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The map label for this gene is pyrG [H]

Identifier: 15594920

GI number: 15594920

Start: 588066

End: 589667

Strand: Direct

Name: pyrG [H]

Synonym: BB0575

Alternate gene names: 15594920

Gene position: 588066-589667 (Clockwise)

Preceding gene: 15594919

Following gene: 15594922

Centisome position: 64.57

GC content: 32.33

Gene sequence:

>1602_bases
ATGAAAAAAAACTTAAAGATTTTAGTAATAACAGGAGGCGTGATCTCTGGAATTGGTAAAGGAGTTACATCGGCAAGTAT
TGCAAGGTTGTTTAGATATGATTTTAGAGTTACTCCAATTAAATGTGATGGGTATTTAAATACTGATCCTGGTACTATTA
ATCCTGTTGAGCACGGAGAAGTTTTTGTGCTTGATGATGGAGGAGAGGTTGATATGGACTTTGGTCATTACGAGAGGTTT
TTAAATCTTAATGCCAAGTCTAGTTGGAACATTACAATGGGCAAAATATACAAAAAGATACTTGAAAATGAGCGAAAGGG
TAAATATTTGGGAAGAACAGTTCAGCTTATTCCCCATGTTACTGATGAGATCAAATCTACAATTTTTCAGATTGCAAGTT
CTGAGAATAGTGATATGTTGATAATTGAAATTGGTGGAACCGTAGGAGATATGGAAAATATTTTATTTATTGAGACAGTA
AGACAAATAAGACAGGAGATTGGGAGTGGTAATATTTCTTTTATTCATTTAACATATGTGCCAAGTCCAGCTGGAATTAA
TGAGCAAAAATCTAAACCTACTCAACAAAGTGTTAAAACCTTAAATAAAGCAGGTATTTTCCCCGATTTAATTATTGCTA
GAAGTTCACAAGTATTGACAGACCAAATCAGAAAAAAAGTGGCAATGTTTTGCAATGTTGAGAGCACTTCTATTATTGAC
AATGTTGATGTTTCTACTATTTATGAAATTCCTATATCTTTTTATAAGCAGGGTGTACATGAGATTTTAAGCTCTAAGTT
AAATATTAAGGTTGATCCAAAAATAGAAGAGCTTTCAAAGCTTGTAGGAGTTATAAAATCTAATTTTTTTGTGCCTAAAA
AAATTATTAATATTGCTATTTGTGGTAAATATGCTGAACTTGATGATTCTTATGCATCAATTAGAGAGTCTTTGGTTCAT
GTTGCAGCCCATTTGGATTTGCTTATTAAAAGCACTTTAATTGATTCTAATGATTTAAATGAGAGCTGTTTAAAAGAGTT
TGACGGCATTATTGTTCCTGGCGGCTTTGGAGGCAAAGGATATGAAGGTAAAATTATGGCTATTAAATATGCTCGTGAGA
ATAATATTCCCTTTCTTGGAATTTGTCTTGGTTTGCAGCTTGCTGTAATAGAATTTGCTCGTAATGTTTGTGGAATACTT
GATGCTGATACGGAGGAAAATTTAGCAAGAGACAAGCCCTTAAAAAGTCCTGTTATCCATTTACTTCCTGAGCAAAAGGG
AATTAAAGATAAGGGCGCTACAATGAGGCTTGGTGGATATCCTGTGATTCTTAAAAAGAATACAATAGCTTTTAAACTTT
ATGGCCAAGATCGGATAATTGAAAGATTTAGACATAGGTATGAAGTCAATAATGATTATATAGATTTATTTGCAAAAAAT
GGGCTTATAGTATCTGGATTTTCAAGTGATTTTAAAATGGCAAAATTAATAGAAATTCCTGAAAATAAATTTTTCGTAGC
TTGCCAGTTTCATCCAGAACTTATTACAAGAATAGAAAATCCAGCCAAGCTTTTTCTAGGATTAATTAAAGCTTGTATTT
GA

Upstream 100 bases:

>100_bases
TGTTTGTTTTAATGCAAGTATATTTTATTATGATTTGTGAATTCTTTTTAAGCATAAGCTTAATTGGATTGAAATTTAAA
GTTTTAATTTTGGGGTATAC

Downstream 100 bases:

>100_bases
GTGTCTATTTGGTTTTTTAGTGAGTAGGCAGGTTTCCAAAATTAATGTTTGTAGTGTTCTCAAATTGCAATATTTTATAG
CTTAAAAATAATTTAGAGAA

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase [H]

Number of amino acids: Translated: 533; Mature: 533

Protein sequence:

>533_residues
MKKNLKILVITGGVISGIGKGVTSASIARLFRYDFRVTPIKCDGYLNTDPGTINPVEHGEVFVLDDGGEVDMDFGHYERF
LNLNAKSSWNITMGKIYKKILENERKGKYLGRTVQLIPHVTDEIKSTIFQIASSENSDMLIIEIGGTVGDMENILFIETV
RQIRQEIGSGNISFIHLTYVPSPAGINEQKSKPTQQSVKTLNKAGIFPDLIIARSSQVLTDQIRKKVAMFCNVESTSIID
NVDVSTIYEIPISFYKQGVHEILSSKLNIKVDPKIEELSKLVGVIKSNFFVPKKIINIAICGKYAELDDSYASIRESLVH
VAAHLDLLIKSTLIDSNDLNESCLKEFDGIIVPGGFGGKGYEGKIMAIKYARENNIPFLGICLGLQLAVIEFARNVCGIL
DADTEENLARDKPLKSPVIHLLPEQKGIKDKGATMRLGGYPVILKKNTIAFKLYGQDRIIERFRHRYEVNNDYIDLFAKN
GLIVSGFSSDFKMAKLIEIPENKFFVACQFHPELITRIENPAKLFLGLIKACI

Sequences:

>Translated_533_residues
MKKNLKILVITGGVISGIGKGVTSASIARLFRYDFRVTPIKCDGYLNTDPGTINPVEHGEVFVLDDGGEVDMDFGHYERF
LNLNAKSSWNITMGKIYKKILENERKGKYLGRTVQLIPHVTDEIKSTIFQIASSENSDMLIIEIGGTVGDMENILFIETV
RQIRQEIGSGNISFIHLTYVPSPAGINEQKSKPTQQSVKTLNKAGIFPDLIIARSSQVLTDQIRKKVAMFCNVESTSIID
NVDVSTIYEIPISFYKQGVHEILSSKLNIKVDPKIEELSKLVGVIKSNFFVPKKIINIAICGKYAELDDSYASIRESLVH
VAAHLDLLIKSTLIDSNDLNESCLKEFDGIIVPGGFGGKGYEGKIMAIKYARENNIPFLGICLGLQLAVIEFARNVCGIL
DADTEENLARDKPLKSPVIHLLPEQKGIKDKGATMRLGGYPVILKKNTIAFKLYGQDRIIERFRHRYEVNNDYIDLFAKN
GLIVSGFSSDFKMAKLIEIPENKFFVACQFHPELITRIENPAKLFLGLIKACI
>Mature_533_residues
MKKNLKILVITGGVISGIGKGVTSASIARLFRYDFRVTPIKCDGYLNTDPGTINPVEHGEVFVLDDGGEVDMDFGHYERF
LNLNAKSSWNITMGKIYKKILENERKGKYLGRTVQLIPHVTDEIKSTIFQIASSENSDMLIIEIGGTVGDMENILFIETV
RQIRQEIGSGNISFIHLTYVPSPAGINEQKSKPTQQSVKTLNKAGIFPDLIIARSSQVLTDQIRKKVAMFCNVESTSIID
NVDVSTIYEIPISFYKQGVHEILSSKLNIKVDPKIEELSKLVGVIKSNFFVPKKIINIAICGKYAELDDSYASIRESLVH
VAAHLDLLIKSTLIDSNDLNESCLKEFDGIIVPGGFGGKGYEGKIMAIKYARENNIPFLGICLGLQLAVIEFARNVCGIL
DADTEENLARDKPLKSPVIHLLPEQKGIKDKGATMRLGGYPVILKKNTIAFKLYGQDRIIERFRHRYEVNNDYIDLFAKN
GLIVSGFSSDFKMAKLIEIPENKFFVACQFHPELITRIENPAKLFLGLIKACI

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen [H]

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI148491070, Length=552, Percent_Identity=39.6739130434783, Blast_Score=408, Evalue=1e-114,
Organism=Homo sapiens, GI28559085, Length=550, Percent_Identity=40.9090909090909, Blast_Score=403, Evalue=1e-112,
Organism=Homo sapiens, GI28559083, Length=550, Percent_Identity=40.9090909090909, Blast_Score=403, Evalue=1e-112,
Organism=Homo sapiens, GI221316689, Length=550, Percent_Identity=40.9090909090909, Blast_Score=403, Evalue=1e-112,
Organism=Escherichia coli, GI1789142, Length=540, Percent_Identity=41.1111111111111, Blast_Score=407, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI25148299, Length=611, Percent_Identity=36.1702127659575, Blast_Score=382, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6319432, Length=560, Percent_Identity=39.6428571428571, Blast_Score=397, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6322563, Length=563, Percent_Identity=39.4316163410302, Blast_Score=396, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24664469, Length=553, Percent_Identity=40.3254972875226, Blast_Score=403, Evalue=1e-112,
Organism=Drosophila melanogaster, GI21357815, Length=497, Percent_Identity=39.2354124748491, Blast_Score=350, Evalue=1e-96,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase [H]

