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The map label for this gene is uvrC

Identifier: 13357942

GI number: 13357942

Start: 437785

End: 439539

Strand: Reverse

Name: uvrC

Synonym: UU381

Alternate gene names: 13357942

Gene position: 439539-437785 (Counterclockwise)

Preceding gene: 13357943

Following gene: 13357941

Centisome position: 58.47

GC content: 22.91

Gene sequence:

>1755_bases
ATGAATGATTTATTAAAAAATAAACTAAAACTGATTCCTCACAAACCTGGTTGTTATTTATGAAAAGATCAATTCAATCA
AATTATTTACATTGGTAAAGCGAAAGATTTATATAATCGAACCCATTCATATTTTAATGGTTGTAAAGACAATAAAACAA
GTAAATTAGTTAATAACATTAATGATCTTGAATATATTGTCGTTAATAATGTTAACGAAGCTTTAATCTTAGAAAACAAT
TTAATTAAAACACATCTTCCAAAATATAATATTTTATTAAAAGATGGTTCAAACTATCCTTATATCATGATTACAAATGA
ACAATATCCCCGTTTAAAATATGTTCGTACTTATGATAAAAATAAAGGAATTTATTTTGGGCCATTAGCTGATAGCACAA
ATAAATATCAATTATTTAATTTATTAAATAGTATTTTTCCATTTAATAAATGTAATCATCAACCATATAAAAAATGTATT
TATTATGACCTGCATCAATGTATTAATCAAGTTCAACAATCAACATATCAAGAAGCAATCAGTGAAGTTAAAGAAATCTT
TAAAGGTAATTTAGATCACATTTTAATGATTCTACAAACTAAAGAACAACATGCAGTTACTAAATTAGATTTTGAAAATG
CTCAAAAATACGCTGAGCAACAAAAAGCACTTACTTCAATTATTAATTCAGGATTAGTGCAATTGGATAATAATGAAAGT
TTCGATATCATCGGTTTTTATGAAAAAAATAATTATTTAGTAATTATAATTTTTAATTATGTTAAAGGCAAATTATTAAA
TAAAAGTGCTGATACATTTGCCATTTATGATTATGAAATTAATGAATTAATAACCTCATTTTTAATGCAATACTATTCAC
AAAATAAAATTAGTTCAAAAATTATTGTAAGTTTAGATGATGATAATTTATTAGCTTTATCACAACGTTTTCACACAAAA
TTTATTAATGCGCAAACAAAATTTCATAAACGAATTCTTAAATTAGCTCTTGATAATGCTATTTTGTATTTTGAATCTAA
TATTAAAAATGTAATTAATAAACAAAATGAATTAGATGATGCTTTAAATCAATTAAAACAAATTTTAAAATTACCAGATT
TAAATATCATTGAGTGTTTTGATAATTCTAATATTAATTTAAGTTTACCAATTGCTGGGATGATTGTTTATCAAAACGGT
AAATTAAATAACAAATTAAATCGTAAATATAATTTAATGACAACTAAAAATGCTTCTGATTATCATTTTATGATTGAAGT
TATCACACGACGTTATCAACGATTAGTTTCACAACATCAAAAATTACCTAATCTAATTGTAGTAGATGGGGGAAAGTTAC
AAGTTAATGCAGCTTTATATGCGTTAGCACAGTTACAAATAAACATTCCATTAATAGGACTAAAAAAAGATCAAAAACAC
AAAACTGATGCCATTGTTTTAACTAATGGCGATGAAATTGTTTTAGATCGTAAAAGTATTTTATATAAATTCTTAGCAAA
TATGCAAAATGATGTTCACAATTATGCAATTTCGTTTTTAAGAGATAAACACACAAAATCTATTTTTAATTCTTTATTAG
ATAATGTTCAAGGTCTAGGTAAAAAACGTTTTAATGAACTTTTAAAATATTATGATAGCATTAATGATTTAAAAAGTGCA
TCTGATCAAGAATTATTACAATTTTTACCTAAAAATGTCTTAGTTAATTTACGTGAAAAACTAAATAAAATATAA

Upstream 100 bases:

>100_bases
TTAAAACAAATCAAATTAGTGCTCCACTTTTCCAAAATTTATATAAGGTAATTATTAACGCCTTAAATCCCCAGGATTTA
TTTGATAAAAGTTTTTGTTA

Downstream 100 bases:

