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The map label for this gene is ytcA

Identifier: 16080138

GI number: 16080138

Start: 3155725

End: 3157011

Strand: Direct

Name: ytcA

Synonym: BSU30860

Alternate gene names: 16080138

Gene position: 3155725-3157011 (Clockwise)

Preceding gene: 50812282

Following gene: 16080139

Centisome position: 74.86

GC content: 46.62

Gene sequence:

>1287_bases
ATGAAAATTTGTGTGGTTGGCGCCGGGTATGTCGGTTTAACCCTATCAGCGGCACTGGCATCCATCGGACATGACATGAT
ATGCACAGACAAAGACGTCAAAAAAATCGGGCAGCTGAAAAAAGGAGTCATTCCCTTTTACGAGCCTGGGCTTTCAGATG
CAATACTTCGTTGCGGCAATCTCTCGTTTTCTTCTGAAGTGAAATCGAGCATGGAGGAATGTCCCGTTATTTTTATCGCA
GTCGGAACTCCGCCGCGTTCGGACGGATCAGCTGATACGAAAGCCCTGCAGTCCGTCATCGGTGATTTAAGCGAGGCGAT
CCGATCGTATAAAACCATTATTACGAAAAGCACTGTTCCGCCCGGGACAAATGAAAACATAGCAAAACAGCTGATTGCCT
CCGGAGTGTCTAAAAACCTCTTTAATATCGTATCCAATCCGGAGTTTCTGCGGGAAGGCAATGCCTTATATGACATGCTG
CATCCTGACAAAACAGTCATCGGTGTTCAGGAAGAAGATCACGTATCGGCAGCCATCGTCAAATCCATTTACAAACACAT
TGATACCCCTTTTATCGTTACAAGCTTAGCGGGAGCAGAGCTGATCAAATATGCCAACAATTTCTTTTTAGCGGCCAAAA
TTTCGTTCATTAACGAAATGGCCCGCATATGTGAAGCCTATCAATCAGATATCTCAGATATTTCCCGCGCTATCGGTCTA
GACCCAAGGATCGGGAAGCACTTTTTGCAGGCAGGCATCGGATACGGAGGCTCTTGTTTTCCAAAGGATCTGCAGGCGCT
GCAATTTGCTGCCCAGGAAAAAAACACGGAGACCTTCCTGCTCCGGGCCGTGCAGCACATTAATGACACCCAGCTTGGCC
TGTATATCAAAAAAATACAGTCATTCTTCGAAACACTTCAAGGCAAGAAAGCGGCTGTACTCGGCATTTCCTTCAAACCG
AATACTGATGACATCCGGAATTCTCAGGCTGTCAGACTGATGGAAAGGCTGGCGGAGCTGGGATGTGATGTTCATGCATA
TGATCCTGAAGCTGTACTTCCAGAACATTTGCGGCAACATGTAACTCAGCATTCTCAAGCTTTTGATGCGATCGAAGAGA
GTGACTTTTTATTTTTGGCGACAGAATGGTCTGAGTTTTTAGCGTTTGATTGGAAAAAGGCTGCAGATATCATGAAAGGG
CGTCTTGTGATTGACGGACGCAACGTACTAAAAAAAGAACTGATCGAGGCTTGCGGCCTGATCTGTACGGGAGTTGGCCG
TCCATGA

Upstream 100 bases:

>100_bases
ATTAGGCGGAAGCAACTGGGCAGAAAGCGGAATCACGAACCAGCCCTTTTTTAATAGGATATTGATATATGACCAGTAAT
CTTGTAAAGGAGCTCAGGTG

Downstream 100 bases:

