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The map label for this gene is clpX

Identifier: 15594957

GI number: 15594957

Start: 638580

End: 639872

Strand: Direct

Name: clpX

Synonym: BB0612

Alternate gene names: 15594957

Gene position: 638580-639872 (Clockwise)

Preceding gene: 15594956

Following gene: 15594958

Centisome position: 70.12

GC content: 32.79

Gene sequence:

>1293_bases
ATGGCAAGAGTAAAAGGTCAAAAAGTAAAAGAGTGTTCTTTTTGTGGACTTAGTGTCGCTGAGCTTGGTGGTAATGTTGT
TATATCTAATGGGGTAGCGATTTGTCCGGAATGTTCTAAAATATGTCACAATCTTTTTAAAGAAAAGTTGTGTAAGCCGC
TAGATTCTAAGTCCAACGGTTTGCCAACTCCCAAACAACTTAAAGATCATTTAGACATGTATGTTGTTGGGCAAGAAGAT
GCTAAAAAAGTCTTATCTGTGGCTGTTTATAATCATTATAAAAGAATATTGAAAAATAATAAATATGACAATGGTATTGA
GATTGAAAAATCTAATATACTTTTGGTTGGTCCTACAGGCAGTGGTAAAACTTTGCTTGCAAAAACGTTGGCTGCAGAGA
TGAATGTGCCATTTGCAATAGCAGATGCTACAACTTTGACAGAAGCAGGATATGTTGGCGAGGATGTAGAAAATATTTTG
CTTAAATTGATACATGCTGCTCATGGGGATGTTAGCTTAGCTGAAAAAGGGATTATCTATATAGACGAGATAGATAAAAT
TGCTAAAAAAAATGAAAACGTCTCAATAACAAGAGATGTTTCTGGGGAAGGGGTTCAACAGGCTTTGTTAAAGATAATTG
AAGGCACGGTTGCCAATGTTCCTCCAAGAGGCGGTAGAAAGCATCCTTATGAGGATACTATTGAAATTAATACTCAAAAT
ATACTCTTTATATGTGGCGGTGCTTTTGTTGGGCTTGAAAACATTGTTAAGAATCGAATAAATAAAAGTTCTATTGGGTT
TTCAGCAATTGAAAAAAAGAATATAAGAGAAGATACTTCATTAAAGTATTTAGAAATGGAAGATTTGATTAAATTTGGCT
TAATACCAGAATTTGTTGGCAGACTTCCTGTGCATTCGTATCTTGAAAAGTTGAATAAAGAAGATTTGTTGAGAATATTG
GTTGATCCTCAAAATTCTATTGTTAAGCAGTATTATCATATGTTTAAAATGGACAATGTTGAATTGGTATTTGAAAAAGA
TGCTTTAGAATCAATTGTAGATGAAGCCATTTTAAAAAATACTGGAGCAAGAGGTCTTAGATCTATTTTAGAGGGTCTTC
TTAAAGATGTTATGTTCGAGGTTCCTTCTATTAGTAAGGCTAAGAAGGTTGTTGTTACAAAAGAATCTGTTTTAAATGCA
GATGTTAACCCATTAATTTTAGTGGGAAATGCAATTAAAAAACCTTGGGCAAAAGAGTTATATGAAATCAATCTTAAATA
TGATAAAAAATAG

Upstream 100 bases:

>100_bases
TGGAAAGAGATTATTTTATGACTTCAAGCGATGCTCTTAAATATGGTCTTATTGATAGTATCTTAGTAAGGGAGTAGTTT
TATTTTCGGTAAAAGTTTTT

Downstream 100 bases:

>100_bases
AAAAGAAGATCTTCCAATTGTTATTTTAAAAGAAAATGTTCTTTTTCCCAATATTACATTGTGGGTAACCTTTGATAATG
AATATGTAATTAATTCCATA

Product: ATP-dependent protease ATP-binding subunit ClpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MARVKGQKVKECSFCGLSVAELGGNVVISNGVAICPECSKICHNLFKEKLCKPLDSKSNGLPTPKQLKDHLDMYVVGQED
AKKVLSVAVYNHYKRILKNNKYDNGIEIEKSNILLVGPTGSGKTLLAKTLAAEMNVPFAIADATTLTEAGYVGEDVENIL
LKLIHAAHGDVSLAEKGIIYIDEIDKIAKKNENVSITRDVSGEGVQQALLKIIEGTVANVPPRGGRKHPYEDTIEINTQN
ILFICGGAFVGLENIVKNRINKSSIGFSAIEKKNIREDTSLKYLEMEDLIKFGLIPEFVGRLPVHSYLEKLNKEDLLRIL
VDPQNSIVKQYYHMFKMDNVELVFEKDALESIVDEAILKNTGARGLRSILEGLLKDVMFEVPSISKAKKVVVTKESVLNA
DVNPLILVGNAIKKPWAKELYEINLKYDKK

Sequences:

>Translated_430_residues
MARVKGQKVKECSFCGLSVAELGGNVVISNGVAICPECSKICHNLFKEKLCKPLDSKSNGLPTPKQLKDHLDMYVVGQED
AKKVLSVAVYNHYKRILKNNKYDNGIEIEKSNILLVGPTGSGKTLLAKTLAAEMNVPFAIADATTLTEAGYVGEDVENIL
LKLIHAAHGDVSLAEKGIIYIDEIDKIAKKNENVSITRDVSGEGVQQALLKIIEGTVANVPPRGGRKHPYEDTIEINTQN
ILFICGGAFVGLENIVKNRINKSSIGFSAIEKKNIREDTSLKYLEMEDLIKFGLIPEFVGRLPVHSYLEKLNKEDLLRIL
VDPQNSIVKQYYHMFKMDNVELVFEKDALESIVDEAILKNTGARGLRSILEGLLKDVMFEVPSISKAKKVVVTKESVLNA
DVNPLILVGNAIKKPWAKELYEINLKYDKK
>Mature_429_residues
ARVKGQKVKECSFCGLSVAELGGNVVISNGVAICPECSKICHNLFKEKLCKPLDSKSNGLPTPKQLKDHLDMYVVGQEDA
KKVLSVAVYNHYKRILKNNKYDNGIEIEKSNILLVGPTGSGKTLLAKTLAAEMNVPFAIADATTLTEAGYVGEDVENILL
KLIHAAHGDVSLAEKGIIYIDEIDKIAKKNENVSITRDVSGEGVQQALLKIIEGTVANVPPRGGRKHPYEDTIEINTQNI
LFICGGAFVGLENIVKNRINKSSIGFSAIEKKNIREDTSLKYLEMEDLIKFGLIPEFVGRLPVHSYLEKLNKEDLLRILV
DPQNSIVKQYYHMFKMDNVELVFEKDALESIVDEAILKNTGARGLRSILEGLLKDVMFEVPSISKAKKVVVTKESVLNAD
VNPLILVGNAIKKPWAKELYEINLKYDKK

Specific function: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP

COG id: COG1219

COG function: function code O; ATP-dependent protease Clp, ATPase subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family

Homologues:

Organism=Homo sapiens, GI7242140, Length=309, Percent_Identity=47.2491909385113, Blast_Score=273, Evalue=3e-73,
Organism=Escherichia coli, GI1786642, Length=414, Percent_Identity=53.8647342995169, Blast_Score=436, Evalue=1e-123,
Organism=Escherichia coli, GI1790366, Length=105, Percent_Identity=40, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71982905, Length=312, Percent_Identity=44.8717948717949, Blast_Score=263, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI71982908, Length=312, Percent_Identity=44.8717948717949, Blast_Score=263, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI71988663, Length=405, Percent_Identity=36.5432098765432, Blast_Score=234, Evalue=9e-62,
Organism=Caenorhabditis elegans, GI71988660, Length=250, Percent_Identity=38, Blast_Score=167, Evalue=9e-42,
Organism=Saccharomyces cerevisiae, GI6319704, Length=414, Percent_Identity=39.3719806763285, Blast_Score=258, Evalue=1e-69,
Organism=Drosophila melanogaster, GI24648291, Length=315, Percent_Identity=43.4920634920635, Blast_Score=269, Evalue=3e-72,
Organism=Drosophila melanogaster, GI24648289, Length=315, Percent_Identity=43.4920634920635, Blast_Score=269, Evalue=3e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPX_BORBU (O51557)

Other databases:

- EMBL:   AE000783
- PIR:   C70176
- RefSeq:   NP_212746.1
- ProteinModelPortal:   O51557
- SMR:   O51557
- EnsemblBacteria:   EBBORT00000008815
- GeneID:   1195461
- GenomeReviews:   AE000783_GR
- KEGG:   bbu:BB0612
- NMPDR:   fig|224326.1.peg.996
- TIGR:   BB_0612
- GeneTree:   EBGT00050000007076
- HOGENOM:   HBG745965
- OMA:   CGKSQEQ
- ProtClustDB:   PRK05342
- BioCyc:   BBUR224326:BB_0612-MONOMER
- GO:   GO:0005622
- HAMAP:   MF_00175
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004487
- InterPro:   IPR002078
- InterPro:   IPR010603
- PANTHER:   PTHR11262:SF4
- PRINTS:   PR00300
- SMART:   SM00382
- TIGRFAMs:   TIGR00382

Pfam domain/function: PF07724 AAA_2; PF10431 ClpB_D2-small; PF06689 zf-C4_ClpX

EC number: NA

Molecular weight: Translated: 47602; Mature: 47471

Theoretical pI: Translated: 8.04; Mature: 8.04

Prosite motif: PS00676 SIGMA54_INTERACT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARVKGQKVKECSFCGLSVAELGGNVVISNGVAICPECSKICHNLFKEKLCKPLDSKSNG
CCCCCCCCCCHHHHCCCCHHHCCCCEEEECCEEECCHHHHHHHHHHHHHHCCCCCCCCCC
LPTPKQLKDHLDMYVVGQEDAKKVLSVAVYNHYKRILKNNKYDNGIEIEKSNILLVGPTG
CCCHHHHHHCCCEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCEEEEECCC
SGKTLLAKTLAAEMNVPFAIADATTLTEAGYVGEDVENILLKLIHAAHGDVSLAEKGIIY
CCCHHHHHHHHHHCCCCEEEECCHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHCCCCEE
IDEIDKIAKKNENVSITRDVSGEGVQQALLKIIEGTVANVPPRGGRKHPYEDTIEINTQN
EHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCHHCCCCCCCCCCCCCCCEEEECCCE
ILFICGGAFVGLENIVKNRINKSSIGFSAIEKKNIREDTSLKYLEMEDLIKFGLIPEFVG
EEEEECCHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCEEEECHHHHHHHCCCHHHHH
RLPVHSYLEKLNKEDLLRILVDPQNSIVKQYYHMFKMDNVELVFEKDALESIVDEAILKN
CCCHHHHHHHHCHHHHHEEEECCHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHC
TGARGLRSILEGLLKDVMFEVPSISKAKKVVVTKESVLNADVNPLILVGNAIKKPWAKEL
CCHHHHHHHHHHHHHHHHHHCCCCCCHHEEEEEHHHHHCCCCCCEEEECCHHCCHHHHHH
YEINLKYDKK
HEEEEEECCC
>Mature Secondary Structure 
ARVKGQKVKECSFCGLSVAELGGNVVISNGVAICPECSKICHNLFKEKLCKPLDSKSNG
CCCCCCCCCHHHHCCCCHHHCCCCEEEECCEEECCHHHHHHHHHHHHHHCCCCCCCCCC
LPTPKQLKDHLDMYVVGQEDAKKVLSVAVYNHYKRILKNNKYDNGIEIEKSNILLVGPTG
CCCHHHHHHCCCEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCEEEEECCC
SGKTLLAKTLAAEMNVPFAIADATTLTEAGYVGEDVENILLKLIHAAHGDVSLAEKGIIY
CCCHHHHHHHHHHCCCCEEEECCHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHCCCCEE
IDEIDKIAKKNENVSITRDVSGEGVQQALLKIIEGTVANVPPRGGRKHPYEDTIEINTQN
EHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCHHCCCCCCCCCCCCCCCEEEECCCE
ILFICGGAFVGLENIVKNRINKSSIGFSAIEKKNIREDTSLKYLEMEDLIKFGLIPEFVG
EEEEECCHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCEEEECHHHHHHHCCCHHHHH
RLPVHSYLEKLNKEDLLRILVDPQNSIVKQYYHMFKMDNVELVFEKDALESIVDEAILKN
CCCHHHHHHHHCHHHHHEEEECCHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHC
TGARGLRSILEGLLKDVMFEVPSISKAKKVVVTKESVLNADVNPLILVGNAIKKPWAKEL
CCHHHHHHHHHHHHHHHHHHCCCCCCHHEEEEEHHHHHCCCCCCEEEECCHHCCHHHHHH
YEINLKYDKK
HEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9403685