>100_bases
TTCTTTTTTATATATTATTCCTTCAAATCCCTTATCAAAAAGAGTTTTCTTTAGAAGATAAGATAAATATTTTATATAGT
TTTTTTCATCATTATTAATA

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 584; Mature: 584

Protein sequence:

>584_residues
MNDLLKNKLKLIPHKPGCYLWKDQFNQIIYIGKAKDLYNRTHSYFNGCKDNKTSKLVNNINDLEYIVVNNVNEALILENN
LIKTHLPKYNILLKDGSNYPYIMITNEQYPRLKYVRTYDKNKGIYFGPLADSTNKYQLFNLLNSIFPFNKCNHQPYKKCI
YYDLHQCINQVQQSTYQEAISEVKEIFKGNLDHILMILQTKEQHAVTKLDFENAQKYAEQQKALTSIINSGLVQLDNNES
FDIIGFYEKNNYLVIIIFNYVKGKLLNKSADTFAIYDYEINELITSFLMQYYSQNKISSKIIVSLDDDNLLALSQRFHTK
FINAQTKFHKRILKLALDNAILYFESNIKNVINKQNELDDALNQLKQILKLPDLNIIECFDNSNINLSLPIAGMIVYQNG
KLNNKLNRKYNLMTTKNASDYHFMIEVITRRYQRLVSQHQKLPNLIVVDGGKLQVNAALYALAQLQINIPLIGLKKDQKH
KTDAIVLTNGDEIVLDRKSILYKFLANMQNDVHNYAISFLRDKHTKSIFNSLLDNVQGLGKKRFNELLKYYDSINDLKSA
SDQELLQFLPKNVLVNLREKLNKI

Sequences:

>Translated_584_residues
MNDLLKNKLKLIPHKPGCYL*KDQFNQIIYIGKAKDLYNRTHSYFNGCKDNKTSKLVNNINDLEYIVVNNVNEALILENN
LIKTHLPKYNILLKDGSNYPYIMITNEQYPRLKYVRTYDKNKGIYFGPLADSTNKYQLFNLLNSIFPFNKCNHQPYKKCI
YYDLHQCINQVQQSTYQEAISEVKEIFKGNLDHILMILQTKEQHAVTKLDFENAQKYAEQQKALTSIINSGLVQLDNNES
FDIIGFYEKNNYLVIIIFNYVKGKLLNKSADTFAIYDYEINELITSFLMQYYSQNKISSKIIVSLDDDNLLALSQRFHTK
FINAQTKFHKRILKLALDNAILYFESNIKNVINKQNELDDALNQLKQILKLPDLNIIECFDNSNINLSLPIAGMIVYQNG
KLNNKLNRKYNLMTTKNASDYHFMIEVITRRYQRLVSQHQKLPNLIVVDGGKLQVNAALYALAQLQINIPLIGLKKDQKH
KTDAIVLTNGDEIVLDRKSILYKFLANMQNDVHNYAISFLRDKHTKSIFNSLLDNVQGLGKKRFNELLKYYDSINDLKSA
SDQELLQFLPKNVLVNLREKLNKI
>Mature_584_residues
MNDLLKNKLKLIPHKPGCYL*KDQFNQIIYIGKAKDLYNRTHSYFNGCKDNKTSKLVNNINDLEYIVVNNVNEALILENN
LIKTHLPKYNILLKDGSNYPYIMITNEQYPRLKYVRTYDKNKGIYFGPLADSTNKYQLFNLLNSIFPFNKCNHQPYKKCI
YYDLHQCINQVQQSTYQEAISEVKEIFKGNLDHILMILQTKEQHAVTKLDFENAQKYAEQQKALTSIINSGLVQLDNNES
FDIIGFYEKNNYLVIIIFNYVKGKLLNKSADTFAIYDYEINELITSFLMQYYSQNKISSKIIVSLDDDNLLALSQRFHTK
FINAQTKFHKRILKLALDNAILYFESNIKNVINKQNELDDALNQLKQILKLPDLNIIECFDNSNINLSLPIAGMIVYQNG
KLNNKLNRKYNLMTTKNASDYHFMIEVITRRYQRLVSQHQKLPNLIVVDGGKLQVNAALYALAQLQINIPLIGLKKDQKH
KTDAIVLTNGDEIVLDRKSILYKFLANMQNDVHNYAISFLRDKHTKSIFNSLLDNVQGLGKKRFNELLKYYDSINDLKSA
SDQELLQFLPKNVLVNLREKLNKI

