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The map label for this gene is fhuC

Identifier: 13357998

GI number: 13357998

Start: 496464

End: 497627

Strand: Direct

Name: fhuC

Synonym: UU435

Alternate gene names: 13357998

Gene position: 496464-497627 (Clockwise)

Preceding gene: 13357989

Following gene: 13357999

Centisome position: 66.04

GC content: 26.37

Gene sequence:

>1164_bases
ATGAGTTTTTTTAAAAAAAAGAATGATTTACAAAAAGAAGAACACAAACACGTTAGTGTTGTAGATATGAATGAAATTTT
AAGCTATGAAGATAGTGAAGAATTTAAAAACGATGAAATTGATTCTAATGAGCCAATTTTTAAACTTAATAATGTTTCAT
TAGGTTACGGAAAAAAAATGATTATTAAAAACCTAACGGCAACAATTCATCGCAACGATTTTGTTGTTGTATTAGGGCCT
AATGGTTCTGGTAAATCCACATTAATCAAAGGATTGTGTCGTATCAATAATCCTTCAAGTGGTTATATAATGTATAGAGA
TAAATTGATATCAAGACCATTATTACCATTTCTTTGATTAGAAAAAGCATGATCTTCTATTGTTAATATATTTACAAAAG
ATCGTAAAGAAGTTATTGAAACAATTGATTGACATATTCAAAATTATAAAAAAATTCATGCCTATAAGTCAAAGGAATTA
GCTTTAAATTTAGCATATGTCCCACAACTTGCTGTATTCCCAGAAGCTACATCAATTTATGATTTTGTTAAAATGGGTCG
TTTTCCAAGTTCAAATGCTTTGGGAATTAATACAAATACAGAACGTGAAAAACAAATTATTGATGAAGCTTTGAAAAATG
TTGGTATTTATGAATTCCGCCACAAAAATCTTGAAGATTTATCAGGTGGTCAAAAACAAAAAGCATTAATTGCTTTAGCA
CTTGCTCAAGATACTGAAACAATTGTTTTAGATGAACCTACTAACCACTTAGATATAAGAAGTCAATTAGAAATTATTGA
ACTTTTACATAAATTACACCACGAAATGAAAAAAACAATTGTTTTAGTTATTCATGATATTAATAATGGTTTAAAATATG
CACATAAAGTCATGATTATGAAAAATGGTGAAATGGTTCGTTATGGAAAATTAAAAGAAACAATCGATCATGAAATTTTA
TTAGATGTTTTTGGTGTTGAATCAATTATTGTGAAAAATGAATCGACATATCCACAAGTTTCTGTAACAGATTTTAGTTT
ACCAAAAGACTATAAAATTAATGAAATCAAAGAAAACGAAAAAACTAATTCAATTTATAATGATGGTGATGAAGTAGAAA
TTGAAAATGAATTAGAAAAAGAAGTTGATAAAACAAAAAAATAA

Upstream 100 bases:

>100_bases
ATAATTTGCATTTATTTTTTTATGGGAATACAAGATAAACTTCTTGTAGATAAAATGAAATTCTAACTTATAATTTAATT
TTTTAGTTTTGGGAGTAAAT

Downstream 100 bases:

>100_bases
ATCAAAATTAAAATAAAAACCGCATTGAAGTGGTTTTTATTTTATTATTAATTAATAATTTATAAAAAAGGTAAGCTTAT
AAATGAATCAAAGGTTAGAT

Product: ferrichrome transport ATP-binding protein

Products: NA

Alternate protein names: Ferric hydroxamate uptake protein C; Ferrichrome transport ATP-binding protein FhuC; Iron(III)-hydroxamate import ATP-binding protein FhuC [H]

Number of amino acids: Translated: 387; Mature: 386

Protein sequence:

>387_residues
MSFFKKKNDLQKEEHKHVSVVDMNEILSYEDSEEFKNDEIDSNEPIFKLNNVSLGYGKKMIIKNLTATIHRNDFVVVLGP
NGSGKSTLIKGLCRINNPSSGYIMYRDKLISRPLLPFLWLEKAWSSIVNIFTKDRKEVIETIDWHIQNYKKIHAYKSKEL
ALNLAYVPQLAVFPEATSIYDFVKMGRFPSSNALGINTNTEREKQIIDEALKNVGIYEFRHKNLEDLSGGQKQKALIALA
LAQDTETIVLDEPTNHLDIRSQLEIIELLHKLHHEMKKTIVLVIHDINNGLKYAHKVMIMKNGEMVRYGKLKETIDHEIL
LDVFGVESIIVKNESTYPQVSVTDFSLPKDYKINEIKENEKTNSIYNDGDEVEIENELEKEVDKTKK

Sequences:

>Translated_387_residues
MSFFKKKNDLQKEEHKHVSVVDMNEILSYEDSEEFKNDEIDSNEPIFKLNNVSLGYGKKMIIKNLTATIHRNDFVVVLGP
NGSGKSTLIKGLCRINNPSSGYIMYRDKLISRPLLPFL*LEKA*SSIVNIFTKDRKEVIETID*HIQNYKKIHAYKSKEL
ALNLAYVPQLAVFPEATSIYDFVKMGRFPSSNALGINTNTEREKQIIDEALKNVGIYEFRHKNLEDLSGGQKQKALIALA
LAQDTETIVLDEPTNHLDIRSQLEIIELLHKLHHEMKKTIVLVIHDINNGLKYAHKVMIMKNGEMVRYGKLKETIDHEIL
LDVFGVESIIVKNESTYPQVSVTDFSLPKDYKINEIKENEKTNSIYNDGDEVEIENELEKEVDKTKK
>Mature_386_residues
SFFKKKNDLQKEEHKHVSVVDMNEILSYEDSEEFKNDEIDSNEPIFKLNNVSLGYGKKMIIKNLTATIHRNDFVVVLGPN
GSGKSTLIKGLCRINNPSSGYIMYRDKLISRPLLPFL*LEKA*SSIVNIFTKDRKEVIETID*HIQNYKKIHAYKSKELA
LNLAYVPQLAVFPEATSIYDFVKMGRFPSSNALGINTNTEREKQIIDEALKNVGIYEFRHKNLEDLSGGQKQKALIALAL
AQDTETIVLDEPTNHLDIRSQLEIIELLHKLHHEMKKTIVLVIHDINNGLKYAHKVMIMKNGEMVRYGKLKETIDHEILL
DVFGVESIIVKNESTYPQVSVTDFSLPKDYKINEIKENEKTNSIYNDGDEVEIENELEKEVDKTKK

Specific function: Part of the ABC transporter complex FhuBGCD involved in iron(3+)-hydroxamate import. Responsible for energy coupling to the transport system [H]

COG id: COG1120

COG function: function code PH; ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Escherichia coli, GI1786803, Length=285, Percent_Identity=30.1754385964912, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI1786345, Length=292, Percent_Identity=30.8219178082192, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI1790739, Length=279, Percent_Identity=26.8817204301075, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI1789032, Length=273, Percent_Identity=26.3736263736264, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788450, Length=263, Percent_Identity=26.615969581749, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI145693107, Length=284, Percent_Identity=25, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1788761, Length=253, Percent_Identity=26.4822134387352, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI87081791, Length=277, Percent_Identity=25.2707581227437, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1787029, Length=262, Percent_Identity=25.1908396946565, Blast_Score=81, Evalue=9e-17,
Organism=Escherichia coli, GI1790544, Length=276, Percent_Identity=24.6376811594203, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788506, Length=255, Percent_Identity=27.843137254902, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1789891, Length=248, Percent_Identity=24.5967741935484, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786563, Length=245, Percent_Identity=25.7142857142857, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1787712, Length=255, Percent_Identity=25.0980392156863, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1788002, Length=266, Percent_Identity=22.5563909774436, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1789963, Length=122, Percent_Identity=35.2459016393443, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1787112, Length=254, Percent_Identity=23.6220472440945, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1789864, Length=261, Percent_Identity=21.455938697318, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1786398, Length=273, Percent_Identity=24.1758241758242, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI48994883, Length=107, Percent_Identity=30.8411214953271, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1787758, Length=119, Percent_Identity=33.6134453781513, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1787548, Length=119, Percent_Identity=32.7731092436975, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17510237, Length=278, Percent_Identity=23.021582733813, Blast_Score=88, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI212646699, Length=370, Percent_Identity=26.2162162162162, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI28574744, Length=226, Percent_Identity=27.8761061946903, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI85724864, Length=285, Percent_Identity=23.5087719298246, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24580555, Length=285, Percent_Identity=23.5087719298246, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI85816269, Length=285, Percent_Identity=23.5087719298246, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24580553, Length=285, Percent_Identity=23.5087719298246, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: =3.6.3.34 [H]

Molecular weight: Translated: 43996; Mature: 43865

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFFKKKNDLQKEEHKHVSVVDMNEILSYEDSEEFKNDEIDSNEPIFKLNNVSLGYGKKM
CCCCCCCCHHHHHHCCCEEEEEHHHHHCCCCCHHHCCCCCCCCCCEEEEECEECCCCCHH
IIKNLTATIHRNDFVVVLGPNGSGKSTLIKGLCRINNPSSGYIMYRDKLISRPLLPFLLE
HHHHHHHEEECCCEEEEECCCCCCHHHHHHHHHHCCCCCCCEEEEHHHHHCCCHHHHHHH
KASSIVNIFTKDRKEVIETIDHIQNYKKIHAYKSKELALNLAYVPQLAVFPEATSIYDFV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEEEECCCEEECCCHHHHHHHH
KMGRFPSSNALGINTNTEREKQIIDEALKNVGIYEFRHKNLEDLSGGQKQKALIALALAQ
HHCCCCCCCEEECCCCCHHHHHHHHHHHHHCCEEEECCCCHHHCCCCCHHHHEEEEEEEC
DTETIVLDEPTNHLDIRSQLEIIELLHKLHHEMKKTIVLVIHDINNGLKYAHKVMIMKNG
CCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCHHHHEEEEEEECC
EMVRYGKLKETIDHEILLDVFGVESIIVKNESTYPQVSVTDFSLPKDYKINEIKENEKTN
CEEEECCHHHHHHHHHHHHHHCCEEEEEECCCCCCEEEEEECCCCCCCCCCHHHCCCCCC
SIYNDGDEVEIENELEKEVDKTKK
CCCCCCCCEEEHHHHHHHHHHCCC
>Mature Secondary Structure 
SFFKKKNDLQKEEHKHVSVVDMNEILSYEDSEEFKNDEIDSNEPIFKLNNVSLGYGKKM
CCCCCCCHHHHHHCCCEEEEEHHHHHCCCCCHHHCCCCCCCCCCEEEEECEECCCCCHH
IIKNLTATIHRNDFVVVLGPNGSGKSTLIKGLCRINNPSSGYIMYRDKLISRPLLPFLLE
HHHHHHHEEECCCEEEEECCCCCCHHHHHHHHHHCCCCCCCEEEEHHHHHCCCHHHHHHH
KASSIVNIFTKDRKEVIETIDHIQNYKKIHAYKSKELALNLAYVPQLAVFPEATSIYDFV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEEEECCCEEECCCHHHHHHHH
KMGRFPSSNALGINTNTEREKQIIDEALKNVGIYEFRHKNLEDLSGGQKQKALIALALAQ
HHCCCCCCCEEECCCCCHHHHHHHHHHHHHCCEEEECCCCHHHCCCCCHHHHEEEEEEEC
DTETIVLDEPTNHLDIRSQLEIIELLHKLHHEMKKTIVLVIHDINNGLKYAHKVMIMKNG
CCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCHHHHEEEEEEECC
EMVRYGKLKETIDHEILLDVFGVESIIVKNESTYPQVSVTDFSLPKDYKINEIKENEKTN
CEEEECCHHHHHHHHHHHHHHCCEEEEEECCCCCCEEEEEECCCCCCCCCCHHHCCCCCC
SIYNDGDEVEIENELEKEVDKTKK
CCCCCCCCEEEHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]