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Identifier: 15004834

GI number: 15004834

Start: 141612

End: 143081

Strand: Direct

Name: Not Available

Synonym: CA_P0131

Alternate gene names: 15004834

Gene position: 141612-143081 (Clockwise)

Preceding gene: 15004831

Following gene: 15004835

Centisome position: 73.76

GC content: 33.2

Gene sequence:

>1470_bases
GTGACACAAATGAATTCTAGAAAGAAAAGCATTATTGCCTCACTAATGGTTGCCATGTTCTTAGGTGCTATTGAGGGAAC
GGTCGTAACAACAGCTATGCCAACCATTGTTAGGGATTTAAATGGTTTTGATAAAATCAGTTTGGTATTTTCTGTGTATT
TATTAACTTCAGCAATTTCTACGCCAATCTACGGCAAAATAGCTGACTTATATGGACGAAAAAGAGCTTTATCTACAGGA
ATTATAATATTTTTACTTGGAAGTGCTTTATGTGGTATTTCCTCAAATATGTACGAGCTTATTTTATTCAGAGCTCTTCA
AGGTATAGGTGCAGGTTCTATATTTACTGTTTCATATACAATAGTTGGAGATGTGTTTTCCTTAGAAGAAAGAGGAAAAG
TTCAAGGCTGGATAAGTTCCGTATGGGGTATTGCAAGTTTACTTGGTCCTTTCATAGGAGGCTTTTTTATTGACTATATG
TCTTGGAACTGGATATTCTACATAAACCTTCCTTTTGGCATATTTTCTTTAGTACTTCTTGAAAAAAATCTAAAGGAAAA
AGTTGAAAAAAAGAAAACCCCTATGGATTATCTTGGTATAGTGACCTTAACTTTAACCATAGTAATATTTTTACTCACTA
TTTTAGGTATAAATGAAAATACAAAAATTTCTTCAGCTAAAATAATATTACCTATGCTTGTTACTGTTCTTTTATTGTTT
GTATTTTACTTTATTGAAAAAAGAGCTAAGGAACCACTAATTCCTTTTGACATATTTTCTAAGCAGAGTAATATTGTAAA
TATAATAAGCTTTCTCGTGTCTGGAATCCTTATAGGAACAGATGTATATTTACCTATATACATACAGAACGTTTTGGGCT
ATAGTGCTACAATTTCAGGGCTTTCCCTTGCATCAATGTCTATATCCTGGATACTATCTTCTTTTGTGCTTTCAAAAGCC
ATCCAAAAGTATGGAGAACGTCCTGTGGTATTTATTTCAACCCTCATTACCTTAGTAAGTACAGTACTTTTTTACACGTT
AACTGGTAATTCTCCTCTTATTTTAGTCATTATATACGGCTTTATAATTGGCTTTGGCTATGGAGGAACCTTAACCACTC
TCACAATAGTAATTCAGGAAGCTGTTTCTAAGGATAAGAGAGGTGCTGCAACAGGGGCAAATTCACTGTTGAGAACCATG
GGTCAGACTATTGGTGTAGCAATTTTCGGAGTTATTTTTAACTTGAATATTGCAAAATATTTATACAAACTTGGAATTAG
AGGAATAAACGTAAACAGCCTATACGGCTCAGGAAACGTACATACCGGTATTCCATTGGATAAAGTTAAGGCATCTCTTA
ATTTTGGAGTCCATACCCTATTTTTTATACTGATACTAATATCGGTTATATGTACTATTATGTCTGTGATGCTTTCAAAC
TCACTAAATAAGAAGAAAAATATGAGGTGA

Upstream 100 bases:

>100_bases
GTAGAAGAAATAATAAAGTGGATATAAAAGTTTCAATTGGTGTTTTCTTTTATGGTTCTCTGTGTTAACATAATAGTATT
TGCATTAATTAAGAAGGCAG

Downstream 100 bases:

>100_bases
TTTTATGTTTAAGGACAATAGATTTGTGGGTACTGTTTTAACCTGCATTCTAATAGCCTTTTTGCTCTCTATTACAATTA
AAAGATTCTTTATAACTAAA

Product: permease, MDR related

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 489; Mature: 488

Protein sequence:

>489_residues
MTQMNSRKKSIIASLMVAMFLGAIEGTVVTTAMPTIVRDLNGFDKISLVFSVYLLTSAISTPIYGKIADLYGRKRALSTG
IIIFLLGSALCGISSNMYELILFRALQGIGAGSIFTVSYTIVGDVFSLEERGKVQGWISSVWGIASLLGPFIGGFFIDYM
SWNWIFYINLPFGIFSLVLLEKNLKEKVEKKKTPMDYLGIVTLTLTIVIFLLTILGINENTKISSAKIILPMLVTVLLLF
VFYFIEKRAKEPLIPFDIFSKQSNIVNIISFLVSGILIGTDVYLPIYIQNVLGYSATISGLSLASMSISWILSSFVLSKA
IQKYGERPVVFISTLITLVSTVLFYTLTGNSPLILVIIYGFIIGFGYGGTLTTLTIVIQEAVSKDKRGAATGANSLLRTM
GQTIGVAIFGVIFNLNIAKYLYKLGIRGINVNSLYGSGNVHTGIPLDKVKASLNFGVHTLFFILILISVICTIMSVMLSN
SLNKKKNMR

Sequences:

>Translated_489_residues
MTQMNSRKKSIIASLMVAMFLGAIEGTVVTTAMPTIVRDLNGFDKISLVFSVYLLTSAISTPIYGKIADLYGRKRALSTG
IIIFLLGSALCGISSNMYELILFRALQGIGAGSIFTVSYTIVGDVFSLEERGKVQGWISSVWGIASLLGPFIGGFFIDYM
SWNWIFYINLPFGIFSLVLLEKNLKEKVEKKKTPMDYLGIVTLTLTIVIFLLTILGINENTKISSAKIILPMLVTVLLLF
VFYFIEKRAKEPLIPFDIFSKQSNIVNIISFLVSGILIGTDVYLPIYIQNVLGYSATISGLSLASMSISWILSSFVLSKA
IQKYGERPVVFISTLITLVSTVLFYTLTGNSPLILVIIYGFIIGFGYGGTLTTLTIVIQEAVSKDKRGAATGANSLLRTM
GQTIGVAIFGVIFNLNIAKYLYKLGIRGINVNSLYGSGNVHTGIPLDKVKASLNFGVHTLFFILILISVICTIMSVMLSN
SLNKKKNMR
>Mature_488_residues
TQMNSRKKSIIASLMVAMFLGAIEGTVVTTAMPTIVRDLNGFDKISLVFSVYLLTSAISTPIYGKIADLYGRKRALSTGI
IIFLLGSALCGISSNMYELILFRALQGIGAGSIFTVSYTIVGDVFSLEERGKVQGWISSVWGIASLLGPFIGGFFIDYMS
WNWIFYINLPFGIFSLVLLEKNLKEKVEKKKTPMDYLGIVTLTLTIVIFLLTILGINENTKISSAKIILPMLVTVLLLFV
FYFIEKRAKEPLIPFDIFSKQSNIVNIISFLVSGILIGTDVYLPIYIQNVLGYSATISGLSLASMSISWILSSFVLSKAI
QKYGERPVVFISTLITLVSTVLFYTLTGNSPLILVIIYGFIIGFGYGGTLTTLTIVIQEAVSKDKRGAATGANSLLRTMG
QTIGVAIFGVIFNLNIAKYLYKLGIRGINVNSLYGSGNVHTGIPLDKVKASLNFGVHTLFFILILISVICTIMSVMLSNS
LNKKKNMR

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=423, Percent_Identity=25.7683215130024, Blast_Score=145, Evalue=5e-36,
Organism=Escherichia coli, GI87081983, Length=421, Percent_Identity=24.7030878859857, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1789042, Length=399, Percent_Identity=25.5639097744361, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI1788710, Length=407, Percent_Identity=26.044226044226, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI1788392, Length=332, Percent_Identity=26.8072289156627, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1790146, Length=165, Percent_Identity=29.6969696969697, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790794, Length=162, Percent_Identity=30.8641975308642, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI1788509, Length=121, Percent_Identity=28.9256198347107, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323735, Length=446, Percent_Identity=27.5784753363229, Blast_Score=130, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6322958, Length=450, Percent_Identity=23.7777777777778, Blast_Score=109, Evalue=9e-25,
Organism=Saccharomyces cerevisiae, GI6325455, Length=494, Percent_Identity=23.6842105263158, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6319770, Length=393, Percent_Identity=26.972010178117, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6321663, Length=146, Percent_Identity=32.1917808219178, Blast_Score=88, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 53543; Mature: 53412

Theoretical pI: Translated: 10.14; Mature: 10.14

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQMNSRKKSIIASLMVAMFLGAIEGTVVTTAMPTIVRDLNGFDKISLVFSVYLLTSAIS
CCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHC
TPIYGKIADLYGRKRALSTGIIIFLLGSALCGISSNMYELILFRALQGIGAGSIFTVSYT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEHH
IVGDVFSLEERGKVQGWISSVWGIASLLGPFIGGFFIDYMSWNWIFYINLPFGIFSLVLL
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHH
EKNLKEKVEKKKTPMDYLGIVTLTLTIVIFLLTILGINENTKISSAKIILPMLVTVLLLF
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
VFYFIEKRAKEPLIPFDIFSKQSNIVNIISFLVSGILIGTDVYLPIYIQNVLGYSATISG
HHHHHHHHCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHCC
LSLASMSISWILSSFVLSKAIQKYGERPVVFISTLITLVSTVLFYTLTGNSPLILVIIYG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEECCCCCEEHHHHHH
FIIGFGYGGTLTTLTIVIQEAVSKDKRGAATGANSLLRTMGQTIGVAIFGVIFNLNIAKY
HHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYKLGIRGINVNSLYGSGNVHTGIPLDKVKASLNFGVHTLFFILILISVICTIMSVMLSN
HHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHC
SLNKKKNMR
CCCHHCCCC
>Mature Secondary Structure 
TQMNSRKKSIIASLMVAMFLGAIEGTVVTTAMPTIVRDLNGFDKISLVFSVYLLTSAIS
CCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHC
TPIYGKIADLYGRKRALSTGIIIFLLGSALCGISSNMYELILFRALQGIGAGSIFTVSYT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEHH
IVGDVFSLEERGKVQGWISSVWGIASLLGPFIGGFFIDYMSWNWIFYINLPFGIFSLVLL
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHH
EKNLKEKVEKKKTPMDYLGIVTLTLTIVIFLLTILGINENTKISSAKIILPMLVTVLLLF
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
VFYFIEKRAKEPLIPFDIFSKQSNIVNIISFLVSGILIGTDVYLPIYIQNVLGYSATISG
HHHHHHHHCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHCC
LSLASMSISWILSSFVLSKAIQKYGERPVVFISTLITLVSTVLFYTLTGNSPLILVIIYG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEECCCCCEEHHHHHH
FIIGFGYGGTLTTLTIVIQEAVSKDKRGAATGANSLLRTMGQTIGVAIFGVIFNLNIAKY
HHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYKLGIRGINVNSLYGSGNVHTGIPLDKVKASLNFGVHTLFFILILISVICTIMSVMLSN
HHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHC
SLNKKKNMR
CCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]