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The map label for this gene is lon2

Identifier: 15594958

GI number: 15594958

Start: 639808

End: 642249

Strand: Direct

Name: lon2

Synonym: BB0613

Alternate gene names: 15594958

Gene position: 639808-642249 (Clockwise)

Preceding gene: 15594957

Following gene: 15594959

Centisome position: 70.25

GC content: 30.59

Gene sequence:

>2442_bases
ATGCAATTAAAAAACCTTGGGCAAAAGAGTTATATGAAATCAATCTTAAATATGATAAAAAATAGAAAAGAAGATCTTCC
AATTGTTATTTTAAAAGAAAATGTTCTTTTTCCCAATATTACATTGTGGGTAACCTTTGATAATGAATATGTAATTAATT
CCATAGCGCAATCCATGTTAGAGGAAAGATTGATTTTATTTGCTTATTCAAATGAGCCTAATTGTGATGAATCTGATAGG
GGAGTAGTTAAAAACCTATGCTCTGTGGGTACTTATTCTAAACTTATTCAGGTTATAAAGATTAGTAAAGACGTAATAAA
AGTTTTAGTTGAGTGTCAAAGTAGGGTTCTTATAGACAGTGTTTCTAAAAAAAATGATTATTTGAGAGCTAAAGTTACTT
TTGTGCCTGATTCTAGTGGATTAAACAGAGAGCTTTTTACCTATTCTAAATTTTTAAAAGAAACCTATGAAGCTTATAGA
AATTCCTTATCTTTAAAATCTTATGATGCGGATAATGAACCAATTAATTATTTTGAGAATCCAAGTAAGCTTGTCGATAT
TATAGCTTCTAATTCAAATTTGGAAAATAGCATAAAATTAGAACTTTTACAAGAGCTAAATGTTAAAACCAGAATAGAAA
AGTTGATTGTTAATTTAAGCATTGAAATTGATCTTTTAGATCTTAAAAAAGATATTAATTCTAAAGTTAGAGCTAAGTTG
GATAAGGGGCAAAGGGATTATTTTCTTTCTGAACAAGTTAAAGAGATACAAAAAAGATTAGGTAAAGATGAAAACGATTA
TATTGATAGATTAAACTCTAAAGATATTCCAGAAGATGTTAAATCTAAGATTGAAAAAGAAATTTCTAGATTGTCTAAAA
TGCAGATGAATTCACCTGATGCTAATATTATTAGAAGTTATATAGAATTAATATTAGATCTTCCATGGAATGAAAATACT
GTTATGAAAAATCATTTAAGCGAGATTGAATTTATCTTAAGAAATTCTCATTATGGTATGGATGAAGCAAAAGAAAAGAT
AATAAATTTTTTGGCTGTTTATCAGATTAATTCTAAGGTCAAAGCTCCTATTTTATGTCTTGTGGGGCCTCCTGGTATTG
GCAAAACATCTCTTGTGGAGTCTATTGCAAGATCACTGTCTAGAGAATTTGTTAAAATATCTCTTGGTGGCTTAAGAGAT
GAGGCAGAAATTAGGGGGCATAGAAGAACTTATGTTGGTTCTCTTCCGGGTGTTTTTATTAGCGCAATGAAAAGATCAGG
TAAATCCAATCCCGTTATTCTTCTTGATGAAATAGATAAAATTAATAGTAGTTATAAGGGAAATCCCGAATCTGCCCTTT
TGGAAGTTTTAGATCCGGAGCAAAATTATAAGTTTATAGATCATTATTTAGAAATTCCTTATGATCTTTCCAATGTTTTA
TTTGTTACAACAGCCAATTCTCTTAATGGTATGTCAAAGCCGCTTTTAGATAGAATGGAAATAATTAAGGTTGAGGGTTA
TTCTTATATTGAAAAGTTAGAGATTGCTAAGATTTTTCTGATTCCAAGCATAATTAAAGAGAGTTTTTTGGACAAAGTTT
ATATAAGAATAGAAGATGATGTTATTTTTAATTTGATTAGAAACTATACTATGGAATCTGGTGTAAGGGGGCTAAAGAGA
GTTTTGACTAATTTGATTAGGAGACTTGTAAGGGAGCTGCTTTATGAGTATTCTAAAGATCAAATCATCAAAGGCAACTT
TTATTCACCAAGTTCTTTGATACATGGGAATAATTCGCTTTTTACTCATGATCCTGATATTCCAGGTATTTATAAAATAA
TCAATATTAATAATTATTATAATTATGTTGATACTGAGGATAACTTGGATTTAATTAAGATTGATTCTTCGGGGTTTGTT
TATGGGCTTGCTTGGACAAATTATGGTGGTACAGTTCTTCCTGTTGAGGCAACTAAGTTTGAGAAAAAGGGAGACATTAT
TCTAACAGGTAGTCTTGGAGCTATTATGAAAGAGAGTGCACAGCTTGCATATTCTATAGTTAAGACCTATTCTTCTAAGC
TTAATTTTGATGTGAAGGAAAGTCCTGAAATTCATTTGCACTTTCCAGAAGGAGCAACACCAAAAGATGGGCCTTCTGCA
GGTATTACCATTGCAACGGCAATTGCTTCGATATTGTCTGACAAGAAAGTTCCTTTGGATCTTGCAATGACTGGTGAGGT
GACTTTAAAGGGCTTTGTTCTTCCTGTGGGCGGCATTAAAGAAAAAGTTTTAGCAGCCTATAGAAACGGTATAAGTAAAG
TTATTTTGCCCAAAGATAATAAAAAAGATTATTCTAAGCTTCCAGAAGAAGTTAAGGACAATATAGATGTTAAGTTTGTC
TCCAGCTTGGAAGAAGTTTTTGATTATTTGAATATTATTTAA