>100_bases
AAATACTCGTCACAGGAGCAGCGGGCTTTATCGGCTCCCACCTCTGCGAAGAATTACTAAAAGATAAGAAACATAACGTT
ATCGGAATCGATGACTTTAT

Product: UDP-glucose dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MKICVVGAGYVGLTLSAALASIGHDMICTDKDVKKIGQLKKGVIPFYEPGLSDAILRCGNLSFSSEVKSSMEECPVIFIA
VGTPPRSDGSADTKALQSVIGDLSEAIRSYKTIITKSTVPPGTNENIAKQLIASGVSKNLFNIVSNPEFLREGNALYDML
HPDKTVIGVQEEDHVSAAIVKSIYKHIDTPFIVTSLAGAELIKYANNFFLAAKISFINEMARICEAYQSDISDISRAIGL
DPRIGKHFLQAGIGYGGSCFPKDLQALQFAAQEKNTETFLLRAVQHINDTQLGLYIKKIQSFFETLQGKKAAVLGISFKP
NTDDIRNSQAVRLMERLAELGCDVHAYDPEAVLPEHLRQHVTQHSQAFDAIEESDFLFLATEWSEFLAFDWKKAADIMKG
RLVIDGRNVLKKELIEACGLICTGVGRP

Sequences:

>Translated_428_residues
MKICVVGAGYVGLTLSAALASIGHDMICTDKDVKKIGQLKKGVIPFYEPGLSDAILRCGNLSFSSEVKSSMEECPVIFIA
VGTPPRSDGSADTKALQSVIGDLSEAIRSYKTIITKSTVPPGTNENIAKQLIASGVSKNLFNIVSNPEFLREGNALYDML
HPDKTVIGVQEEDHVSAAIVKSIYKHIDTPFIVTSLAGAELIKYANNFFLAAKISFINEMARICEAYQSDISDISRAIGL
DPRIGKHFLQAGIGYGGSCFPKDLQALQFAAQEKNTETFLLRAVQHINDTQLGLYIKKIQSFFETLQGKKAAVLGISFKP
NTDDIRNSQAVRLMERLAELGCDVHAYDPEAVLPEHLRQHVTQHSQAFDAIEESDFLFLATEWSEFLAFDWKKAADIMKG
RLVIDGRNVLKKELIEACGLICTGVGRP
>Mature_428_residues
MKICVVGAGYVGLTLSAALASIGHDMICTDKDVKKIGQLKKGVIPFYEPGLSDAILRCGNLSFSSEVKSSMEECPVIFIA
VGTPPRSDGSADTKALQSVIGDLSEAIRSYKTIITKSTVPPGTNENIAKQLIASGVSKNLFNIVSNPEFLREGNALYDML
HPDKTVIGVQEEDHVSAAIVKSIYKHIDTPFIVTSLAGAELIKYANNFFLAAKISFINEMARICEAYQSDISDISRAIGL
DPRIGKHFLQAGIGYGGSCFPKDLQALQFAAQEKNTETFLLRAVQHINDTQLGLYIKKIQSFFETLQGKKAAVLGISFKP
NTDDIRNSQAVRLMERLAELGCDVHAYDPEAVLPEHLRQHVTQHSQAFDAIEESDFLFLATEWSEFLAFDWKKAADIMKG
RLVIDGRNVLKKELIEACGLICTGVGRP

Specific function: Catalyzes the conversion of UDP-glucose into UDP- glucuronate, one of the precursors of teichuronic acid

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family

Homologues:

Organism=Homo sapiens, GI4507813, Length=441, Percent_Identity=31.7460317460317, Blast_Score=222, Evalue=5e-58,
Organism=Homo sapiens, GI296040438, Length=344, Percent_Identity=31.3953488372093, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI296040443, Length=321, Percent_Identity=31.1526479750779, Blast_Score=158, Evalue=9e-39,
Organism=Escherichia coli, GI1788340, Length=383, Percent_Identity=28.7206266318538, Blast_Score=145, Evalue=5e-36,
Organism=Escherichia coli, GI48994968, Length=440, Percent_Identity=25, Blast_Score=118, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI17560350, Length=456, Percent_Identity=32.2368421052632, Blast_Score=215, Evalue=3e-56,
Organism=Drosophila melanogaster, GI17136908, Length=459, Percent_Identity=35.0762527233115, Blast_Score=271, Evalue=9e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): YTCA_BACSU (O34862)

Other databases:

- EMBL:   AF008220
- EMBL:   AL009126
- PIR:   G69988
- RefSeq:   NP_390964.1
- HSSP:   P11759
- ProteinModelPortal:   O34862
- SMR:   O34862
- EnsemblBacteria:   EBBACT00000003197
- GeneID:   936155
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU30860
- NMPDR:   fig|224308.1.peg.3089
- GenoList:   BSU30860
- GeneTree:   EBGT00050000001585
- HOGENOM:   HBG400967
- OMA:   INEMARI
- PhylomeDB:   O34862
- ProtClustDB:   CLSK887767
- BioCyc:   BSUB:BSU30860-MONOMER
- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732
- Gene3D:   G3DSA:1.20.5.100
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR11374
- PIRSF:   PIRSF000124
- TIGRFAMs:   TIGR03026

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N; SSF48179 6DGDH_C_like; SSF52413 UDP-Glc/GDP-Man_DH_C

EC number: =1.1.1.22

Molecular weight: Translated: 46833; Mature: 46833

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: ACT_SITE 259-259

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKICVVGAGYVGLTLSAALASIGHDMICTDKDVKKIGQLKKGVIPFYEPGLSDAILRCGN
CEEEEEECCHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHCCCCCCCCCHHHHHHHHCC
LSFSSEVKSSMEECPVIFIAVGTPPRSDGSADTKALQSVIGDLSEAIRSYKTIITKSTVP
CCCHHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PGTNENIAKQLIASGVSKNLFNIVSNPEFLREGNALYDMLHPDKTVIGVQEEDHVSAAIV
CCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHHHHCCCCCEEECCCCHHHHHHHHH
KSIYKHIDTPFIVTSLAGAELIKYANNFFLAAKISFINEMARICEAYQSDISDISRAIGL
HHHHHHCCCCHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DPRIGKHFLQAGIGYGGSCFPKDLQALQFAAQEKNTETFLLRAVQHINDTQLGLYIKKIQ
CCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHH
SFFETLQGKKAAVLGISFKPNTDDIRNSQAVRLMERLAELGCDVHAYDPEAVLPEHLRQH
HHHHHHCCCCEEEEEEEECCCCHHHCCHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHH
VTQHSQAFDAIEESDFLFLATEWSEFLAFDWKKAADIMKGRLVIDGRNVLKKELIEACGL
HHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHHHH
ICTGVGRP
HHHCCCCC
>Mature Secondary Structure
MKICVVGAGYVGLTLSAALASIGHDMICTDKDVKKIGQLKKGVIPFYEPGLSDAILRCGN
CEEEEEECCHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHCCCCCCCCCHHHHHHHHCC
LSFSSEVKSSMEECPVIFIAVGTPPRSDGSADTKALQSVIGDLSEAIRSYKTIITKSTVP
CCCHHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PGTNENIAKQLIASGVSKNLFNIVSNPEFLREGNALYDMLHPDKTVIGVQEEDHVSAAIV
CCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHHHHCCCCCEEECCCCHHHHHHHHH
KSIYKHIDTPFIVTSLAGAELIKYANNFFLAAKISFINEMARICEAYQSDISDISRAIGL
HHHHHHCCCCHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DPRIGKHFLQAGIGYGGSCFPKDLQALQFAAQEKNTETFLLRAVQHINDTQLGLYIKKIQ
CCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHH
SFFETLQGKKAAVLGISFKPNTDDIRNSQAVRLMERLAELGCDVHAYDPEAVLPEHLRQH
HHHHHHCCCCEEEEEEEECCCCHHHCCHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHH
VTQHSQAFDAIEESDFLFLATEWSEFLAFDWKKAADIMKGRLVIDGRNVLKKELIEACGL
HHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHHHH
ICTGVGRP
HHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377