminases family

Homologues:

Organism=Homo sapiens, GI47078295, Length=350, Percent_Identity=27.1428571428571, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI226693318, Length=355, Percent_Identity=24.5070422535211, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI61175224, Length=231, Percent_Identity=27.2727272727273, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1787910, Length=337, Percent_Identity=30.2670623145401, Blast_Score=141, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI32565969, Length=346, Percent_Identity=26.5895953757225, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI115537133, Length=334, Percent_Identity=24.251497005988, Blast_Score=88, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17538512, Length=340, Percent_Identity=25.8823529411765, Blast_Score=88, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6324188, Length=348, Percent_Identity=23.5632183908046, Blast_Score=87, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24645260, Length=297, Percent_Identity=24.9158249158249, Blast_Score=92, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ADD_LACLA (Q9CIR9)

Other databases:

- EMBL:   AE005176
- PIR:   G86660
- RefSeq:   NP_266443.1
- ProteinModelPortal:   Q9CIR9
- SMR:   Q9CIR9
- GeneID:   1113897
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L87453
- NMPDR:   fig|272623.1.peg.295
- HOGENOM:   HBG630382
- OMA:   VSGTTMT
- ProtClustDB:   PRK09358
- BioCyc:   LLAC272623:L87453-MONOMER
- BRENDA:   3.5.4.4
- HAMAP:   MF_00540
- InterPro:   IPR001365
- InterPro:   IPR006330
- PANTHER:   PTHR11409
- TIGRFAMs:   TIGR01430

Pfam domain/function: PF00962 A_deaminase

EC number: =3.5.4.4

Molecular weight: Translated: 40068; Mature: 40068

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS00485 A_DEAMINASE

Important sites: ACT_SITE 211-211 BINDING 26-26 BINDING 28-28 BINDING 181-181

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKKREKLVLKSEIIAQMPKVELHCHLDGSLSLSVIKELAKNAGIHMTMSDEEILEKAQA
CCCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEECHHHHHHHHCC
PENTKNLLEYLQRFDFVLPLLQTYKNLELAAYDVVRQAANDNIKYIEIRFAPSQHLLENL
CCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEEECCHHHHHHHC
TLEEAVEAVIAGLSRAENDFDIRANALVCGLKQEPIQKLQKLLPLFDKIPDEHLVGFDMA
CHHHHHHHHHHHHHHCCCCCCEEECCEEECCCHHHHHHHHHHHHHHHCCCCCCEEECCCC
GDELNYPQEKFVDLIHDIKIKGVNVTLHAGECPACEKNILDSIAMGASRIGHGIMTKNLS
CCCCCCCHHHHHHHHHHCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHCCHH
EAEQKMMIEKQIVLEMAPTSNFQTKAVTELAQYPFKELYDKGIHVTLNTDNRMVSATNLS
HHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHCCHHHHHHCCEEEEECCCCCEEEHHHHH
KEYEKISAWYPDFSLSDFEKINHYAIDGAFIGQEEKEELHQRFTKEYKKISE
HHHHHHHHCCCCCCHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKKREKLVLKSEIIAQMPKVELHCHLDGSLSLSVIKELAKNAGIHMTMSDEEILEKAQA
CCCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEECHHHHHHHHCC
PENTKNLLEYLQRFDFVLPLLQTYKNLELAAYDVVRQAANDNIKYIEIRFAPSQHLLENL
CCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEEECCHHHHHHHC
TLEEAVEAVIAGLSRAENDFDIRANALVCGLKQEPIQKLQKLLPLFDKIPDEHLVGFDMA
CHHHHHHHHHHHHHHCCCCCCEEECCEEECCCHHHHHHHHHHHHHHHCCCCCCEEECCCC
GDELNYPQEKFVDLIHDIKIKGVNVTLHAGECPACEKNILDSIAMGASRIGHGIMTKNLS
CCCCCCCHHHHHHHHHHCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHCCHH
EAEQKMMIEKQIVLEMAPTSNFQTKAVTELAQYPFKELYDKGIHVTLNTDNRMVSATNLS
HHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHCCHHHHHHCCEEEEECCCCCEEEHHHHH
KEYEKISAWYPDFSLSDFEKINHYAIDGAFIGQEEKEELHQRFTKEYKKISE
HHHHHHHHCCCCCCHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471