Upstream 100 bases:

>100_bases
GTTATGTTCGAGGTTCCTTCTATTAGTAAGGCTAAGAAGGTTGTTGTTACAAAAGAATCTGTTTTAAATGCAGATGTTAA
CCCATTAATTTTAGTGGGAA

Downstream 100 bases:

>100_bases
AAATTTACATATTTAAATTTATATTTTAGGAGTAGATCTATGAAAGATGGAGTTAGAAAGCCTTCGGGCAATAGAGCGTC
TTTTAGCGCTCAGCCTAATG

Product: ATP-dependent protease LA

Products: NA

Alternate protein names: ATP-dependent protease La 2

Number of amino acids: Translated: 813; Mature: 813

Protein sequence:

>813_residues
MQLKNLGQKSYMKSILNMIKNRKEDLPIVILKENVLFPNITLWVTFDNEYVINSIAQSMLEERLILFAYSNEPNCDESDR
GVVKNLCSVGTYSKLIQVIKISKDVIKVLVECQSRVLIDSVSKKNDYLRAKVTFVPDSSGLNRELFTYSKFLKETYEAYR
NSLSLKSYDADNEPINYFENPSKLVDIIASNSNLENSIKLELLQELNVKTRIEKLIVNLSIEIDLLDLKKDINSKVRAKL
DKGQRDYFLSEQVKEIQKRLGKDENDYIDRLNSKDIPEDVKSKIEKEISRLSKMQMNSPDANIIRSYIELILDLPWNENT
VMKNHLSEIEFILRNSHYGMDEAKEKIINFLAVYQINSKVKAPILCLVGPPGIGKTSLVESIARSLSREFVKISLGGLRD
EAEIRGHRRTYVGSLPGVFISAMKRSGKSNPVILLDEIDKINSSYKGNPESALLEVLDPEQNYKFIDHYLEIPYDLSNVL
FVTTANSLNGMSKPLLDRMEIIKVEGYSYIEKLEIAKIFLIPSIIKESFLDKVYIRIEDDVIFNLIRNYTMESGVRGLKR
VLTNLIRRLVRELLYEYSKDQIIKGNFYSPSSLIHGNNSLFTHDPDIPGIYKIININNYYNYVDTEDNLDLIKIDSSGFV
YGLAWTNYGGTVLPVEATKFEKKGDIILTGSLGAIMKESAQLAYSIVKTYSSKLNFDVKESPEIHLHFPEGATPKDGPSA
GITIATAIASILSDKKVPLDLAMTGEVTLKGFVLPVGGIKEKVLAAYRNGISKVILPKDNKKDYSKLPEEVKDNIDVKFV
SSLEEVFDYLNII

Sequences:

>Translated_813_residues
MQLKNLGQKSYMKSILNMIKNRKEDLPIVILKENVLFPNITLWVTFDNEYVINSIAQSMLEERLILFAYSNEPNCDESDR
GVVKNLCSVGTYSKLIQVIKISKDVIKVLVECQSRVLIDSVSKKNDYLRAKVTFVPDSSGLNRELFTYSKFLKETYEAYR
NSLSLKSYDADNEPINYFENPSKLVDIIASNSNLENSIKLELLQELNVKTRIEKLIVNLSIEIDLLDLKKDINSKVRAKL
DKGQRDYFLSEQVKEIQKRLGKDENDYIDRLNSKDIPEDVKSKIEKEISRLSKMQMNSPDANIIRSYIELILDLPWNENT
VMKNHLSEIEFILRNSHYGMDEAKEKIINFLAVYQINSKVKAPILCLVGPPGIGKTSLVESIARSLSREFVKISLGGLRD
EAEIRGHRRTYVGSLPGVFISAMKRSGKSNPVILLDEIDKINSSYKGNPESALLEVLDPEQNYKFIDHYLEIPYDLSNVL
FVTTANSLNGMSKPLLDRMEIIKVEGYSYIEKLEIAKIFLIPSIIKESFLDKVYIRIEDDVIFNLIRNYTMESGVRGLKR
VLTNLIRRLVRELLYEYSKDQIIKGNFYSPSSLIHGNNSLFTHDPDIPGIYKIININNYYNYVDTEDNLDLIKIDSSGFV
YGLAWTNYGGTVLPVEATKFEKKGDIILTGSLGAIMKESAQLAYSIVKTYSSKLNFDVKESPEIHLHFPEGATPKDGPSA
GITIATAIASILSDKKVPLDLAMTGEVTLKGFVLPVGGIKEKVLAAYRNGISKVILPKDNKKDYSKLPEEVKDNIDVKFV
SSLEEVFDYLNII
>Mature_813_residues
MQLKNLGQKSYMKSILNMIKNRKEDLPIVILKENVLFPNITLWVTFDNEYVINSIAQSMLEERLILFAYSNEPNCDESDR
GVVKNLCSVGTYSKLIQVIKISKDVIKVLVECQSRVLIDSVSKKNDYLRAKVTFVPDSSGLNRELFTYSKFLKETYEAYR
NSLSLKSYDADNEPINYFENPSKLVDIIASNSNLENSIKLELLQELNVKTRIEKLIVNLSIEIDLLDLKKDINSKVRAKL
DKGQRDYFLSEQVKEIQKRLGKDENDYIDRLNSKDIPEDVKSKIEKEISRLSKMQMNSPDANIIRSYIELILDLPWNENT
VMKNHLSEIEFILRNSHYGMDEAKEKIINFLAVYQINSKVKAPILCLVGPPGIGKTSLVESIARSLSREFVKISLGGLRD
EAEIRGHRRTYVGSLPGVFISAMKRSGKSNPVILLDEIDKINSSYKGNPESALLEVLDPEQNYKFIDHYLEIPYDLSNVL
FVTTANSLNGMSKPLLDRMEIIKVEGYSYIEKLEIAKIFLIPSIIKESFLDKVYIRIEDDVIFNLIRNYTMESGVRGLKR
VLTNLIRRLVRELLYEYSKDQIIKGNFYSPSSLIHGNNSLFTHDPDIPGIYKIININNYYNYVDTEDNLDLIKIDSSGFV
YGLAWTNYGGTVLPVEATKFEKKGDIILTGSLGAIMKESAQLAYSIVKTYSSKLNFDVKESPEIHLHFPEGATPKDGPSA
GITIATAIASILSDKKVPLDLAMTGEVTLKGFVLPVGGIKEKVLAAYRNGISKVILPKDNKKDYSKLPEEVKDNIDVKFV
SSLEEVFDYLNII

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain

Homologues:

Organism=Homo sapiens, GI21396489, Length=649, Percent_Identity=39.4453004622496, Blast_Score=469, Evalue=1e-132,
Organism=Homo sapiens, GI31377667, Length=833, Percent_Identity=34.9339735894358, Blast_Score=466, Evalue=1e-131,
Organism=Escherichia coli, GI1786643, Length=801, Percent_Identity=39.8252184769039, Blast_Score=586, Evalue=1e-168,
Organism=Caenorhabditis elegans, GI17505831, Length=667, Percent_Identity=38.3808095952024, Blast_Score=454, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI17556486, Length=546, Percent_Identity=39.1941391941392, Blast_Score=422, Evalue=1e-118,
Organism=Saccharomyces cerevisiae, GI6319449, Length=714, Percent_Identity=38.655462184874, Blast_Score=473, Evalue=1e-134,
Organism=Drosophila melanogaster, GI24666867, Length=651, Percent_Identity=39.63133640553, Blast_Score=473, Evalue=1e-133,
Organism=Drosophila melanogaster, GI221513036, Length=651, Percent_Identity=39.63133640553, Blast_Score=472, Evalue=1e-133,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): LON2_BORBU (O51558)

Other databases:

- EMBL:   AE000783
- PIR:   D70176
- RefSeq:   NP_212747.1
- ProteinModelPortal:   O51558
- SMR:   O51558
- MEROPS:   S16.009
- EnsemblBacteria:   EBBORT00000008963
- GeneID:   1195462
- GenomeReviews:   AE000783_GR
- KEGG:   bbu:BB0613
- NMPDR:   fig|224326.1.peg.997
- TIGR:   BB_0613
- GeneTree:   EBGT00050000007303
- HOGENOM:   HBG566281
- OMA:   FVYGLAW
- ProtClustDB:   CLSK507703
- BioCyc:   BBUR224326:BB_0613-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568
- PRINTS:   PR00830
- SMART:   SM00382
- SMART:   SM00464
- TIGRFAMs:   TIGR00763

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C; SSF88697 PUA-like; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =3.4.21.53

Molecular weight: Translated: 92314; Mature: 92314

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS01046 LON_SER

Important sites: ACT_SITE 719-719 ACT_SITE 762-762

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLKNLGQKSYMKSILNMIKNRKEDLPIVILKENVLFPNITLWVTFDNEYVINSIAQSML
CCCHHCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCEEEEEEECCHHHHHHHHHHHH
EERLILFAYSNEPNCDESDRGVVKNLCSVGTYSKLIQVIKISKDVIKVLVECQSRVLIDS
HCCEEEEEECCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSKKNDYLRAKVTFVPDSSGLNRELFTYSKFLKETYEAYRNSLSLKSYDADNEPINYFEN
HHCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
PSKLVDIIASNSNLENSIKLELLQELNVKTRIEKLIVNLSIEIDLLDLKKDINSKVRAKL
HHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHEEEEEEEEEHHHHHHHHHHHHHH
DKGQRDYFLSEQVKEIQKRLGKDENDYIDRLNSKDIPEDVKSKIEKEISRLSKMQMNSPD
CCCCCCHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
ANIIRSYIELILDLPWNENTVMKNHLSEIEFILRNSHYGMDEAKEKIINFLAVYQINSKV
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHEEECCCC
KAPILCLVGPPGIGKTSLVESIARSLSREFVKISLGGLRDEAEIRGHRRTYVGSLPGVFI
CCCEEEEECCCCCCHHHHHHHHHHHHHHHEEEEECCCCCCHHHHCCCCHHHHCCCHHHHH
SAMKRSGKSNPVILLDEIDKINSSYKGNPESALLEVLDPEQNYKFIDHYLEIPYDLSNVL
HHHHHCCCCCCEEEEECHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCEE
FVTTANSLNGMSKPLLDRMEIIKVEGYSYIEKLEIAKIFLIPSIIKESFLDKVYIRIEDD
EEEECCCCCCCHHHHHHHHHEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECHH
VIFNLIRNYTMESGVRGLKRVLTNLIRRLVRELLYEYSKDQIIKGNFYSPSSLIHGNNSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCEEECCCCE
FTHDPDIPGIYKIININNYYNYVDTEDNLDLIKIDSSGFVYGLAWTNYGGTVLPVEATKF
EECCCCCCCEEEEEEECCCCCCCCCCCCCEEEEECCCCEEEEEEEECCCCEEEEEEHHCC
EKKGDIILTGSLGAIMKESAQLAYSIVKTYSSKLNFDVKESPEIHLHFPEGATPKDGPSA
CCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCC
GITIATAIASILSDKKVPLDLAMTGEVTLKGFVLPVGGIKEKVLAAYRNGISKVILPKDN
CHHHHHHHHHHHCCCCCCEEEEEECCEEEEEEEEECCCHHHHHHHHHHCCCCEEEECCCC
KKDYSKLPEEVKDNIDVKFVSSLEEVFDYLNII
CCHHHHCCHHHHCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQLKNLGQKSYMKSILNMIKNRKEDLPIVILKENVLFPNITLWVTFDNEYVINSIAQSML
CCCHHCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCEEEEEEECCHHHHHHHHHHHH
EERLILFAYSNEPNCDESDRGVVKNLCSVGTYSKLIQVIKISKDVIKVLVECQSRVLIDS
HCCEEEEEECCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSKKNDYLRAKVTFVPDSSGLNRELFTYSKFLKETYEAYRNSLSLKSYDADNEPINYFEN
HHCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
PSKLVDIIASNSNLENSIKLELLQELNVKTRIEKLIVNLSIEIDLLDLKKDINSKVRAKL
HHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHEEEEEEEEEHHHHHHHHHHHHHH
DKGQRDYFLSEQVKEIQKRLGKDENDYIDRLNSKDIPEDVKSKIEKEISRLSKMQMNSPD
CCCCCCHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
ANIIRSYIELILDLPWNENTVMKNHLSEIEFILRNSHYGMDEAKEKIINFLAVYQINSKV
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHEEECCCC
KAPILCLVGPPGIGKTSLVESIARSLSREFVKISLGGLRDEAEIRGHRRTYVGSLPGVFI
CCCEEEEECCCCCCHHHHHHHHHHHHHHHEEEEECCCCCCHHHHCCCCHHHHCCCHHHHH
SAMKRSGKSNPVILLDEIDKINSSYKGNPESALLEVLDPEQNYKFIDHYLEIPYDLSNVL
HHHHHCCCCCCEEEEECHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCEE
FVTTANSLNGMSKPLLDRMEIIKVEGYSYIEKLEIAKIFLIPSIIKESFLDKVYIRIEDD
EEEECCCCCCCHHHHHHHHHEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECHH
VIFNLIRNYTMESGVRGLKRVLTNLIRRLVRELLYEYSKDQIIKGNFYSPSSLIHGNNSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCEEECCCCE
FTHDPDIPGIYKIININNYYNYVDTEDNLDLIKIDSSGFVYGLAWTNYGGTVLPVEATKF
EECCCCCCCEEEEEEECCCCCCCCCCCCCEEEEECCCCEEEEEEEECCCCEEEEEEHHCC
EKKGDIILTGSLGAIMKESAQLAYSIVKTYSSKLNFDVKESPEIHLHFPEGATPKDGPSA
CCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCC
GITIATAIASILSDKKVPLDLAMTGEVTLKGFVLPVGGIKEKVLAAYRNGISKVILPKDN
CHHHHHHHHHHHCCCCCCEEEEEECCEEEEEEEEECCCHHHHHHHHHHCCCCEEEECCCC
KKDYSKLPEEVKDNIDVKFVSSLEEVFDYLNII
CCHHHHCCHHHHCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9403685