EC number: =6.3.4.2 [H]

Molecular weight: Translated: 59399; Mature: 59399

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKNLKILVITGGVISGIGKGVTSASIARLFRYDFRVTPIKCDGYLNTDPGTINPVEHGE
CCCCCEEEEEECHHHHHHCCCCHHHHHHHHHHHCCEEEEEEECCEECCCCCCCCCCCCCE
VFVLDDGGEVDMDFGHYERFLNLNAKSSWNITMGKIYKKILENERKGKYLGRTVQLIPHV
EEEEECCCCCCCCHHHHHHHEECCCCCCCCEEHHHHHHHHHCCCCCCCHHCHHHHHHHHH
TDEIKSTIFQIASSENSDMLIIEIGGTVGDMENILFIETVRQIRQEIGSGNISFIHLTYV
HHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEC
PSPAGINEQKSKPTQQSVKTLNKAGIFPDLIIARSSQVLTDQIRKKVAMFCNVESTSIID
CCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCC
NVDVSTIYEIPISFYKQGVHEILSSKLNIKVDPKIEELSKLVGVIKSNFFVPKKIINIAI
CCCHHHHHHCCHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHCCCCCCHHHEEEEE
CGKYAELDDSYASIRESLVHVAAHLDLLIKSTLIDSNDLNESCLKEFDGIIVPGGFGGKG
ECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCEEEECCCCCCC
YEGKIMAIKYARENNIPFLGICLGLQLAVIEFARNVCGILDADTEENLARDKPLKSPVIH
CCCEEEEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCEE
LLPEQKGIKDKGATMRLGGYPVILKKNTIAFKLYGQDRIIERFRHRYEVNNDYIDLFAKN
ECCCCCCCCCCCCEEEECCEEEEEECCEEEEEEECCHHHHHHHHHHHCCCCCEEEEEECC
GLIVSGFSSDFKMAKLIEIPENKFFVACQFHPELITRIENPAKLFLGLIKACI
CEEEECCCCCCCEEEEEECCCCCEEEEEEECHHHHHHCCCHHHHHHHHHHHHC
>Mature Secondary Structure
MKKNLKILVITGGVISGIGKGVTSASIARLFRYDFRVTPIKCDGYLNTDPGTINPVEHGE
CCCCCEEEEEECHHHHHHCCCCHHHHHHHHHHHCCEEEEEEECCEECCCCCCCCCCCCCE
VFVLDDGGEVDMDFGHYERFLNLNAKSSWNITMGKIYKKILENERKGKYLGRTVQLIPHV
EEEEECCCCCCCCHHHHHHHEECCCCCCCCEEHHHHHHHHHCCCCCCCHHCHHHHHHHHH
TDEIKSTIFQIASSENSDMLIIEIGGTVGDMENILFIETVRQIRQEIGSGNISFIHLTYV
HHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEC
PSPAGINEQKSKPTQQSVKTLNKAGIFPDLIIARSSQVLTDQIRKKVAMFCNVESTSIID
CCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCC
NVDVSTIYEIPISFYKQGVHEILSSKLNIKVDPKIEELSKLVGVIKSNFFVPKKIINIAI
CCCHHHHHHCCHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHCCCCCCHHHEEEEE
CGKYAELDDSYASIRESLVHVAAHLDLLIKSTLIDSNDLNESCLKEFDGIIVPGGFGGKG
ECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCEEEECCCCCCC
YEGKIMAIKYARENNIPFLGICLGLQLAVIEFARNVCGILDADTEENLARDKPLKSPVIH
CCCEEEEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCEE
LLPEQKGIKDKGATMRLGGYPVILKKNTIAFKLYGQDRIIERFRHRYEVNNDYIDLFAKN
ECCCCCCCCCCCCEEEECCEEEEEECCEEEEEEECCHHHHHHHHHHHCCCCCEEEEEECC
GLIVSGFSSDFKMAKLIEIPENKFFVACQFHPELITRIENPAKLFLGLIKACI
CEEEECCCCCCCEEEEEECCCCCEEEEEEECHHHHHHCCCHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA