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Identifier: 15004831

GI number: 15004831

Start: 138365

End: 139810

Strand: Direct

Name: Not Available

Synonym: CA_P0128

Alternate gene names: 15004831

Gene position: 138365-139810 (Clockwise)

Preceding gene: 15004826

Following gene: 15004834

Centisome position: 72.07

GC content: 33.2

Gene sequence:

>1446_bases
ATGGAAGAAACAAACAAAACTTCGTACTGGCCAATGATGATTGCAATATTTCTAGGATCTTTTTTAGTTAGTTTAGGTAC
TAGTACTATTAACCTAGCTTTACCGTTTTTAATGAAATCTTTTAGCGCAAACTTAGATACTGTAAAATGGACACTTACTG
GCTTCATGCTAGCTATGGGAACTATGGCTCCCCTGACCGCCTATTTAGGAGAGCGTTTTAGCTATAAAAGAGTTTATTTA
ACTTCTATTGTTGGTTTCATACTCGCTTCAATACTATGTATATTTTCAATAAATATAACAACACTTATTATTTCACGTAT
TATTCAAGGCGCTTTTAGTGGTGTGATTGTGCCTGCAACCATGGCTATAATCTATCAAGCTGTTCCAAAGAAAAGACAAG
TATCTGCAACCAGTCTTTGGAGTATGGCATCAATGCTTGCACCCGCTATCGGCCCTACTTTAAGTGGTTTTTTAATACAA
TATTTTAGTTGGCAGTCAATATTTATAATAAACATACCTATAGGACTTATTATTTTAATTTTAGGTTTAAAATATATACC
ATACTTCAAGTTAAATGTTCCAGAGTCTTTTGATTTCAAAGGTTTTGGCTTTATTGTTTTAGGAAGCTTGGCTCTTCTAA
TAGCCTTTAGTGAAGGTGGTGTTTTGGGCTGGACATCGTTACCTATAATATTTTCCTTAGCTATTGGAGTAATACTTCTT
GGAATCTTTGTTTATAGATCATTATCCATGGATTCCTCAATTCTTGATTTATGTGTATTTAAATATAAAAAGTATAGTTT
TAGTGTAGTTGTATATTCAATTGTAATGATGAGCCTTTATGCTGGAACTCTTTTAACACCTATTTTCTTGCAAAATCTTC
AGCACATGTCTGCTTTAGATTCAGGAATAATTTTGCTTCCAGCATCTTTGTGTATGGCACTGGCAATGCCTATTGTAGGA
AAATTATATAATAAAATAAATTCACGTATAATAATTATGACTGGAATATTATTAATAGCTCTAGGCTCCTTTGAACTTAC
ACATTTGACAGTTACTACTTCTAAAGCCTTTATAATAGTTTGGATGATAGTTAGAAACGTGGGAATCTCATTTTGTACAA
TGCCTGTGACCTATTCAGGAATGACAGTACTTCCAAAGGCCATATCTGGACATGGTTCTTCAGTTAACAATTGGCTAGCC
AGACTTGTGAGTTCACTTTCTATGGCAATATTTGCTTCCCTGCTTACCTCAAGAGCTTCCATGCACGTTACCTCACTTAT
AAAATCAGGTAAAGCACATATAGTAGCTCAAAGTACGGGGTACGTAATGGGAATAAACGATGTGTACTTTGTTTCTTTTA
TAATAATACTTATTGCATTACCTTTTAGCTATTTTTTAAATAATAGAAAAGTAAAAACTAGAGAAACTAGTAAAGAAGTA
GCTTAA

Upstream 100 bases:

>100_bases
TTACTTATTTTTTAATTTAATATTCTAACTACAGTCATAGTAATGGATTTATTAGAGTTACTATGTTTTTTTAACGCAAA
AAATGAATGGAGGATAATGG

Downstream 100 bases:

>100_bases
AGTTTAAAACCACATTTCTAAAGTAAGTTAACAACTTTAGAAATGTGGTTTTGTTAAATTCAGGGTATCCTTTAATTTAC
ATAAAAAATAAAAGATAGAC

Product: permease, MDR related

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MEETNKTSYWPMMIAIFLGSFLVSLGTSTINLALPFLMKSFSANLDTVKWTLTGFMLAMGTMAPLTAYLGERFSYKRVYL
TSIVGFILASILCIFSINITTLIISRIIQGAFSGVIVPATMAIIYQAVPKKRQVSATSLWSMASMLAPAIGPTLSGFLIQ
YFSWQSIFIINIPIGLIILILGLKYIPYFKLNVPESFDFKGFGFIVLGSLALLIAFSEGGVLGWTSLPIIFSLAIGVILL
GIFVYRSLSMDSSILDLCVFKYKKYSFSVVVYSIVMMSLYAGTLLTPIFLQNLQHMSALDSGIILLPASLCMALAMPIVG
KLYNKINSRIIIMTGILLIALGSFELTHLTVTTSKAFIIVWMIVRNVGISFCTMPVTYSGMTVLPKAISGHGSSVNNWLA
RLVSSLSMAIFASLLTSRASMHVTSLIKSGKAHIVAQSTGYVMGINDVYFVSFIIILIALPFSYFLNNRKVKTRETSKEV
A

Sequences:

>Translated_481_residues
MEETNKTSYWPMMIAIFLGSFLVSLGTSTINLALPFLMKSFSANLDTVKWTLTGFMLAMGTMAPLTAYLGERFSYKRVYL
TSIVGFILASILCIFSINITTLIISRIIQGAFSGVIVPATMAIIYQAVPKKRQVSATSLWSMASMLAPAIGPTLSGFLIQ
YFSWQSIFIINIPIGLIILILGLKYIPYFKLNVPESFDFKGFGFIVLGSLALLIAFSEGGVLGWTSLPIIFSLAIGVILL
GIFVYRSLSMDSSILDLCVFKYKKYSFSVVVYSIVMMSLYAGTLLTPIFLQNLQHMSALDSGIILLPASLCMALAMPIVG
KLYNKINSRIIIMTGILLIALGSFELTHLTVTTSKAFIIVWMIVRNVGISFCTMPVTYSGMTVLPKAISGHGSSVNNWLA
RLVSSLSMAIFASLLTSRASMHVTSLIKSGKAHIVAQSTGYVMGINDVYFVSFIIILIALPFSYFLNNRKVKTRETSKEV
A
>Mature_481_residues
MEETNKTSYWPMMIAIFLGSFLVSLGTSTINLALPFLMKSFSANLDTVKWTLTGFMLAMGTMAPLTAYLGERFSYKRVYL
TSIVGFILASILCIFSINITTLIISRIIQGAFSGVIVPATMAIIYQAVPKKRQVSATSLWSMASMLAPAIGPTLSGFLIQ
YFSWQSIFIINIPIGLIILILGLKYIPYFKLNVPESFDFKGFGFIVLGSLALLIAFSEGGVLGWTSLPIIFSLAIGVILL
GIFVYRSLSMDSSILDLCVFKYKKYSFSVVVYSIVMMSLYAGTLLTPIFLQNLQHMSALDSGIILLPASLCMALAMPIVG
KLYNKINSRIIIMTGILLIALGSFELTHLTVTTSKAFIIVWMIVRNVGISFCTMPVTYSGMTVLPKAISGHGSSVNNWLA
RLVSSLSMAIFASLLTSRASMHVTSLIKSGKAHIVAQSTGYVMGINDVYFVSFIIILIALPFSYFLNNRKVKTRETSKEV
A

Specific function: Translocase That Confers Resistance To Substances Of High Hydrophobicity. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1789042, Length=422, Percent_Identity=26.5402843601896, Blast_Score=161, Evalue=1e-40,
Organism=Escherichia coli, GI1788710, Length=449, Percent_Identity=27.3942093541203, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1790195, Length=422, Percent_Identity=24.1706161137441, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI87081983, Length=415, Percent_Identity=23.855421686747, Blast_Score=118, Evalue=8e-28,
Organism=Escherichia coli, GI1788392, Length=444, Percent_Identity=24.5495495495495, Blast_Score=109, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6323735, Length=321, Percent_Identity=25.2336448598131, Blast_Score=71, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 52687; Mature: 52687

Theoretical pI: Translated: 10.13; Mature: 10.13

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEETNKTSYWPMMIAIFLGSFLVSLGTSTINLALPFLMKSFSANLDTVKWTLTGFMLAMG
CCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
TMAPLTAYLGERFSYKRVYLTSIVGFILASILCIFSINITTLIISRIIQGAFSGVIVPAT
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
MAIIYQAVPKKRQVSATSLWSMASMLAPAIGPTLSGFLIQYFSWQSIFIINIPIGLIILI
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCEEEEEECCHHHHHHH
LGLKYIPYFKLNVPESFDFKGFGFIVLGSLALLIAFSEGGVLGWTSLPIIFSLAIGVILL
HHHHHCCEEEECCCCCCCCCCHHHHHHHHHHHHHEECCCCEECHHHHHHHHHHHHHHHHH
GIFVYRSLSMDSSILDLCVFKYKKYSFSVVVYSIVMMSLYAGTLLTPIFLQNLQHMSALD
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SGIILLPASLCMALAMPIVGKLYNKINSRIIIMTGILLIALGSFELTHLTVTTSKAFIIV
CCCEEHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHCCCEEEEEEEECCCHHHHH
WMIVRNVGISFCTMPVTYSGMTVLPKAISGHGSSVNNWLARLVSSLSMAIFASLLTSRAS
HHHHHHCCCCEEECCEEECCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MHVTSLIKSGKAHIVAQSTGYVMGINDVYFVSFIIILIALPFSYFLNNRKVKTRETSKEV
HHHHHHHHCCCCEEEEECCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCC
A
C
>Mature Secondary Structure
MEETNKTSYWPMMIAIFLGSFLVSLGTSTINLALPFLMKSFSANLDTVKWTLTGFMLAMG
CCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
TMAPLTAYLGERFSYKRVYLTSIVGFILASILCIFSINITTLIISRIIQGAFSGVIVPAT
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
MAIIYQAVPKKRQVSATSLWSMASMLAPAIGPTLSGFLIQYFSWQSIFIINIPIGLIILI
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCEEEEEECCHHHHHHH
LGLKYIPYFKLNVPESFDFKGFGFIVLGSLALLIAFSEGGVLGWTSLPIIFSLAIGVILL
HHHHHCCEEEECCCCCCCCCCHHHHHHHHHHHHHEECCCCEECHHHHHHHHHHHHHHHHH
GIFVYRSLSMDSSILDLCVFKYKKYSFSVVVYSIVMMSLYAGTLLTPIFLQNLQHMSALD
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SGIILLPASLCMALAMPIVGKLYNKINSRIIIMTGILLIALGSFELTHLTVTTSKAFIIV
CCCEEHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHCCCEEEEEEEECCCHHHHH
WMIVRNVGISFCTMPVTYSGMTVLPKAISGHGSSVNNWLARLVSSLSMAIFASLLTSRAS
HHHHHHCCCCEEECCEEECCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MHVTSLIKSGKAHIVAQSTGYVMGINDVYFVSFIIILIALPFSYFLNNRKVKTRETSKEV
HHHHHHHHCCCCEEEEECCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 8969498 [H]