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=597, Percent_Identity=30.1507537688442, Blast_Score=253, Evalue=3e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008985
- InterPro:   IPR010994
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 67822; Mature: 67822

Theoretical pI: Translated: 9.53; Mature: 9.53

Prosite motif: PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDLLKNKLKLIPHKPGCYLKDQFNQIIYIGKAKDLYNRTHSYFNGCKDNKTSKLVNNIN
CCHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHCCCCCCHHHHHHHCCC
DLEYIVVNNVNEALILENNLIKTHLPKYNILLKDGSNYPYIMITNEQYPRLKYVRTYDKN
CEEEEEEECCCCEEEEECCCHHHCCCCEEEEEECCCCCCEEEEECCCCCCEEEEEEEECC
KGIYFGPLADSTNKYQLFNLLNSIFPFNKCNHQPYKKCIYYDLHQCINQVQQSTYQEAIS
CCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
EVKEIFKGNLDHILMILQTKEQHAVTKLDFENAQKYAEQQKALTSIINSGLVQLDNNESF
HHHHHHHCCCCCEEEEEECCCHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEECCCCCE
DIIGFYEKNNYLVIIIFNYVKGKLLNKSADTFAIYDYEINELITSFLMQYYSQNKISSKI
EEEEEEECCCEEEEEEEECCCCHHCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCCCEE
IVSLDDDNLLALSQRFHTKFINAQTKFHKRILKLALDNAILYFESNIKNVINKQNELDDA
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHHHCCCHHHHHH
LNQLKQILKLPDLNIIECFDNSNINLSLPIAGMIVYQNGKLNNKLNRKYNLMTTKNASDY
HHHHHHHHCCCCCCEEEEECCCCCEEEECEEEEEEEECCCCCCCCCCEEEEEEECCCCCH
HFMIEVITRRYQRLVSQHQKLPNLIVVDGGKLQVNAALYALAQLQINIPLIGLKKDQKHK
HHHHHHHHHHHHHHHHHHHCCCCEEEEECCEEEEHHHHHEEEHEEEECEEEECCCCCCCC
TDAIVLTNGDEIVLDRKSILYKFLANMQNDVHNYAISFLRDKHTKSIFNSLLDNVQGLGK
CCEEEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
KRFNELLKYYDSINDLKSASDQELLQFLPKNVLVNLREKLNKI
HHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MNDLLKNKLKLIPHKPGCYLKDQFNQIIYIGKAKDLYNRTHSYFNGCKDNKTSKLVNNIN
CCHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHCCCCCCHHHHHHHCCC
DLEYIVVNNVNEALILENNLIKTHLPKYNILLKDGSNYPYIMITNEQYPRLKYVRTYDKN
CEEEEEEECCCCEEEEECCCHHHCCCCEEEEEECCCCCCEEEEECCCCCCEEEEEEEECC
KGIYFGPLADSTNKYQLFNLLNSIFPFNKCNHQPYKKCIYYDLHQCINQVQQSTYQEAIS
CCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
EVKEIFKGNLDHILMILQTKEQHAVTKLDFENAQKYAEQQKALTSIINSGLVQLDNNESF
HHHHHHHCCCCCEEEEEECCCHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEECCCCCE
DIIGFYEKNNYLVIIIFNYVKGKLLNKSADTFAIYDYEINELITSFLMQYYSQNKISSKI
EEEEEEECCCEEEEEEEECCCCHHCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCCCEE
IVSLDDDNLLALSQRFHTKFINAQTKFHKRILKLALDNAILYFESNIKNVINKQNELDDA
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHHHCCCHHHHHH
LNQLKQILKLPDLNIIECFDNSNINLSLPIAGMIVYQNGKLNNKLNRKYNLMTTKNASDY
HHHHHHHHCCCCCCEEEEECCCCCEEEECEEEEEEEECCCCCCCCCCEEEEEEECCCCCH
HFMIEVITRRYQRLVSQHQKLPNLIVVDGGKLQVNAALYALAQLQINIPLIGLKKDQKHK
HHHHHHHHHHHHHHHHHHHCCCCEEEEECCEEEEHHHHHEEEHEEEECEEEECCCCCCCC
TDAIVLTNGDEIVLDRKSILYKFLANMQNDVHNYAISFLRDKHTKSIFNSLLDNVQGLGK
CCEEEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
KRFNELLKYYDSINDLKSASDQELLQFLPKNVLVNLREKLNKI
HHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA