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The map label for this gene is pepP

Identifier: 13358096

GI number: 13358096

Start: 661048

End: 662121

Strand: Reverse

Name: pepP

Synonym: UU532

Alternate gene names: 13358096

Gene position: 662121-661048 (Counterclockwise)

Preceding gene: 13358097

Following gene: 13358095

Centisome position: 88.08

GC content: 31.1

Gene sequence:

>1074_bases
ATGAGTGATTTCAAATTACAACAAGTTTTAAAAACAATTAAAGAACATGAAGCACAAGGCGCTGACGGTATGATTTTATT
TTCTAATTATAACCGTTATTGATTTTTAGAATTTGCTTCAAGTGATGGTTTTGTGTTTATTAATAAAGATGGTAAAGCAA
TTTATCTAGTGGATGCTCGTTATTATACAGCAGCGTCTGAAACTGTAAAAAACGCAAAGGTAATTTTATTAGCTCGCACA
CCACAAAAATCAACTTTTGATCTACTAAAAGACGCAATGGTTGAATTAAATATTACTAATGCATTAGTTGAAGCTGATTA
TGTAACATTAGATGTTCATGAAATGTTAAAAAAATTAGTAAAAAATACTACTCCTTTTACATCAGCTACATTACGTGCTA
TTAAAACTGAAAAAGAACTTGAATATTTACAAAAAGCTGCTGATATTGCAGCTTTAACATGTAATTGAATTCGAGAACAA
GATATTATTGGTCGAACAGAACTTGAAATTGCAACATTAGTTTCAAAACATATGTTAGAATTAGGTGGAGAATTAAATTC
ATTTGATCCAATTATTGCTTCAGGTCCAAATGGCGGATCACCACATCATCATCCAGGAAATCGTGTAATTGAAGATGGAG
ATATGGTAACTGTTGACATTGGTTGTACTTATAAAGGTTATTGTTCTGATATTACAAGATCTTTTATTGTTGGAAATAAA
GCAAATCCACAAATGCAAGAAATTTATGATAAAGTTCTTGAATCTCAAACAGCAGGGATTAATCTATTGAGTACAAAAGT
AACAGGTCAAGAAGTTGATAAAGTATGTCGCGACATTGTTGATAATTCTAAATTTAAGGGCTATTTCACACATGGAACAG
GTCATGGTGTAGGTTTACAAGTACATGAATTACCAAATACTAATGCTGGTAATCCTAATAAATTGCCATTAAATGCAGTT
GTTACTGTTGAACCAGGAATTTATATCCCAAATGTTGGTGGTGTAAGAATTGAAGATACAATTGTAGTAAAAGACGGACA
AGCCCTGGTTTTAACAAGGTTAGCATATAAATAA

Upstream 100 bases:

>100_bases
GCAAAAAATAATCCAGACAGACTTTCTTTAAATAAATTTTGTCCTAAATGTCGAAAAGTAACAACTCACGTTGAAATTAA
GAAAAAATAGGTATTAAATT

Downstream 100 bases:

>100_bases
ACTACAAAAAAAGGGTATAGTTCAATTGGTAGAACAGCAGACTCCAAATCTGCGTGTTGCGGGTTCGAGTCCTGTTACCC
TTGCCATTTAAAATAAAAAC

Product: XAA-Pro aminopeptidase

Products: NA

Alternate protein names: X-Pro aminopeptidase; Aminoacylproline aminopeptidase; Aminopeptidase P; APP [H]

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MSDFKLQQVLKTIKEHEAQGADGMILFSNYNRYWFLEFASSDGFVFINKDGKAIYLVDARYYTAASETVKNAKVILLART
PQKSTFDLLKDAMVELNITNALVEADYVTLDVHEMLKKLVKNTTPFTSATLRAIKTEKELEYLQKAADIAALTCNWIREQ
DIIGRTELEIATLVSKHMLELGGELNSFDPIIASGPNGGSPHHHPGNRVIEDGDMVTVDIGCTYKGYCSDITRSFIVGNK
ANPQMQEIYDKVLESQTAGINLLSTKVTGQEVDKVCRDIVDNSKFKGYFTHGTGHGVGLQVHELPNTNAGNPNKLPLNAV
VTVEPGIYIPNVGGVRIEDTIVVKDGQALVLTRLAYK

Sequences:

>Translated_357_residues
MSDFKLQQVLKTIKEHEAQGADGMILFSNYNRY*FLEFASSDGFVFINKDGKAIYLVDARYYTAASETVKNAKVILLART
PQKSTFDLLKDAMVELNITNALVEADYVTLDVHEMLKKLVKNTTPFTSATLRAIKTEKELEYLQKAADIAALTCN*IREQ
DIIGRTELEIATLVSKHMLELGGELNSFDPIIASGPNGGSPHHHPGNRVIEDGDMVTVDIGCTYKGYCSDITRSFIVGNK
ANPQMQEIYDKVLESQTAGINLLSTKVTGQEVDKVCRDIVDNSKFKGYFTHGTGHGVGLQVHELPNTNAGNPNKLPLNAV
VTVEPGIYIPNVGGVRIEDTIVVKDGQALVLTRLAYK
>Mature_356_residues
SDFKLQQVLKTIKEHEAQGADGMILFSNYNRY*FLEFASSDGFVFINKDGKAIYLVDARYYTAASETVKNAKVILLARTP
QKSTFDLLKDAMVELNITNALVEADYVTLDVHEMLKKLVKNTTPFTSATLRAIKTEKELEYLQKAADIAALTCN*IREQD
IIGRTELEIATLVSKHMLELGGELNSFDPIIASGPNGGSPHHHPGNRVIEDGDMVTVDIGCTYKGYCSDITRSFIVGNKA
NPQMQEIYDKVLESQTAGINLLSTKVTGQEVDKVCRDIVDNSKFKGYFTHGTGHGVGLQVHELPNTNAGNPNKLPLNAVV
TVEPGIYIPNVGGVRIEDTIVVKDGQALVLTRLAYK

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=253, Percent_Identity=32.4110671936759, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI264681563, Length=279, Percent_Identity=29.0322580645161, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI149589008, Length=283, Percent_Identity=25.4416961130742, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI260593665, Length=283, Percent_Identity=25.4416961130742, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI93141226, Length=264, Percent_Identity=28.7878787878788, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1788728, Length=340, Percent_Identity=33.5294117647059, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI1789275, Length=287, Percent_Identity=30.6620209059233, Blast_Score=109, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17509539, Length=232, Percent_Identity=30.1724137931034, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17508215, Length=279, Percent_Identity=26.1648745519713, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320922, Length=251, Percent_Identity=27.8884462151394, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6321118, Length=278, Percent_Identity=27.3381294964029, Blast_Score=90, Evalue=5e-19,
Organism=Drosophila melanogaster, GI21357079, Length=276, Percent_Identity=25.3623188405797, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19920384, Length=259, Percent_Identity=25.4826254826255, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17137632, Length=170, Percent_Identity=33.5294117647059, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 39006; Mature: 38875

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDFKLQQVLKTIKEHEAQGADGMILFSNYNRYFLEFASSDGFVFINKDGKAIYLVDARY
CCCHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEEEEECCCCEEEEECCCCEEEEEECCE
YTAASETVKNAKVILLARTPQKSTFDLLKDAMVELNITNALVEADYVTLDVHEMLKKLVK
EEHHHHHHCCCEEEEEEECCCCHHHHHHHHHHEEEEEHHHEEECCEEEEEHHHHHHHHHH
NTTPFTSATLRAIKTEKELEYLQKAADIAALTCNIREQDIIGRTELEIATLVSKHMLELG
CCCCCHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCHHCCCCCCHHHHHHHHHHHHHHHC
GELNSFDPIIASGPNGGSPHHHPGNRVIEDGDMVTVDIGCTYKGYCSDITRSFIVGNKAN
CCCCCCCCEEECCCCCCCCCCCCCCCEEECCCEEEEEECCCCCHHHHHHHHHHHCCCCCC
PQMQEIYDKVLESQTAGINLLSTKVTGQEVDKVCRDIVDNSKFKGYFTHGTGHGVGLQVH
CHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCEEEE
ELPNTNAGNPNKLPLNAVVTVEPGIYIPNVGGVRIEDTIVVKDGQALVLTRLAYK
ECCCCCCCCCCCCCEEEEEEECCCEEECCCCCEEEEEEEEEECCCEEEEEEECCC
>Mature Secondary Structure 
SDFKLQQVLKTIKEHEAQGADGMILFSNYNRYFLEFASSDGFVFINKDGKAIYLVDARY
CCHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEEEEECCCCEEEEECCCCEEEEEECCE
YTAASETVKNAKVILLARTPQKSTFDLLKDAMVELNITNALVEADYVTLDVHEMLKKLVK
EEHHHHHHCCCEEEEEEECCCCHHHHHHHHHHEEEEEHHHEEECCEEEEEHHHHHHHHHH
NTTPFTSATLRAIKTEKELEYLQKAADIAALTCNIREQDIIGRTELEIATLVSKHMLELG
CCCCCHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCHHCCCCCCHHHHHHHHHHHHHHHC
GELNSFDPIIASGPNGGSPHHHPGNRVIEDGDMVTVDIGCTYKGYCSDITRSFIVGNKAN
CCCCCCCCEEECCCCCCCCCCCCCCCEEECCCEEEEEECCCCCHHHHHHHHHHHCCCCCC
PQMQEIYDKVLESQTAGINLLSTKVTGQEVDKVCRDIVDNSKFKGYFTHGTGHGVGLQVH
CHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCEEEE
ELPNTNAGNPNKLPLNAVVTVEPGIYIPNVGGVRIEDTIVVKDGQALVLTRLAYK
ECCCCCCCCCCCCCEEEEEEECCCEEECCCCCEEEEEEEEEECCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7569993; 8253680 [H]