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The map label for this gene is guaB

Identifier: 15672202

GI number: 15672202

Start: 221285

End: 222766

Strand: Direct

Name: guaB

Synonym: L21264

Alternate gene names: 15672202

Gene position: 221285-222766 (Clockwise)

Preceding gene: 15672200

Following gene: 15672203

Centisome position: 9.35

GC content: 39.47

Gene sequence:

>1482_bases
ATGTCAAACTGGGAAACTAAGTTTTTGAAAAAGGGATTTACTTTTGATGATGTATTGCTGATTCCAGCAGAGTCTCATGT
TTTACCAAATGAGGTGAGTATGAAGACAAAGTTGGCTAAAAATTTGACTTTGAATATTCCAATTATCTCTGCTGCCATGG
ATACTGTAACTGACTCAAAAATGGCTATTTCAATGGCGCGTCAAGGTGGACTTGGTGTAGTTCATAAAAATATGTCAGTT
GAGGAACAAGCTGAAGAAATTCATAAAGTGAAACGTTCAGAATCTGGTGTTATTACAGATCCATTTTTCTTGACTCCAAA
TCATAAAATTGAAGAAGCTGAAAACTTGATGGCAACTTACCGAATTTCTGGTGTACCAATCGTTGATACGCTTGAAAATC
GTAAATTGGTAGGGATTATTACTAACCGTGATTTGCGTTTTATTACGGATTATAATCAACAAATCAAAAATATGATGACT
TCTGAAAATCTGATTACTGCTCCGGTTGGAACAACTTTAGATACAGCTGCTCGTATTTTGCAAGAGCATAAAATTGAAAA
ATTACCTTTGGTTGATGAAGCTGGTAAATTGGCTGGTTTGATTACAATTAAAGATATTGAACGTGTGATTGAATTCCCAA
ATGCTGCTAAAGATGAGCAAGGTCGTTTGCTTGTTGCTGGAGCAGTTGGTGTATCTTCTGATACTTTTGAGCGTGCGGAA
GCTTTGTTTGCTGCAGGGGCTGATGCGATTGTTATTGATACGGCTCATGGACATTCAGCTGGTGTTTTACGTAAAATCCG
TGAAATACGTAATCATTTCCCAGACCGTACTTTGATTGCTGGTAATATTGCTACTGGTGAGGGTGCTCGTGCTTTGTTTG
AAGCTGGTGTTGATGTGGTTAAAGTTGGGATTGGTCCTGGTTCTATCTGTACGACTCGTGTTGTTGCTGGTGTAGGTGTT
CCGCAAATTACAGCCATTTATGATGCGGCAAATGTGGCGCGTGAATTTGGTAAAACAATTATCGCTGATGGTGGGATTAA
ATATTCTGGTGATATTGTTAAGGCGCTTGCTGCTGGTGGAGACGCTGTTATGCTTGGTTCAATGCTTGCAGGTACTGACG
AATCTCCTGGGGAATTTGAAATCTTCCAAGGTCGTAAGTTTAAAACTTACCGTGGAATGGGTAGCTTGGCAGCAATGAAA
AAAGGTTCTAAAGACCGTTATTTCCAAGGGGCTGTTAATGAAGCTAACAAACTTGTTCCAGAGGGAATTGAAGGACGTGT
GGCTTATAAAGGGACAGCGACAGATATCGTTTTCCAAATGCTTGGTGGTTTGAAAGCAGGAATGGGATATACTGGTGCGG
CTGATATTACTGCTTTGCATGATTCAGCACAATTTATCGAAATGTCTGGTGCTGGTTTGAAAGAATCACATCCGCATGAT
GTACAAATTACTAAAGAAGCACCTAACTATTCTGTACAATAA

Upstream 100 bases:

>100_bases
TGGGAATAGTGGTAGAATAGTAAAAATAAAATATTGGCGAATGCCATAGAAATATAGCTATATTGCGTATATATAGCACG
ATAATGGAGGAATATTTTCG

Downstream 100 bases:

>100_bases
AAATTACTGACAAGAATTCTGTCAGTAAAAAAAGGGAATTGACAAGTTGTCGTTCTCTTTTTTATTTTGAAATTTACTGA
CAGAAAAATTTGTCAGTAAA

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 493; Mature: 492

Protein sequence:

>493_residues
MSNWETKFLKKGFTFDDVLLIPAESHVLPNEVSMKTKLAKNLTLNIPIISAAMDTVTDSKMAISMARQGGLGVVHKNMSV
EEQAEEIHKVKRSESGVITDPFFLTPNHKIEEAENLMATYRISGVPIVDTLENRKLVGIITNRDLRFITDYNQQIKNMMT
SENLITAPVGTTLDTAARILQEHKIEKLPLVDEAGKLAGLITIKDIERVIEFPNAAKDEQGRLLVAGAVGVSSDTFERAE
ALFAAGADAIVIDTAHGHSAGVLRKIREIRNHFPDRTLIAGNIATGEGARALFEAGVDVVKVGIGPGSICTTRVVAGVGV
PQITAIYDAANVAREFGKTIIADGGIKYSGDIVKALAAGGDAVMLGSMLAGTDESPGEFEIFQGRKFKTYRGMGSLAAMK
KGSKDRYFQGAVNEANKLVPEGIEGRVAYKGTATDIVFQMLGGLKAGMGYTGAADITALHDSAQFIEMSGAGLKESHPHD
VQITKEAPNYSVQ

Sequences:

>Translated_493_residues
MSNWETKFLKKGFTFDDVLLIPAESHVLPNEVSMKTKLAKNLTLNIPIISAAMDTVTDSKMAISMARQGGLGVVHKNMSV
EEQAEEIHKVKRSESGVITDPFFLTPNHKIEEAENLMATYRISGVPIVDTLENRKLVGIITNRDLRFITDYNQQIKNMMT
SENLITAPVGTTLDTAARILQEHKIEKLPLVDEAGKLAGLITIKDIERVIEFPNAAKDEQGRLLVAGAVGVSSDTFERAE
ALFAAGADAIVIDTAHGHSAGVLRKIREIRNHFPDRTLIAGNIATGEGARALFEAGVDVVKVGIGPGSICTTRVVAGVGV
PQITAIYDAANVAREFGKTIIADGGIKYSGDIVKALAAGGDAVMLGSMLAGTDESPGEFEIFQGRKFKTYRGMGSLAAMK
KGSKDRYFQGAVNEANKLVPEGIEGRVAYKGTATDIVFQMLGGLKAGMGYTGAADITALHDSAQFIEMSGAGLKESHPHD
VQITKEAPNYSVQ
>Mature_492_residues
SNWETKFLKKGFTFDDVLLIPAESHVLPNEVSMKTKLAKNLTLNIPIISAAMDTVTDSKMAISMARQGGLGVVHKNMSVE
EQAEEIHKVKRSESGVITDPFFLTPNHKIEEAENLMATYRISGVPIVDTLENRKLVGIITNRDLRFITDYNQQIKNMMTS
ENLITAPVGTTLDTAARILQEHKIEKLPLVDEAGKLAGLITIKDIERVIEFPNAAKDEQGRLLVAGAVGVSSDTFERAEA
LFAAGADAIVIDTAHGHSAGVLRKIREIRNHFPDRTLIAGNIATGEGARALFEAGVDVVKVGIGPGSICTTRVVAGVGVP
QITAIYDAANVAREFGKTIIADGGIKYSGDIVKALAAGGDAVMLGSMLAGTDESPGEFEIFQGRKFKTYRGMGSLAAMKK
GSKDRYFQGAVNEANKLVPEGIEGRVAYKGTATDIVFQMLGGLKAGMGYTGAADITALHDSAQFIEMSGAGLKESHPHDV
QITKEAPNYSVQ

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=455, Percent_Identity=40.6593406593407, Blast_Score=337, Evalue=2e-92,
Organism=Homo sapiens, GI34328928, Length=455, Percent_Identity=40.6593406593407, Blast_Score=337, Evalue=2e-92,
Organism=Homo sapiens, GI156616279, Length=455, Percent_Identity=40.6593406593407, Blast_Score=336, Evalue=2e-92,
Organism=Homo sapiens, GI34328930, Length=455, Percent_Identity=40.6593406593407, Blast_Score=336, Evalue=2e-92,
Organism=Homo sapiens, GI66933016, Length=453, Percent_Identity=40.1766004415011, Blast_Score=333, Evalue=1e-91,
Organism=Homo sapiens, GI217035152, Length=450, Percent_Identity=40.6666666666667, Blast_Score=330, Evalue=3e-90,
Organism=Homo sapiens, GI217035148, Length=455, Percent_Identity=40, Blast_Score=324, Evalue=1e-88,
Organism=Homo sapiens, GI217035150, Length=456, Percent_Identity=37.9385964912281, Blast_Score=298, Evalue=7e-81,
Organism=Homo sapiens, GI50541956, Length=247, Percent_Identity=39.2712550607287, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI50541954, Length=247, Percent_Identity=39.2712550607287, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI50541952, Length=247, Percent_Identity=39.2712550607287, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI50541948, Length=247, Percent_Identity=39.2712550607287, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI156104880, Length=220, Percent_Identity=40.4545454545455, Blast_Score=162, Evalue=5e-40,
Organism=Escherichia coli, GI1788855, Length=487, Percent_Identity=55.2361396303901, Blast_Score=504, Evalue=1e-144,
Organism=Escherichia coli, GI1786293, Length=257, Percent_Identity=36.1867704280156, Blast_Score=156, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI71994385, Length=464, Percent_Identity=34.2672413793103, Blast_Score=263, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI71994389, Length=428, Percent_Identity=35.981308411215, Blast_Score=257, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI17560440, Length=220, Percent_Identity=40.4545454545455, Blast_Score=166, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6322012, Length=465, Percent_Identity=38.0645161290323, Blast_Score=323, Evalue=3e-89,
Organism=Saccharomyces cerevisiae, GI6323464, Length=464, Percent_Identity=38.7931034482759, Blast_Score=313, Evalue=5e-86,
Organism=Saccharomyces cerevisiae, GI6323585, Length=464, Percent_Identity=38.1465517241379, Blast_Score=311, Evalue=1e-85,
Organism=Saccharomyces cerevisiae, GI6319352, Length=341, Percent_Identity=37.8299120234604, Blast_Score=247, Evalue=4e-66,
Organism=Saccharomyces cerevisiae, GI6319353, Length=120, Percent_Identity=40, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24641071, Length=459, Percent_Identity=39.4335511982571, Blast_Score=332, Evalue=2e-91,
Organism=Drosophila melanogaster, GI24641073, Length=459, Percent_Identity=39.4335511982571, Blast_Score=332, Evalue=2e-91,
Organism=Drosophila melanogaster, GI28571163, Length=417, Percent_Identity=40.0479616306954, Blast_Score=301, Evalue=6e-82,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52827; Mature: 52696

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNWETKFLKKGFTFDDVLLIPAESHVLPNEVSMKTKLAKNLTLNIPIISAAMDTVTDSK
CCCCHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCEEECEEHHHHHHHHCCCH
MAISMARQGGLGVVHKNMSVEEQAEEIHKVKRSESGVITDPFFLTPNHKIEEAENLMATY
HHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHCCCCCEECCEEECCCCCHHHHHHHEEEE
RISGVPIVDTLENRKLVGIITNRDLRFITDYNQQIKNMMTSENLITAPVGTTLDTAARIL
EECCCCEEEECCCCEEEEEEECCCEEEEEHHHHHHHHHHHCCCEEECCCCCHHHHHHHHH
QEHKIEKLPLVDEAGKLAGLITIKDIERVIEFPNAAKDEQGRLLVAGAVGVSSDTFERAE
HHHCCCCCCCCCCCCCEEEEEEHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHH
ALFAAGADAIVIDTAHGHSAGVLRKIREIRNHFPDRTLIAGNIATGEGARALFEAGVDVV
HHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHCCCEEE
KVGIGPGSICTTRVVAGVGVPQITAIYDAANVAREFGKTIIADGGIKYSGDIVKALAAGG
EECCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCEEEECCCEEECCHHHHHHHCCC
DAVMLGSMLAGTDESPGEFEIFQGRKFKTYRGMGSLAAMKKGSKDRYFQGAVNEANKLVP
CCEEHHHHHCCCCCCCCCEEEECCCEEEHHCCCCHHHHHHCCCCCCHHHHHHHHHHHCCC
EGIEGRVAYKGTATDIVFQMLGGLKAGMGYTGAADITALHDSAQFIEMSGAGLKESHPHD
CCCCCEEEECCCHHHHHHHHHCCHHCCCCCCCCCCEEEECCCCCEEEECCCCCCCCCCCC
VQITKEAPNYSVQ
EEEEECCCCCCCC
>Mature Secondary Structure 
SNWETKFLKKGFTFDDVLLIPAESHVLPNEVSMKTKLAKNLTLNIPIISAAMDTVTDSK
CCCHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCEEECEEHHHHHHHHCCCH
MAISMARQGGLGVVHKNMSVEEQAEEIHKVKRSESGVITDPFFLTPNHKIEEAENLMATY
HHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHCCCCCEECCEEECCCCCHHHHHHHEEEE
RISGVPIVDTLENRKLVGIITNRDLRFITDYNQQIKNMMTSENLITAPVGTTLDTAARIL
EECCCCEEEECCCCEEEEEEECCCEEEEEHHHHHHHHHHHCCCEEECCCCCHHHHHHHHH
QEHKIEKLPLVDEAGKLAGLITIKDIERVIEFPNAAKDEQGRLLVAGAVGVSSDTFERAE
HHHCCCCCCCCCCCCCEEEEEEHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHH
ALFAAGADAIVIDTAHGHSAGVLRKIREIRNHFPDRTLIAGNIATGEGARALFEAGVDVV
HHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHCCCEEE
KVGIGPGSICTTRVVAGVGVPQITAIYDAANVAREFGKTIIADGGIKYSGDIVKALAAGG
EECCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCEEEECCCEEECCHHHHHHHCCC
DAVMLGSMLAGTDESPGEFEIFQGRKFKTYRGMGSLAAMKKGSKDRYFQGAVNEANKLVP
CCEEHHHHHCCCCCCCCCEEEECCCEEEHHCCCCHHHHHHCCCCCCHHHHHHHHHHHCCC
EGIEGRVAYKGTATDIVFQMLGGLKAGMGYTGAADITALHDSAQFIEMSGAGLKESHPHD
CCCCCEEEECCCHHHHHHHHHCCHHCCCCCCCCCCEEEECCCCCEEEECCCCCCCCCCCC
VQITKEAPNYSVQ
EEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]